Advances in nanotechnology-based delivery systems for EGFR tyrosine kinases inhibitors in cancer therapy
Identifieur interne : 000B04 ( Main/Exploration ); précédent : 000B03; suivant : 000B05Advances in nanotechnology-based delivery systems for EGFR tyrosine kinases inhibitors in cancer therapy
Auteurs : Xiaohan Zhou ; Kun Shi ; Ying Hao ; Chengli Yang ; Ruoyu Zha ; Cheng Yi ; Zhiyong QianSource :
- Asian Journal of Pharmaceutical Sciences [ 1818-0876 ] ; 2019.
Abstract
Oral tyrosine kinase inhibitors (TKIs) against epidermal growth factor receptor (EGFR) family have been introduced into the clinic to treat human malignancies for decades. Despite superior properties of EGFR-TKIs as small molecule targeted drugs, their applications are still restricted due to their low solubility, capricious oral bioavailability, large requirement of daily dose, high binding tendency to plasma albumin and initial/acquired drug resistance. Nanotechnology is a promising tool to improve efficacy of these drugs. Through non-oral routes. Various nanotechnology-based delivery approaches have been developed for providing efficient delivery of EGFR-TKIs with a better pharmacokinetic profile and tissue-targeting ability. This review aims to indicate the advantage of nanocarriers for EGFR-TKIs delivery.
Url:
DOI: 10.1016/j.ajps.2019.06.001
PubMed: 32175016
PubMed Central: 7066044
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Advances in nanotechnology-based delivery systems for EGFR tyrosine kinases inhibitors in cancer therapy</title><author><name sortKey="Zhou, Xiaohan" sort="Zhou, Xiaohan" uniqKey="Zhou X" first="Xiaohan" last="Zhou">Xiaohan Zhou</name></author><author><name sortKey="Shi, Kun" sort="Shi, Kun" uniqKey="Shi K" first="Kun" last="Shi">Kun Shi</name></author><author><name sortKey="Hao, Ying" sort="Hao, Ying" uniqKey="Hao Y" first="Ying" last="Hao">Ying Hao</name></author><author><name sortKey="Yang, Chengli" sort="Yang, Chengli" uniqKey="Yang C" first="Chengli" last="Yang">Chengli Yang</name></author><author><name sortKey="Zha, Ruoyu" sort="Zha, Ruoyu" uniqKey="Zha R" first="Ruoyu" last="Zha">Ruoyu Zha</name></author><author><name sortKey="Yi, Cheng" sort="Yi, Cheng" uniqKey="Yi C" first="Cheng" last="Yi">Cheng Yi</name></author><author><name sortKey="Qian, Zhiyong" sort="Qian, Zhiyong" uniqKey="Qian Z" first="Zhiyong" last="Qian">Zhiyong Qian</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32175016</idno><idno type="pmc">7066044</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066044</idno><idno type="RBID">PMC:7066044</idno><idno type="doi">10.1016/j.ajps.2019.06.001</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000865</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000865</idno><idno type="wicri:Area/Pmc/Curation">000865</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000865</idno><idno type="wicri:Area/Pmc/Checkpoint">000A29</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A29</idno><idno type="wicri:Area/Ncbi/Merge">001021</idno><idno type="wicri:Area/Ncbi/Curation">001021</idno><idno type="wicri:Area/Ncbi/Checkpoint">001021</idno><idno type="wicri:doubleKey">1818-0876:2019:Zhou X:advances:in:nanotechnology</idno><idno type="wicri:Area/Main/Merge">000B04</idno><idno type="wicri:Area/Main/Curation">000B04</idno><idno type="wicri:Area/Main/Exploration">000B04</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Advances in nanotechnology-based delivery systems for EGFR tyrosine kinases inhibitors in cancer therapy</title><author><name sortKey="Zhou, Xiaohan" sort="Zhou, Xiaohan" uniqKey="Zhou X" first="Xiaohan" last="Zhou">Xiaohan Zhou</name></author><author><name sortKey="Shi, Kun" sort="Shi, Kun" uniqKey="Shi K" first="Kun" last="Shi">Kun Shi</name></author><author><name sortKey="Hao, Ying" sort="Hao, Ying" uniqKey="Hao Y" first="Ying" last="Hao">Ying Hao</name></author><author><name sortKey="Yang, Chengli" sort="Yang, Chengli" uniqKey="Yang C" first="Chengli" last="Yang">Chengli Yang</name></author><author><name sortKey="Zha, Ruoyu" sort="Zha, Ruoyu" uniqKey="Zha R" first="Ruoyu" last="Zha">Ruoyu Zha</name></author><author><name sortKey="Yi, Cheng" sort="Yi, Cheng" uniqKey="Yi C" first="Cheng" last="Yi">Cheng Yi</name></author><author><name sortKey="Qian, Zhiyong" sort="Qian, Zhiyong" uniqKey="Qian Z" first="Zhiyong" last="Qian">Zhiyong Qian</name></author></analytic><series><title level="j">Asian Journal of Pharmaceutical Sciences</title><idno type="ISSN">1818-0876</idno><idno type="eISSN">2221-285X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Oral tyrosine kinase inhibitors (TKIs) against epidermal growth factor receptor (EGFR) family have been introduced into the clinic to treat human malignancies for decades. Despite superior properties of EGFR-TKIs as small molecule targeted drugs, their applications are still restricted due to their low solubility, capricious oral bioavailability, large requirement of daily dose, high binding tendency to plasma albumin and initial/acquired drug resistance. Nanotechnology is a promising tool to improve efficacy of these drugs. Through non-oral routes. Various nanotechnology-based delivery approaches have been developed for providing efficient delivery of EGFR-TKIs with a better pharmacokinetic profile and tissue-targeting ability. This review aims to indicate the advantage of nanocarriers for EGFR-TKIs delivery.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Roskoski, R" uniqKey="Roskoski R">R. Roskoski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Batty, K M" uniqKey="Batty K">K.M. 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Calani</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Hao, Ying" sort="Hao, Ying" uniqKey="Hao Y" first="Ying" last="Hao">Ying Hao</name><name sortKey="Qian, Zhiyong" sort="Qian, Zhiyong" uniqKey="Qian Z" first="Zhiyong" last="Qian">Zhiyong Qian</name><name sortKey="Shi, Kun" sort="Shi, Kun" uniqKey="Shi K" first="Kun" last="Shi">Kun Shi</name><name sortKey="Yang, Chengli" sort="Yang, Chengli" uniqKey="Yang C" first="Chengli" last="Yang">Chengli Yang</name><name sortKey="Yi, Cheng" sort="Yi, Cheng" uniqKey="Yi C" first="Cheng" last="Yi">Cheng Yi</name><name sortKey="Zha, Ruoyu" sort="Zha, Ruoyu" uniqKey="Zha R" first="Ruoyu" last="Zha">Ruoyu Zha</name><name sortKey="Zhou, Xiaohan" sort="Zhou, Xiaohan" uniqKey="Zhou X" first="Xiaohan" last="Zhou">Xiaohan Zhou</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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