Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells.
Identifieur interne : 000D61 ( Main/Exploration ); précédent : 000D60; suivant : 000D62Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells.
Auteurs : Lili Zhang [République populaire de Chine] ; Shuli Man [République populaire de Chine] ; Yongshuai Wang [République populaire de Chine] ; Jing Liu [République populaire de Chine] ; Zhen Liu [République populaire de Chine] ; Peng Yu [République populaire de Chine] ; Wenyuan Gao [République populaire de Chine]Source :
- Chemico-biological interactions [ 1872-7786 ] ; 2016.
Descripteurs français
- KwdFr :
- Acétylcystéine (pharmacologie), Apoptose (), Autophagie (), Cellules A549, Chloroquine (toxicité), Espèces réactives de l'oxygène (métabolisme), Glutathion (métabolisme), Humains, JNK Mitogen-Activated Protein Kinases (métabolisme), Lignée cellulaire, Microscopie de fluorescence, Microscopie électronique à transmission, Phosphatidylinositol 3-kinases (métabolisme), Protéines proto-oncogènes c-akt (métabolisme), Rhizome (), Rhizome (métabolisme), Saponines (pharmacologie), Technique de Western, Transduction du signal (), Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (métabolisme).
- MESH :
- anatomopathologie : Tumeurs du poumon.
- métabolisme : Espèces réactives de l'oxygène, Glutathion, JNK Mitogen-Activated Protein Kinases, Phosphatidylinositol 3-kinases, Protéines proto-oncogènes c-akt, Rhizome, Tumeurs du poumon.
- pharmacologie : Acétylcystéine, Saponines.
- toxicité : Chloroquine.
- Apoptose, Autophagie, Cellules A549, Humains, Lignée cellulaire, Microscopie de fluorescence, Microscopie électronique à transmission, Rhizome, Technique de Western, Transduction du signal.
English descriptors
- KwdEn :
- A549 Cells, Acetylcysteine (pharmacology), Apoptosis (drug effects), Autophagy (drug effects), Blotting, Western, Cell Line, Chloroquine (toxicity), Glutathione (metabolism), Humans, JNK Mitogen-Activated Protein Kinases (metabolism), Lung Neoplasms (metabolism), Lung Neoplasms (pathology), Microscopy, Electron, Transmission, Microscopy, Fluorescence, Phosphatidylinositol 3-Kinases (metabolism), Proto-Oncogene Proteins c-akt (metabolism), Reactive Oxygen Species (metabolism), Rhizome (chemistry), Rhizome (metabolism), Saponins (pharmacology), Signal Transduction (drug effects).
- MESH :
- chemical , metabolism : Glutathione, JNK Mitogen-Activated Protein Kinases, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Reactive Oxygen Species.
- chemical , pharmacology : Acetylcysteine, Saponins.
- chemistry : Rhizome.
- drug effects : Apoptosis, Autophagy, Signal Transduction.
- metabolism : Lung Neoplasms, Rhizome.
- pathology : Lung Neoplasms.
- chemical , toxicity : Chloroquine.
- A549 Cells, Blotting, Western, Cell Line, Humans, Microscopy, Electron, Transmission, Microscopy, Fluorescence.
Abstract
Paris Saponin II (PSII) has been shown anticancer activity against several cancer lines through the pro-apoptotic pathway. The aim of the study was to investigate the relationship between apoptosis and autophagy taking part in the anti-cancer mechanisms of PSII. In this study, PSII induced autophagy and apoptosis in dose- and time-dependent manners. Meanwhile, it induced autophagy as early as 2 h after exposure to 1 μM of PSII accompanying with apoptosis. Blockade of autophagy with chloroquine (CQ) attenuated apoptosis, while regulation of reactive oxygen species (ROS) by N-acetyl cysteine (NAC), gallic acid (GA) and H2O2 could not influence autophagy. In addition, PSII induced apoptosis via activation of autophagy, which might be associated with the activation of JNK and inhibition of PI3K/AKT/mTOR pathway. All in all, our research increased the understanding of the role of PSII regulating autophagy and apoptosis, which would hopefully provide prospective strategies for cancer therapy.
