Advances in nanotechnology-based delivery systems for EGFR tyrosine kinases inhibitors in cancer therapy
Identifieur interne : 001021 ( Ncbi/Merge ); précédent : 001020; suivant : 001022Advances in nanotechnology-based delivery systems for EGFR tyrosine kinases inhibitors in cancer therapy
Auteurs : Xiaohan Zhou ; Kun Shi ; Ying Hao ; Chengli Yang ; Ruoyu Zha ; Cheng Yi ; Zhiyong QianSource :
- Asian Journal of Pharmaceutical Sciences [ 1818-0876 ] ; 2019.
Abstract
Oral tyrosine kinase inhibitors (TKIs) against epidermal growth factor receptor (EGFR) family have been introduced into the clinic to treat human malignancies for decades. Despite superior properties of EGFR-TKIs as small molecule targeted drugs, their applications are still restricted due to their low solubility, capricious oral bioavailability, large requirement of daily dose, high binding tendency to plasma albumin and initial/acquired drug resistance. Nanotechnology is a promising tool to improve efficacy of these drugs. Through non-oral routes. Various nanotechnology-based delivery approaches have been developed for providing efficient delivery of EGFR-TKIs with a better pharmacokinetic profile and tissue-targeting ability. This review aims to indicate the advantage of nanocarriers for EGFR-TKIs delivery.
Url:
DOI: 10.1016/j.ajps.2019.06.001
PubMed: 32175016
PubMed Central: 7066044
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Advances in nanotechnology-based delivery systems for EGFR tyrosine kinases inhibitors in cancer therapy</title><author><name sortKey="Zhou, Xiaohan" sort="Zhou, Xiaohan" uniqKey="Zhou X" first="Xiaohan" last="Zhou">Xiaohan Zhou</name></author><author><name sortKey="Shi, Kun" sort="Shi, Kun" uniqKey="Shi K" first="Kun" last="Shi">Kun Shi</name></author><author><name sortKey="Hao, Ying" sort="Hao, Ying" uniqKey="Hao Y" first="Ying" last="Hao">Ying Hao</name></author><author><name sortKey="Yang, Chengli" sort="Yang, Chengli" uniqKey="Yang C" first="Chengli" last="Yang">Chengli Yang</name></author><author><name sortKey="Zha, Ruoyu" sort="Zha, Ruoyu" uniqKey="Zha R" first="Ruoyu" last="Zha">Ruoyu Zha</name></author><author><name sortKey="Yi, Cheng" sort="Yi, Cheng" uniqKey="Yi C" first="Cheng" last="Yi">Cheng Yi</name></author><author><name sortKey="Qian, Zhiyong" sort="Qian, Zhiyong" uniqKey="Qian Z" first="Zhiyong" last="Qian">Zhiyong Qian</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32175016</idno><idno type="pmc">7066044</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066044</idno><idno type="RBID">PMC:7066044</idno><idno type="doi">10.1016/j.ajps.2019.06.001</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000865</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000865</idno><idno type="wicri:Area/Pmc/Curation">000865</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000865</idno><idno type="wicri:Area/Pmc/Checkpoint">000A29</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A29</idno><idno type="wicri:Area/Ncbi/Merge">001021</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Advances in nanotechnology-based delivery systems for EGFR tyrosine kinases inhibitors in cancer therapy</title><author><name sortKey="Zhou, Xiaohan" sort="Zhou, Xiaohan" uniqKey="Zhou X" first="Xiaohan" last="Zhou">Xiaohan Zhou</name></author><author><name sortKey="Shi, Kun" sort="Shi, Kun" uniqKey="Shi K" first="Kun" last="Shi">Kun Shi</name></author><author><name sortKey="Hao, Ying" sort="Hao, Ying" uniqKey="Hao Y" first="Ying" last="Hao">Ying Hao</name></author><author><name sortKey="Yang, Chengli" sort="Yang, Chengli" uniqKey="Yang C" first="Chengli" last="Yang">Chengli Yang</name></author><author><name sortKey="Zha, Ruoyu" sort="Zha, Ruoyu" uniqKey="Zha R" first="Ruoyu" last="Zha">Ruoyu Zha</name></author><author><name sortKey="Yi, Cheng" sort="Yi, Cheng" uniqKey="Yi C" first="Cheng" last="Yi">Cheng Yi</name></author><author><name sortKey="Qian, Zhiyong" sort="Qian, Zhiyong" uniqKey="Qian Z" first="Zhiyong" last="Qian">Zhiyong Qian</name></author></analytic><series><title level="j">Asian Journal of Pharmaceutical Sciences</title><idno type="ISSN">1818-0876</idno><idno type="eISSN">2221-285X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Oral tyrosine kinase inhibitors (TKIs) against epidermal growth factor receptor (EGFR) family have been introduced into the clinic to treat human malignancies for decades. Despite superior properties of EGFR-TKIs as small molecule targeted drugs, their applications are still restricted due to their low solubility, capricious oral bioavailability, large requirement of daily dose, high binding tendency to plasma albumin and initial/acquired drug resistance. Nanotechnology is a promising tool to improve efficacy of these drugs. Through non-oral routes. Various nanotechnology-based delivery approaches have been developed for providing efficient delivery of EGFR-TKIs with a better pharmacokinetic profile and tissue-targeting ability. This review aims to indicate the advantage of nanocarriers for EGFR-TKIs delivery.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Roskoski, R" uniqKey="Roskoski R">R. Roskoski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Batty, K M" uniqKey="Batty K">K.M. 