SPA: a peptide antagonist that acts as a cell-penetrating peptide for drug delivery
Identifieur interne : 000494 ( Pmc/Curation ); précédent : 000493; suivant : 000495SPA: a peptide antagonist that acts as a cell-penetrating peptide for drug delivery
Auteurs : Jingjing Song [République populaire de Chine] ; Sujie Huang [République populaire de Chine] ; Zhengzheng Zhang [République populaire de Chine] ; Bo Jia [République populaire de Chine] ; Huan Xie [République populaire de Chine] ; Ming Kai [République populaire de Chine] ; Wei Zhang [République populaire de Chine]Source :
- Drug Delivery [ 1071-7544 ] ; 2019.
Abstract
Although cell-penetrating peptides (CPPs) has been proven to be efficient transporter for drug delivery, ideal peptide vectors for tumor therapy are still being urgently sought. Peptide antagonists have attracted substantial attention as targeting molecules because of their high tumor accumulation and antitumor activity compared with agonists. SPA, a derivative of substance P, is a potent antagonist that exhibits antitumor activity. Based on the amino acid composition of SPA, we speculate that it can translocate across cell membranes as CPPs do. In this study, our results demonstrated that SPA could enter cells similarly to a CPP. As a vector, SPA could efficiently deliver camptothecin and plasmids into cells. In addition, our results showed that SPA exhibited low toxicity to normal cells and high enzymatic stability. Taken together, our results validated the ability of SPA for efficient drug delivery. More importantly, our study opens a new avenue for designing ideal CPPs based on peptide antagonists.
Url:
DOI: 10.1080/10717544.2019.1706669
PubMed: 31870182
PubMed Central: 6968712
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Province, School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xie, Huan" sort="Xie, Huan" uniqKey="Xie H" first="Huan" last="Xie">Huan Xie</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kai, Ming" sort="Kai, Ming" uniqKey="Kai M" first="Ming" last="Kai">Ming Kai</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Institute of Biochemistry and 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University</institution>, Lanzhou,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Sujie" sort="Huang, Sujie" uniqKey="Huang S" first="Sujie" last="Huang">Sujie Huang</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Zhengzheng" sort="Zhang, Zhengzheng" uniqKey="Zhang Z" first="Zhengzheng" last="Zhang">Zhengzheng Zhang</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Institute of Physiology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jia, Bo" sort="Jia, Bo" uniqKey="Jia B" first="Bo" last="Jia">Bo Jia</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Institute of Physiology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xie, Huan" sort="Xie, Huan" uniqKey="Xie H" first="Huan" last="Xie">Huan Xie</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kai, Ming" sort="Kai, Ming" uniqKey="Kai M" first="Ming" last="Kai">Ming Kai</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country>;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Institute of Physiology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Drug Delivery</title><idno type="ISSN">1071-7544</idno><idno type="eISSN">1521-0464</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Although cell-penetrating peptides (CPPs) has been proven to be efficient transporter for drug delivery, ideal peptide vectors for tumor therapy are still being urgently sought. Peptide antagonists have attracted substantial attention as targeting molecules because of their high tumor accumulation and antitumor activity compared with agonists. SPA, a derivative of substance P, is a potent antagonist that exhibits antitumor activity. Based on the amino acid composition of SPA, we speculate that it can translocate across cell membranes as CPPs do. In this study, our results demonstrated that SPA could enter cells similarly to a CPP. As a vector, SPA could efficiently deliver camptothecin and plasmids into cells. In addition, our results showed that SPA exhibited low toxicity to normal cells and high enzymatic stability. Taken together, our results validated the ability of SPA for efficient drug delivery. More importantly, our study opens a new avenue for designing ideal CPPs based on peptide antagonists.