Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease?
Identifieur interne : 000057 ( PubMed/Corpus ); précédent : 000056; suivant : 000058Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease?
Auteurs : C. Lemaitre ; S. Dominique ; E. Billoud ; M. Eliezer ; H. Montialoux ; M. Quillard ; G. Riachi ; E. Koning ; H. Morisse-Pradier ; G. Savoye ; C. Savoye-Collet ; O. GoriaSource :
- Canadian respiratory journal [ 1916-7245 ] ; 2016.
Abstract
Background. Cystic fibrosis-associated liver disease (CFLD) is a major cause of death. The objective of our retrospective study was to describe the relevance of magnetic resonance imaging (MRI) and liver stiffness measurement (LSM) for CFLD evaluation. Methods. All cystic fibrosis adult patients evaluated by MRI and LSM were included. MR signs of portal hypertension (PHT), dysmorphia, or cholangitis were collected and LSM expressed in kPa and Metavir. Results. Of 25 patients, 52% had abnormal MRI. Median LSM was 5.7 kPa (3.4-9.9). Three patients had F2 score and one had F3 score. In patients with PHT, LSM was 7.85 kPa (3.7-9.9) compared to 5 (3.4-7.5) in others, p = 0.02. In patients with abnormal liver function tests, 50% had increased LSM (≥F2), whereas 94% with normal tests had normal LSM (p = 0.04). Seven patients had abnormal MRI despite normal ultrasonography. Conclusions. MRI and LSM provide useful information on CFLD and may help to screen patients with PHT.
DOI: 10.1155/2016/4592702
PubMed: 27445541
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease?</title><author><name sortKey="Lemaitre, C" sort="Lemaitre, C" uniqKey="Lemaitre C" first="C" last="Lemaitre">C. Lemaitre</name><affiliation><nlm:affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Dominique, S" sort="Dominique, S" uniqKey="Dominique S" first="S" last="Dominique">S. Dominique</name><affiliation><nlm:affiliation>Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Billoud, E" sort="Billoud, E" uniqKey="Billoud E" first="E" last="Billoud">E. Billoud</name><affiliation><nlm:affiliation>Department of Gastroenterology, Le Havre General Hospital, Le Havre, France.</nlm:affiliation></affiliation></author><author><name sortKey="Eliezer, M" sort="Eliezer, M" uniqKey="Eliezer M" first="M" last="Eliezer">M. Eliezer</name><affiliation><nlm:affiliation>Department of Radiology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Montialoux, H" sort="Montialoux, H" uniqKey="Montialoux H" first="H" last="Montialoux">H. Montialoux</name><affiliation><nlm:affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Quillard, M" sort="Quillard, M" uniqKey="Quillard M" first="M" last="Quillard">M. Quillard</name><affiliation><nlm:affiliation>Clinical Biology Institute, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Riachi, G" sort="Riachi, G" uniqKey="Riachi G" first="G" last="Riachi">G. Riachi</name><affiliation><nlm:affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Koning, E" sort="Koning, E" uniqKey="Koning E" first="E" last="Koning">E. Koning</name><affiliation><nlm:affiliation>Department of Radiology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Morisse Pradier, H" sort="Morisse Pradier, H" uniqKey="Morisse Pradier H" first="H" last="Morisse-Pradier">H. Morisse-Pradier</name><affiliation><nlm:affiliation>Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Savoye, G" sort="Savoye, G" uniqKey="Savoye G" first="G" last="Savoye">G. Savoye</name><affiliation><nlm:affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France; INSERM U1073, Institute for Research and Innovation in Biomedicine, Faculty of Medicine, University of Rouen, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Savoye Collet, C" sort="Savoye Collet, C" uniqKey="Savoye Collet C" first="C" last="Savoye-Collet">C. Savoye-Collet</name><affiliation><nlm:affiliation>Department of Radiology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Goria, O" sort="Goria, O" uniqKey="Goria O" first="O" last="Goria">O. Goria</name><affiliation><nlm:affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27445541</idno><idno type="pmid">27445541</idno><idno type="doi">10.1155/2016/4592702</idno><idno type="wicri:Area/PubMed/Corpus">000057</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease?</title><author><name sortKey="Lemaitre, C" sort="Lemaitre, C" uniqKey="Lemaitre C" first="C" last="Lemaitre">C. Lemaitre</name><affiliation><nlm:affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Dominique, S" sort="Dominique, S" uniqKey="Dominique S" first="S" last="Dominique">S. Dominique</name><affiliation><nlm:affiliation>Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Billoud, E" sort="Billoud, E" uniqKey="Billoud E" first="E" last="Billoud">E. Billoud</name><affiliation><nlm:affiliation>Department of Gastroenterology, Le Havre General Hospital, Le Havre, France.</nlm:affiliation></affiliation></author><author><name sortKey="Eliezer, M" sort="Eliezer, M" uniqKey="Eliezer M" first="M" last="Eliezer">M. Eliezer</name><affiliation><nlm:affiliation>Department of Radiology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Montialoux, H" sort="Montialoux, H" uniqKey="Montialoux H" first="H" last="Montialoux">H. Montialoux</name><affiliation><nlm:affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Quillard, M" sort="Quillard, M" uniqKey="Quillard M" first="M" last="Quillard">M. Quillard</name><affiliation><nlm:affiliation>Clinical Biology Institute, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Riachi, G" sort="Riachi, G" uniqKey="Riachi G" first="G" last="Riachi">G. Riachi</name><affiliation><nlm:affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Koning, E" sort="Koning, E" uniqKey="Koning E" first="E" last="Koning">E. Koning</name><affiliation><nlm:affiliation>Department of Radiology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Morisse Pradier, H" sort="Morisse Pradier, H" uniqKey="Morisse Pradier