The effect of increased genetic risk for Alzheimer’s disease on hippocampal and amygdala volume
Identifieur interne : 001580 ( Main/Merge ); précédent : 001579; suivant : 001581The effect of increased genetic risk for Alzheimer’s disease on hippocampal and amygdala volume
Auteurs : Michelle K. Lupton [Australie] ; Lachlan Strike [Australie] ; Narelle K. Hansell [Australie] ; Wei Wen [Australie] ; Karen A. Mather [Australie] ; Nicola J. Armstrong [Australie] ; Anbupalam Thalamuthu [Australie] ; Katie L. Mcmahon [Australie] ; Greig I. De Zubicaray [Australie] ; Amelia A. Assareh [Australie] ; Andrew Simmons [Royaume-Uni] ; Petroula Proitsi [Royaume-Uni] ; John F. Powell [Royaume-Uni] ; Grant W. Montgomery [Australie] ; Derrek P. Hibar [États-Unis] ; Eric Westman [Suède] ; Magda Tsolaki [Grèce] ; Iwona Kloszewska [Pologne] ; Hilkka Soininen [Finlande] ; Patrizia Mecocci [Italie] ; Bruno Velas [France] ; Simon Lovestone [Royaume-Uni] ; Henry Brodaty [Australie] ; David Ames [Australie] ; Julian N. Trollor [Australie] ; Nicholas G. Martin [Australie] ; Paul M. Thompson [États-Unis] ; Perminder S. Sachdev [Australie] ; Margaret J. Wright [Australie]Source :
- Neurobiology of aging [ 0197-4580 ] ; 2016.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Amygdale (système limbique) (anatomopathologie), Amygdale (système limbique) (imagerie diagnostique), Apolipoprotéines E (génétique), Dysfonctionnement cognitif (anatomopathologie), Dysfonctionnement cognitif (génétique), Dysfonctionnement cognitif (imagerie diagnostique), Femelle, Glycoprotéines membranaires (génétique), Hippocampe (anatomopathologie), Hippocampe (imagerie diagnostique), Humains, Imagerie par résonance magnétique, Jeune adulte, Maladie d'Alzheimer (anatomopathologie), Maladie d'Alzheimer (génétique), Maladie d'Alzheimer (imagerie diagnostique), Mâle, Risque, Récepteurs immunologiques (génétique), Sujet âgé, Sujet âgé de 80 ans ou plus, Études cas-témoins, Études d'associations génétiques, Études de cohortes.
- MESH :
- anatomopathologie : Amygdale (système limbique), Dysfonctionnement cognitif, Hippocampe, Maladie d'Alzheimer.
- génétique : Apolipoprotéines E, Dysfonctionnement cognitif, Glycoprotéines membranaires, Maladie d'Alzheimer, Récepteurs immunologiques.
- imagerie diagnostique : Amygdale (système limbique), Dysfonctionnement cognitif, Hippocampe, Maladie d'Alzheimer.
- Adolescent, Adulte, Adulte d'âge moyen, Femelle, Humains, Imagerie par résonance magnétique, Jeune adulte, Mâle, Risque, Sujet âgé, Sujet âgé de 80 ans ou plus, Études cas-témoins, Études d'associations génétiques, Études de cohortes.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Alzheimer Disease (diagnostic imaging), Alzheimer Disease (genetics), Alzheimer Disease (pathology), Amygdala (diagnostic imaging), Amygdala (pathology), Apolipoproteins E (genetics), Case-Control Studies, Cognitive Dysfunction (diagnostic imaging), Cognitive Dysfunction (genetics), Cognitive Dysfunction (pathology), Cohort Studies, Female, Genetic Association Studies, Hippocampus (diagnostic imaging), Hippocampus (pathology), Humans, Magnetic Resonance Imaging, Male, Membrane Glycoproteins (genetics), Middle Aged, Receptors, Immunologic (genetics), Risk, Young Adult.