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Araste, F" uniqKey="Araste F">F Araste</name></author><author><name sortKey="Abnous, K" uniqKey="Abnous K">K Abnous</name></author><author><name sortKey="Hashemi, M" uniqKey="Hashemi M">M Hashemi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arukuusk, P" uniqKey="Arukuusk P">P Arukuusk</name></author><author><name sortKey="Parnaste, L" uniqKey="Parnaste L">L Parnaste</name></author><author><name sortKey="Margus, H" uniqKey="Margus H">H Margus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boisguerin, P" uniqKey="Boisguerin P">P Boisguerin</name></author><author><name sortKey="Deshayes, S" uniqKey="Deshayes S">S Deshayes</name></author><author><name sortKey="Gait, Mj" uniqKey="Gait M">MJ Gait</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cescato, R" uniqKey="Cescato R">R Cescato</name></author><author><name sortKey="Maina, T" uniqKey="Maina T">T Maina</name></author><author><name sortKey="Nock, B" uniqKey="Nock B">B Nock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Copolovici, Dm" uniqKey="Copolovici D">DM Copolovici</name></author><author><name sortKey="Langel, K" uniqKey="Langel K">K Langel</name></author><author><name sortKey="Eriste, E" uniqKey="Eriste E">E Eriste</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Datar, P" uniqKey="Datar P">P Datar</name></author><author><name sortKey="Srivastava, S" uniqKey="Srivastava S">S Srivastava</name></author><author><name sortKey="Coutinho, E" uniqKey="Coutinho E">E Coutinho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dissanayake, S" uniqKey="Dissanayake S">S Dissanayake</name></author><author><name sortKey="Denny, Wa" uniqKey="Denny W">WA Denny</name></author><author><name sortKey="Gamage, S" uniqKey="Gamage S">S Gamage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dubikovskaya, Ea" uniqKey="Dubikovskaya E">EA Dubikovskaya</name></author><author><name sortKey="Thorne, Sh" uniqKey="Thorne S">SH Thorne</name></author><author><name sortKey="Pillow, Th" uniqKey="Pillow T">TH Pillow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ginj, M" uniqKey="Ginj M">M Ginj</name></author><author><name sortKey="Zhang, Hw" uniqKey="Zhang H">HW Zhang</name></author><author><name sortKey="Waser, B" uniqKey="Waser B">B Waser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guha, S" uniqKey="Guha S">S Guha</name></author><author><name sortKey="Eibl, G" uniqKey="Eibl G">G Eibl</name></author><author><name sortKey="Kisfalvi, K" uniqKey="Kisfalvi K">K Kisfalvi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guidotti, G" uniqKey="Guidotti G">G Guidotti</name></author><author><name sortKey="Brambilla, L" uniqKey="Brambilla L">L Brambilla</name></author><author><name sortKey="Rossi, D" uniqKey="Rossi D">D Rossi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gupta, A" uniqKey="Gupta A">A Gupta</name></author><author><name sortKey="Mandal, D" uniqKey="Mandal D">D Mandal</name></author><author><name sortKey="Ahmadibeni, Y" uniqKey="Ahmadibeni Y">Y Ahmadibeni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Henne, Wa" uniqKey="Henne W">WA Henne</name></author><author><name sortKey="Doorneweerd, Dd" uniqKey="Doorneweerd D">DD Doorneweerd</name></author><author><name sortKey="Hilgenbrink, Ar" uniqKey="Hilgenbrink A">AR Hilgenbrink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoyer, J" uniqKey="Hoyer J">J Hoyer</name></author><author><name sortKey="Neundorf, I" uniqKey="Neundorf I">I Neundorf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoyer, J" uniqKey="Hoyer J">J Hoyer</name></author><author><name sortKey="Neundorf, I" uniqKey="Neundorf I">I Neundorf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Illien, F" uniqKey="Illien F">F Illien</name></author><author><name sortKey="Rodriguez, N" uniqKey="Rodriguez N">N Rodriguez</name></author><author><name sortKey="Amoura, M" uniqKey="Amoura M">M Amoura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jarver, P" uniqKey="Jarver