Generalized lipidosis in newborn rats and guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals
Identifieur interne : 000491 ( Istex/Corpus ); précédent : 000490; suivant : 000492Generalized lipidosis in newborn rats and guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals
Auteurs : Renate Lüllmann-Rauch ; Brigitte StoermerSource :
- Virchows Archiv B [ 0340-6075 ] ; 1982-12-01.
English descriptors
- KwdEn :
- Teeft :
- Abnormal lamellar inclusions, Abnormal lamellated inclusions, Adrenal, Adrenal cortex, Adrenal medulla, Adult animals, Adult rats, Adult tissues, Altromin gmbh, Alveolar epithelial cells, Alveolar macrophages, Amphiphilic, Amphiphilic drugs, Animal species, Anterior horn perikarya, Cell pathol, Cell tissue, Cellular factors, Chlorcyclizine, Chlorcyclizine treatment, Chloroquine, Chloroquine treatment, Chloroquine treatments, Chlorphentermine, Chlorphentermine administration, Chlorphentermine treatment, Control newborns, Corresponding mothers, Drinking water, Epithelial cells, Fetal, Fetal lipidosis, Fetal tissues, Ganglion cells, General organization, Generalized lipidosis, Granulated cells, Guinea, Guinea pigs, Higher magnification, Inclusion, Inclusion bodies, Initial body weight, Inset, Kupffer cells, Lamellar, Lamellar inclusions, Lamellated, Lamellated inclusions, Lamellated material, Lesser degree, Lipidosis, Little alteration, Little effect, Liver tissues, Lysosomal apparatus, Macrophage, Many macrophages, Medulla, Microglial, Microglial cells, Nerve cells, Nervous system, Neurosecretory perikarya, Newborn, Newborn animals, Newborn controls, Newborn guinea, Newborn rats, Perikarya, Polar lipids, Polymorphous osmiophilic material, Posterior horn, Pregnant animals, Prenatal development, Proximal tubule, Rat, Significant lipidosis, Slight alterations, Spinal cord, Stomach tube, Subcutaneous injection, Treatment periods, Ultrastructure, Virchows arch, Zona fasciculata.
Abstract
Summary: Pregnant rats and guinea pigs were treated throughout the second half of gestation with amphiphilic drugs (chlorphentermine, chlorcyclizine, chloroquine) known to induce generalized lipidosis. The offspring were sacrificed immediately after birth, and several tissues (lung, liver, kidney, spleen, pituitary gland, adrenal gland, spinal cord, hypothalamus) were examined by electron microscopy. Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers. The results show that fetal and adult tissues respond to lipidosis-inducing drugs in a qualitatively similar way ; the quantitative differences found may be related to pharmacokinetic and cellular factors.
Url:
DOI: 10.1007/BF02892837
Links to Exploration step
ISTEX:A8FCD529CDA25960BE3AD5C9E682E5038E7F2E73Le document en format XML
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The offspring were sacrificed immediately after birth, and several tissues (lung, liver, kidney, spleen, pituitary gland, adrenal gland, spinal cord, hypothalamus) were examined by electron microscopy. Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers. 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lipidosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Chlorphentermine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Chlorcyclizine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Chloroquine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Rat</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Guinea pig</value></json:item></subject><articleId><json:string>BF02892837</json:string><json:string>Art7</json:string></articleId><arkIstex>ark:/67375/1BB-6JHN210P-3</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Summary: Pregnant rats and guinea pigs were treated throughout the second half of gestation with amphiphilic drugs (chlorphentermine, chlorcyclizine, chloroquine) known to induce generalized lipidosis. The offspring were sacrificed immediately after birth, and several tissues (lung, liver, kidney, spleen, pituitary gland, adrenal gland, spinal cord, hypothalamus) were examined by electron microscopy. Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers. 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The offspring were sacrificed immediately after birth, and several tissues (lung, liver, kidney, spleen, pituitary gland, adrenal gland, spinal cord, hypothalamus) were examined by electron microscopy. Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers. The results show that fetal and adult tissues respond to lipidosis-inducing drugs in a qualitatively similar way ; the quantitative differences found may be related to pharmacokinetic and cellular factors.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key words</head><item><term>Prenatal development</term></item><item><term>Experimental lipidosis</term></item><item><term>Chlorphentermine</term></item><item><term>Chlorcyclizine</term></item><item><term>Chloroquine</term></item><item><term>Rat</term></item><item><term>Guinea pig</term></item></list></keywords></textClass><textClass><keywords scheme="Journal-Subject-Group"><list><label>HX</label><item><term>Medicine & Public Health</term></item><label>H4800X</label><item><term>Pathology</term></item><label>L16008</label><item><term>Cell Biology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1981-10-03">Created</change><change 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Pathology</JournalSubTitle><JournalAbbreviatedTitle>Virchows Archiv B Cell Pathol</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Code="HX" Type="Primary">Medicine & Public Health</JournalSubject><JournalSubject Code="H4800X" Priority="1" Type="Secondary">Pathology</JournalSubject><JournalSubject Code="L16008" Priority="2" Type="Secondary">Cell Biology</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo TocLevels="0" VolumeType="Regular"><VolumeIDStart>39</VolumeIDStart><VolumeIDEnd>39</VolumeIDEnd><VolumeIssueCount>0</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd><IssueArticleCount>30</IssueArticleCount><IssueHistory><CoverDate><Year>1982</Year><Month>12</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1982</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art7"><ArticleInfo