- MESH :
- chemical , genetics : Apolipoproteins E, Membrane Glycoproteins, Receptors, Immunologic.
- diagnostic imaging : Alzheimer Disease, Amygdala, Cognitive Dysfunction, Hippocampus.
- genetics : Alzheimer Disease, Cognitive Dysfunction.
- pathology : Alzheimer Disease, Amygdala, Cognitive Dysfunction, Hippocampus.
- Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Cohort Studies, Female, Genetic Association Studies, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Risk, Young Adult.
Abstract
Reduction in hippocampal and amygdala volume measured via structural magnetic resonance imaging is an early marker of Alzheimer’s disease (AD). Whether genetic risk factors for AD exert an effect on these subcortical structures independent of clinical status has not been fully investigated. We examine whether increased genetic risk for AD influences hippocampal and amygdala volumes in case-control and population cohorts at different ages, in 1674 older (aged >53 years; 17% AD, 39% mild cognitive impairment [MCI]) and 467 young (16–30 years) adults. An AD polygenic risk score combining common risk variants excluding apolipoprotein E (
Url:
DOI: 10.1016/j.neurobiolaging.2015.12.023
PubMed: 26973105
PubMed Central: 4883003
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PMC:4883003Le document en format XML
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<author><name sortKey="Lupton, Michelle K" sort="Lupton, Michelle K" uniqKey="Lupton M" first="Michelle K." last="Lupton">Michelle K. Lupton</name>
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<author><name sortKey="Wen, Wei" sort="Wen, Wei" uniqKey="Wen W" first="Wei" last="Wen">Wei Wen</name>
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<author><name sortKey="Mather, Karen A" sort="Mather, Karen A" uniqKey="Mather K" first="Karen A." last="Mather">Karen A. Mather</name>
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<author><name sortKey="Armstrong, Nicola J" sort="Armstrong, Nicola J" uniqKey="Armstrong N" first="Nicola J." last="Armstrong">Nicola J. Armstrong</name>
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<author><name sortKey="Thalamuthu, Anbupalam" sort="Thalamuthu, Anbupalam" uniqKey="Thalamuthu A" first="Anbupalam" last="Thalamuthu">Anbupalam Thalamuthu</name>
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<author><name sortKey="Mcmahon, Katie L" sort="Mcmahon, Katie L" uniqKey="Mcmahon K" first="Katie L." last="Mcmahon">Katie L. Mcmahon</name>
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<author><name sortKey="De Zubicaray, Greig I" sort="De Zubicaray, Greig I" uniqKey="De Zubicaray G" first="Greig I." last="De Zubicaray">Greig I. De Zubicaray</name>
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<author><name sortKey="Assareh, Amelia A" sort="Assareh, Amelia A" uniqKey="Assareh A" first="Amelia A." last="Assareh">Amelia A. Assareh</name>
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<author><name sortKey="Simmons, Andrew" sort="Simmons, Andrew" uniqKey="Simmons A" first="Andrew" last="Simmons">Andrew Simmons</name>
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<author><name sortKey="Proitsi, Petroula" sort="Proitsi, Petroula" uniqKey="Proitsi P" first="Petroula" last="Proitsi">Petroula Proitsi</name>
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<author><name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F." last="Powell">John F. Powell</name>
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<author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name>
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<author><name sortKey="Hibar, Derrek P" sort="Hibar, Derrek P" uniqKey="Hibar D" first="Derrek P." last="Hibar">Derrek P. Hibar</name>
<affiliation wicri:level="4"><nlm:aff id="A8">Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Ray, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Ray, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
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<author><name sortKey="Westman, Eric" sort="Westman, Eric" uniqKey="Westman E" first="Eric" last="Westman">Eric Westman</name>
<affiliation wicri:level="3"><nlm:aff id="A9">Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Alzheimer’s Disease Research Centre, Karolinska Institute, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Alzheimer’s Disease Research Centre, Karolinska Institute, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
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<author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Memory and Dementia Centre, Aristotle University of Thessaloniki, Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Memory and Dementia Centre, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea>
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<author><name sortKey="Kloszewska, Iwona" sort="Kloszewska, Iwona" uniqKey="Kloszewska I" first="Iwona" last="Kloszewska">Iwona Kloszewska</name>