P">P Jarver</name></author><author><name sortKey="Mager, I" uniqKey="Mager I">I Mager</name></author><author><name sortKey="Langel, U" uniqKey="Langel U">U Langel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, T" uniqKey="Jiang T">T Jiang</name></author><author><name sortKey="Olson, Es" uniqKey="Olson E">ES Olson</name></author><author><name sortKey="Nguyen, Qt" uniqKey="Nguyen Q">QT Nguyen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jobin, Ml" uniqKey="Jobin M">ML Jobin</name></author><author><name sortKey="Blanchet, M" uniqKey="Blanchet M">M Blanchet</name></author><author><name sortKey="Henry, S" uniqKey="Henry S">S Henry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, At" uniqKey="Jones A">AT Jones</name></author><author><name sortKey="Sayers, Ej" uniqKey="Sayers E">EJ Sayers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kabelka, I" uniqKey="Kabelka I">I Kabelka</name></author><author><name sortKey="Vacha, R" uniqKey="Vacha R">R Vacha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kauffman, Wb" uniqKey="Kauffman W">WB Kauffman</name></author><author><name sortKey="Fuselier, T" uniqKey="Fuselier T">T Fuselier</name></author><author><name sortKey="He, J" uniqKey="He J">J He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, S" uniqKey="Kim S">S Kim</name></author><author><name sortKey="Kim, Ss" uniqKey="Kim S">SS Kim</name></author><author><name sortKey="Lee, Bj" uniqKey="Lee B">BJ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Komin, A" uniqKey="Komin A">A Komin</name></author><author><name sortKey="Russell, Lm" uniqKey="Russell L">LM Russell</name></author><author><name sortKey="Hristova, Ka" uniqKey="Hristova K">KA Hristova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koren, E" uniqKey="Koren E">E Koren</name></author><author><name sortKey="Torchilin, Vp" uniqKey="Torchilin V">VP Torchilin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lehto, T" uniqKey="Lehto T">T Lehto</name></author><author><name sortKey="Ezzat, K" uniqKey="Ezzat K">K Ezzat</name></author><author><name sortKey="Wood, Mja" uniqKey="Wood M">MJA Wood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Majumdar, S" uniqKey="Majumdar S">S Majumdar</name></author><author><name sortKey="Siahaan, Tj" uniqKey="Siahaan T">TJ Siahaan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mickan, A" uniqKey="Mickan A">A Mickan</name></author><author><name sortKey="Sarko, D" uniqKey="Sarko D">D Sarko</name></author><author><name sortKey="Haberkorn, U" uniqKey="Haberkorn U">U Haberkorn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Milletti, F" uniqKey="Milletti F">F Milletti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Najjar, K" uniqKey="Najjar K">K Najjar</name></author><author><name sortKey="Erazo Oliveras, A" uniqKey="Erazo Oliveras A">A Erazo-Oliveras</name></author><author><name sortKey="Brock, Dj" uniqKey="Brock D">DJ Brock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakase, I" uniqKey="Nakase I">I Nakase</name></author><author><name sortKey="Akita, H" uniqKey="Akita H">H Akita</name></author><author><name sortKey="Kogure, K" uniqKey="Kogure K">K Kogure</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakase, I" uniqKey="Nakase I">I Nakase</name></author><author><name sortKey="Konishi, Y" uniqKey="Konishi Y">Y Konishi</name></author><author><name sortKey="Ueda, M" uniqKey="Ueda M">M Ueda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Papo, N" uniqKey="Papo N">N Papo</name></author><author><name sortKey="Braunstein, A" uniqKey="Braunstein A">A Braunstein</name></author><author><name sortKey="Eshhar, Z" uniqKey="Eshhar Z">Z Eshhar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patel, Ln" uniqKey="Patel L">LN Patel</name></author><author><name sortKey="Zaro, Jl" uniqKey="Zaro J">JL Zaro</name></author><author><name sortKey="Shen, Wc" uniqKey="Shen W">WC Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peraro, L" uniqKey="Peraro L">L Peraro</name></author><author><name sortKey="Kritzer, Ja" uniqKey="Kritzer J">JA Kritzer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richard, Jp" uniqKey="Richard J">JP Richard</name></author><author><name