Cisplatin-mediated radiosensitization of non-small cell lung cancer cells is stimulated by ATM inhibition.
Identifieur interne : 001030 ( Main/Exploration ); précédent : 001029; suivant : 001031Cisplatin-mediated radiosensitization of non-small cell lung cancer cells is stimulated by ATM inhibition.
Auteurs : Mahmoud Toulany [Allemagne] ; Julia Mihatsch [Allemagne] ; Marina Holler [Allemagne] ; Hassan Chaachouay [Suisse] ; H Peter Rodemann [Allemagne]Source :
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [ 1879-0887 ] ; 2014.
Descripteurs français
- KwdFr :
- AMP-Activated Protein Kinases (métabolisme), Activation enzymatique (), Apoptose (), Carcinome pulmonaire non à petites cellules (anatomopathologie), Carcinome pulmonaire non à petites cellules (radiothérapie), Cassures double-brin de l'ADN (), Cisplatine (pharmacologie), Cycle cellulaire (), Fibroblastes (), Fibroblastes (effets des radiations), Humains, Lignée cellulaire tumorale, Protéine p53 suppresseur de tumeur (métabolisme), Protéines mutées dans l'ataxie-télangiectasie (antagonistes et inhibiteurs), Protéines mutées dans l'ataxie-télangiectasie (physiologie), Radiosensibilisants (pharmacologie), Radiotolérance (), Radiotolérance (physiologie), Réparation de l'ADN (), Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (radiothérapie).
- MESH :
- anatomopathologie : Carcinome pulmonaire non à petites cellules, Tumeurs du poumon.
- antagonistes et inhibiteurs : Protéines mutées dans l'ataxie-télangiectasie.
- effets des radiations : Fibroblastes.
- métabolisme : AMP-Activated Protein Kinases, Protéine p53 suppresseur de tumeur.
- pharmacologie : Cisplatine, Radiosensibilisants.
- physiologie : Protéines mutées dans l'ataxie-télangiectasie, Radiotolérance.
- radiothérapie : Carcinome pulmonaire non à petites cellules, Tumeurs du poumon.
- Activation enzymatique, Apoptose, Cassures double-brin de l'ADN, Cycle cellulaire, Fibroblastes, Humains, Lignée cellulaire tumorale, Radiotolérance, Réparation de l'ADN.
English descriptors
- KwdEn :
- AMP-Activated Protein Kinases (metabolism), Apoptosis (drug effects), Ataxia Telangiectasia Mutated Proteins (antagonists & inhibitors), Ataxia Telangiectasia Mutated Proteins (physiology), Carcinoma, Non-Small-Cell Lung (pathology), Carcinoma, Non-Small-Cell Lung (radiotherapy), Cell Cycle (drug effects), Cell Line, Tumor, Cisplatin (pharmacology), DNA Breaks, Double-Stranded (drug effects), DNA Repair (drug effects), Enzyme Activation (drug effects), Fibroblasts (drug effects), Fibroblasts (radiation effects), Humans, Lung Neoplasms (pathology), Lung Neoplasms (radiotherapy), Radiation Tolerance (drug effects), Radiation Tolerance (physiology), Radiation-Sensitizing Agents (pharmacology), Tumor Suppressor Protein p53 (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Ataxia Telangiectasia Mutated Proteins.
- chemical , metabolism : AMP-Activated Protein Kinases, Tumor Suppressor Protein p53.
- drug effects : Apoptosis, Cell Cycle, DNA Breaks, Double-Stranded, DNA Repair, Enzyme Activation, Fibroblasts, Radiation Tolerance.
- pathology : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- chemical , pharmacology : Cisplatin, Radiation-Sensitizing Agents.
- chemical , physiology : Ataxia Telangiectasia Mutated Proteins, Radiation Tolerance.
- radiation effects : Fibroblasts.
- radiotherapy : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- Cell Line, Tumor, Humans.
Abstract
Cisplatin activates ataxia-telangiectasia-mutated (ATM), a protein with roles in DNA repair, cell cycle progression and autophagy. We investigated the radiosensitizing effect of cisplatin with respect to its effect on ATM pathway activation.
