SPA: a peptide antagonist that acts as a cell-penetrating peptide for drug delivery
Identifieur interne : 000447 ( Main/Exploration ); précédent : 000446; suivant : 000448SPA: a peptide antagonist that acts as a cell-penetrating peptide for drug delivery
Auteurs : Jingjing Song [République populaire de Chine] ; Sujie Huang [République populaire de Chine] ; Zhengzheng Zhang [République populaire de Chine] ; Bo Jia [République populaire de Chine] ; Huan Xie [République populaire de Chine] ; Ming Kai [République populaire de Chine] ; Wei Zhang [République populaire de Chine]Source :
- Drug Delivery [ 1071-7544 ] ; 2019.
Abstract
Although cell-penetrating peptides (CPPs) has been proven to be efficient transporter for drug delivery, ideal peptide vectors for tumor therapy are still being urgently sought. Peptide antagonists have attracted substantial attention as targeting molecules because of their high tumor accumulation and antitumor activity compared with agonists. SPA, a derivative of substance P, is a potent antagonist that exhibits antitumor activity. Based on the amino acid composition of SPA, we speculate that it can translocate across cell membranes as CPPs do. In this study, our results demonstrated that SPA could enter cells similarly to a CPP. As a vector, SPA could efficiently deliver camptothecin and plasmids into cells. In addition, our results showed that SPA exhibited low toxicity to normal cells and high enzymatic stability. Taken together, our results validated the ability of SPA for efficient drug delivery. More importantly, our study opens a new avenue for designing ideal CPPs based on peptide antagonists.
Url:
DOI: 10.1080/10717544.2019.1706669
PubMed: 31870182
PubMed Central: 6968712
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SPA: a peptide antagonist that acts as a cell-penetrating peptide for drug delivery</title><author><name sortKey="Song, Jingjing" sort="Song, Jingjing" uniqKey="Song J" first="Jingjing" last="Song">Jingjing Song</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Sujie" sort="Huang, Sujie" uniqKey="Huang S" first="Sujie" last="Huang">Sujie Huang</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Zhengzheng" sort="Zhang, Zhengzheng" uniqKey="Zhang Z" first="Zhengzheng" last="Zhang">Zhengzheng Zhang</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Institute of Physiology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jia, Bo" sort="Jia, Bo" uniqKey="Jia B" first="Bo" last="Jia">Bo Jia</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Institute of Physiology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xie, Huan" sort="Xie, Huan" uniqKey="Xie H" first="Huan" last="Xie">Huan Xie</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kai, Ming" sort="Kai, Ming" uniqKey="Kai M" first="Ming" last="Kai">Ming Kai</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Institute of Physiology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31870182</idno><idno type="pmc">6968712</idno><idno 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type="wicri:Area/Main/Exploration">000447</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">SPA: a peptide antagonist that acts as a cell-penetrating peptide for drug delivery</title><author><name sortKey="Song, Jingjing" sort="Song, Jingjing" uniqKey="Song J" first="Jingjing" last="Song">Jingjing Song</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Sujie" sort="Huang, Sujie" uniqKey="Huang S" first="Sujie" last="Huang">Sujie Huang</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Zhengzheng" sort="Zhang, Zhengzheng" uniqKey="Zhang Z" first="Zhengzheng" last="Zhang">Zhengzheng Zhang</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Institute of Physiology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jia, Bo" sort="Jia, Bo" uniqKey="Jia B" first="Bo" last="Jia">Bo Jia</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Institute of Physiology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xie, Huan" sort="Xie, Huan" uniqKey="Xie H" first="Huan" last="Xie">Huan Xie</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kai, Ming" sort="Kai, Ming" uniqKey="Kai M" first="Ming" last="Kai">Ming Kai</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Institute of