Platelet mitochondrial activity and pesticide exposure in early Parkinson's disease.
Identifieur interne : 000088 ( PubMed/Curation ); précédent : 000087; suivant : 000089Platelet mitochondrial activity and pesticide exposure in early Parkinson's disease.
Auteurs : Jeff M. Bronstein [États-Unis] ; Kimberly Paul [États-Unis] ; Laurice Yang [États-Unis] ; Richard H. Haas [États-Unis] ; Clifford W. Shults [États-Unis] ; Thuy Le [États-Unis] ; Beate Ritz [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Blood Platelets (drug effects), Blood Platelets (enzymology), Case-Control Studies, Electron Transport Chain Complex Proteins (metabolism), Electron Transport Complex I (metabolism), Electron Transport Complex III (metabolism), Environmental Exposure (adverse effects), Female, Geographic Information Systems (statistics & numerical data), Humans, Male, Middle Aged, Mitochondria (drug effects), Mitochondria (enzymology), NADPH-Ferrihemoprotein Reductase (metabolism), Parkinson Disease (etiology), Parkinson Disease (metabolism), Pesticides (toxicity), Risk Factors.
- MESH :
- chemical , metabolism : Electron Transport Chain Complex Proteins, Electron Transport Complex I, Electron Transport Complex III, NADPH-Ferrihemoprotein Reductase.
- adverse effects : Environmental Exposure.
- drug effects : Blood Platelets, Mitochondria.
- enzymology : Blood Platelets, Mitochondria.
- etiology : Parkinson Disease.
- metabolism : Parkinson Disease.
- statistics & numerical data : Geographic Information Systems.
- chemical , toxicity : Pesticides.
- Aged, Case-Control Studies, Female, Humans, Male, Middle Aged, Risk Factors.
Abstract
Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD), but the cause of this dysfunction is unclear.
DOI: 10.1002/mds.26164
PubMed: 25757798
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Bronstein</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, David Geffen School of Medicine, Los Angeles, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, David Geffen School of Medicine, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Paul, Kimberly" sort="Paul, Kimberly" uniqKey="Paul K" first="Kimberly" last="Paul">Kimberly Paul</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Laurice" sort="Yang, Laurice" uniqKey="Yang L" first="Laurice" last="Yang">Laurice Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, David Geffen School of Medicine, Los Angeles, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, David Geffen School of Medicine, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Haas, Richard H" sort="Haas, Richard H" uniqKey="Haas R" first="Richard H" last="Haas">Richard H. Haas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosciences, University of California San Diego, La Jolla, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosciences, University of California San Diego, La Jolla, California</wicri:regionArea></affiliation></author><author><name sortKey="Shults, Clifford W" sort="Shults, Clifford W" uniqKey="Shults C" first="Clifford W" last="Shults">Clifford W. Shults</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosciences, University of California San Diego, La Jolla, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosciences, University of California San Diego, La Jolla, California</wicri:regionArea></affiliation></author><author><name sortKey="Le, Thuy" sort="Le, Thuy" uniqKey="Le T" first="Thuy" last="Le">Thuy Le</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosciences, University of California San Diego, La Jolla, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosciences, University of California San Diego, La Jolla, California</wicri:regionArea></affiliation></author><author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California</wicri:regionArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Blood Platelets (drug effects)</term><term>Blood Platelets (enzymology)</term><term>Case-Control Studies</term><term>Electron Transport Chain Complex Proteins (metabolism)</term><term>Electron Transport Complex I (metabolism)</term><term>Electron Transport Complex III (metabolism)</term><term>Environmental Exposure (adverse effects)</term><term>Female</term><term>Geographic Information Systems (statistics & numerical data)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mitochondria (drug effects)</term><term>Mitochondria (enzymology)</term><term>NADPH-Ferrihemoprotein Reductase (metabolism)</term><term>Parkinson Disease (etiology)</term><term>Parkinson Disease (metabolism)</term><term>Pesticides (toxicity)</term><term>Risk Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Electron Transport Chain Complex Proteins</term><term>Electron Transport Complex I</term><term>Electron Transport Complex III</term><term>NADPH-Ferrihemoprotein Reductase</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Environmental Exposure</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blood Platelets</term><term>Mitochondria</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Blood Platelets</term><term>Mitochondria</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Geographic Information Systems</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Pesticides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD), but the cause of this dysfunction is unclear.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25757798</PMID><DateCreated><Year>2015</Year><Month>05</Month><Day>20</Day></DateCreated><DateCompleted><Year>2016</Year><Month>04</Month><Day>07</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>6</Issue><PubDate><Year>2015</Year><Month>May</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Platelet mitochondrial activity and pesticide exposure in early Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>862-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26164</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD), but the cause of this dysfunction is unclear.