sortKey="Melikov, K" uniqKey="Melikov K">K Melikov</name></author><author><name sortKey="Vives, E" uniqKey="Vives E">E Vives</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rydberg, Ha" uniqKey="Rydberg H">HA Rydberg</name></author><author><name sortKey="Matson, M" uniqKey="Matson M">M Matson</name></author><author><name sortKey="Amand, Hl" uniqKey="Amand H">HL Amand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seckl, Mj" uniqKey="Seckl M">MJ Seckl</name></author><author><name sortKey="Higgins, T" uniqKey="Higgins T">T Higgins</name></author><author><name sortKey="Widmer, F" uniqKey="Widmer F">F Widmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, J" uniqKey="Song J">J Song</name></author><author><name sortKey="Kai, M" uniqKey="Kai M">M Kai</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, Jj" uniqKey="Song J">JJ Song</name></author><author><name sortKey="Kai, M" uniqKey="Kai M">M Kai</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, Jj" uniqKey="Song J">JJ Song</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Kai, M" uniqKey="Kai M">M Kai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, Jj" uniqKey="Song J">JJ Song</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steinhoff, Ms" uniqKey="Steinhoff M">MS Steinhoff</name></author><author><name sortKey="Von Mentzer, B" uniqKey="Von Mentzer B">B von Mentzer</name></author><author><name sortKey="Geppetti, P" uniqKey="Geppetti P">P Geppetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, Xl" uniqKey="Sun X">XL Sun</name></author><author><name sortKey="Li, Ys" uniqKey="Li Y">YS Li</name></author><author><name sortKey="Liu, T" uniqKey="Liu T">T Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Svensen, N" uniqKey="Svensen N">N Svensen</name></author><author><name sortKey="Walton, Jg" uniqKey="Walton J">JG Walton</name></author><author><name sortKey="Bradley, M" uniqKey="Bradley M">M Bradley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Fh" uniqKey="Wang F">FH Wang</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yau, Wm" uniqKey="Yau W">WM Yau</name></author><author><name sortKey="Wimley, Wc" uniqKey="Wimley W">WC Wimley</name></author><author><name sortKey="Gawrisch, K" uniqKey="Gawrisch K">K Gawrisch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Song, J" uniqKey="Song J">J Song</name></author><author><name sortKey="Liang, R" uniqKey="Liang R">R Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Song, J" uniqKey="Song J">J Song</name></author><author><name sortKey="Liang, R" uniqKey="Liang R">R Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Song, Jj" uniqKey="Song J">JJ Song</name></author><author><name sortKey="Zhang, Bz" uniqKey="Zhang B">BZ Zhang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Drug Deliv</journal-id><journal-id journal-id-type="iso-abbrev">Drug Deliv</journal-id><journal-id journal-id-type="publisher-id">IDRD</journal-id><journal-id journal-id-type="publisher-id">idrd20</journal-id><journal-title-group><journal-title>Drug Delivery</journal-title></journal-title-group><issn pub-type="ppub">1071-7544</issn><issn pub-type="epub">1521-0464</issn><publisher><publisher-name>Taylor & Francis</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31870182</article-id><article-id pub-id-type="pmc">6968712</article-id><article-id pub-id-type="doi">10.1080/10717544.2019.1706669</article-id><article-id pub-id-type="publisher-id">1706669</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>SPA: a peptide antagonist that acts as a cell-penetrating peptide for drug delivery</article-title><alt-title alt-title-type="running-authors">J. Song et al.