Physiology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Drug Delivery</title><idno type="ISSN">1071-7544</idno><idno type="eISSN">1521-0464</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Although cell-penetrating peptides (CPPs) has been proven to be efficient transporter for drug delivery, ideal peptide vectors for tumor therapy are still being urgently sought. Peptide antagonists have attracted substantial attention as targeting molecules because of their high tumor accumulation and antitumor activity compared with agonists. SPA, a derivative of substance P, is a potent antagonist that exhibits antitumor activity. Based on the amino acid composition of SPA, we speculate that it can translocate across cell membranes as CPPs do. In this study, our results demonstrated that SPA could enter cells similarly to a CPP. As a vector, SPA could efficiently deliver camptothecin and plasmids into cells. In addition, our results showed that SPA exhibited low toxicity to normal cells and high enzymatic stability. Taken together, our results validated the ability of SPA for efficient drug delivery. More importantly, our study opens a new avenue for designing ideal CPPs based on peptide antagonists.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Araste, F" uniqKey="Araste F">F Araste</name></author><author><name sortKey="Abnous, K" uniqKey="Abnous K">K Abnous</name></author><author><name sortKey="Hashemi, M" uniqKey="Hashemi M">M Hashemi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arukuusk, P" uniqKey="Arukuusk P">P Arukuusk</name></author><author><name sortKey="Parnaste, L" uniqKey="Parnaste L">L Parnaste</name></author><author><name sortKey="Margus, H" uniqKey="Margus H">H Margus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boisguerin, P" uniqKey="Boisguerin P">P Boisguerin</name></author><author><name sortKey="Deshayes, S" uniqKey="Deshayes S">S Deshayes</name></author><author><name sortKey="Gait, Mj" uniqKey="Gait M">MJ Gait</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cescato, R" uniqKey="Cescato R">R Cescato</name></author><author><name sortKey="Maina, T" uniqKey="Maina T">T Maina</name></author><author><name sortKey="Nock, B" uniqKey="Nock B">B Nock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Copolovici, Dm" uniqKey="Copolovici D">DM Copolovici</name></author><author><name sortKey="Langel, K" uniqKey="Langel K">K Langel</name></author><author><name sortKey="Eriste, E" uniqKey="Eriste E">E Eriste</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Datar, P" uniqKey="Datar P">P Datar</name></author><author><name sortKey="Srivastava, S" uniqKey="Srivastava S">S Srivastava</name></author><author><name sortKey="Coutinho, E" uniqKey="Coutinho E">E Coutinho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dissanayake, S" uniqKey="Dissanayake S">S Dissanayake</name></author><author><name sortKey="Denny, Wa" uniqKey="Denny W">WA Denny</name></author><author><name sortKey="Gamage, S" uniqKey="Gamage S">S Gamage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dubikovskaya, Ea" uniqKey="Dubikovskaya E">EA Dubikovskaya</name></author><author><name sortKey="Thorne, Sh" uniqKey="Thorne S">SH Thorne</name></author><author><name sortKey="Pillow, Th" uniqKey="Pillow T">TH Pillow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ginj, M" uniqKey="Ginj M">M Ginj</name></author><author><name sortKey="Zhang, Hw" uniqKey="Zhang H">HW Zhang</name></author><author><name sortKey="Waser, B" uniqKey="Waser B">B Waser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guha, S" uniqKey="Guha S">S Guha</name></author><author><name sortKey="Eibl, G" uniqKey="Eibl G">G Eibl</name></author><author><name sortKey="Kisfalvi, K" uniqKey="Kisfalvi K">K Kisfalvi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guidotti, G" uniqKey="Guidotti G">G Guidotti</name></author><author><name sortKey="Brambilla, L" uniqKey="Brambilla L">L Brambilla</name></author><author><name sortKey="Rossi, D" uniqKey="Rossi D">D Rossi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gupta, A" uniqKey="Gupta A">A Gupta</name></author><author><name sortKey="Mandal, D" uniqKey="Mandal D">D Mandal</name></author><author><name sortKey="Ahmadibeni, Y" uniqKey="Ahmadibeni Y">Y Ahmadibeni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Henne, Wa" uniqKey="Henne