ArticleType="OriginalPaper" ContainsESM="No" Language="En" NumberingStyle="Unnumbered" TocLevels="0"><ArticleID>BF02892837</ArticleID><ArticleDOI>10.1007/BF02892837</ArticleDOI><ArticleCitationID>59</ArticleCitationID><ArticleSequenceNumber>7</ArticleSequenceNumber><ArticleTitle Language="En">Generalized lipidosis in newborn rats and guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals</ArticleTitle><ArticleFirstPage>59</ArticleFirstPage><ArticleLastPage>73</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2008</Year><Month>4</Month><Day>10</Day></RegistrationDate><Received><Year>1981</Year><Month>10</Month><Day>3</Day></Received><Accepted><Year>1981</Year><Month>11</Month><Day>4</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1982</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>443</JournalID><VolumeIDStart>39</VolumeIDStart><VolumeIDEnd>39</VolumeIDEnd><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Renate</GivenName><FamilyName>Lüllmann-Rauch</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Brigitte</GivenName><FamilyName>Stoermer</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Department of Anatomy</OrgDivision><OrgName>University of Kiel</OrgName><OrgAddress><Street>Olshausenstrasse 40-60</Street><Postcode>D-2300</Postcode><City>Kiel</City><Country>Federal Republic of Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para TextBreak="No">Pregnant rats and guinea pigs were treated throughout the second half of gestation with amphiphilic drugs (chlorphentermine, chlorcyclizine, chloroquine) known to induce generalized lipidosis. The offspring were sacrificed immediately after birth, and several tissues (lung, liver, kidney, spleen, pituitary gland, adrenal gland, spinal cord, hypothalamus) were examined by electron microscopy. Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers. The results show that fetal and adult tissues respond to lipidosis-inducing drugs in a qualitatively similar way ; the quantitative differences found may be related to pharmacokinetic and cellular factors.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Prenatal development</Keyword><Keyword>Experimental lipidosis</Keyword><Keyword>Chlorphentermine</Keyword><Keyword>Chlorcyclizine</Keyword><Keyword>Chloroquine</Keyword><Keyword>Rat</Keyword><Keyword>Guinea pig</Keyword></KeywordGroup><ArticleNote Type="Misc"><SimplePara>This study was supported by the Deutsche Forschungsgemeinschaft (Lu 172/4)</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Generalized lipidosis in newborn rats and guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Generalized lipidosis in newborn rats and guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Renate</namePart><namePart type="family">Lüllmann-Rauch</namePart><affiliation>Department of Anatomy, University of Kiel, Olshausenstrasse 40-60, D-2300, Kiel, Federal Republic of Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Brigitte</namePart><namePart type="family">Stoermer</namePart><affiliation>Department of Anatomy, University of Kiel, Olshausenstrasse 40-60, D-2300, Kiel, Federal Republic of Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1981-10-03</dateCreated><dateIssued encoding="w3cdtf">1982-12-01</dateIssued><copyrightDate encoding="w3cdtf">1982</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Summary: Pregnant rats and guinea pigs were treated throughout the second half of gestation with amphiphilic drugs (chlorphentermine, chlorcyclizine, chloroquine) known to induce generalized lipidosis. The offspring were sacrificed immediately after birth, and several tissues (lung, liver, kidney, spleen, pituitary gland, adrenal gland, spinal cord, hypothalamus) were examined by electron microscopy. Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers. The results show that fetal and adult tissues respond to lipidosis-inducing drugs in a qualitatively similar way ; the quantitative differences found may be related to pharmacokinetic and cellular factors.</abstract><subject lang="en"><genre>Key words</genre><topic>Prenatal development</topic><topic>Experimental lipidosis</topic><topic>Chlorphentermine</topic><topic>Chlorcyclizine</topic><topic>Chloroquine</topic><topic>Rat</topic><topic>Guinea pig</topic></subject><relatedItem type="host"><titleInfo><title>Virchows Archiv B</title><subTitle>Cell Pathology</subTitle></titleInfo><titleInfo type="abbreviated"><title>Virchows Archiv B Cell Pathol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1982-12-01</dateIssued><copyrightDate encoding="w3cdtf">1982</copyrightDate></originInfo><subject><genre>Journal-Subject-Group</genre><topic authority="SpringerSubjectCodes" authorityURI="HX">Medicine & Public Health</topic><topic authority="SpringerSubjectCodes" authorityURI="H4800X">Pathology</topic><topic authority="SpringerSubjectCodes" authorityURI="L16008">Cell Biology</topic></subject><identifier type="ISSN">0340-6075</identifier><identifier type="JournalID">443</identifier><identifier type="IssueArticleCount">30</identifier><identifier type="VolumeIssueCount">0</identifier><part><date>1982</date><detail type="volume"><number>39</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="pages"><start>59</start><end>73</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1982</recordOrigin></recordInfo></relatedItem><identifier type="istex">A8FCD529CDA25960BE3AD5C9E682E5038E7F2E73</identifier><identifier type="ark">ark:/67375/1BB-6JHN210P-3</identifier><identifier type="DOI">10.1007/BF02892837</identifier><identifier type="ArticleID">BF02892837</identifier><identifier type="ArticleID">Art7</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1982</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 1982</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-6JHN210P-3/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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