</alt-title><alt-title alt-title-type="running-title">Drug Delivery</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Song</surname><given-names>Jingjing</given-names></name><xref ref-type="aff" rid="AF0001"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Sujie</given-names></name><xref ref-type="aff" rid="AF0002"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Zhengzheng</given-names></name><xref ref-type="aff" rid="AF0003"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jia</surname><given-names>Bo</given-names></name><xref ref-type="aff" rid="AF0003"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Xie</surname><given-names>Huan</given-names></name><xref ref-type="aff" rid="AF0001"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kai</surname><given-names>Ming</given-names></name><xref ref-type="aff" rid="AF0002"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Wei</given-names></name><xref ref-type="aff" rid="AF0003"><sup>c</sup></xref><xref ref-type="corresp" rid="AN0001"></xref></contrib><aff id="AF0001"><label>a</label><institution>Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country>;</aff><aff id="AF0002"><label>b</label><institution>Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country>;</aff><aff id="AF0003"><label>c</label><institution>Institute of Physiology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou,<country>China</country></aff></contrib-group><author-notes><fn id="AUFN1"><p>Supplemental data for this article can be accessed <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1080/10717544.2019.1706669"><underline>here</underline></ext-link>.</p></fn><corresp id="AN0001"><bold>CONTACT</bold> Wei Zhang <email>zhangwei@lzu.edu.cn</email><institution>School of Basic Medical Sciences, Lanzhou University</institution>, Lanzhou 730000, <country>China</country></corresp></author-notes><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>24</day><month>12</month><year>2019</year></pub-date><volume>27</volume><issue>1</issue><fpage seq="8">91</fpage><lpage>99</lpage><history><date date-type="received"><day>28</day><month>10</month><year>2019</year></date><date date-type="rev-recd"><day>16</day><month>12</month><year>2019</year></date><date date-type="accepted"><day>16</day><month>12</month><year>2019</year></date></history><permissions><copyright-statement>© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder>The Author(s)</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="IDRD_27_1706669.pdf"></self-uri><abstract><title>Abstract</title><p>Although cell-penetrating peptides (CPPs) has been proven to be efficient transporter for drug delivery, ideal peptide vectors for tumor therapy are still being urgently sought. Peptide antagonists have attracted substantial attention as targeting molecules because of their high tumor accumulation and antitumor activity compared with agonists. SPA, a derivative of substance P, is a potent antagonist that exhibits antitumor activity. Based on the amino acid composition of SPA, we speculate that it can translocate across cell membranes as CPPs do. In this study, our results demonstrated that SPA could enter cells similarly to a CPP. As a vector, SPA could efficiently deliver camptothecin and plasmids into cells. In addition, our results showed that SPA exhibited low toxicity to normal cells and high enzymatic stability. Taken together, our results validated the ability of SPA for efficient drug delivery. More importantly, our study opens a new avenue for designing ideal CPPs based on peptide antagonists.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords</title><kwd>Peptide antagonist</kwd><kwd>cell penetrating peptide</kwd><kwd>camptothecin delivery</kwd><kwd>gene delivery</kwd></kwd-group><funding-group><award-group><funding-source><named-content content-type="funder-name">National Natural Science Foundation of China</named-content></funding-source><award-id>21602092</award-id><award-id>81773566</award-id></award-group><award-group><funding-source><named-content content-type="funder-name">Fundamental Research Funds for the Central Universities</named-content></funding-source><award-id>2017-120</award-id><award-id>2018-83</award-id></award-group><funding-statement>We are grateful for the grants from the National Natural Science Foundation of China [Nos. 21602092, 81773566], the Fundamental Research Funds for the Central Universities [lzujbky-2017-120, lzujbky-2018-83]. </funding-statement></funding-group><counts><fig-count count="7"></fig-count><table-count count="0"></table-count><page-count count="9"></page-count><word-count count="5979"></word-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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