<affiliation wicri:level="1"><nlm:aff id="A11">Department of Old Age Psychiatry & Psychotic Disorders, Medical University of Lodz, Lodz, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Old Age Psychiatry & Psychotic Disorders, Medical University of Lodz, Lodz</wicri:regionArea>
<wicri:noRegion>Lodz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name>
<affiliation wicri:level="1"><nlm:aff id="A12">Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio</wicri:regionArea>
<wicri:noRegion>Kuopio</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Velas, Bruno" sort="Velas, Bruno" uniqKey="Velas B" first="Bruno" last="Velas">Bruno Velas</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Gerontopole, CHU, UMR INSERM 1027, University of Toulouse, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Gerontopole, CHU, UMR INSERM 1027, University of Toulouse</wicri:regionArea>
<wicri:noRegion>University of Toulouse</wicri:noRegion>
<wicri:noRegion>University of Toulouse</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name>
<affiliation wicri:level="3"><nlm:aff id="A7">Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A15">Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Brodaty, Henry" sort="Brodaty, Henry" uniqKey="Brodaty H" first="Henry" last="Brodaty">Henry Brodaty</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ames, David" sort="Ames, David" uniqKey="Ames D" first="David" last="Ames">David Ames</name>
<affiliation wicri:level="1"><nlm:aff id="A16">National Ageing Research Institute, Parkville, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>National Ageing Research Institute, Parkville, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A17">Academic Unit for Psychiatry of Old Age, University of Melbourne, Kew, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Academic Unit for Psychiatry of Old Age, University of Melbourne, Kew, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Trollor, Julian N" sort="Trollor, Julian N" uniqKey="Trollor J" first="Julian N." last="Trollor">Julian N. Trollor</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name>
<affiliation wicri:level="4"><nlm:aff id="A8">Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Ray, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Ray, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Sachdev, Perminder S" sort="Sachdev, Perminder S" uniqKey="Sachdev P" first="Perminder S." last="Sachdev">Perminder S. Sachdev</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Brain Institute, The University of Queensland, St Lucia, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A18">The Centre for Advanced Imaging, The University of Queensland, St Lucia, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Centre for Advanced Imaging, The University of Queensland, St Lucia, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26973105</idno>
<idno type="pmc">4883003</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883003</idno>
<idno type="RBID">PMC:4883003</idno>
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<author><name sortKey="Strike, Lachlan" sort="Strike, Lachlan" uniqKey="Strike L" first="Lachlan" last="Strike">Lachlan Strike</name>
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</author>
<author><name sortKey="Hansell, Narelle K" sort="Hansell, Narelle K" uniqKey="Hansell N" first="Narelle K." last="Hansell">Narelle K. Hansell</name>
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<affiliation wicri:level="1"><nlm:aff id="A2">Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia</nlm:aff>
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</author>
<author><name sortKey="Wen, Wei" sort="Wen, Wei" uniqKey="Wen W" first="Wei" last="Wen">Wei Wen</name>
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</author>
<author><name sortKey="Mather, Karen A" sort="Mather, Karen A" uniqKey="Mather K" first="Karen A." last="Mather">Karen A. Mather</name>
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</author>
<author><name sortKey="Armstrong, Nicola J" sort="Armstrong, Nicola J" uniqKey="Armstrong N" first="Nicola J." last="Armstrong">Nicola J. Armstrong</name>
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<wicri:noRegion>Western Australia</wicri:noRegion>
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</author>
<author><name sortKey="Thalamuthu, Anbupalam" sort="Thalamuthu, Anbupalam" uniqKey="Thalamuthu A" first="Anbupalam" last="Thalamuthu">Anbupalam Thalamuthu</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Mcmahon, Katie L" sort="Mcmahon, Katie L" uniqKey="Mcmahon K" first="Katie L." last="Mcmahon">Katie L. Mcmahon</name>
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</affiliation>
</author>
<author><name sortKey="De Zubicaray, Greig I" sort="De Zubicaray, Greig I" uniqKey="De Zubicaray G" first="Greig I." last="De Zubicaray">Greig I. De Zubicaray</name>
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</affiliation>
</author>
