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Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects

Identifieur interne : 001725 ( Main/Exploration ); précédent : 001724; suivant : 001726

Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects

Auteurs : O. Ukkola [Finlande] ; Y. A. Kes Niemi [Finlande]

Source :

European journal of clinical nutrition [ 0954-3007 ] ; 2007.

RBID : Pascal:07-0426249

Descripteurs français

Pascal (Inist)
- Diabète type 2, Polymorphisme, Association, Facteur risque, Risque, Age mûr, Homme, Nutrition.
Wicri :
- topic : Association, Homme, Nutrition.

English descriptors

KwdEn :
- Adult, Association, Blood Glucose (metabolism), Blood Pressure, Diabetes Mellitus, Type 2 (genetics), Female, Gene Frequency, Genotype, Ghrelin (blood), Human, Humans, Hypertension (genetics), Insulin (blood), Insulin (secretion), Leucine (genetics), Leucine (metabolism), Male, Middle Aged, Middle age, Neuropeptide Y (genetics), Nutrition, Peptide Hormones (blood), Polymorphism, Polymorphism, Genetic, Proline (genetics), Proline (metabolism), Protein Precursors (genetics), Risk, Risk Factors, Risk factor, Type 2 diabetes.
MESH :
- chemical , blood : Ghrelin, Insulin, Peptide Hormones.
- chemical , genetics : Leucine, Neuropeptide Y, Proline, Protein Precursors.
- chemical , metabolism : Blood Glucose, Leucine, Proline.
- genetics : Diabetes Mellitus, Type 2, Hypertension.
- chemical , secretion : Insulin.
- Adult, Blood Pressure, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Risk Factors.

Abstract

Objectives: Neuropeptide Y (NPY) plays a central in energy homeostasis and potentially in the development of obesity-related comorbidities, like type II diabetes. As the PreproNPY Leu7Pro polymorphism probably changes the intracellular processing of the synthesized preproNPY peptide, we assessed the hypothesis that PreproNPY Leu7Pro polymorphism is a risk factor for type II diabetes, impaired glucose tolerance and hypertension. Design: Blood pressure recordings and oral glucose tolerance test were performed in the hypertensive (n= 515) and control cohorts (n = 525) of our well-defined Oulu Project Elucidating Risk of Atherosclerosis (OPERA) study. The prevalence of type II diabetes was 9% (n=93). The genotypes, insulin and glucose metabolism indexes and plasma ghrelin of the subjects were determined. Results: Pro7 allele frequencies were 5.9, 5.3 and 11.3% in the total cohort, in subjects without and with type II diabetes, respectively. The PreproNPY Pro7 carrier status was a significant risk factor for type II diabetes, and the effect remained significant after adjustment for age, sex, waist circumference and study group (odds ratio = 3.02, confidence interval: 1.67-5.44 and P<0.001). Pro7 carriers were more insulin resistant and showed lower ghrelin levels compared to non-carriers. Conclusions: The PreproNPY Pro7 allele is associated with an increased risk for type II diabetes. The risk seems to be associated with a higher insulin resistance among Pro7 carriers whereas low ghrelin concentrations in Pro7 carriers are possibly a consequence of high insulin levels. Sponsorship: None.

Affiliations:

Finlande

Le document en format XML

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<series><title level="j" type="main">European journal of clinical nutrition</title>
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<term>Blood Pressure</term>
<term>Diabetes Mellitus, Type 2 (genetics)</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genotype</term>
<term>Ghrelin (blood)</term>
<term>Human</term>
<term>Humans</term>
<term>Hypertension (genetics)</term>
<term>Insulin (blood)</term>
<term>Insulin (secretion)</term>
<term>Leucine (genetics)</term>
<term>Leucine (metabolism)</term>
<term>Male</term>
<term>Middle Aged</term>
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<term>Neuropeptide Y (genetics)</term>
<term>Nutrition</term>
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<term>Proline (metabolism)</term>
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<term>Peptide Hormones</term>
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<term>Proline</term>
<term>Protein Precursors</term>
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<term>Leucine</term>
<term>Proline</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Diabetes Mellitus, Type 2</term>
<term>Hypertension</term>
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<term>Blood Pressure</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Polymorphism, Genetic</term>
<term>Risk Factors</term>
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<term>Polymorphisme</term>
<term>Association</term>
<term>Facteur risque</term>
<term>Risque</term>
<term>Age mûr</term>
<term>Homme</term>
<term>Nutrition</term>
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<front><div type="abstract" xml:lang="en">Objectives: Neuropeptide Y (NPY) plays a central in energy homeostasis and potentially in the development of obesity-related comorbidities, like type II diabetes. As the PreproNPY Leu7Pro polymorphism probably changes the intracellular processing of the synthesized preproNPY peptide, we assessed the hypothesis that PreproNPY Leu7Pro polymorphism is a risk factor for type II diabetes, impaired glucose tolerance and hypertension. Design: Blood pressure recordings and oral glucose tolerance test were performed in the hypertensive (n= 515) and control cohorts (n = 525) of our well-defined Oulu Project Elucidating Risk of Atherosclerosis (OPERA) study. The prevalence of type II diabetes was 9% (n=93). The genotypes, insulin and glucose metabolism indexes and plasma ghrelin of the subjects were determined. Results: Pro7 allele frequencies were 5.9, 5.3 and 11.3% in the total cohort, in subjects without and with type II diabetes, respectively. The PreproNPY Pro7 carrier status was a significant risk factor for type II diabetes, and the effect remained significant after adjustment for age, sex, waist circumference and study group (odds ratio = 3.02, confidence interval: 1.67-5.44 and P<0.001). Pro7 carriers were more insulin resistant and showed lower ghrelin levels compared to non-carriers. Conclusions: The PreproNPY Pro7 allele is associated with an increased risk for type II diabetes. The risk seems to be associated with a higher insulin resistance among Pro7 carriers whereas low ghrelin concentrations in Pro7 carriers are possibly a consequence of high insulin levels. Sponsorship: None.</div>
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Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects

Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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