H" first="H" last="Morisse-Pradier">H. Morisse-Pradier</name><affiliation><nlm:affiliation>Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Savoye, G" sort="Savoye, G" uniqKey="Savoye G" first="G" last="Savoye">G. Savoye</name><affiliation><nlm:affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France; INSERM U1073, Institute for Research and Innovation in Biomedicine, Faculty of Medicine, University of Rouen, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Savoye Collet, C" sort="Savoye Collet, C" uniqKey="Savoye Collet C" first="C" last="Savoye-Collet">C. Savoye-Collet</name><affiliation><nlm:affiliation>Department of Radiology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author><author><name sortKey="Goria, O" sort="Goria, O" uniqKey="Goria O" first="O" last="Goria">O. Goria</name><affiliation><nlm:affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Canadian respiratory journal</title><idno type="eISSN">1916-7245</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. Cystic fibrosis-associated liver disease (CFLD) is a major cause of death. The objective of our retrospective study was to describe the relevance of magnetic resonance imaging (MRI) and liver stiffness measurement (LSM) for CFLD evaluation. Methods. All cystic fibrosis adult patients evaluated by MRI and LSM were included. MR signs of portal hypertension (PHT), dysmorphia, or cholangitis were collected and LSM expressed in kPa and Metavir. Results. Of 25 patients, 52% had abnormal MRI. Median LSM was 5.7 kPa (3.4-9.9). Three patients had F2 score and one had F3 score. In patients with PHT, LSM was 7.85 kPa (3.7-9.9) compared to 5 (3.4-7.5) in others, p = 0.02. In patients with abnormal liver function tests, 50% had increased LSM (≥F2), whereas 94% with normal tests had normal LSM (p = 0.04). Seven patients had abnormal MRI despite normal ultrasonography. Conclusions. MRI and LSM provide useful information on CFLD and may help to screen patients with PHT.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">27445541</PMID><DateCreated><Year>2016</Year><Month>7</Month><Day>22</Day></DateCreated><DateRevised><Year>2016</Year><Month>7</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1916-7245</ISSN><JournalIssue CitedMedium="Internet"><Volume>2016</Volume><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>Canadian respiratory journal</Title><ISOAbbreviation>Can. Respir. J.</ISOAbbreviation></Journal><ArticleTitle>Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease?</ArticleTitle><Pagination><MedlinePgn>4592702</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1155/2016/4592702</ELocationID><Abstract><AbstractText>Background. Cystic fibrosis-associated liver disease (CFLD) is a major cause of death. The objective of our retrospective study was to describe the relevance of magnetic resonance imaging (MRI) and liver stiffness measurement (LSM) for CFLD evaluation. Methods. All cystic fibrosis adult patients evaluated by MRI and LSM were included. MR signs of portal hypertension (PHT), dysmorphia, or cholangitis were collected and LSM expressed in kPa and Metavir. Results. Of 25 patients, 52% had abnormal MRI. Median LSM was 5.7 kPa (3.4-9.9). Three patients had F2 score and one had F3 score. In patients with PHT, LSM was 7.85 kPa (3.7-9.9) compared to 5 (3.4-7.5) in others, p = 0.02. In patients with abnormal liver function tests, 50% had increased LSM (≥F2), whereas 94% with normal tests had normal LSM (p = 0.04). Seven patients had abnormal MRI despite normal ultrasonography. Conclusions. MRI and LSM provide useful information on CFLD and may help to screen patients with PHT.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lemaitre</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dominique</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Billoud</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology, Le Havre General Hospital, Le Havre, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eliezer</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Radiology, Rouen University Hospital, Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Montialoux</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quillard</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Clinical Biology Institute, Rouen University Hospital, Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riachi</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koning</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Radiology, Rouen University Hospital, Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morisse-Pradier</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Savoye</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France; INSERM U1073, Institute for Research and Innovation in Biomedicine, Faculty of Medicine, University of Rouen, Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Savoye-Collet</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Radiology, Rouen University Hospital, Rouen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goria</LastName><ForeName>O</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>Jun</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>Egypt</Country><MedlineTA>Can Respir J</MedlineTA><NlmUniqueID>9433332</NlmUniqueID><ISSNLinking>1198-2241</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><OtherID Source="NLM">PMC4939173</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>9</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>5</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>6</Month><Day>2</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>7</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>7</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>7</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27445541</ArticleId><ArticleId IdType="doi">10.1155/2016/4592702</ArticleId><ArticleId IdType="pmc">PMC4939173</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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