Platelet mitochondrial activity and pesticide exposure in early Parkinson's disease.
Identifieur interne : 000541 ( Ncbi/Merge ); précédent : 000540; suivant : 000542Platelet mitochondrial activity and pesticide exposure in early Parkinson's disease.
Auteurs : Jeff M. Bronstein [États-Unis] ; Kimberly Paul [États-Unis] ; Laurice Yang [États-Unis] ; Richard H. Haas [États-Unis] ; Clifford W. Shults [États-Unis] ; Thuy Le [États-Unis] ; Beate Ritz [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Blood Platelets (drug effects), Blood Platelets (enzymology), Case-Control Studies, Electron Transport Chain Complex Proteins (metabolism), Electron Transport Complex I (metabolism), Electron Transport Complex III (metabolism), Environmental Exposure (adverse effects), Female, Geographic Information Systems (statistics & numerical data), Humans, Male, Middle Aged, Mitochondria (drug effects), Mitochondria (enzymology), NADPH-Ferrihemoprotein Reductase (metabolism), Parkinson Disease (etiology), Parkinson Disease (metabolism), Pesticides (toxicity), Risk Factors.
- MESH :
- chemical , metabolism : Electron Transport Chain Complex Proteins, Electron Transport Complex I, Electron Transport Complex III, NADPH-Ferrihemoprotein Reductase.
- adverse effects : Environmental Exposure.
- drug effects : Blood Platelets, Mitochondria.
- enzymology : Blood Platelets, Mitochondria.
- etiology : Parkinson Disease.
- metabolism : Parkinson Disease.
- statistics & numerical data : Geographic Information Systems.
- chemical , toxicity : Pesticides.
- Aged, Case-Control Studies, Female, Humans, Male, Middle Aged, Risk Factors.
Abstract
Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD), but the cause of this dysfunction is unclear.
DOI: 10.1002/mds.26164
PubMed: 25757798
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000088
- to stream PubMed, to step Curation: 000088
- to stream PubMed, to step Checkpoint: 000088
Links to Exploration step
pubmed:25757798Le document en format XML
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<front><div type="abstract" xml:lang="en">Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD), but the cause of this dysfunction is unclear.</div>
</front>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD), but the cause of this dysfunction is unclear.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Platelet mitochondrial complex I and I/III (nicotinamide adenine dinucleotide cytochrome c reductase, NCCR) activities were measured in early PD patients and matched controls enrolled in a population-based case-control study. Ambient agricultural pesticide exposures were assessed with a geographic information system and California Pesticide Use Registry.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In contrast to some previous reports, we found no differences in complex I and I/III activities in subjects with PD and controls. We did find that NCCR activity correlated with subjects' exposure to pesticides known to inhibit mitochondrial activity regardless of their diagnosis.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Electron transport chain (ETC) activity is not altered in PD in this well-characterized cohort when compared with community-matched controls but appears to be affected by environmental toxins, such as mitochondria-inhibiting pesticides.</AbstractText>
<CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation>
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<AffiliationInfo><Affiliation>Greater Los Angeles Veterans Administration Medical Center, Los Angeles, California, USA.</Affiliation>
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<CommentsCorrections RefType="Cites"><RefSource>Crit Rev Toxicol. 2013 Jul;43(6):515-34</RefSource>
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<CommentsCorrections RefType="Cites"><RefSource>Neurology. 2014 Feb 4;82(5):419-26</RefSource>
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<CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2002 Oct;59(10):1541-50</RefSource>
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<CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 1989 Dec;26(6):719-23</RefSource>
<PMID Version="1">2557792</PMID>
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<MeshHeading><DescriptorName UI="D009251" MajorTopicYN="N">NADPH-Ferrihemoprotein Reductase</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
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<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D010575" MajorTopicYN="N">Pesticides</DescriptorName>
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<affiliations><list><country><li>États-Unis</li>
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<name sortKey="Haas, Richard H" sort="Haas, Richard H" uniqKey="Haas R" first="Richard H" last="Haas">Richard H. Haas</name>
<name sortKey="Le, Thuy" sort="Le, Thuy" uniqKey="Le T" first="Thuy" last="Le">Thuy Le</name>
<name sortKey="Paul, Kimberly" sort="Paul, Kimberly" uniqKey="Paul K" first="Kimberly" last="Paul">Kimberly Paul</name>
<name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
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