DOI: 10.1016/j.radonc.2014.04.001
PubMed: 24857596
Affiliations:
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Le document en format XML
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Section of Radiation Oncology, Vetsuisse Faculty, University of Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tuebingen, Germany; Section of Radiation Oncology, Vetsuisse Faculty, University of Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName><orgName type="university">Université de Zurich</orgName></affiliation></author><author><name sortKey="Rodemann, H Peter" sort="Rodemann, H Peter" uniqKey="Rodemann H" first="H Peter" last="Rodemann">H Peter Rodemann</name><affiliation wicri:level="1"><nlm:affiliation>Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tuebingen, Germany. Electronic address: hans-peter.rodemann@uni-tuebingen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tuebingen</wicri:regionArea><wicri:noRegion>Eberhard Karls University Tuebingen</wicri:noRegion><wicri:noRegion>Eberhard Karls University Tuebingen</wicri:noRegion><wicri:noRegion>Eberhard Karls University Tuebingen</wicri:noRegion></affiliation></author></analytic><series><title level="j">Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology</title><idno type="eISSN">1879-0887</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AMP-Activated Protein Kinases (metabolism)</term><term>Apoptosis (drug effects)</term><term>Ataxia Telangiectasia Mutated Proteins (antagonists & inhibitors)</term><term>Ataxia Telangiectasia Mutated Proteins (physiology)</term><term>Carcinoma, Non-Small-Cell Lung (pathology)</term><term>Carcinoma, Non-Small-Cell Lung (radiotherapy)</term><term>Cell Cycle (drug effects)</term><term>Cell Line, Tumor</term><term>Cisplatin (pharmacology)</term><term>DNA Breaks, Double-Stranded (drug effects)</term><term>DNA Repair (drug effects)</term><term>Enzyme Activation (drug effects)</term><term>Fibroblasts (drug effects)</term><term>Fibroblasts (radiation effects)</term><term>Humans</term><term>Lung Neoplasms (pathology)</term><term>Lung Neoplasms (radiotherapy)</term><term>Radiation Tolerance (drug effects)</term><term>Radiation Tolerance (physiology)</term><term>Radiation-Sensitizing Agents (pharmacology)</term><term>Tumor Suppressor Protein p53 (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>AMP-Activated Protein Kinases (métabolisme)</term><term>Activation enzymatique ()</term><term>Apoptose ()</term><term>Carcinome pulmonaire non à petites cellules (anatomopathologie)</term><term>Carcinome pulmonaire non à petites cellules (radiothérapie)</term><term>Cassures double-brin de l'ADN ()</term><term>Cisplatine (pharmacologie)</term><term>Cycle cellulaire ()</term><term>Fibroblastes ()</term><term>Fibroblastes (effets des radiations)</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Protéine p53 suppresseur de tumeur (métabolisme)</term><term>Protéines mutées dans l'ataxie-télangiectasie (antagonistes et inhibiteurs)</term><term>Protéines mutées dans l'ataxie-télangiectasie (physiologie)</term><term>Radiosensibilisants (pharmacologie)</term><term>Radiotolérance ()</term><term>Radiotolérance (physiologie)</term><term>Réparation de l'ADN ()</term><term>Tumeurs du poumon (anatomopathologie)</term><term>Tumeurs du poumon (radiothérapie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Ataxia Telangiectasia Mutated Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>AMP-Activated Protein Kinases</term><term>Tumor Suppressor Protein p53</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéines mutées dans l'ataxie-télangiectasie</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Cell Cycle</term><term>DNA Breaks, Double-Stranded</term><term>DNA Repair</term><term>Enzyme Activation</term><term>Fibroblasts</term><term>Radiation Tolerance</term></keywords><keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Fibroblastes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>AMP-Activated Protein Kinases</term><term>Protéine p53 suppresseur de tumeur</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Cisplatine</term><term>Radiosensibilisants</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Cisplatin</term><term>Radiation-Sensitizing Agents</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Protéines mutées dans l'ataxie-télangiectasie</term><term>Radiotolérance</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Ataxia Telangiectasia Mutated Proteins</term><term>Radiation Tolerance</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Fibroblasts</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation enzymatique</term><term>Apoptose</term><term>Cassures double-brin de l'ADN</term><term>Cycle cellulaire</term><term>Fibroblastes</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Radiotolérance</term><term>Réparation de l'ADN</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cisplatin activates ataxia-telangiectasia-mutated (ATM), a protein with roles in DNA repair, cell cycle progression and autophagy. We investigated the radiosensitizing effect of cisplatin with respect to its effect on ATM pathway activation.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Suisse</li></country><region><li>Canton de Zurich</li></region><settlement><li>Zurich</li></settlement><orgName><li>Université de Zurich</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Toulany, Mahmoud" sort="Toulany, Mahmoud" uniqKey="Toulany M" first="Mahmoud" last="Toulany">Mahmoud Toulany</name></noRegion><name sortKey="Holler, Marina" sort="Holler, Marina" uniqKey="Holler M" first="Marina" last="Holler">Marina Holler</name><name sortKey="Mihatsch, Julia" sort="Mihatsch, Julia" uniqKey="Mihatsch J" first="Julia" last="Mihatsch">Julia Mihatsch</name><name sortKey="Rodemann, H Peter" sort="Rodemann, H Peter" uniqKey="Rodemann H" first="H Peter" last="Rodemann">H Peter Rodemann</name></country><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Chaachouay, Hassan" sort="Chaachouay, Hassan" uniqKey="Chaachouay H" first="Hassan" last="Chaachouay">Hassan Chaachouay</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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