Generalized lipidosis in newborn rats and guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals
Identifieur interne : 000491 ( Istex/Curation ); précédent : 000490; suivant : 000492Generalized lipidosis in newborn rats and guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals
Auteurs : Renate Lüllmann-Rauch [Allemagne] ; Brigitte Stoermer [Allemagne]Source :
- Virchows Archiv B [ 0340-6075 ] ; 1982-12-01.
English descriptors
- KwdEn :
- Teeft :
- Abnormal lamellar inclusions, Abnormal lamellated inclusions, Adrenal, Adrenal cortex, Adrenal medulla, Adult animals, Adult rats, Adult tissues, Altromin gmbh, Alveolar epithelial cells, Alveolar macrophages, Amphiphilic, Amphiphilic drugs, Animal species, Anterior horn perikarya, Cell pathol, Cell tissue, Cellular factors, Chlorcyclizine, Chlorcyclizine treatment, Chloroquine, Chloroquine treatment, Chloroquine treatments, Chlorphentermine, Chlorphentermine administration, Chlorphentermine treatment, Control newborns, Corresponding mothers, Drinking water, Epithelial cells, Fetal, Fetal lipidosis, Fetal tissues, Ganglion cells, General organization, Generalized lipidosis, Granulated cells, Guinea, Guinea pigs, Higher magnification, Inclusion, Inclusion bodies, Initial body weight, Inset, Kupffer cells, Lamellar, Lamellar inclusions, Lamellated, Lamellated inclusions, Lamellated material, Lesser degree, Lipidosis, Little alteration, Little effect, Liver tissues, Lysosomal apparatus, Macrophage, Many macrophages, Medulla, Microglial, Microglial cells, Nerve cells, Nervous system, Neurosecretory perikarya, Newborn, Newborn animals, Newborn controls, Newborn guinea, Newborn rats, Perikarya, Polar lipids, Polymorphous osmiophilic material, Posterior horn, Pregnant animals, Prenatal development, Proximal tubule, Rat, Significant lipidosis, Slight alterations, Spinal cord, Stomach tube, Subcutaneous injection, Treatment periods, Ultrastructure, Virchows arch, Zona fasciculata.
Abstract
Summary: Pregnant rats and guinea pigs were treated throughout the second half of gestation with amphiphilic drugs (chlorphentermine, chlorcyclizine, chloroquine) known to induce generalized lipidosis. The offspring were sacrificed immediately after birth, and several tissues (lung, liver, kidney, spleen, pituitary gland, adrenal gland, spinal cord, hypothalamus) were examined by electron microscopy. Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers. The results show that fetal and adult tissues respond to lipidosis-inducing drugs in a qualitatively similar way ; the quantitative differences found may be related to pharmacokinetic and cellular factors.
Url:
DOI: 10.1007/BF02892837
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amphiphilic drugs to pregnant animals</title><author><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name><affiliation wicri:level="1"><mods:affiliation>Department of Anatomy, University of Kiel, Olshausenstrasse 40-60, D-2300, Kiel, Federal Republic of Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anatomy, University of Kiel, Olshausenstrasse 40-60, D-2300, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Stoermer, Brigitte" sort="Stoermer, Brigitte" uniqKey="Stoermer B" first="Brigitte" last="Stoermer">Brigitte Stoermer</name><affiliation wicri:level="1"><mods:affiliation>Department of Anatomy, University of Kiel, Olshausenstrasse 40-60, D-2300, Kiel, Federal Republic of Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anatomy, University of Kiel, Olshausenstrasse 40-60, D-2300, Kiel</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Virchows Archiv B</title><title level="j" type="sub">Cell Pathology</title><title level="j" type="abbrev">Virchows Archiv B Cell Pathol</title><idno type="ISSN">0340-6075</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1982-12-01">1982-12-01</date><biblScope unit="volume">39</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="59">59</biblScope><biblScope unit="page" to="73">73</biblScope></imprint><idno type="ISSN">0340-6075</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0340-6075</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chlorcyclizine</term><term>Chloroquine</term><term>Chlorphentermine</term><term>Experimental lipidosis</term><term>Guinea pig</term><term>Prenatal development</term><term>Rat</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Abnormal lamellar inclusions</term><term>Abnormal lamellated inclusions</term><term>Adrenal</term><term>Adrenal cortex</term><term>Adrenal medulla</term><term>Adult animals</term><term>Adult rats</term><term>Adult tissues</term><term>Altromin gmbh</term><term>Alveolar epithelial cells</term><term>Alveolar macrophages</term><term>Amphiphilic</term><term>Amphiphilic drugs</term><term>Animal species</term><term>Anterior horn perikarya</term><term>Cell pathol</term><term>Cell tissue</term><term>Cellular factors</term><term>Chlorcyclizine</term><term>Chlorcyclizine treatment</term><term>Chloroquine</term><term>Chloroquine treatment</term><term>Chloroquine treatments</term><term>Chlorphentermine</term><term>Chlorphentermine administration</term><term>Chlorphentermine treatment</term><term>Control newborns</term><term>Corresponding mothers</term><term>Drinking water</term><term>Epithelial cells</term><term>Fetal</term><term>Fetal lipidosis</term><term>Fetal tissues</term><term>Ganglion cells</term><term>General organization</term><term>Generalized lipidosis</term><term>Granulated cells</term><term>Guinea</term><term>Guinea pigs</term><term>Higher magnification</term><term>Inclusion</term><term>Inclusion bodies</term><term>Initial body weight</term><term>Inset</term><term>Kupffer cells</term><term>Lamellar</term><term>Lamellar inclusions</term><term>Lamellated</term><term>Lamellated inclusions</term><term>Lamellated material</term><term>Lesser degree</term><term>Lipidosis</term><term>Little alteration</term><term>Little effect</term><term>Liver tissues</term><term>Lysosomal apparatus</term><term>Macrophage</term><term>Many macrophages</term><term>Medulla</term><term>Microglial</term><term>Microglial cells</term><term>Nerve cells</term><term>Nervous system</term><term>Neurosecretory perikarya</term><term>Newborn</term><term>Newborn animals</term><term>Newborn controls</term><term>Newborn guinea</term><term>Newborn rats</term><term>Perikarya</term><term>Polar lipids</term><term>Polymorphous osmiophilic material</term><term>Posterior horn</term><term>Pregnant animals</term><term>Prenatal development</term><term>Proximal tubule</term><term>Rat</term><term>Significant lipidosis</term><term>Slight alterations</term><term>Spinal cord</term><term>Stomach tube</term><term>Subcutaneous injection</term><term>Treatment periods</term><term>Ultrastructure</term><term>Virchows arch</term><term>Zona fasciculata</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Pregnant rats and guinea pigs were treated throughout the second half of gestation with amphiphilic drugs (chlorphentermine, chlorcyclizine, chloroquine) known to induce generalized lipidosis. The offspring were sacrificed immediately after birth, and several tissues (lung, liver, kidney, spleen, pituitary gland, adrenal gland, spinal cord, hypothalamus) were examined by electron microscopy. Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers. The results show that fetal and adult tissues respond to lipidosis-inducing drugs in a qualitatively similar way ; the quantitative differences found may be related to pharmacokinetic and cellular factors.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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