Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects.
Identifieur interne : 000471 ( PubMed/Curation ); précédent : 000470; suivant : 000472Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects.
Auteurs : O. Ukkola [Finlande] ; Y A Kes NiemiSource :
- European journal of clinical nutrition [ 0954-3007 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Blood Glucose (metabolism), Blood Pressure, Diabetes Mellitus, Type 2 (genetics), Female, Gene Frequency, Genotype, Ghrelin (blood), Humans, Hypertension (genetics), Insulin (blood), Insulin (secretion), Leucine (genetics), Leucine (metabolism), Male, Middle Aged, Neuropeptide Y (genetics), Peptide Hormones (blood), Polymorphism, Genetic, Proline (genetics), Proline (metabolism), Protein Precursors (genetics), Risk Factors.
- MESH :
- chemical , blood : Ghrelin, Insulin, Peptide Hormones.
- chemical , genetics : Leucine, Neuropeptide Y, Proline, Protein Precursors.
- chemical , metabolism : Blood Glucose, Leucine, Proline.
- genetics : Diabetes Mellitus, Type 2, Hypertension.
- chemical , secretion : Insulin.
- Adult, Blood Pressure, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Risk Factors.
Abstract
Neuropeptide Y (NPY) plays a central in energy homeostasis and potentially in the development of obesity-related comorbidities, like type II diabetes. As the PreproNPY Leu7Pro polymorphism probably changes the intracellular processing of the synthesized preproNPY peptide, we assessed the hypothesis that PreproNPY Leu7Pro polymorphism is a risk factor for type II diabetes, impaired glucose tolerance and hypertension.
DOI: 10.1038/sj.ejcn.1602621
PubMed: 17268419
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects.</title><author><name sortKey="Ukkola, O" sort="Ukkola, O" uniqKey="Ukkola O" first="O" last="Ukkola">O. Ukkola</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland. olavi.ukkola@oulu.fi</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Kes Niemi, Y A" sort="Kes Niemi, Y A" uniqKey="Kes Niemi Y" first="Y A" last="Kes Niemi">Y A Kes Niemi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1038/sj.ejcn.1602621</idno><idno type="RBID">pubmed:17268419</idno><idno type="pmid">17268419</idno><idno type="wicri:Area/PubMed/Corpus">000471</idno><idno type="wicri:Area/PubMed/Curation">000471</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects.</title><author><name sortKey="Ukkola, O" sort="Ukkola, O" uniqKey="Ukkola O" first="O" last="Ukkola">O. Ukkola</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland. olavi.ukkola@oulu.fi</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Kes Niemi, Y A" sort="Kes Niemi, Y A" uniqKey="Kes Niemi Y" first="Y A" last="Kes Niemi">Y A Kes Niemi</name></author></analytic><series><title level="j">European journal of clinical nutrition</title><idno type="ISSN">0954-3007</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Blood Glucose (metabolism)</term><term>Blood Pressure</term><term>Diabetes Mellitus, Type 2 (genetics)</term><term>Female</term><term>Gene Frequency</term><term>Genotype</term><term>Ghrelin (blood)</term><term>Humans</term><term>Hypertension (genetics)</term><term>Insulin (blood)</term><term>Insulin (secretion)</term><term>Leucine (genetics)</term><term>Leucine (metabolism)</term><term>Male</term><term>Middle Aged</term><term>Neuropeptide Y (genetics)</term><term>Peptide Hormones (blood)</term><term>Polymorphism, Genetic</term><term>Proline (genetics)</term><term>Proline (metabolism)</term><term>Protein Precursors (genetics)</term><term>Risk Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Ghrelin</term><term>Insulin</term><term>Peptide Hormones</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Leucine</term><term>Neuropeptide Y</term><term>Proline</term><term>Protein Precursors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Blood Glucose</term><term>Leucine</term><term>Proline</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Diabetes Mellitus, Type 2</term><term>Hypertension</term></keywords><keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Insulin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Blood Pressure</term><term>Female</term><term>Gene Frequency</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Genetic</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Neuropeptide Y (NPY) plays a central in energy homeostasis and potentially in the development of obesity-related comorbidities, like type II diabetes. As the PreproNPY Leu7Pro polymorphism probably changes the intracellular processing of the synthesized preproNPY peptide, we assessed the hypothesis that PreproNPY Leu7Pro polymorphism is a risk factor for type II diabetes, impaired glucose tolerance and hypertension.