Generalized lipidosis in newborn rats and guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals
Identifieur interne : 002492 ( Istex/Checkpoint ); précédent : 002491; suivant : 002493Generalized lipidosis in newborn rats and guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals
Auteurs : Renate Lüllmann-Rauch [Allemagne] ; Brigitte Stoermer [Allemagne]Source :
- Virchows Archiv B [ 0340-6075 ] ; 1982-12-01.
English descriptors
- KwdEn :
- Teeft :
- Abnormal lamellar inclusions, Abnormal lamellated inclusions, Adrenal, Adrenal cortex, Adrenal medulla, Adult animals, Adult rats, Adult tissues, Altromin gmbh, Alveolar epithelial cells, Alveolar macrophages, Amphiphilic, Amphiphilic drugs, Animal species, Anterior horn perikarya, Cell pathol, Cell tissue, Cellular factors, Chlorcyclizine, Chlorcyclizine treatment, Chloroquine, Chloroquine treatment, Chloroquine treatments, Chlorphentermine, Chlorphentermine administration, Chlorphentermine treatment, Control newborns, Corresponding mothers, Drinking water, Epithelial cells, Fetal, Fetal lipidosis, Fetal tissues, Ganglion cells, General organization, Generalized lipidosis, Granulated cells, Guinea, Guinea pigs, Higher magnification, Inclusion, Inclusion bodies, Initial body weight, Inset, Kupffer cells, Lamellar, Lamellar inclusions, Lamellated, Lamellated inclusions, Lamellated material, Lesser degree, Lipidosis, Little alteration, Little effect, Liver tissues, Lysosomal apparatus, Macrophage, Many macrophages, Medulla, Microglial, Microglial cells, Nerve cells, Nervous system, Neurosecretory perikarya, Newborn, Newborn animals, Newborn controls, Newborn guinea, Newborn rats, Perikarya, Polar lipids, Polymorphous osmiophilic material, Posterior horn, Pregnant animals, Prenatal development, Proximal tubule, Rat, Significant lipidosis, Slight alterations, Spinal cord, Stomach tube, Subcutaneous injection, Treatment periods, Ultrastructure, Virchows arch, Zona fasciculata.
Abstract
Summary: Pregnant rats and guinea pigs were treated throughout the second half of gestation with amphiphilic drugs (chlorphentermine, chlorcyclizine, chloroquine) known to induce generalized lipidosis. The offspring were sacrificed immediately after birth, and several tissues (lung, liver, kidney, spleen, pituitary gland, adrenal gland, spinal cord, hypothalamus) were examined by electron microscopy. Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers. The results show that fetal and adult tissues respond to lipidosis-inducing drugs in a qualitatively similar way ; the quantitative differences found may be related to pharmacokinetic and cellular factors.
Url:
DOI: 10.1007/BF02892837
Affiliations:
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ISTEX:A8FCD529CDA25960BE3AD5C9E682E5038E7F2E73Le document en format XML
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<series><title level="j">Virchows Archiv B</title>
<title level="j" type="sub">Cell Pathology</title>
<title level="j" type="abbrev">Virchows Archiv B Cell Pathol</title>
<idno type="ISSN">0340-6075</idno>
<imprint><publisher>Springer-Verlag</publisher>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chlorcyclizine</term>
<term>Chloroquine</term>
<term>Chlorphentermine</term>
<term>Experimental lipidosis</term>
<term>Guinea pig</term>
<term>Prenatal development</term>
<term>Rat</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Abnormal lamellar inclusions</term>
<term>Abnormal lamellated inclusions</term>
<term>Adrenal</term>
<term>Adrenal cortex</term>
<term>Adrenal medulla</term>
<term>Adult animals</term>
<term>Adult rats</term>
<term>Adult tissues</term>
<term>Altromin gmbh</term>
<term>Alveolar epithelial cells</term>
<term>Alveolar macrophages</term>
<term>Amphiphilic</term>
<term>Amphiphilic drugs</term>
<term>Animal species</term>
<term>Anterior horn perikarya</term>
<term>Cell pathol</term>
<term>Cell tissue</term>
<term>Cellular factors</term>
<term>Chlorcyclizine</term>
<term>Chlorcyclizine treatment</term>
<term>Chloroquine</term>
<term>Chloroquine treatment</term>
<term>Chloroquine treatments</term>
<term>Chlorphentermine</term>
<term>Chlorphentermine administration</term>
<term>Chlorphentermine treatment</term>
<term>Control newborns</term>
<term>Corresponding mothers</term>
<term>Drinking water</term>
<term>Epithelial cells</term>
<term>Fetal</term>
<term>Fetal lipidosis</term>
<term>Fetal tissues</term>
<term>Ganglion cells</term>
<term>General organization</term>
<term>Generalized lipidosis</term>
<term>Granulated cells</term>
<term>Guinea</term>
<term>Guinea pigs</term>
<term>Higher magnification</term>
<term>Inclusion</term>
<term>Inclusion bodies</term>
<term>Initial body weight</term>
<term>Inset</term>
<term>Kupffer cells</term>
<term>Lamellar</term>
<term>Lamellar inclusions</term>
<term>Lamellated</term>
<term>Lamellated inclusions</term>
<term>Lamellated material</term>
<term>Lesser degree</term>
<term>Lipidosis</term>
<term>Little alteration</term>
<term>Little effect</term>
<term>Liver tissues</term>
<term>Lysosomal apparatus</term>
<term>Macrophage</term>
<term>Many macrophages</term>
<term>Medulla</term>
<term>Microglial</term>
<term>Microglial cells</term>
<term>Nerve cells</term>
<term>Nervous system</term>
<term>Neurosecretory perikarya</term>
<term>Newborn</term>
<term>Newborn animals</term>
<term>Newborn controls</term>
<term>Newborn guinea</term>
<term>Newborn rats</term>
<term>Perikarya</term>
<term>Polar lipids</term>
<term>Polymorphous osmiophilic material</term>
<term>Posterior horn</term>
<term>Pregnant animals</term>
<term>Prenatal development</term>
<term>Proximal tubule</term>
<term>Rat</term>
<term>Significant lipidosis</term>
<term>Slight alterations</term>
<term>Spinal cord</term>
<term>Stomach tube</term>
<term>Subcutaneous injection</term>
<term>Treatment periods</term>
<term>Ultrastructure</term>
<term>Virchows arch</term>
<term>Zona fasciculata</term>
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<front><div type="abstract" xml:lang="en">Summary: Pregnant rats and guinea pigs were treated throughout the second half of gestation with amphiphilic drugs (chlorphentermine, chlorcyclizine, chloroquine) known to induce generalized lipidosis. The offspring were sacrificed immediately after birth, and several tissues (lung, liver, kidney, spleen, pituitary gland, adrenal gland, spinal cord, hypothalamus) were examined by electron microscopy. Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers. The results show that fetal and adult tissues respond to lipidosis-inducing drugs in a qualitatively similar way ; the quantitative differences found may be related to pharmacokinetic and cellular factors.</div>
</front>
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<region><li>Schleswig-Holstein</li>
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<settlement><li>Kiel</li>
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