Segment 4 and the left lateral segment regeneration pattern after resection of the middle hepatic vein in a living donor right hepatectomy
Identifieur interne : 001344 ( Pmc/Curation ); précédent : 001343; suivant : 001345Segment 4 and the left lateral segment regeneration pattern after resection of the middle hepatic vein in a living donor right hepatectomy
Auteurs : Nir Lubezky ; Irina Oyfe ; Alan G. Contreras ; Juan P. Rocca ; Dianne Lapointe Rudow ; Tara Keegan ; Bashir Taouli ; Leona Kim-Schluger ; Sander Florman ; Thomas Schiano ; Marcelo FacciutoSource :
- HPB : The Official Journal of the International Hepato Pancreato Biliary Association [ 1365-182X ] ; 2014.
Abstract
Inclusion of the middle hepatic vein (MHV) with a right hepatectomy (RH) in live donor liver transplantation improves venous drainage of the anterior sector of the graft. Its long-term effects on donor left liver (LL) regeneration are not well described.
Donors who underwent RH with MHV (MHV+,
There was a trend towards a higher complication rate in the MHV+ group (41% versus 25%), without reaching statistical significance (
Regeneration of S4 is impaired in MHV+ donors. Caution should be taken when considering MHV removal on donors with dominant S4, especially on those with potential increased demand for liver regeneration, such as males, higher BMI and a smaller RLV.
Url:
DOI: 10.1111/hpb.12303
PubMed: 25212437
PubMed Central: 4266443
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Rocca</name></author><author><name sortKey="Rudow, Dianne Lapointe" sort="Rudow, Dianne Lapointe" uniqKey="Rudow D" first="Dianne Lapointe" last="Rudow">Dianne Lapointe Rudow</name></author><author><name sortKey="Keegan, Tara" sort="Keegan, Tara" uniqKey="Keegan T" first="Tara" last="Keegan">Tara Keegan</name></author><author><name sortKey="Taouli, Bashir" sort="Taouli, Bashir" uniqKey="Taouli B" first="Bashir" last="Taouli">Bashir Taouli</name></author><author><name sortKey="Kim Schluger, Leona" sort="Kim Schluger, Leona" uniqKey="Kim Schluger L" first="Leona" last="Kim-Schluger">Leona Kim-Schluger</name></author><author><name sortKey="Florman, Sander" sort="Florman, Sander" uniqKey="Florman S" first="Sander" last="Florman">Sander Florman</name></author><author><name sortKey="Schiano, Thomas" sort="Schiano, Thomas" uniqKey="Schiano T" first="Thomas" last="Schiano">Thomas Schiano</name></author><author><name sortKey="Facciuto, Marcelo" sort="Facciuto, Marcelo" uniqKey="Facciuto M" first="Marcelo" last="Facciuto">Marcelo Facciuto</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25212437</idno><idno type="pmc">4266443</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266443</idno><idno type="RBID">PMC:4266443</idno><idno type="doi">10.1111/hpb.12303</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001344</idno><idno type="wicri:Area/Pmc/Curation">001344</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Segment 4 and the left lateral segment regeneration pattern after resection of the middle hepatic vein in a living donor right hepatectomy</title><author><name sortKey="Lubezky, Nir" sort="Lubezky, Nir" uniqKey="Lubezky N" first="Nir" last="Lubezky">Nir Lubezky</name></author><author><name sortKey="Oyfe, Irina" sort="Oyfe, Irina" uniqKey="Oyfe I" first="Irina" last="Oyfe">Irina Oyfe</name></author><author><name sortKey="Contreras, Alan G" sort="Contreras, Alan G" uniqKey="Contreras A" first="Alan G" last="Contreras">Alan G. Contreras</name></author><author><name sortKey="Rocca, Juan P" sort="Rocca, Juan P" uniqKey="Rocca J" first="Juan P" last="Rocca">Juan P. Rocca</name></author><author><name sortKey="Rudow, Dianne Lapointe" sort="Rudow, Dianne Lapointe" uniqKey="Rudow D" first="Dianne Lapointe" last="Rudow">Dianne Lapointe Rudow</name></author><author><name sortKey="Keegan, Tara" sort="Keegan, Tara" uniqKey="Keegan T" first="Tara" last="Keegan">Tara Keegan</name></author><author><name sortKey="Taouli, Bashir" sort="Taouli, Bashir" uniqKey="Taouli B" first="Bashir" last="Taouli">Bashir Taouli</name></author><author><name sortKey="Kim Schluger, Leona" sort="Kim Schluger, Leona" uniqKey="Kim Schluger L" first="Leona" last="Kim-Schluger">Leona Kim-Schluger</name></author><author><name sortKey="Florman, Sander" sort="Florman, Sander" uniqKey="Florman S" first="Sander" last="Florman">Sander Florman</name></author><author><name sortKey="Schiano, Thomas" sort="Schiano, Thomas" uniqKey="Schiano T" first="Thomas" last="Schiano">Thomas Schiano</name></author><author><name sortKey="Facciuto, Marcelo" sort="Facciuto, Marcelo" uniqKey="Facciuto M" first="Marcelo" last="Facciuto">Marcelo Facciuto</name></author></analytic><series><title level="j">HPB : The Official Journal of the International Hepato Pancreato Biliary Association</title><idno type="ISSN">1365-182X</idno><idno type="eISSN">1477-2574</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Inclusion of the middle hepatic vein (MHV) with a right hepatectomy (RH) in live donor liver transplantation improves venous drainage of the anterior sector of the graft. Its long-term effects on donor left liver (LL) regeneration are not well described.</p></sec><sec><title>Methods</title><p>Donors who underwent RH with MHV (MHV+, <italic>n</italic> = 12) were compared with donors who underwent RH with preservation of the MHV (MHV–, <italic>n</italic> = 24). Peri-operative complications and volume of the entire liver and individual segments were evaluated at 1 year post-donation.