Overcoming Physiological Barriers to Nanoparticle Delivery—Are We There Yet?
Identifieur interne : 000564 ( Main/Exploration ); précédent : 000563; suivant : 000565Overcoming Physiological Barriers to Nanoparticle Delivery—Are We There Yet?
Auteurs : Oliver S. Thomas [Allemagne] ; Wilfried Weber [Allemagne]Source :
- Frontiers in Bioengineering and Biotechnology [ 2296-4185 ] ; 2019.
Abstract
The exploitation of nanosized materials for the delivery of therapeutic agents is already a clinical reality and still holds unrealized potential for the treatment of a variety of diseases. This review discusses physiological barriers a nanocarrier must overcome in order to reach its target, with an emphasis on cancer nanomedicine. Stages of delivery include residence in the blood stream, passive accumulation by virtue of the enhanced permeability and retention effect, diffusion within the tumor lesion, cellular uptake, and arrival at the site of action. We also briefly outline strategies for engineering nanoparticles to more efficiently overcome these challenges: Increasing circulation half-life by shielding with hydrophilic polymers, such as PEG, the limitations of PEG and potential alternatives, targeting and controlled activation approaches. Future developments in these areas will allow us to harness the full potential of nanomedicine.
Url:
DOI: 10.3389/fbioe.2019.00415
PubMed: 31921819
PubMed Central: 6928054
Affiliations:
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Thomas</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Faculty of Biology, University of Freiburg</institution>,<addr-line>Freiburg</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Signalling Research Centres BIOSS and CIBSS, University of Freiburg</institution>,<addr-line>Freiburg</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Spemann Graduate School of Biology and Medicine, University of Freiburg</institution>,<addr-line>Freiburg</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Weber, Wilfried" sort="Weber, Wilfried" uniqKey="Weber W" first="Wilfried" last="Weber">Wilfried Weber</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Faculty of Biology, University of Freiburg</institution>,<addr-line>Freiburg</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Signalling Research Centres BIOSS and CIBSS, University of Freiburg</institution>,<addr-line>Freiburg</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Spemann Graduate School of Biology and Medicine, University of Freiburg</institution>,<addr-line>Freiburg</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Bioengineering and Biotechnology</title><idno type="eISSN">2296-4185</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The exploitation of nanosized materials for the delivery of therapeutic agents is already a clinical reality and still holds unrealized potential for the treatment of a variety of diseases. This review discusses physiological barriers a nanocarrier must overcome in order to reach its target, with an emphasis on cancer nanomedicine. Stages of delivery include residence in the blood stream, passive accumulation by virtue of the enhanced permeability and retention effect, diffusion within the tumor lesion, cellular uptake, and arrival at the site of action. We also briefly outline strategies for engineering nanoparticles to more efficiently overcome these challenges: Increasing circulation half-life by shielding with hydrophilic polymers, such as PEG, the limitations of PEG and potential alternatives, targeting and controlled activation approaches. Future developments in these areas will allow us to harness the full potential of nanomedicine.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abu Lila, A S" uniqKey="Abu Lila A">A. S. Abu Lila</name></author><author><name sortKey="Kiwada, H" uniqKey="Kiwada H">H. 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Alyan</name></author><author><name sortKey="Yaari, Z" uniqKey="Yaari Z">Z. Yaari</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Thomas, Oliver S" sort="Thomas, Oliver S" uniqKey="Thomas O" first="Oliver S." last="Thomas">Oliver S. Thomas</name></noRegion><name sortKey="Thomas, Oliver S" sort="Thomas, Oliver S" uniqKey="Thomas O" first="Oliver S." last="Thomas">Oliver S. Thomas</name><name sortKey="Thomas, Oliver S" sort="Thomas, Oliver S" uniqKey="Thomas O" first="Oliver S." last="Thomas">Oliver S. Thomas</name><name sortKey="Weber, Wilfried" sort="Weber, Wilfried" uniqKey="Weber W" first="Wilfried" last="Weber">Wilfried Weber</name><name sortKey="Weber, Wilfried" sort="Weber, Wilfried" uniqKey="Weber W" first="Wilfried" last="Weber">Wilfried Weber</name><name sortKey="Weber, Wilfried" sort="Weber, Wilfried" uniqKey="Weber W" first="Wilfried" last="Weber">Wilfried Weber</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
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