Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease?
Identifieur interne : 000558 ( Ncbi/Merge ); précédent : 000557; suivant : 000559Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease?
Auteurs : C. Lemaitre [France] ; S. Dominique [France] ; E. Billoud [France] ; M. Eliezer [France] ; H. Montialoux [France] ; M. Quillard [France] ; G. Riachi [France] ; E. Koning [France] ; H. Morisse-Pradier [France] ; G. Savoye [France] ; C. Savoye-Collet [France] ; O. Goria [France]Source :
- Canadian Respiratory Journal [ 1198-2241 ] ; 2016.
Abstract
Url:
DOI: 10.1155/2016/4592702
PubMed: 27445541
PubMed Central: 4939173
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease?</title>
<author><name sortKey="Lemaitre, C" sort="Lemaitre, C" uniqKey="Lemaitre C" first="C." last="Lemaitre">C. Lemaitre</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France</nlm:aff>
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<placeName><settlement type="city">Rouen</settlement>
</placeName>
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<author><name sortKey="Dominique, S" sort="Dominique, S" uniqKey="Dominique S" first="S." last="Dominique">S. Dominique</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
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<author><name sortKey="Billoud, E" sort="Billoud, E" uniqKey="Billoud E" first="E." last="Billoud">E. Billoud</name>
<affiliation wicri:level="1"><nlm:aff id="I3">Department of Gastroenterology, Le Havre General Hospital, Le Havre, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology, Le Havre General Hospital, Le Havre</wicri:regionArea>
<placeName><settlement type="city">Le Havre</settlement>
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</author>
<author><name sortKey="Eliezer, M" sort="Eliezer, M" uniqKey="Eliezer M" first="M." last="Eliezer">M. Eliezer</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Department of Radiology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
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<author><name sortKey="Montialoux, H" sort="Montialoux, H" uniqKey="Montialoux H" first="H." last="Montialoux">H. Montialoux</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
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<author><name sortKey="Quillard, M" sort="Quillard, M" uniqKey="Quillard M" first="M." last="Quillard">M. Quillard</name>
<affiliation wicri:level="1"><nlm:aff id="I5">Clinical Biology Institute, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clinical Biology Institute, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
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<author><name sortKey="Riachi, G" sort="Riachi, G" uniqKey="Riachi G" first="G." last="Riachi">G. Riachi</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koning, E" sort="Koning, E" uniqKey="Koning E" first="E." last="Koning">E. Koning</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Department of Radiology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morisse Pradier, H" sort="Morisse Pradier, H" uniqKey="Morisse Pradier H" first="H." last="Morisse-Pradier">H. Morisse-Pradier</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Savoye, G" sort="Savoye, G" uniqKey="Savoye G" first="G." last="Savoye">G. Savoye</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I6">INSERM U1073, Institute for Research and Innovation in Biomedicine, Faculty of Medicine, University of Rouen, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U1073, Institute for Research and Innovation in Biomedicine, Faculty of Medicine, University of Rouen, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Savoye Collet, C" sort="Savoye Collet, C" uniqKey="Savoye Collet C" first="C." last="Savoye-Collet">C. Savoye-Collet</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Department of Radiology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goria, O" sort="Goria, O" uniqKey="Goria O" first="O." last="Goria">O. Goria</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Canadian Respiratory Journal</title>
<idno type="ISSN">1198-2241</idno>
<idno type="eISSN">1916-7245</idno>
<imprint><date when="2016">2016</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><p><italic>Background.</italic>
Cystic fibrosis-associated liver disease (CFLD) is a major cause of death. The objective of our retrospective study was to describe the relevance of magnetic resonance imaging (MRI) and liver stiffness measurement (LSM) for CFLD evaluation.<italic> Methods.</italic>
All cystic fibrosis adult patients evaluated by MRI and LSM were included. MR signs of portal hypertension (PHT), dysmorphia, or cholangitis were collected and LSM expressed in kPa and Metavir.<italic> Results.</italic>
Of 25 patients, 52% had abnormal MRI. Median LSM was 5.7 kPa (3.4–9.9). Three patients had F2 score and one had F3 score. In patients with PHT, LSM was 7.85 kPa (3.7–9.9) compared to 5 (3.4–7.5) in others, <italic>p</italic>
= 0.02. In patients with abnormal liver function tests, 50% had increased LSM (≥F2), whereas 94% with normal tests had normal LSM (<italic>p</italic>
= 0.04). Seven patients had abnormal MRI despite normal ultrasonography.<italic> Conclusions.</italic>
MRI and LSM provide useful information on CFLD and may help to screen patients with PHT.</p>
</div>
</front>
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</TEI>
<double pmid="27445541"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease?</title>
<author><name sortKey="Lemaitre, C" sort="Lemaitre, C" uniqKey="Lemaitre C" first="C." last="Lemaitre">C. Lemaitre</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dominique, S" sort="Dominique, S" uniqKey="Dominique S" first="S." last="Dominique">S. Dominique</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Billoud, E" sort="Billoud, E" uniqKey="Billoud E" first="E." last="Billoud">E. Billoud</name>