W">WA Henne</name></author><author><name sortKey="Doorneweerd, Dd" uniqKey="Doorneweerd D">DD Doorneweerd</name></author><author><name sortKey="Hilgenbrink, Ar" uniqKey="Hilgenbrink A">AR Hilgenbrink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoyer, J" uniqKey="Hoyer J">J Hoyer</name></author><author><name sortKey="Neundorf, I" uniqKey="Neundorf I">I Neundorf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoyer, J" uniqKey="Hoyer J">J Hoyer</name></author><author><name sortKey="Neundorf, I" uniqKey="Neundorf I">I Neundorf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Illien, F" uniqKey="Illien F">F Illien</name></author><author><name sortKey="Rodriguez, N" uniqKey="Rodriguez N">N Rodriguez</name></author><author><name sortKey="Amoura, M" uniqKey="Amoura M">M Amoura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jarver, P" uniqKey="Jarver P">P Jarver</name></author><author><name sortKey="Mager, I" uniqKey="Mager I">I Mager</name></author><author><name sortKey="Langel, U" uniqKey="Langel U">U Langel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, T" uniqKey="Jiang T">T Jiang</name></author><author><name sortKey="Olson, Es" uniqKey="Olson E">ES Olson</name></author><author><name sortKey="Nguyen, Qt" uniqKey="Nguyen Q">QT Nguyen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jobin, Ml" uniqKey="Jobin M">ML Jobin</name></author><author><name sortKey="Blanchet, M" uniqKey="Blanchet M">M Blanchet</name></author><author><name sortKey="Henry, S" uniqKey="Henry S">S Henry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, At" uniqKey="Jones A">AT Jones</name></author><author><name sortKey="Sayers, Ej" uniqKey="Sayers E">EJ Sayers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kabelka, I" uniqKey="Kabelka I">I Kabelka</name></author><author><name sortKey="Vacha, R" uniqKey="Vacha R">R Vacha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kauffman, Wb" uniqKey="Kauffman W">WB Kauffman</name></author><author><name sortKey="Fuselier, T" uniqKey="Fuselier T">T Fuselier</name></author><author><name sortKey="He, J" uniqKey="He J">J He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, S" uniqKey="Kim S">S Kim</name></author><author><name sortKey="Kim, Ss" uniqKey="Kim S">SS Kim</name></author><author><name sortKey="Lee, Bj" uniqKey="Lee B">BJ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Komin, A" uniqKey="Komin A">A Komin</name></author><author><name sortKey="Russell, Lm" uniqKey="Russell L">LM Russell</name></author><author><name sortKey="Hristova, Ka" uniqKey="Hristova K">KA Hristova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koren, E" uniqKey="Koren E">E Koren</name></author><author><name sortKey="Torchilin, Vp" uniqKey="Torchilin V">VP Torchilin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lehto, T" uniqKey="Lehto T">T Lehto</name></author><author><name sortKey="Ezzat, K" uniqKey="Ezzat K">K Ezzat</name></author><author><name sortKey="Wood, Mja" uniqKey="Wood M">MJA Wood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Majumdar, S" uniqKey="Majumdar S">S Majumdar</name></author><author><name sortKey="Siahaan, Tj" uniqKey="Siahaan T">TJ Siahaan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mickan, A" uniqKey="Mickan A">A Mickan</name></author><author><name sortKey="Sarko, D" uniqKey="Sarko D">D Sarko</name></author><author><name sortKey="Haberkorn, U" uniqKey="Haberkorn U">U Haberkorn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Milletti, F" uniqKey="Milletti F">F Milletti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Najjar, K" uniqKey="Najjar K">K Najjar</name></author><author><name sortKey="Erazo Oliveras, A" uniqKey="Erazo Oliveras A">A Erazo-Oliveras</name></author><author><name sortKey="Brock, Dj" uniqKey="Brock D">DJ Brock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakase, I" uniqKey="Nakase I">I Nakase</name></author><author><name sortKey="Akita, H" uniqKey="Akita H">H Akita</name></author><author><name sortKey="Kogure, K" uniqKey="Kogure K">K Kogure</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakase, I" uniqKey="Nakase I">I Nakase</name></author><author><name sortKey="Konishi, Y" uniqKey="Konishi Y">Y Konishi</name></author><author><name sortKey="Ueda, M" uniqKey="Ueda M">M Ueda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Papo, N" uniqKey="Papo