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Vauzour</name></author><author><name sortKey="Krueger, C G" uniqKey="Krueger C">C.G. Krueger</name></author><author><name sortKey="Shanmuganayagam, D" uniqKey="Shanmuganayagam D">D. Shanmuganayagam</name></author><author><name sortKey="Reed, J" uniqKey="Reed J">J. Reed</name></author><author><name sortKey="Calani, L" uniqKey="Calani L">L. Calani</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Asian J Pharm Sci</journal-id><journal-id journal-id-type="iso-abbrev">Asian J Pharm Sci</journal-id><journal-title-group><journal-title>Asian Journal of Pharmaceutical Sciences</journal-title></journal-title-group><issn pub-type="ppub">1818-0876</issn><issn pub-type="epub">2221-285X</issn><publisher><publisher-name>Shenyang Pharmaceutical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32175016</article-id><article-id pub-id-type="pmc">7066044</article-id><article-id pub-id-type="publisher-id">S1818-0876(19)30393-9</article-id><article-id pub-id-type="doi">10.1016/j.ajps.2019.06.001</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review article</subject></subj-group></article-categories><title-group><article-title>Advances in nanotechnology-based delivery systems for EGFR tyrosine kinases inhibitors in cancer therapy</article-title></title-group><contrib-group><contrib contrib-type="author" id="au0001"><name><surname>Zhou</surname><given-names>Xiaohan</given-names></name></contrib><contrib contrib-type="author" id="au0002"><name><surname>Shi</surname><given-names>Kun</given-names></name></contrib><contrib contrib-type="author" id="au0003"><name><surname>Hao</surname><given-names>Ying</given-names></name></contrib><contrib contrib-type="author" id="au0004"><name><surname>Yang</surname><given-names>Chengli</given-names></name></contrib><contrib contrib-type="author" id="au0005"><name><surname>Zha</surname><given-names>Ruoyu</given-names></name></contrib><contrib contrib-type="author" id="au0006"><name><surname>Yi</surname><given-names>Cheng</given-names></name></contrib><contrib contrib-type="author" id="au0007"><name><surname>Qian</surname><given-names>Zhiyong</given-names></name><email>anderson-qian@163.com</email><xref rid="cor0001" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="aff0001">Department of Medical Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China</aff><author-notes><corresp id="cor0001"><label>⁎</label>Corresponding author. Department of Medical Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China. Tel.: +86 28 85502796. <email>anderson-qian@163.com</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>05</day><month>7</month><year>2019</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>1</month><year>2020</year></pub-date><pub-date pub-type="epub"><day>05</day><month>7</month><year>2019</year></pub-date><volume>15</volume><issue>1</issue><fpage>26</fpage><lpage>41</lpage><history><date date-type="received"><day>8</day><month>4</month><year>2019</year></date><date date-type="rev-recd"><day>30</day><month>5</month><year>2019</year></date><date date-type="accepted"><day>14</day><month>6</month><year>2019</year></date></history><permissions><copyright-statement>© 2019 Shenyang Pharmaceutical University. Published by Elsevier B.V.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder>Shenyang Pharmaceutical University</copyright-holder><license license-type="CC BY-NC-ND" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/"><license-p>This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).</license-p></license></permissions><abstract id="abs0001"><p>Oral tyrosine kinase inhibitors (TKIs) against epidermal growth factor receptor (EGFR) family have been introduced into the clinic to treat human malignancies for decades. Despite superior properties of EGFR-TKIs as small molecule targeted drugs, their applications are still restricted due to their low solubility, capricious oral bioavailability, large requirement of daily dose, high binding tendency to plasma albumin and initial/acquired drug resistance. Nanotechnology is a promising tool to improve efficacy of these drugs. Through non-oral routes. Various nanotechnology-based delivery approaches have been developed for providing efficient delivery of EGFR-TKIs with a better pharmacokinetic profile and tissue-targeting ability. This review aims to indicate the advantage of nanocarriers for EGFR-TKIs delivery.</p></abstract><abstract abstract-type="graphical" id="abs0002"><title>Graphical abstract</title><p>(A). Various types of EGFR-TKIs loaded nanocarriers (a) liposome, (b) polymer nanoparticle, (c) micelle, (d) nanogold particles.(B) Schematic illustration of nanocarriers are intended to exploit the enhanced permeability and retention effect to exit the blood vessels through leaky vasculature and accumulate within tumor tissues.(C) Schematic of increased targeting ability of nanocarriers via surface modification and the anti-cancer mechanism of EGFR inhibition.<fig id="fig0006" position="anchor"><alt-text id="alttx001">Image, graphical abstract</alt-text><graphic xlink:href="fx1"></graphic></fig></p></abstract><kwd-group id="keys0001"><title>Keywords</title><kwd>Nanotechnology</kwd><kwd>EGFR</kwd><kwd>Tyrosine kinase inhibitor</kwd><kwd>Cancer therapy</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Hao, Ying" sort="Hao, Ying" uniqKey="Hao Y" first="Ying" last="Hao">Ying Hao</name><name sortKey="Qian, Zhiyong" sort="Qian, Zhiyong" uniqKey="Qian Z" first="Zhiyong" last="Qian">Zhiyong Qian</name><name sortKey="Shi, Kun" sort="Shi, Kun" uniqKey="Shi K" first="Kun" last="Shi">Kun Shi</name><name sortKey="Yang, Chengli" sort="Yang, Chengli" uniqKey="Yang C" first="Chengli" last="Yang">Chengli Yang</name><name sortKey="Yi, Cheng" sort="Yi, Cheng" uniqKey="Yi C" first="Cheng" last="Yi">Cheng Yi</name><name sortKey="Zha, Ruoyu" sort="Zha, Ruoyu" uniqKey="Zha R" first="Ruoyu" last="Zha">Ruoyu Zha</name><name sortKey="Zhou, Xiaohan" sort="Zhou, Xiaohan" uniqKey="Zhou X" first="Xiaohan" last="Zhou">Xiaohan Zhou</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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