<affiliation wicri:level="1"><nlm:aff id="I3">Department of Gastroenterology, Le Havre General Hospital, Le Havre, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology, Le Havre General Hospital, Le Havre</wicri:regionArea>
<placeName><settlement type="city">Le Havre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eliezer, M" sort="Eliezer, M" uniqKey="Eliezer M" first="M." last="Eliezer">M. Eliezer</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Department of Radiology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Montialoux, H" sort="Montialoux, H" uniqKey="Montialoux H" first="H." last="Montialoux">H. Montialoux</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Quillard, M" sort="Quillard, M" uniqKey="Quillard M" first="M." last="Quillard">M. Quillard</name>
<affiliation wicri:level="1"><nlm:aff id="I5">Clinical Biology Institute, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clinical Biology Institute, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Riachi, G" sort="Riachi, G" uniqKey="Riachi G" first="G." last="Riachi">G. Riachi</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koning, E" sort="Koning, E" uniqKey="Koning E" first="E." last="Koning">E. Koning</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Department of Radiology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morisse Pradier, H" sort="Morisse Pradier, H" uniqKey="Morisse Pradier H" first="H." last="Morisse-Pradier">H. Morisse-Pradier</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Savoye, G" sort="Savoye, G" uniqKey="Savoye G" first="G." last="Savoye">G. Savoye</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I6">INSERM U1073, Institute for Research and Innovation in Biomedicine, Faculty of Medicine, University of Rouen, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U1073, Institute for Research and Innovation in Biomedicine, Faculty of Medicine, University of Rouen, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Savoye Collet, C" sort="Savoye Collet, C" uniqKey="Savoye Collet C" first="C." last="Savoye-Collet">C. Savoye-Collet</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Department of Radiology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goria, O" sort="Goria, O" uniqKey="Goria O" first="O." last="Goria">O. Goria</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27445541</idno>
<idno type="pmc">4939173</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939173</idno>
<idno type="RBID">PMC:4939173</idno>
<idno type="doi">10.1155/2016/4592702</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000018</idno>
<idno type="wicri:Area/Pmc/Curation">000018</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000003</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease?</title>
<author><name sortKey="Lemaitre, C" sort="Lemaitre, C" uniqKey="Lemaitre C" first="C." last="Lemaitre">C. Lemaitre</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dominique, S" sort="Dominique, S" uniqKey="Dominique S" first="S." last="Dominique">S. Dominique</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Billoud, E" sort="Billoud, E" uniqKey="Billoud E" first="E." last="Billoud">E. Billoud</name>
<affiliation wicri:level="1"><nlm:aff id="I3">Department of Gastroenterology, Le Havre General Hospital, Le Havre, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology, Le Havre General Hospital, Le Havre</wicri:regionArea>
<placeName><settlement type="city">Le Havre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eliezer, M" sort="Eliezer, M" uniqKey="Eliezer M" first="M." last="Eliezer">M. Eliezer</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Department of Radiology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Montialoux, H" sort="Montialoux, H" uniqKey="Montialoux H" first="H." last="Montialoux">H. Montialoux</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Quillard, M" sort="Quillard, M" uniqKey="Quillard M" first="M." last="Quillard">M. Quillard</name>
<affiliation wicri:level="1"><nlm:aff id="I5">Clinical Biology Institute, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clinical Biology Institute, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Riachi, G" sort="Riachi, G" uniqKey="Riachi G" first="G." last="Riachi">G. Riachi</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koning, E" sort="Koning, E" uniqKey="Koning E" first="E." last="Koning">E. Koning</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Department of Radiology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morisse Pradier, H" sort="Morisse Pradier, H" uniqKey="Morisse Pradier H" first="H." last="Morisse-Pradier">H. Morisse-Pradier</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Savoye, G" sort="Savoye, G" uniqKey="Savoye G" first="G." last="Savoye">G. Savoye</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="I6">INSERM U1073, Institute for Research and Innovation in Biomedicine, Faculty of Medicine, University of Rouen, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U1073, Institute for Research and Innovation in Biomedicine, Faculty of Medicine, University of Rouen, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Savoye Collet, C" sort="Savoye Collet, C" uniqKey="Savoye Collet C" first="C." last="Savoye-Collet">C. Savoye-Collet</name>
<affiliation wicri:level="1"><nlm:aff id="I4">Department of Radiology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goria, O" sort="Goria, O" uniqKey="Goria O" first="O." last="Goria">O. Goria</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Canadian Respiratory Journal</title>
<idno type="ISSN">1198-2241</idno>
<idno type="eISSN">1916-7245</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><italic>Background.</italic>