N">N Papo</name></author><author><name sortKey="Braunstein, A" uniqKey="Braunstein A">A Braunstein</name></author><author><name sortKey="Eshhar, Z" uniqKey="Eshhar Z">Z Eshhar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patel, Ln" uniqKey="Patel L">LN Patel</name></author><author><name sortKey="Zaro, Jl" uniqKey="Zaro J">JL Zaro</name></author><author><name sortKey="Shen, Wc" uniqKey="Shen W">WC Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peraro, L" uniqKey="Peraro L">L Peraro</name></author><author><name sortKey="Kritzer, Ja" uniqKey="Kritzer J">JA Kritzer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richard, Jp" uniqKey="Richard J">JP Richard</name></author><author><name sortKey="Melikov, K" uniqKey="Melikov K">K Melikov</name></author><author><name sortKey="Vives, E" uniqKey="Vives E">E Vives</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rydberg, Ha" uniqKey="Rydberg H">HA Rydberg</name></author><author><name sortKey="Matson, M" uniqKey="Matson M">M Matson</name></author><author><name sortKey="Amand, Hl" uniqKey="Amand H">HL Amand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seckl, Mj" uniqKey="Seckl M">MJ Seckl</name></author><author><name sortKey="Higgins, T" uniqKey="Higgins T">T Higgins</name></author><author><name sortKey="Widmer, F" uniqKey="Widmer F">F Widmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, J" uniqKey="Song J">J Song</name></author><author><name sortKey="Kai, M" uniqKey="Kai M">M Kai</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, Jj" uniqKey="Song J">JJ Song</name></author><author><name sortKey="Kai, M" uniqKey="Kai M">M Kai</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, Jj" uniqKey="Song J">JJ Song</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Kai, M" uniqKey="Kai M">M Kai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, Jj" uniqKey="Song J">JJ Song</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steinhoff, Ms" uniqKey="Steinhoff M">MS Steinhoff</name></author><author><name sortKey="Von Mentzer, B" uniqKey="Von Mentzer B">B von Mentzer</name></author><author><name sortKey="Geppetti, P" uniqKey="Geppetti P">P Geppetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, Xl" uniqKey="Sun X">XL Sun</name></author><author><name sortKey="Li, Ys" uniqKey="Li Y">YS Li</name></author><author><name sortKey="Liu, T" uniqKey="Liu T">T Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Svensen, N" uniqKey="Svensen N">N Svensen</name></author><author><name sortKey="Walton, Jg" uniqKey="Walton J">JG Walton</name></author><author><name sortKey="Bradley, M" uniqKey="Bradley M">M Bradley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Fh" uniqKey="Wang F">FH Wang</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yau, Wm" uniqKey="Yau W">WM Yau</name></author><author><name sortKey="Wimley, Wc" uniqKey="Wimley W">WC Wimley</name></author><author><name sortKey="Gawrisch, K" uniqKey="Gawrisch K">K Gawrisch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Song, J" uniqKey="Song J">J Song</name></author><author><name sortKey="Liang, R" uniqKey="Liang R">R Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Song, J" uniqKey="Song J">J Song</name></author><author><name sortKey="Liang, R" uniqKey="Liang R">R Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Song, Jj" uniqKey="Song J">JJ Song</name></author><author><name sortKey="Zhang, Bz" uniqKey="Zhang B">BZ Zhang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Song, Jingjing" sort="Song, Jingjing" uniqKey="Song J" first="Jingjing" last="Song">Jingjing Song</name></noRegion><name sortKey="Huang, Sujie" sort="Huang, Sujie" uniqKey="Huang S" first="Sujie" last="Huang">Sujie Huang</name><name sortKey="Jia, Bo" sort="Jia, Bo" uniqKey="Jia B" first="Bo" last="Jia">Bo Jia</name><name sortKey="Kai, Ming" sort="Kai, Ming" uniqKey="Kai M" first="Ming" last="Kai">Ming Kai</name><name sortKey="Xie, Huan" sort="Xie, Huan" uniqKey="Xie H" first="Huan" last="Xie">Huan Xie</name><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name><name sortKey="Zhang, Zhengzheng" sort="Zhang, Zhengzheng" uniqKey="Zhang Z" first="Zhengzheng" last="Zhang">Zhengzheng Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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