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17268419</PMID><DateCreated><Year>2007</Year><Month>09</Month><Day>05</Day></DateCreated><DateCompleted><Year>2007</Year><Month>11</Month><Day>30</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0954-3007</ISSN><JournalIssue CitedMedium="Print"><Volume>61</Volume><Issue>9</Issue><PubDate><Year>2007</Year><Month>Sep</Month></PubDate></JournalIssue><Title>European journal of clinical nutrition</Title><ISOAbbreviation>Eur J Clin Nutr</ISOAbbreviation></Journal><ArticleTitle>Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects.</ArticleTitle><Pagination><MedlinePgn>1102-5</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Neuropeptide Y (NPY) plays a central in energy homeostasis and potentially in the development of obesity-related comorbidities, like type II diabetes. As the PreproNPY Leu7Pro polymorphism probably changes the intracellular processing of the synthesized preproNPY peptide, we assessed the hypothesis that PreproNPY Leu7Pro polymorphism is a risk factor for type II diabetes, impaired glucose tolerance and hypertension.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Blood pressure recordings and oral glucose tolerance test were performed in the hypertensive (n=515) and control cohorts (n=525) of our well-defined Oulu Project Elucidating Risk of Atherosclerosis (OPERA) study. The prevalence of type II diabetes was 9% (n=93). The genotypes, insulin and glucose metabolism indexes and plasma ghrelin of the subjects were determined.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Pro7 allele frequencies were 5.9, 5.3 and 11.3% in the total cohort, in subjects without and with type II diabetes, respectively. The PreproNPY Pro7 carrier status was a significant risk factor for type II diabetes, and the effect remained significant after adjustment for age, sex, waist circumference and study group (odds ratio=3.02, confidence interval: 1.67-5.44 and P<0.001). Pro7 carriers were more insulin resistant and showed lower ghrelin levels compared to non-carriers.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The PreproNPY Pro7 allele is associated with an increased risk for type II diabetes. The risk seems to be associated with a higher insulin resistance among Pro7 carriers whereas low ghrelin concentrations in Pro7 carriers are possibly a consequence of high insulin levels.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ukkola</LastName><ForeName>O</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland. olavi.ukkola@oulu.fi</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kesäniemi</LastName><ForeName>Y A</ForeName><Initials>YA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2007</Year><Month>01</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Eur J Clin Nutr</MedlineTA><NlmUniqueID>8804070</NlmUniqueID><ISSNLinking>0954-3007</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001786">Blood Glucose</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054439">Ghrelin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007328">Insulin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009478">Neuropeptide Y</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D036361">Peptide Hormones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011498">Protein Precursors</NameOfSubstance></Chemical><Chemical><RegistryNumber>92307-59-0</RegistryNumber><NameOfSubstance UI="C042084">preproneuropeptide Y</NameOfSubstance></Chemical><Chemical><RegistryNumber>9DLQ4CIU6V</RegistryNumber><NameOfSubstance UI="D011392">Proline</NameOfSubstance></Chemical><Chemical><RegistryNumber>GMW67QNF9C</RegistryNumber><NameOfSubstance UI="D007930">Leucine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001786">Blood Glucose</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001794">Blood Pressure</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003924">Diabetes Mellitus, Type 2</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005787">Gene Frequency</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005838">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D054439">Ghrelin</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006973">Hypertension</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007328">Insulin</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000557">secretion</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007930">Leucine</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009478">Neuropeptide Y</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D036361">Peptide Hormones</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D011110">Polymorphism, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011392">Proline</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011498">Protein Precursors</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012307">Risk Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2007</Year><Month>1</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>2</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>12</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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