<author><name sortKey="Assareh, Amelia A" sort="Assareh, Amelia A" uniqKey="Assareh A" first="Amelia A." last="Assareh">Amelia A. Assareh</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Simmons, Andrew" sort="Simmons, Andrew" uniqKey="Simmons A" first="Andrew" last="Simmons">Andrew Simmons</name>
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</affiliation>
</author>
<author><name sortKey="Proitsi, Petroula" sort="Proitsi, Petroula" uniqKey="Proitsi P" first="Petroula" last="Proitsi">Petroula Proitsi</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F." last="Powell">John F. Powell</name>
<affiliation wicri:level="3"><nlm:aff id="A7">Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK</nlm:aff>
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<wicri:regionArea>Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name>
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<country xml:lang="fr">Australie</country>
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</affiliation>
</author>
<author><name sortKey="Hibar, Derrek P" sort="Hibar, Derrek P" uniqKey="Hibar D" first="Derrek P." last="Hibar">Derrek P. Hibar</name>
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</placeName>
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</author>
<author><name sortKey="Westman, Eric" sort="Westman, Eric" uniqKey="Westman E" first="Eric" last="Westman">Eric Westman</name>
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</affiliation>
</author>
<author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name>
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</affiliation>
</author>
<author><name sortKey="Kloszewska, Iwona" sort="Kloszewska, Iwona" uniqKey="Kloszewska I" first="Iwona" last="Kloszewska">Iwona Kloszewska</name>
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</affiliation>
</author>
<author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name>
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</affiliation>
</author>
<author><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name>
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<country xml:lang="fr">Italie</country>
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</affiliation>
</author>
<author><name sortKey="Velas, Bruno" sort="Velas, Bruno" uniqKey="Velas B" first="Bruno" last="Velas">Bruno Velas</name>
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<country xml:lang="fr">France</country>
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<wicri:noRegion>University of Toulouse</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name>
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<placeName><settlement type="city">Londres</settlement>
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</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A15">Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK</nlm:aff>
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<wicri:regionArea>Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
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<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
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</author>
<author><name sortKey="Brodaty, Henry" sort="Brodaty, Henry" uniqKey="Brodaty H" first="Henry" last="Brodaty">Henry Brodaty</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Ames, David" sort="Ames, David" uniqKey="Ames D" first="David" last="Ames">David Ames</name>
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<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A17">Academic Unit for Psychiatry of Old Age, University of Melbourne, Kew, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Academic Unit for Psychiatry of Old Age, University of Melbourne, Kew, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Trollor, Julian N" sort="Trollor, Julian N" uniqKey="Trollor J" first="Julian N." last="Trollor">Julian N. Trollor</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
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<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name>
<affiliation wicri:level="4"><nlm:aff id="A8">Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Ray, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Sachdev, Perminder S" sort="Sachdev, Perminder S" uniqKey="Sachdev P" first="Perminder S." last="Sachdev">Perminder S. Sachdev</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
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<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name>
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<country xml:lang="fr">Australie</country>
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</affiliation>
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<country xml:lang="fr">Australie</country>
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<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A18">The Centre for Advanced Imaging, The University of Queensland, St Lucia, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Centre for Advanced Imaging, The University of Queensland, St Lucia, Queensland</wicri:regionArea>