Cystic fibrosis-associated liver disease (CFLD) is a major cause of death. The objective of our retrospective study was to describe the relevance of magnetic resonance imaging (MRI) and liver stiffness measurement (LSM) for CFLD evaluation.<italic> Methods.</italic>
All cystic fibrosis adult patients evaluated by MRI and LSM were included. MR signs of portal hypertension (PHT), dysmorphia, or cholangitis were collected and LSM expressed in kPa and Metavir.<italic> Results.</italic>
Of 25 patients, 52% had abnormal MRI. Median LSM was 5.7 kPa (3.4–9.9). Three patients had F2 score and one had F3 score. In patients with PHT, LSM was 7.85 kPa (3.7–9.9) compared to 5 (3.4–7.5) in others, <italic>p</italic>
= 0.02. In patients with abnormal liver function tests, 50% had increased LSM (≥F2), whereas 94% with normal tests had normal LSM (<italic>p</italic>
= 0.04). Seven patients had abnormal MRI despite normal ultrasonography.<italic> Conclusions.</italic>
MRI and LSM provide useful information on CFLD and may help to screen patients with PHT.</p>
</div>
</front>
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<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease?</title>
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<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
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<affiliation wicri:level="1"><nlm:affiliation>Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen</wicri:regionArea>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology, Le Havre General Hospital, Le Havre</wicri:regionArea>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
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<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, Rouen University Hospital, Rouen</wicri:regionArea>
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<country xml:lang="fr">France</country>
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<country xml:lang="fr">France</country>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
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<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
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<wicri:regionArea>Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen</wicri:regionArea>
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</author>
<author><name sortKey="Eliezer, M" sort="Eliezer, M" uniqKey="Eliezer M" first="M" last="Eliezer">M. Eliezer</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Rouen University Hospital, Rouen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Montialoux, H" sort="Montialoux, H" uniqKey="Montialoux H" first="H" last="Montialoux">H. Montialoux</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Quillard, M" sort="Quillard, M" uniqKey="Quillard M" first="M" last="Quillard">M. Quillard</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Biology Institute, Rouen University Hospital, Rouen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clinical Biology Institute, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Riachi, G" sort="Riachi, G" uniqKey="Riachi G" first="G" last="Riachi">G. Riachi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Koning, E" sort="Koning, E" uniqKey="Koning E" first="E" last="Koning">E. Koning</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Rouen University Hospital, Rouen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morisse Pradier, H" sort="Morisse Pradier, H" uniqKey="Morisse Pradier H" first="H" last="Morisse-Pradier">H. Morisse-Pradier</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Savoye, G" sort="Savoye, G" uniqKey="Savoye G" first="G" last="Savoye">G. Savoye</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France; INSERM U1073, Institute for Research and Innovation in Biomedicine, Faculty of Medicine, University of Rouen, Rouen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France; INSERM U1073, Institute for Research and Innovation in Biomedicine, Faculty of Medicine, University of Rouen, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Savoye Collet, C" sort="Savoye Collet, C" uniqKey="Savoye Collet C" first="C" last="Savoye-Collet">C. Savoye-Collet</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Rouen University Hospital, Rouen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Radiology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goria, O" sort="Goria, O" uniqKey="Goria O" first="O" last="Goria">O. Goria</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen</wicri:regionArea>
<placeName><settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Canadian respiratory journal</title>
<idno type="eISSN">1916-7245</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background. Cystic fibrosis-associated liver disease (CFLD) is a major cause of death. The objective of our retrospective study was to describe the relevance of magnetic resonance imaging (MRI) and liver stiffness measurement (LSM) for CFLD evaluation. Methods. All cystic fibrosis adult patients evaluated by MRI and LSM were included. MR signs of portal hypertension (PHT), dysmorphia, or cholangitis were collected and LSM expressed in kPa and Metavir. Results. Of 25 patients, 52% had abnormal MRI. Median LSM was 5.7 kPa (3.4-9.9). Three patients had F2 score and one had F3 score. In patients with PHT, LSM was 7.85 kPa (3.7-9.9) compared to 5 (3.4-7.5) in others, p = 0.02. In patients with abnormal liver function tests, 50% had increased LSM (≥F2), whereas 94% with normal tests had normal LSM (p = 0.04). Seven patients had abnormal MRI despite normal ultrasonography. Conclusions. MRI and LSM provide useful information on CFLD and may help to screen patients with PHT.</div>
</front>
</TEI>
</pubmed>
</double>
</record>
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