</p></sec><sec><title>Results</title><p>There was a trend towards a higher complication rate in the MHV+ group (41% versus 25%), without reaching statistical significance (<italic>P</italic> = 0.3). Males, high body mass index (BMI) and a smaller residual liver volume (RLV) were predictors for greater LL regeneration. MHV+ donors had impaired regeneration of segment 4 (S4) at 1 year, and compensatory greater left lateral segment regeneration. The absence of venous drainage of S4 (V4) to left hepatic vein (LHV) was a predictor of impaired S4 regeneration.</p></sec><sec><title>Conclusions</title><p>Regeneration of S4 is impaired in MHV+ donors. Caution should be taken when considering MHV removal on donors with dominant S4, especially on those with potential increased demand for liver regeneration, such as males, higher BMI and a smaller RLV.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">HPB (Oxford)</journal-id><journal-id journal-id-type="iso-abbrev">HPB (Oxford)</journal-id><journal-id journal-id-type="publisher-id">hpb</journal-id><journal-title-group><journal-title>HPB : The Official Journal of the International Hepato Pancreato Biliary Association</journal-title></journal-title-group><issn pub-type="ppub">1365-182X</issn><issn pub-type="epub">1477-2574</issn><publisher><publisher-name>BlackWell Publishing Ltd</publisher-name><publisher-loc>Oxford, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25212437</article-id><article-id pub-id-type="pmc">4266443</article-id><article-id pub-id-type="doi">10.1111/hpb.12303</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Segment 4 and the left lateral segment regeneration pattern after resection of the middle hepatic vein in a living donor right hepatectomy</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lubezky</surname><given-names>Nir</given-names></name></contrib><contrib contrib-type="author"><name><surname>Oyfe</surname><given-names>Irina</given-names></name></contrib><contrib contrib-type="author"><name><surname>Contreras</surname><given-names>Alan G</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rocca</surname><given-names>Juan P</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rudow</surname><given-names>Dianne LaPointe</given-names></name></contrib><contrib contrib-type="author"><name><surname>Keegan</surname><given-names>Tara</given-names></name></contrib><contrib contrib-type="author"><name><surname>Taouli</surname><given-names>Bashir</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kim-Schluger</surname><given-names>Leona</given-names></name></contrib><contrib contrib-type="author"><name><surname>Florman</surname><given-names>Sander</given-names></name></contrib><contrib contrib-type="author"><name><surname>Schiano</surname><given-names>Thomas</given-names></name></contrib><contrib contrib-type="author"><name><surname>Facciuto</surname><given-names>Marcelo</given-names></name><xref ref-type="corresp" rid="cor1"></xref></contrib><aff><institution>Recanati-Miller Transplantation Institute, The Mount Sinai Medical Center</institution><addr-line>New York, NY, USA</addr-line></aff></contrib-group><author-notes><corresp id="cor1"><bold>Correspondence</bold>, Marcelo Facciuto, Recanati-Miller Transplant Institute, The Mount Sinai Medical Center, 1 Gustave L. Levy Place Box 1104, New York, NY 10029-6574, USA. Tel: 212 659 8711. Fax: 212 348 2474. E-mail: <email>marcelo.facciuto@moutnsinai.org</email></corresp></author-notes><pub-date pub-type="ppub"><month>1</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>11</day><month>9</month><year>2014</year></pub-date><volume>17</volume><issue>1</issue><fpage>72</fpage><lpage>78</lpage><history><date date-type="received"><day>13</day><month>1</month><year>2014</year></date><date date-type="accepted"><day>15</day><month>5</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 International Hepato-Pancreato-Biliary Association</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><sec><title>Background</title><p>Inclusion of the middle hepatic vein (MHV) with a right hepatectomy (RH) in live donor liver transplantation improves venous drainage of the anterior sector of the graft. Its long-term effects on donor left liver (LL) regeneration are not well described.</p></sec><sec><title>Methods</title><p>Donors who underwent RH with MHV (MHV+, <italic>n</italic> = 12) were compared with donors who underwent RH with preservation of the MHV (MHV–, <italic>n</italic> = 24). Peri-operative complications and volume of the entire liver and individual segments were evaluated at 1 year post-donation.</p></sec><sec><title>Results</title><p>There was a trend towards a higher complication rate in the MHV+ group (41% versus 25%), without reaching statistical significance (<italic>P</italic> = 0.3). Males, high body mass index (BMI) and a smaller residual liver volume (RLV) were predictors for greater LL regeneration. MHV+ donors had impaired regeneration of segment 4 (S4) at 1 year, and compensatory greater left lateral segment regeneration. The absence of venous drainage of S4 (V4) to left hepatic vein (LHV) was a predictor of impaired S4 regeneration.</p></sec><sec><title>Conclusions</title><p>Regeneration of S4 is impaired in MHV+ donors. Caution should be taken when considering MHV removal on donors with dominant S4, especially on those with potential increased demand for liver regeneration, such as males, higher BMI and a smaller RLV.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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