Acetylcholinesterase activity in copepods (Tigriopus brevicornis) from the Vilaine River estuary, France, as a biomarker of neurotoxic contaminants.
Identifieur interne : 000342 ( PubMed/Checkpoint ); précédent : 000341; suivant : 000343Acetylcholinesterase activity in copepods (Tigriopus brevicornis) from the Vilaine River estuary, France, as a biomarker of neurotoxic contaminants.
Auteurs : J. Forget [France] ; B. Beliaeff ; G. BocquenéSource :
- Aquatic toxicology (Amsterdam, Netherlands) [ 0166-445X ] ; 2003.
Descripteurs français
- Wicri :
- geographic : France.
English descriptors
- KwdEn :
- Acetylcholinesterase (analysis), Animals, Biomarkers (analysis), Copepoda (drug effects), Copepoda (enzymology), Dose-Response Relationship, Drug, Environmental Exposure (analysis), France, Fresh Water, Neurotoxins (toxicity), Pesticides (toxicity), Seawater, Triazines (toxicity), Water Pollutants, Chemical (toxicity).
- MESH :
- chemical , analysis : Acetylcholinesterase, Biomarkers.
- chemical , toxicity : Neurotoxins, Pesticides, Triazines, Water Pollutants, Chemical.
- geographic : France.
- analysis : Environmental Exposure.
- drug effects : Copepoda.
- enzymology : Copepoda.
- Animals, Dose-Response Relationship, Drug, Fresh Water, Seawater.
Abstract
From April 1997 to June 1998, 14 measurements of acetylcholinesterase (AChE) enzymatic activity were performed with the copepod, Tigriopus brevicornis, collected at five stations in the Vilaine River estuary (South Brittany, France). Simultaneously, four chemical analyses of triazines and one analysis of total pesticides in water were undertaken. AChE activity levels in T. brevicornis were compared to the levels measured at a reference site not exposed to effluents from Vilaine River. Results reveal significant differences between AChE activity levels depending on location of stations in the plume of the river with an increasing gradient of activity from the upstream to the downstream stations, thus indicating that neurotoxic contaminants are mainly brought by the river. The average degree of AChE inhibition between the reference site and the most upstream site is 70-80% during spring in 1997 and 1998. In May 1997, live copepods from the different sites were brought back and transferred to clean seawater. After 14 days, recovery of AChE activity was almost total when compared to the control. Moreover, using a linear regression model and the atrazine concentration as marker of the presence of pesticides, low levels of AChE activity were significantly explained by atrazine concentration in water.
PubMed: 12560168
Affiliations:
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Forget</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire d'Ecotoxicologie, UPRES-EA 3222, Faculté des Sciences et Techniques, Université du Havre, 25 rue Philippe Lebon, BP540, 76058 Le Havre cedex, France. joelle.forget@univ-lehavre.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Ecotoxicologie, UPRES-EA 3222, Faculté des Sciences et Techniques, Université du Havre, 25 rue Philippe Lebon, BP540, 76058 Le Havre cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName><orgName type="university">Université du Havre</orgName></affiliation></author><author><name sortKey="Beliaeff, B" sort="Beliaeff, B" uniqKey="Beliaeff B" first="B" last="Beliaeff">B. Beliaeff</name></author><author><name sortKey="Bocquene, G" sort="Bocquene, G" uniqKey="Bocquene G" first="G" last="Bocquené">G. 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Forget</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire d'Ecotoxicologie, UPRES-EA 3222, Faculté des Sciences et Techniques, Université du Havre, 25 rue Philippe Lebon, BP540, 76058 Le Havre cedex, France. joelle.forget@univ-lehavre.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d'Ecotoxicologie, UPRES-EA 3222, Faculté des Sciences et Techniques, Université du Havre, 25 rue Philippe Lebon, BP540, 76058 Le Havre cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName><orgName type="university">Université du Havre</orgName></affiliation></author><author><name sortKey="Beliaeff, B" sort="Beliaeff, B" uniqKey="Beliaeff B" first="B" last="Beliaeff">B. Beliaeff</name></author><author><name sortKey="Bocquene, G" sort="Bocquene, G" uniqKey="Bocquene G" first="G" last="Bocquené">G. Bocquené</name></author></analytic><series><title level="j">Aquatic toxicology (Amsterdam, Netherlands)</title><idno type="ISSN">0166-445X</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcholinesterase (analysis)</term><term>Animals</term><term>Biomarkers (analysis)</term><term>Copepoda (drug effects)</term><term>Copepoda (enzymology)</term><term>Dose-Response Relationship, Drug</term><term>Environmental Exposure (analysis)</term><term>France</term><term>Fresh Water</term><term>Neurotoxins (toxicity)</term><term>Pesticides (toxicity)</term><term>Seawater</term><term>Triazines (toxicity)</term><term>Water Pollutants, Chemical (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Acetylcholinesterase</term><term>Biomarkers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Neurotoxins</term><term>Pesticides</term><term>Triazines</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Environmental Exposure</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Copepoda</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Copepoda</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Fresh Water</term><term>Seawater</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">From April 1997 to June 1998, 14 measurements of acetylcholinesterase (AChE) enzymatic activity were performed with the copepod, Tigriopus brevicornis, collected at five stations in the Vilaine River estuary (South Brittany, France). Simultaneously, four chemical analyses of triazines and one analysis of total pesticides in water were undertaken. AChE activity levels in T. brevicornis were compared to the levels measured at a reference site not exposed to effluents from Vilaine River. Results reveal significant differences between AChE activity levels depending on location of stations in the plume of the river with an increasing gradient of activity from the upstream to the downstream stations, thus indicating that neurotoxic contaminants are mainly brought by the river. The average degree of AChE inhibition between the reference site and the most upstream site is 70-80% during spring in 1997 and 1998. In May 1997, live copepods from the different sites were brought back and transferred to clean seawater. After 14 days, recovery of AChE activity was almost total when compared to the control. Moreover, using a linear regression model and the atrazine concentration as marker of the presence of pesticides, low levels of AChE activity were significantly explained by atrazine concentration in water.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12560168</PMID><DateCreated><Year>2003</Year><Month>1</Month><Day>31</Day></DateCreated><DateCompleted><Year>2003</Year><Month>03</Month><Day>27</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0166-445X</ISSN><JournalIssue CitedMedium="Print"><Volume>62</Volume><Issue>3</Issue><PubDate><Year>2003</Year><Month>Feb</Month><Day>12</Day></PubDate></JournalIssue><Title>Aquatic toxicology (Amsterdam, Netherlands)</Title><ISOAbbreviation>Aquat. Toxicol.</ISOAbbreviation></Journal><ArticleTitle>Acetylcholinesterase activity in copepods (Tigriopus brevicornis) from the Vilaine River estuary, France, as a biomarker of neurotoxic contaminants.</ArticleTitle><Pagination><MedlinePgn>195-204</MedlinePgn></Pagination><Abstract><AbstractText>From April 1997 to June 1998, 14 measurements of acetylcholinesterase (AChE) enzymatic activity were performed with the copepod, Tigriopus brevicornis, collected at five stations in the Vilaine River estuary (South Brittany, France). Simultaneously, four chemical analyses of triazines and one analysis of total pesticides in water were undertaken. AChE activity levels in T. brevicornis were compared to the levels measured at a reference site not exposed to effluents from Vilaine River. Results reveal significant differences between AChE activity levels depending on location of stations in the plume of the river with an increasing gradient of activity from the upstream to the downstream stations, thus indicating that neurotoxic contaminants are mainly brought by the river. The average degree of AChE inhibition between the reference site and the most upstream site is 70-80% during spring in 1997 and 1998. In May 1997, live copepods from the different sites were brought back and transferred to clean seawater. After 14 days, recovery of AChE activity was almost total when compared to the control. 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Beliaeff</name><name sortKey="Bocquene, G" sort="Bocquene, G" uniqKey="Bocquene G" first="G" last="Bocquené">G. Bocquené</name></noCountry><country name="France"><region name="Région Normandie"><name sortKey="Forget, J" sort="Forget, J" uniqKey="Forget J" first="J" last="Forget">J. Forget</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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