DOI: 10.1016/j.cbi.2016.05.016
PubMed: 27180204
Affiliations:
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Electronic address: msl@tust.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China; Tianjin Key Laboratory of Industry Microbiology, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457</wicri:regionArea><wicri:noRegion>300457</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yongshuai" sort="Wang, Yongshuai" uniqKey="Wang Y" first="Yongshuai" last="Wang">Yongshuai Wang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457</wicri:regionArea><wicri:noRegion>300457</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Jing" sort="Liu, Jing" uniqKey="Liu J" first="Jing" last="Liu">Jing Liu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457</wicri:regionArea><wicri:noRegion>300457</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Zhen" sort="Liu, Zhen" uniqKey="Liu Z" first="Zhen" last="Liu">Zhen Liu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457</wicri:regionArea><wicri:noRegion>300457</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Peng" sort="Yu, Peng" uniqKey="Yu P" first="Peng" last="Yu">Peng Yu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457</wicri:regionArea><wicri:noRegion>300457</wicri:noRegion></affiliation></author><author><name sortKey="Gao, Wenyuan" sort="Gao, Wenyuan" uniqKey="Gao W" first="Wenyuan" last="Gao">Wenyuan Gao</name><affiliation wicri:level="1"><nlm:affiliation>Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, China. Electronic address: biochemgao@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072</wicri:regionArea><wicri:noRegion>300072</wicri:noRegion></affiliation></author></analytic><series><title level="j">Chemico-biological interactions</title><idno type="eISSN">1872-7786</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A549 Cells</term><term>Acetylcysteine (pharmacology)</term><term>Apoptosis (drug effects)</term><term>Autophagy (drug effects)</term><term>Blotting, Western</term><term>Cell Line</term><term>Chloroquine (toxicity)</term><term>Glutathione (metabolism)</term><term>Humans</term><term>JNK Mitogen-Activated Protein Kinases (metabolism)</term><term>Lung Neoplasms (metabolism)</term><term>Lung Neoplasms (pathology)</term><term>Microscopy, Electron, Transmission</term><term>Microscopy, Fluorescence</term><term>Phosphatidylinositol 3-Kinases (metabolism)</term><term>Proto-Oncogene Proteins c-akt (metabolism)</term><term>Reactive Oxygen Species (metabolism)</term><term>Rhizome (chemistry)</term><term>Rhizome (metabolism)</term><term>Saponins (pharmacology)</term><term>Signal Transduction (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acétylcystéine (pharmacologie)</term><term>Apoptose ()</term><term>Autophagie ()</term><term>Cellules A549</term><term>Chloroquine (toxicité)</term><term>Espèces réactives de l'oxygène (métabolisme)</term><term>Glutathion (métabolisme)</term><term>Humains</term><term>JNK Mitogen-Activated Protein Kinases (métabolisme)</term><term>Lignée cellulaire</term><term>Microscopie de fluorescence</term><term>Microscopie électronique à transmission</term><term>Phosphatidylinositol 3-kinases (métabolisme)</term><term>Protéines proto-oncogènes c-akt (métabolisme)</term><term>Rhizome ()</term><term>Rhizome (métabolisme)</term><term>Saponines (pharmacologie)</term><term>Technique de Western</term><term>Transduction du signal ()</term><term>Tumeurs du poumon (anatomopathologie)</term><term>Tumeurs du poumon (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glutathione</term><term>JNK Mitogen-Activated Protein Kinases</term><term>Phosphatidylinositol 3-Kinases</term><term>Proto-Oncogene Proteins c-akt</term><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Acetylcysteine</term><term>Saponins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Rhizome</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Autophagy</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lung Neoplasms</term><term>Rhizome</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Espèces réactives de l'oxygène</term><term>Glutathion</term><term>JNK Mitogen-Activated Protein Kinases</term><term>Phosphatidylinositol 3-kinases</term><term>Protéines proto-oncogènes c-akt</term><term>Rhizome</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acétylcystéine</term><term>Saponines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Chloroquine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>A549 Cells</term><term>Blotting, Western</term><term>Cell Line</term><term>Humans</term><term>Microscopy, Electron, Transmission</term><term>Microscopy, Fluorescence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Apoptose</term><term>Autophagie</term><term>Cellules A549</term><term>Humains</term><term>Lignée cellulaire</term><term>Microscopie de fluorescence</term><term>Microscopie électronique à transmission</term><term>Rhizome</term><term>Technique de Western</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Paris Saponin II (PSII) has been shown anticancer activity against several cancer lines through the pro-apoptotic pathway. The aim of the study was to investigate the relationship between apoptosis and autophagy taking part in the anti-cancer mechanisms of PSII. In this study, PSII induced autophagy and apoptosis in dose- and time-dependent manners. Meanwhile, it induced autophagy as early as 2 h after exposure to 1 μM of PSII accompanying with apoptosis. Blockade of autophagy with chloroquine (CQ) attenuated apoptosis, while regulation of reactive oxygen species (ROS) by N-acetyl cysteine (NAC), gallic acid (GA) and H2O2 could not influence autophagy. In addition, PSII induced apoptosis via activation of autophagy, which might be associated with the activation of JNK and inhibition of PI3K/AKT/mTOR pathway. All in all, our research increased the understanding of the role of PSII regulating autophagy and apoptosis, which would hopefully provide prospective strategies for cancer therapy. </div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Lili" sort="Zhang, Lili" uniqKey="Zhang L" first="Lili" last="Zhang">Lili Zhang</name></noRegion><name sortKey="Gao, Wenyuan" sort="Gao, Wenyuan" uniqKey="Gao W" first="Wenyuan" last="Gao">Wenyuan Gao</name><name sortKey="Liu, Jing" sort="Liu, Jing" uniqKey="Liu J" first="Jing" last="Liu">Jing Liu</name><name sortKey="Liu, Zhen" sort="Liu, Zhen" uniqKey="Liu Z" first="Zhen" last="Liu">Zhen Liu</name><name sortKey="Man, Shuli" sort="Man, Shuli" uniqKey="Man S" first="Shuli" last="Man">Shuli Man</name><name sortKey="Wang, Yongshuai" sort="Wang, Yongshuai" uniqKey="Wang Y" first="Yongshuai" last="Wang">Yongshuai Wang</name><name sortKey="Yu, Peng" sort="Yu, Peng" uniqKey="Yu P" first="Peng" last="Yu">Peng Yu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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