Intraperitoneal injections of prostaglandin E2 attenuate hyperthermia induced by restraint or interleukin-1 in rats.
Identifieur interne : 000A42 ( Main/Merge ); précédent : 000A41; suivant : 000A43Intraperitoneal injections of prostaglandin E2 attenuate hyperthermia induced by restraint or interleukin-1 in rats.
Auteurs : N C Long ; A. Morimoto ; T. Nakamori ; O. Yamashiro ; N. MurakamiSource :
- The Journal of Physiology [ 0022-3751 ] ; 1991.
Abstract
1. The purpose of this study was to investigate the effect of the intraperitoneal (I.P.), intravenous (I.V.) or intrapreoptic area (POA) injection of prostaglandin E2 (PGE2) on the body temperature of restrained and unrestrained rats. The effect of I.P. PGE2 on the body temperature of rats during fever induced by I.P. injection of interleukin-1 beta (IL-1 beta) was also investigated. 2. Prior to injection, restrained rats had body temperatures of approximately 1 degree C higher than unrestrained rats. The I.P. injection of PGE2 (0.05 and 0.5 mg kg-1) caused body temperature to fall towards the pre-restraint levels in a dose-dependent manner. This fall in body temperature was preceded by a sharp increase in tail skin temperature that was also dependent on dose. The I.P. injection of PGE2 had no effect on the body temperature of unrestrained animals. 3. The I.V. injection of PGE2 caused very little change in the body temperature of restrained rats. However, when injected I.V. into unrestrained animals, PGE2 caused dose-dependent fevers. The injection of PGE2 (50 ng) into the POA resulted in fever in both restrained and unrestrained animals. 4. The I.P. injection of IL-1 beta (10 micrograms kg-1) caused a biphasic fever that lasted at least 420 min. The I.P. injection of PGE2 180 min after the injection of IL-1 beta caused a transient decrease in the rats' body temperature. This drop in body temperature was not associated with a decrease in metabolic rate. 5. These data support the hypothesis that during restraint stress hyperthermia and IL-1 beta fever, the I.P. injection of PGE2 acts peripherally to lower the body temperature of rats.
Url:
PubMed: 1822555
PubMed Central: 1179938
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000154
- to stream Pmc, to step Curation: 000154
- to stream Pmc, to step Checkpoint: 000046
- to stream Ncbi, to step Merge: 000033
- to stream Ncbi, to step Curation: 000033
- to stream Ncbi, to step Checkpoint: 000033
Links to Exploration step
PMC:1179938Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Intraperitoneal injections of prostaglandin E2 attenuate hyperthermia induced by restraint or interleukin-1 in rats.</title><author><name sortKey="Long, N C" sort="Long, N C" uniqKey="Long N" first="N C" last="Long">N C Long</name></author><author><name sortKey="Morimoto, A" sort="Morimoto, A" uniqKey="Morimoto A" first="A" last="Morimoto">A. Morimoto</name></author><author><name sortKey="Nakamori, T" sort="Nakamori, T" uniqKey="Nakamori T" first="T" last="Nakamori">T. Nakamori</name></author><author><name sortKey="Yamashiro, O" sort="Yamashiro, O" uniqKey="Yamashiro O" first="O" last="Yamashiro">O. Yamashiro</name></author><author><name sortKey="Murakami, N" sort="Murakami, N" uniqKey="Murakami N" first="N" last="Murakami">N. Murakami</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">1822555</idno><idno type="pmc">1179938</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1179938</idno><idno type="RBID">PMC:1179938</idno><date when="1991">1991</date><idno type="wicri:Area/Pmc/Corpus">000154</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000154</idno><idno type="wicri:Area/Pmc/Curation">000154</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000154</idno><idno type="wicri:Area/Pmc/Checkpoint">000046</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000046</idno><idno type="wicri:Area/Ncbi/Merge">000033</idno><idno type="wicri:Area/Ncbi/Curation">000033</idno><idno type="wicri:Area/Ncbi/Checkpoint">000033</idno><idno type="wicri:doubleKey">0022-3751:1991:Long N:intraperitoneal:injections:of</idno><idno type="wicri:Area/Main/Merge">000A42</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Intraperitoneal injections of prostaglandin E2 attenuate hyperthermia induced by restraint or interleukin-1 in rats.</title><author><name sortKey="Long, N C" sort="Long, N C" uniqKey="Long N" first="N C" last="Long">N C Long</name></author><author><name sortKey="Morimoto, A" sort="Morimoto, A" uniqKey="Morimoto A" first="A" last="Morimoto">A. Morimoto</name></author><author><name sortKey="Nakamori, T" sort="Nakamori, T" uniqKey="Nakamori T" first="T" last="Nakamori">T. Nakamori</name></author><author><name sortKey="Yamashiro, O" sort="Yamashiro, O" uniqKey="Yamashiro O" first="O" last="Yamashiro">O. Yamashiro</name></author><author><name sortKey="Murakami, N" sort="Murakami, N" uniqKey="Murakami N" first="N" last="Murakami">N. Murakami</name></author></analytic><series><title level="j">The Journal of Physiology</title><idno type="ISSN">0022-3751</idno><idno type="eISSN">1469-7793</idno><imprint><date when="1991">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>1. The purpose of this study was to investigate the effect of the intraperitoneal (I.P.), intravenous (I.V.) or intrapreoptic area (POA) injection of prostaglandin E2 (PGE2) on the body temperature of restrained and unrestrained rats. The effect of I.P. PGE2 on the body temperature of rats during fever induced by I.P. injection of interleukin-1 beta (IL-1 beta) was also investigated. 2. Prior to injection, restrained rats had body temperatures of approximately 1 degree C higher than unrestrained rats. The I.P. injection of PGE2 (0.05 and 0.5 mg kg-1) caused body temperature to fall towards the pre-restraint levels in a dose-dependent manner. This fall in body temperature was preceded by a sharp increase in tail skin temperature that was also dependent on dose. The I.P. injection of PGE2 had no effect on the body temperature of unrestrained animals. 3. The I.V. injection of PGE2 caused very little change in the body temperature of restrained rats. However, when injected I.V. into unrestrained animals, PGE2 caused dose-dependent fevers. The injection of PGE2 (50 ng) into the POA resulted in fever in both restrained and unrestrained animals. 4. The I.P. injection of IL-1 beta (10 micrograms kg-1) caused a biphasic fever that lasted at least 420 min. The I.P. injection of PGE2 180 min after the injection of IL-1 beta caused a transient decrease in the rats' body temperature. This drop in body temperature was not associated with a decrease in metabolic rate. 5. These data support the hypothesis that during restraint stress hyperthermia and IL-1 beta fever, the I.P. injection of PGE2 acts peripherally to lower the body temperature of rats.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Psychologie/explor/BernheimV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A42 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000A42 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Psychologie
|area= BernheimV1
|flux= Main
|étape= Merge
|type= RBID
|clé= PMC:1179938
|texte= Intraperitoneal injections of prostaglandin E2 attenuate hyperthermia induced by restraint or interleukin-1 in rats.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:1822555" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a BernheimV1
| This area was generated with Dilib version V0.6.33. |  |