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Platelet mitochondrial complex I and I/III (nicotinamide adenine dinucleotide cytochrome c reductase, NCCR) activities were measured in early PD patients and matched controls enrolled in a population-based case-control study. Ambient agricultural pesticide exposures were assessed with a geographic information system and California Pesticide Use Registry.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In contrast to some previous reports, we found no differences in complex I and I/III activities in subjects with PD and controls. We did find that NCCR activity correlated with subjects' exposure to pesticides known to inhibit mitochondrial activity regardless of their diagnosis.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Electron transport chain (ETC) activity is not altered in PD in this well-characterized cohort when compared with community-matched controls but appears to be affected by environmental toxins, such as mitochondria-inhibiting pesticides.</AbstractText><CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bronstein</LastName><ForeName>Jeff M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Neurology, David Geffen School of Medicine, Los Angeles, California, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Greater Los Angeles Veterans Administration Medical Center, Los Angeles, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paul</LastName><ForeName>Kimberly</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Laurice</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Neurology, David Geffen School of Medicine, Los Angeles, California, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Greater Los Angeles Veterans Administration Medical Center, Los Angeles, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haas</LastName><ForeName>Richard H</ForeName><Initials>RH</Initials><AffiliationInfo><Affiliation>Department of Neurosciences, University of California San Diego, La Jolla, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shults</LastName><ForeName>Clifford W</ForeName><Initials>CW</Initials><AffiliationInfo><Affiliation>Department of Neurosciences, University of California San Diego, La Jolla, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le</LastName><ForeName>Thuy</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Neurosciences, University of California San Diego, La Jolla, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ritz</LastName><ForeName>Beate</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>U54 ES012078</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01ES010544</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 ES016446</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 ES010544</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>5R21ES16446-2</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01ES016732</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 ES016732</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54ES012078</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>03</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D045222">Electron Transport Chain Complex Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010575">Pesticides</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.10.2.2</RegistryNumber><NameOfSubstance UI="D014450">Electron Transport Complex III</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.6.2.4</RegistryNumber><NameOfSubstance UI="D009251">NADPH-Ferrihemoprotein Reductase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.6.5.3</RegistryNumber><NameOfSubstance UI="D042967">Electron Transport Complex I</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Science. 1983 Feb 25;219(4587):979-80</RefSource><PMID Version="1">6823561</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurochem. 2003 Jan;84(2):336-46</RefSource><PMID Version="1">12558996</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neural Transm Park Dis Dement Sect. 1992;4(1):27-34</RefSource><PMID Version="1">1347219</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 1992 Apr;115 ( Pt 2):333-42</RefSource><PMID Version="1">1606472</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 1992;7(3):228-31</RefSource><PMID 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MajorTopicYN="N">Blood Platelets</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045222" MajorTopicYN="N">Electron Transport Chain Complex Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042967" MajorTopicYN="N">Electron Transport Complex I</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014450" MajorTopicYN="N">Electron Transport Complex III</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004781" MajorTopicYN="N">Environmental Exposure</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D040362" MajorTopicYN="N">Geographic Information Systems</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008928" MajorTopicYN="N">Mitochondria</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009251" MajorTopicYN="N">NADPH-Ferrihemoprotein Reductase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010575" MajorTopicYN="N">Pesticides</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS659608</OtherID><OtherID Source="NLM">PMC4439327</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">complex I</Keyword><Keyword MajorTopicYN="N">electron transport chain</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>08</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>12</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>12</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>3</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>3</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>4</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25757798</ArticleId><ArticleId IdType="doi">10.1002/mds.26164</ArticleId><ArticleId IdType="pmc">PMC4439327</ArticleId><ArticleId IdType="mid">NIHMS659608</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce 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