Chloroquine potentiates the anti-cancer effect of lidamycin on non-small cell lung cancer cells in vitro.
Identifieur interne : 001031 ( Main/Exploration ); précédent : 001030; suivant : 001032Chloroquine potentiates the anti-cancer effect of lidamycin on non-small cell lung cancer cells in vitro.
Auteurs : Fang Liu [République populaire de Chine] ; Yue Shang [République populaire de Chine] ; Shu-Zhen Chen [République populaire de Chine]Source :
- Acta pharmacologica Sinica [ 1745-7254 ] ; 2014.
Descripteurs français
- KwdFr :
- Aminosides (administration et posologie), Animaux, Antinéoplasiques (administration et posologie), Apoptose (), Carcinome pulmonaire non à petites cellules (métabolisme), Carcinome pulmonaire non à petites cellules (traitement médicamenteux), Caspase-3 (métabolisme), Chloroquine (administration et posologie), Femelle, Humains, Lignée cellulaire tumorale, Poly(ADP-ribose) polymerases (métabolisme), Protocoles de polychimiothérapie antinéoplasique (pharmacologie), Protéine Bax (métabolisme), Protéine p53 suppresseur de tumeur (métabolisme), Protéines associées aux microtubules (métabolisme), Souris, Souris de lignée BALB C, Souris nude, Synergie des médicaments, Tumeurs du poumon (métabolisme), Tumeurs du poumon (traitement médicamenteux), Ènediynes (administration et posologie).
- MESH :
- administration et posologie : Aminosides, Antinéoplasiques, Chloroquine, Ènediynes.
- métabolisme : Carcinome pulmonaire non à petites cellules, Caspase-3, Poly(ADP-ribose) polymerases, Protéine Bax, Protéine p53 suppresseur de tumeur, Protéines associées aux microtubules, Tumeurs du poumon.
- pharmacologie : Protocoles de polychimiothérapie antinéoplasique.
- traitement médicamenteux : Carcinome pulmonaire non à petites cellules, Tumeurs du poumon.
- Animaux, Apoptose, Femelle, Humains, Lignée cellulaire tumorale, Souris, Souris de lignée BALB C, Souris nude, Synergie des médicaments.
English descriptors
- KwdEn :
- Aminoglycosides (administration & dosage), Animals, Antineoplastic Agents (administration & dosage), Antineoplastic Combined Chemotherapy Protocols (pharmacology), Apoptosis (drug effects), Carcinoma, Non-Small-Cell Lung (drug therapy), Carcinoma, Non-Small-Cell Lung (metabolism), Caspase 3 (metabolism), Cell Line, Tumor, Chloroquine (administration & dosage), Drug Synergism, Enediynes (administration & dosage), Female, Humans, Lung Neoplasms (drug therapy), Lung Neoplasms (metabolism), Mice, Mice, Inbred BALB C, Mice, Nude, Microtubule-Associated Proteins (metabolism), Poly(ADP-ribose) Polymerases (metabolism), Tumor Suppressor Protein p53 (metabolism), bcl-2-Associated X Protein (metabolism).
- MESH :
- chemical , administration & dosage : Aminoglycosides, Antineoplastic Agents, Chloroquine, Enediynes.
- drug effects : Apoptosis.
- drug therapy : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- metabolism : Carcinoma, Non-Small-Cell Lung, Caspase 3, Lung Neoplasms, Microtubule-Associated Proteins, Poly(ADP-ribose) Polymerases, Tumor Suppressor Protein p53, bcl-2-Associated X Protein.
- pharmacology : Antineoplastic Combined Chemotherapy Protocols.
- Animals, Cell Line, Tumor, Drug Synergism, Female, Humans, Mice, Mice, Inbred BALB C, Mice, Nude.
Abstract
To assess the synergistic actions of lidamycin (LDM) and chloroquine (CQ), a lysosomal enzyme inhibitor, in human non-small cell lung cancer (NSCLC) cells, and to elucidate the potential mechanisms.
DOI: 10.1038/aps.2014.3
PubMed: 24727941
Affiliations:
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Le document en format XML
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Combined Chemotherapy Protocols</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Drug Synergism</term><term>Female</term><term>Humans</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Nude</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Apoptose</term><term>Femelle</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris nude</term><term>Synergie des médicaments</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To assess the synergistic actions of lidamycin (LDM) and chloroquine (CQ), a lysosomal enzyme inhibitor, in human non-small cell lung cancer (NSCLC) cells, and to elucidate the potential mechanisms.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Fang" sort="Liu, Fang" uniqKey="Liu F" first="Fang" last="Liu">Fang Liu</name></noRegion><name sortKey="Chen, Shu Zhen" sort="Chen, Shu Zhen" uniqKey="Chen S" first="Shu-Zhen" last="Chen">Shu-Zhen Chen</name><name sortKey="Shang, Yue" sort="Shang, Yue" uniqKey="Shang Y" first="Yue" last="Shang">Yue Shang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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