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<series><title level="j">Neurobiology of aging</title>
<idno type="ISSN">0197-4580</idno>
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<imprint><date when="2016">2016</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Alzheimer Disease (diagnostic imaging)</term>
<term>Alzheimer Disease (genetics)</term>
<term>Alzheimer Disease (pathology)</term>
<term>Amygdala (diagnostic imaging)</term>
<term>Amygdala (pathology)</term>
<term>Apolipoproteins E (genetics)</term>
<term>Case-Control Studies</term>
<term>Cognitive Dysfunction (diagnostic imaging)</term>
<term>Cognitive Dysfunction (genetics)</term>
<term>Cognitive Dysfunction (pathology)</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Genetic Association Studies</term>
<term>Hippocampus (diagnostic imaging)</term>
<term>Hippocampus (pathology)</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Membrane Glycoproteins (genetics)</term>
<term>Middle Aged</term>
<term>Receptors, Immunologic (genetics)</term>
<term>Risk</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Amygdale (système limbique) (anatomopathologie)</term>
<term>Amygdale (système limbique) (imagerie diagnostique)</term>
<term>Apolipoprotéines E (génétique)</term>
<term>Dysfonctionnement cognitif (anatomopathologie)</term>
<term>Dysfonctionnement cognitif (génétique)</term>
<term>Dysfonctionnement cognitif (imagerie diagnostique)</term>
<term>Femelle</term>
<term>Glycoprotéines membranaires (génétique)</term>
<term>Hippocampe (anatomopathologie)</term>
<term>Hippocampe (imagerie diagnostique)</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Jeune adulte</term>
<term>Maladie d'Alzheimer (anatomopathologie)</term>
<term>Maladie d'Alzheimer (génétique)</term>
<term>Maladie d'Alzheimer (imagerie diagnostique)</term>
<term>Mâle</term>
<term>Risque</term>
<term>Récepteurs immunologiques (génétique)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études cas-témoins</term>
<term>Études d'associations génétiques</term>
<term>Études de cohortes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoproteins E</term>
<term>Membrane Glycoproteins</term>
<term>Receptors, Immunologic</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Amygdale (système limbique)</term>
<term>Dysfonctionnement cognitif</term>
<term>Hippocampe</term>
<term>Maladie d'Alzheimer</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Alzheimer Disease</term>
<term>Amygdala</term>
<term>Cognitive Dysfunction</term>
<term>Hippocampus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alzheimer Disease</term>
<term>Cognitive Dysfunction</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Apolipoprotéines E</term>
<term>Dysfonctionnement cognitif</term>
<term>Glycoprotéines membranaires</term>
<term>Maladie d'Alzheimer</term>
<term>Récepteurs immunologiques</term>
</keywords>
<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Amygdale (système limbique)</term>
<term>Dysfonctionnement cognitif</term>
<term>Hippocampe</term>
<term>Maladie d'Alzheimer</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alzheimer Disease</term>
<term>Amygdala</term>
<term>Cognitive Dysfunction</term>
<term>Hippocampus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Case-Control Studies</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Genetic Association Studies</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Risk</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Risque</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études cas-témoins</term>
<term>Études d'associations génétiques</term>
<term>Études de cohortes</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Reduction in hippocampal and amygdala volume measured via structural magnetic resonance imaging is an early marker of Alzheimer’s disease (AD). Whether genetic risk factors for AD exert an effect on these subcortical structures independent of clinical status has not been fully investigated. We examine whether increased genetic risk for AD influences hippocampal and amygdala volumes in case-control and population cohorts at different ages, in 1674 older (aged >53 years; 17% AD, 39% mild cognitive impairment [MCI]) and 467 young (16–30 years) adults. An AD polygenic risk score combining common risk variants excluding apolipoprotein E (<italic>APOE</italic>
), and a single nucleotide polymorphism in <italic>TREM2</italic>
, were both associated with reduced hippocampal volume in healthy older adults and those with MCI. <italic>APOE</italic>
ɛ4 was associated with hippocampal and amygdala volume in those with AD and MCI but was not associated in healthy older adults. No associations were found in young adults. Genetic risk for AD affects the hippocampus before the clinical symptoms of AD, reflecting a neurodegenerative effect before clinical manifestations in older adults.</p>
</div>
</front>
</TEI>
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