Segment 4 and the left lateral segment regeneration pattern after resection of the middle hepatic vein in a living donor right hepatectomy
Identifieur interne : 000E55 ( Main/Merge ); précédent : 000E54; suivant : 000E56Segment 4 and the left lateral segment regeneration pattern after resection of the middle hepatic vein in a living donor right hepatectomy
Auteurs : Nir Lubezky ; Irina Oyfe ; Alan G. Contreras ; Juan P. Rocca ; Dianne Lapointe Rudow ; Tara Keegan ; Bashir Taouli ; Leona Kim-Schluger ; Sander Florman ; Thomas Schiano ; Marcelo FacciutoSource :
- HPB : The Official Journal of the International Hepato Pancreato Biliary Association [ 1365-182X ] ; 2014.
Abstract
Inclusion of the middle hepatic vein (MHV) with a right hepatectomy (RH) in live donor liver transplantation improves venous drainage of the anterior sector of the graft. Its long-term effects on donor left liver (LL) regeneration are not well described.
Donors who underwent RH with MHV (MHV+,
There was a trend towards a higher complication rate in the MHV+ group (41% versus 25%), without reaching statistical significance (
Regeneration of S4 is impaired in MHV+ donors. Caution should be taken when considering MHV removal on donors with dominant S4, especially on those with potential increased demand for liver regeneration, such as males, higher BMI and a smaller RLV.
Url:
DOI: 10.1111/hpb.12303
PubMed: 25212437
PubMed Central: 4266443
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PMC:4266443Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Segment 4 and the left lateral segment regeneration pattern after resection of the middle hepatic vein in a living donor right hepatectomy</title>
<author><name sortKey="Lubezky, Nir" sort="Lubezky, Nir" uniqKey="Lubezky N" first="Nir" last="Lubezky">Nir Lubezky</name>
</author>
<author><name sortKey="Oyfe, Irina" sort="Oyfe, Irina" uniqKey="Oyfe I" first="Irina" last="Oyfe">Irina Oyfe</name>
</author>
<author><name sortKey="Contreras, Alan G" sort="Contreras, Alan G" uniqKey="Contreras A" first="Alan G" last="Contreras">Alan G. Contreras</name>
</author>
<author><name sortKey="Rocca, Juan P" sort="Rocca, Juan P" uniqKey="Rocca J" first="Juan P" last="Rocca">Juan P. Rocca</name>
</author>
<author><name sortKey="Rudow, Dianne Lapointe" sort="Rudow, Dianne Lapointe" uniqKey="Rudow D" first="Dianne Lapointe" last="Rudow">Dianne Lapointe Rudow</name>
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<author><name sortKey="Keegan, Tara" sort="Keegan, Tara" uniqKey="Keegan T" first="Tara" last="Keegan">Tara Keegan</name>
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<author><name sortKey="Taouli, Bashir" sort="Taouli, Bashir" uniqKey="Taouli B" first="Bashir" last="Taouli">Bashir Taouli</name>
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<author><name sortKey="Kim Schluger, Leona" sort="Kim Schluger, Leona" uniqKey="Kim Schluger L" first="Leona" last="Kim-Schluger">Leona Kim-Schluger</name>
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<author><name sortKey="Florman, Sander" sort="Florman, Sander" uniqKey="Florman S" first="Sander" last="Florman">Sander Florman</name>
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<author><name sortKey="Schiano, Thomas" sort="Schiano, Thomas" uniqKey="Schiano T" first="Thomas" last="Schiano">Thomas Schiano</name>
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<author><name sortKey="Facciuto, Marcelo" sort="Facciuto, Marcelo" uniqKey="Facciuto M" first="Marcelo" last="Facciuto">Marcelo Facciuto</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Segment 4 and the left lateral segment regeneration pattern after resection of the middle hepatic vein in a living donor right hepatectomy</title>
<author><name sortKey="Lubezky, Nir" sort="Lubezky, Nir" uniqKey="Lubezky N" first="Nir" last="Lubezky">Nir Lubezky</name>
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<author><name sortKey="Oyfe, Irina" sort="Oyfe, Irina" uniqKey="Oyfe I" first="Irina" last="Oyfe">Irina Oyfe</name>
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<author><name sortKey="Contreras, Alan G" sort="Contreras, Alan G" uniqKey="Contreras A" first="Alan G" last="Contreras">Alan G. Contreras</name>
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<author><name sortKey="Rocca, Juan P" sort="Rocca, Juan P" uniqKey="Rocca J" first="Juan P" last="Rocca">Juan P. Rocca</name>
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<author><name sortKey="Rudow, Dianne Lapointe" sort="Rudow, Dianne Lapointe" uniqKey="Rudow D" first="Dianne Lapointe" last="Rudow">Dianne Lapointe Rudow</name>
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<author><name sortKey="Keegan, Tara" sort="Keegan, Tara" uniqKey="Keegan T" first="Tara" last="Keegan">Tara Keegan</name>
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<author><name sortKey="Taouli, Bashir" sort="Taouli, Bashir" uniqKey="Taouli B" first="Bashir" last="Taouli">Bashir Taouli</name>
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<author><name sortKey="Kim Schluger, Leona" sort="Kim Schluger, Leona" uniqKey="Kim Schluger L" first="Leona" last="Kim-Schluger">Leona Kim-Schluger</name>
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<author><name sortKey="Florman, Sander" sort="Florman, Sander" uniqKey="Florman S" first="Sander" last="Florman">Sander Florman</name>
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<author><name sortKey="Schiano, Thomas" sort="Schiano, Thomas" uniqKey="Schiano T" first="Thomas" last="Schiano">Thomas Schiano</name>
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<author><name sortKey="Facciuto, Marcelo" sort="Facciuto, Marcelo" uniqKey="Facciuto M" first="Marcelo" last="Facciuto">Marcelo Facciuto</name>
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<series><title level="j">HPB : The Official Journal of the International Hepato Pancreato Biliary Association</title>
<idno type="ISSN">1365-182X</idno>
<idno type="eISSN">1477-2574</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Inclusion of the middle hepatic vein (MHV) with a right hepatectomy (RH) in live donor liver transplantation improves venous drainage of the anterior sector of the graft. Its long-term effects on donor left liver (LL) regeneration are not well described.</p>
</sec>
<sec><title>Methods</title>
<p>Donors who underwent RH with MHV (MHV+, <italic>n</italic>
= 12) were compared with donors who underwent RH with preservation of the MHV (MHV–, <italic>n</italic>
= 24). Peri-operative complications and volume of the entire liver and individual segments were evaluated at 1 year post-donation.</p>
</sec>
<sec><title>Results</title>
<p>There was a trend towards a higher complication rate in the MHV+ group (41% versus 25%), without reaching statistical significance (<italic>P</italic>
= 0.3). Males, high body mass index (BMI) and a smaller residual liver volume (RLV) were predictors for greater LL regeneration. MHV+ donors had impaired regeneration of segment 4 (S4) at 1 year, and compensatory greater left lateral segment regeneration. The absence of venous drainage of S4 (V4) to left hepatic vein (LHV) was a predictor of impaired S4 regeneration.</p>
</sec>
<sec><title>Conclusions</title>
<p>Regeneration of S4 is impaired in MHV+ donors. Caution should be taken when considering MHV removal on donors with dominant S4, especially on those with potential increased demand for liver regeneration, such as males, higher BMI and a smaller RLV.</p>
</sec>
</div>
</front>
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</record>
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