BernheimV1, Main, Merge, bibRecord, 000A43

The effect of prostaglandin E2 on the body temperature of restrained rats

Identifieur interne : 000A43 ( Main/Merge ); précédent : 000A42; suivant : 000A44

The effect of prostaglandin E2 on the body temperature of restrained rats

Auteurs : Akio Morimoto [Japon] ; Nancy C. Long [Japon] ; Tomoki Nakamori [Japon] ; Naotoshi Murakami [Japon]

Source :

Physiology & Behavior [ 0031-9384 ] ; 1991.

RBID : ISTEX:FE4710824CB4960038F167470509E9093B5F54D8

English descriptors

Teeft :
- Anova, Body temperature, Endotoxin, Factorial anova, High rectal temperatures, Hyperthermia, Hypothermia, Initial rectal temperature, Initial rectal temperatures, Injection, Intravenous injection, Maximum increase, Maximum increases, Pge2, Physiol, Prostaglandin, Rat, Rectal, Rectal temperature, Rectal temperatures, Stress hyperthermia, Systemic injection, Temperature changes.

Abstract

Abstract: We examined the effects of intravenous (IV) or intracerebroventricular (ICV) injection of prostaglandin E2 (PGE2) on the rectal temperature of restrained rats. The IV injection of PGE2 (0.5 mg/kg) caused hypothermia in rats with high initial rectal temperatures, but caused an elevation in rectal temperature in those animals whose starting temperatures were low. In contrast, the ICV injection of PGE2 induced fever, regardless of the rectal temperature at the time of injection. We also examined whether temperature changes due to the IV injection of endotoxin (lipopolysaccharide, LPS, 10 μg/kg) or interleukin-1β (IL-1β, 0.2 μg/kg) were dependent upon the rats' initial rectal temperatures. Rats with low rectal temperatures developed fevers in response to LPS, while animals with high starting temperatures showed hypothermia. In contrast, the IV injection of IL-1β produced fever regardless of initial rectal temperature. These data suggest that PGE2 acts centrally to cause fever and peripherally to cause hypothermia, and that following the injection of LPS, these opposing actions of PGE2 may act together to determine the thermoregulatory response.

Url:

https://api.istex.fr/document/FE4710824CB4960038F167470509E9093B5F54D8/fulltext/pdf

DOI: 10.1016/0031-9384(91)90528-V

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000733
to stream Istex, to step Curation: 000732
to stream Istex, to step Checkpoint: 000721

