Overcoming Physiological Barriers to Nanoparticle Delivery—Are We There Yet?
Identifieur interne : 000E21 ( Ncbi/Merge ); précédent : 000E20; suivant : 000E22Overcoming Physiological Barriers to Nanoparticle Delivery—Are We There Yet?
Auteurs : Oliver S. Thomas [Allemagne] ; Wilfried Weber [Allemagne]Source :
- Frontiers in Bioengineering and Biotechnology [ 2296-4185 ] ; 2019.
Abstract
The exploitation of nanosized materials for the delivery of therapeutic agents is already a clinical reality and still holds unrealized potential for the treatment of a variety of diseases. This review discusses physiological barriers a nanocarrier must overcome in order to reach its target, with an emphasis on cancer nanomedicine. Stages of delivery include residence in the blood stream, passive accumulation by virtue of the enhanced permeability and retention effect, diffusion within the tumor lesion, cellular uptake, and arrival at the site of action. We also briefly outline strategies for engineering nanoparticles to more efficiently overcome these challenges: Increasing circulation half-life by shielding with hydrophilic polymers, such as PEG, the limitations of PEG and potential alternatives, targeting and controlled activation approaches. Future developments in these areas will allow us to harness the full potential of nanomedicine.
Url:
DOI: 10.3389/fbioe.2019.00415
PubMed: 31921819
PubMed Central: 6928054
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Thomas</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Faculty of Biology, University of Freiburg</institution>,<addr-line>Freiburg</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Signalling Research Centres BIOSS and CIBSS, University of Freiburg</institution>,<addr-line>Freiburg</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Spemann Graduate School of Biology and Medicine, University of Freiburg</institution>,<addr-line>Freiburg</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Weber, Wilfried" sort="Weber, Wilfried" uniqKey="Weber W" first="Wilfried" last="Weber">Wilfried Weber</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Faculty of Biology, University of Freiburg</institution>,<addr-line>Freiburg</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Signalling Research Centres BIOSS and CIBSS, University of Freiburg</institution>,<addr-line>Freiburg</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Spemann Graduate School of Biology and Medicine, University of Freiburg</institution>,<addr-line>Freiburg</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Bioengineering and Biotechnology</title><idno type="eISSN">2296-4185</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The exploitation of nanosized materials for the delivery of therapeutic agents is already a clinical reality and still holds unrealized potential for the treatment of a variety of diseases. This review discusses physiological barriers a nanocarrier must overcome in order to reach its target, with an emphasis on cancer nanomedicine. Stages of delivery include residence in the blood stream, passive accumulation by virtue of the enhanced permeability and retention effect, diffusion within the tumor lesion, cellular uptake, and arrival at the site of action. We also briefly outline strategies for engineering nanoparticles to more efficiently overcome these challenges: Increasing circulation half-life by shielding with hydrophilic polymers, such as PEG, the limitations of PEG and potential alternatives, targeting and controlled activation approaches. Future developments in these areas will allow us to harness the full potential of nanomedicine.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abu Lila, A S" uniqKey="Abu Lila A">A. S. Abu Lila</name></author><author><name sortKey="Kiwada, H" uniqKey="Kiwada H">H. 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Alyan</name></author><author><name sortKey="Yaari, Z" uniqKey="Yaari Z">Z. Yaari</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Bioeng Biotechnol</journal-id><journal-id journal-id-type="iso-abbrev">Front Bioeng Biotechnol</journal-id><journal-id journal-id-type="publisher-id">Front. Bioeng. Biotechnol.</journal-id><journal-title-group><journal-title>Frontiers in Bioengineering and Biotechnology</journal-title></journal-title-group><issn pub-type="epub">2296-4185</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31921819</article-id><article-id pub-id-type="pmc">6928054</article-id><article-id pub-id-type="doi">10.3389/fbioe.2019.00415</article-id><article-categories><subj-group subj-group-type="heading"><subject>Bioengineering and Biotechnology</subject><subj-group><subject>Review</subject></subj-group></subj-group></article-categories><title-group><article-title>Overcoming Physiological Barriers to Nanoparticle Delivery—Are We There Yet?</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Thomas</surname><given-names>Oliver S.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/863746/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Weber</surname><given-names>Wilfried</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="corresp" rid="c001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/816251/overview"></uri></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Faculty of Biology, University of Freiburg</institution>,<addr-line>Freiburg</addr-line>,<country>Germany</country></aff><aff id="aff2"><sup>2</sup><institution>Signalling Research Centres BIOSS and CIBSS, University of Freiburg</institution>,<addr-line>Freiburg</addr-line>,<country>Germany</country></aff><aff id="aff3"><sup>3</sup><institution>Spemann Graduate School of Biology and Medicine, University of Freiburg</institution>,<addr-line>Freiburg</addr-line>,<country>Germany</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Francesco Cellesi, Politecnico di Milano, Italy</p></fn><fn fn-type="edited-by"><p>Reviewed by: Hongwei Chen, University of Michigan, United States; Clara Mattu, Politecnico di Torino, Italy; Paolo Bigini, Istituto Di Ricerche Farmacologiche Mario Negri, Italy</p></fn><corresp id="c001">*Correspondence: Wilfried Weber <email>wilfried.weber@biologie.uni-freiburg.de</email></corresp><fn fn-type="other" id="fn001"><p>This article was submitted to Nanobiotechnology, a section of the journal Frontiers in Bioengineering and Biotechnology</p></fn></author-notes><pub-date pub-type="epub"><day>17</day><month>12</month><year>2019</year></pub-date><pub-date pub-type="collection"><year>2019</year></pub-date><volume>7</volume><elocation-id>415</elocation-id><history><date date-type="received"><day>25</day><month>9</month><year>2019</year></date><date date-type="accepted"><day>29</day><month>11</month><year>2019</year></date></history><permissions><copyright-statement>Copyright © 2019 Thomas and Weber.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder>Thomas and Weber</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>The exploitation of nanosized materials for the delivery of therapeutic agents is already a clinical reality and still holds unrealized potential for the treatment of a variety of diseases. This review discusses physiological barriers a nanocarrier must overcome in order to reach its target, with an emphasis on cancer nanomedicine. Stages of delivery include residence in the blood stream, passive accumulation by virtue of the enhanced permeability and retention effect, diffusion within the tumor lesion, cellular uptake, and arrival at the site of action. We also briefly outline strategies for engineering nanoparticles to more efficiently overcome these challenges: Increasing circulation half-life by shielding with hydrophilic polymers, such as PEG, the limitations of PEG and potential alternatives, targeting and controlled activation approaches. Future developments in these areas will allow us to harness the full potential of nanomedicine.</p></abstract><kwd-group><kwd>nanomedicine</kwd><kwd>nanoparticle</kwd><kwd>nanocarrier</kwd><kwd>drug delivery</kwd><kwd>barrier</kwd><kwd>EPR effect</kwd><kwd>stimulus-responsive</kwd><kwd>PEG</kwd></kwd-group><funding-group><award-group><funding-source id="cn001">Deutsche Forschungsgemeinschaft<named-content content-type="fundref-id">10.13039/501100001659</named-content></funding-source><award-id rid="cn001">GSC-4</award-id><award-id rid="cn001">EXC-294</award-id><award-id rid="cn001">EXC-2189</award-id><award-id rid="cn001">390939984</award-id></award-group></funding-group><counts><fig-count count="4"></fig-count><table-count count="0"></table-count><equation-count count="0"></equation-count><ref-count count="228"></ref-count><page-count count="21"></page-count><word-count count="19221"></word-count></counts></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Thomas, Oliver S" sort="Thomas, Oliver S" uniqKey="Thomas O" first="Oliver S." last="Thomas">Oliver S. Thomas</name></noRegion><name sortKey="Thomas, Oliver S" sort="Thomas, Oliver S" uniqKey="Thomas O" first="Oliver S." last="Thomas">Oliver S. Thomas</name><name sortKey="Thomas, Oliver S" sort="Thomas, Oliver S" uniqKey="Thomas O" first="Oliver S." last="Thomas">Oliver S. Thomas</name><name sortKey="Weber, Wilfried" sort="Weber, Wilfried" uniqKey="Weber W" first="Wilfried" last="Weber">Wilfried Weber</name><name sortKey="Weber, Wilfried" sort="Weber, Wilfried" uniqKey="Weber W" first="Wilfried" last="Weber">Wilfried Weber</name><name sortKey="Weber, Wilfried" sort="Weber, Wilfried" uniqKey="Weber W" first="Wilfried" last="Weber">Wilfried Weber</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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