Links to Exploration step

ISTEX:FE4710824CB4960038F167470509E9093B5F54D8

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>The effect of prostaglandin E2 on the body temperature of restrained rats</title>
<author><name sortKey="Morimoto, Akio" sort="Morimoto, Akio" uniqKey="Morimoto A" first="Akio" last="Morimoto">Akio Morimoto</name>
</author>
<author><name sortKey="Long, Nancy C" sort="Long, Nancy C" uniqKey="Long N" first="Nancy C." last="Long">Nancy C. Long</name>
</author>
<author><name sortKey="Nakamori, Tomoki" sort="Nakamori, Tomoki" uniqKey="Nakamori T" first="Tomoki" last="Nakamori">Tomoki Nakamori</name>
</author>
<author><name sortKey="Murakami, Naotoshi" sort="Murakami, Naotoshi" uniqKey="Murakami N" first="Naotoshi" last="Murakami">Naotoshi Murakami</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:FE4710824CB4960038F167470509E9093B5F54D8</idno>
<date when="1991" year="1991">1991</date>
<idno type="doi">10.1016/0031-9384(91)90528-V</idno>
<idno type="url">https://api.istex.fr/document/FE4710824CB4960038F167470509E9093B5F54D8/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000733</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000733</idno>
<idno type="wicri:Area/Istex/Curation">000732</idno>
<idno type="wicri:Area/Istex/Checkpoint">000721</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000721</idno>
<idno type="wicri:doubleKey">0031-9384:1991:Morimoto A:the:effect:of</idno>
<idno type="wicri:Area/Main/Merge">000A43</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">The effect of prostaglandin E2 on the body temperature of restrained rats</title>
<author><name sortKey="Morimoto, Akio" sort="Morimoto, Akio" uniqKey="Morimoto A" first="Akio" last="Morimoto">Akio Morimoto</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Physiology, Yamaguchi University School of Medicine, Ube</wicri:regionArea>
<wicri:noRegion>Ube</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Long, Nancy C" sort="Long, Nancy C" uniqKey="Long N" first="Nancy C." last="Long">Nancy C. Long</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Physiology, Yamaguchi University School of Medicine, Ube</wicri:regionArea>
<wicri:noRegion>Ube</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nakamori, Tomoki" sort="Nakamori, Tomoki" uniqKey="Nakamori T" first="Tomoki" last="Nakamori">Tomoki Nakamori</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Physiology, Yamaguchi University School of Medicine, Ube</wicri:regionArea>
<wicri:noRegion>Ube</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Murakami, Naotoshi" sort="Murakami, Naotoshi" uniqKey="Murakami N" first="Naotoshi" last="Murakami">Naotoshi Murakami</name>
<affiliation wicri:level="1"><country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Physiology, Yamaguchi University School of Medicine, Ube</wicri:regionArea>
<wicri:noRegion>Ube</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Physiology & Behavior</title>
<title level="j" type="abbrev">PHB</title>
<idno type="ISSN">0031-9384</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1991">1991</date>
<biblScope unit="volume">50</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="249">249</biblScope>
<biblScope unit="page" to="253">253</biblScope>
</imprint>
<idno type="ISSN">0031-9384</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0031-9384</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Anova</term>
<term>Body temperature</term>
<term>Endotoxin</term>
<term>Factorial anova</term>
<term>High rectal temperatures</term>
<term>Hyperthermia</term>
<term>Hypothermia</term>
<term>Initial rectal temperature</term>
<term>Initial rectal temperatures</term>
<term>Injection</term>
<term>Intravenous injection</term>
<term>Maximum increase</term>
<term>Maximum increases</term>
<term>Pge2</term>
<term>Physiol</term>
<term>Prostaglandin</term>
<term>Rat</term>
<term>Rectal</term>
<term>Rectal temperature</term>
<term>Rectal temperatures</term>
<term>Stress hyperthermia</term>
<term>Systemic injection</term>
<term>Temperature changes</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: We examined the effects of intravenous (IV) or intracerebroventricular (ICV) injection of prostaglandin E2 (PGE2) on the rectal temperature of restrained rats. The IV injection of PGE2 (0.5 mg/kg) caused hypothermia in rats with high initial rectal temperatures, but caused an elevation in rectal temperature in those animals whose starting temperatures were low. In contrast, the ICV injection of PGE2 induced fever, regardless of the rectal temperature at the time of injection. We also examined whether temperature changes due to the IV injection of endotoxin (lipopolysaccharide, LPS, 10 μg/kg) or interleukin-1β (IL-1β, 0.2 μg/kg) were dependent upon the rats' initial rectal temperatures. Rats with low rectal temperatures developed fevers in response to LPS, while animals with high starting temperatures showed hypothermia. In contrast, the IV injection of IL-1β produced fever regardless of initial rectal temperature. These data suggest that PGE2 acts centrally to cause fever and peripherally to cause hypothermia, and that following the injection of LPS, these opposing actions of PGE2 may act together to determine the thermoregulatory response.</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Psychologie/explor/BernheimV1/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A43 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000A43 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Psychologie
   |area=    BernheimV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     ISTEX:FE4710824CB4960038F167470509E9093B5F54D8
   |texte=   The effect of prostaglandin E2 on the body temperature of restrained rats
}}

This area was generated with Dilib version V0.6.33.
Data generation: Mon Mar 5 17:33:33 2018. Site generation: Thu Apr 29 15:49:51 2021

	Serveur d'exploration Hippolyte Bernheim
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Hippolyte Bernheim

The effect of prostaglandin E2 on the body temperature of restrained rats

The effect of prostaglandin E2 on the body temperature of restrained rats

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri