The effect of different doses of near infrared light on dopaminergic cell survival and gliosis in MPTP-treated mice.
Identifieur interne : 001581 ( Main/Merge ); précédent : 001580; suivant : 001582The effect of different doses of near infrared light on dopaminergic cell survival and gliosis in MPTP-treated mice.
Auteurs : Nabil El Massri [Australie] ; Daniel M. Johnstone [Australie] ; Cassandra L. Peoples [Australie] ; Cécile Moro [France] ; Florian Reinhart [France] ; Napoleon Torres [France] ; Jonathan Stone [Australie] ; Alim-Louis Benabid [France] ; John Mitrofanis [Australie]Source :
- The International journal of neuroscience [ 1563-5279 ] ; 2016.
Descripteurs français
- KwdFr :
- 1-Méthyl-4-phényl-1,2,3,6-tétrahydropyridine (administration et posologie), Animaux, Astrocytes (anatomopathologie), Astrocytes (effets des radiations), Gliose (anatomopathologie), Gliose (radiothérapie), Intoxication au MPTP (anatomopathologie), Intoxication au MPTP (radiothérapie), Mâle, Neurones dopaminergiques (), Neurones dopaminergiques (effets des radiations), Noyau caudé (anatomopathologie), Noyau caudé (effets des radiations), Numération cellulaire, Pars compacta (anatomopathologie), Pars compacta (effets des radiations), Protéines de tissu nerveux (analyse), Putamen (anatomopathologie), Putamen (effets des radiations), Rayons infrarouges (usage thérapeutique), Relation dose-effet des médicaments, Relation dose-effet des radiations, Souris, Souris de lignée BALB C, Survie cellulaire (effets des radiations), Syndromes parkinsoniens (anatomopathologie), Syndromes parkinsoniens (radiothérapie), Tyrosine 3-monooxygenase (analyse).
- MESH :
- administration et posologie : 1-Méthyl-4-phényl-1,2,3,6-tétrahydropyridine.
- analyse : Protéines de tissu nerveux, Tyrosine 3-monooxygenase.
- anatomopathologie : Astrocytes, Gliose, Intoxication au MPTP, Noyau caudé, Pars compacta, Putamen, Syndromes parkinsoniens.
- effets des radiations : Astrocytes, Neurones dopaminergiques, Noyau caudé, Pars compacta, Putamen, Survie cellulaire.
- radiothérapie : Gliose, Intoxication au MPTP, Syndromes parkinsoniens.
- usage thérapeutique : Rayons infrarouges.
- Animaux, Mâle, Neurones dopaminergiques, Numération cellulaire, Relation dose-effet des médicaments, Relation dose-effet des radiations, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (administration & dosage), Animals, Astrocytes (pathology), Astrocytes (radiation effects), Caudate Nucleus (pathology), Caudate Nucleus (radiation effects), Cell Count, Cell Survival (radiation effects), Dopaminergic Neurons (drug effects), Dopaminergic Neurons (radiation effects), Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Gliosis (pathology), Gliosis (radiotherapy), Infrared Rays (therapeutic use), MPTP Poisoning (pathology), MPTP Poisoning (radiotherapy), Male, Mice, Mice, Inbred BALB C, Nerve Tissue Proteins (analysis), Parkinsonian Disorders (pathology), Parkinsonian Disorders (radiotherapy), Pars Compacta (pathology), Pars Compacta (radiation effects), Putamen (pathology), Putamen (radiation effects), Tyrosine 3-Monooxygenase (analysis).
- MESH :
- chemical , administration & dosage : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- chemical , analysis : Nerve Tissue Proteins, Tyrosine 3-Monooxygenase.
- drug effects : Dopaminergic Neurons.
- pathology : Astrocytes, Caudate Nucleus, Gliosis, MPTP Poisoning, Parkinsonian Disorders, Pars Compacta, Putamen.
- radiation effects : Astrocytes, Caudate Nucleus, Cell Survival, Dopaminergic Neurons, Pars Compacta, Putamen.
- radiotherapy : Gliosis, MPTP Poisoning, Parkinsonian Disorders.
- therapeutic use : Infrared Rays.
- Animals, Cell Count, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Male, Mice, Mice, Inbred BALB C.
Abstract
We have used the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model to explore whether (i) the neuroprotective effect of near infrared light (NIr) treatment in the SNc is dose-dependent and (ii) the relationship between tyrosine hydroxylase (TH)+ terminal density and glial cells in the caudate-putamen complex (CPu). Mice received MPTP injections (50 mg/kg) and 2 J/cm2 NIr dose with either 2 d or 7 d survival period. In another series, with a longer 14 d survival period, mice had a stronger MPTP regime (100 mg/kg) and either 2 J/cm2 or 4 J/cm2 NIr dose. Brains were processed for routine immunohistochemistry and cell counts were made using stereology. Our findings were that in the 2 d series, no change in SNc TH+ cell number was evident after any treatment. In the 7 d series however, MPTP insult resulted in ∼45% reduction in TH+ cell number; after NIr (2 J/cm2) treatment, many cells were protected from the toxic insult. In the 14 d series, MPTP induced a similar reduction in TH+ cell number. NIr mitigated the loss of TH+ cells, but only at the higher dose of 4 J/cm2; the lower dose of 2 J/cm2 had no neuroprotective effect in this series. The higher dose of NIr, unlike the lower dose, also mitigated the MPTP- induced increase in CPu astrocytes after 14 d; these changes were independent of TH+ terminal density, of which, did not vary across the different experimental groups. In summary, we showed that neuroprotection by NIr irradiation in MPTP-treated mice was dose-dependent; with increasing MPTP toxicity, higher doses of NIr were required to protect cells and reduce astrogliosis.
DOI: 10.3109/00207454.2014.994063
PubMed: 25469453
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type="wicri:Area/Main/Merge">001581</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The effect of different doses of near infrared light on dopaminergic cell survival and gliosis in MPTP-treated mice.</title><author><name sortKey="El Massri, Nabil" sort="El Massri, Nabil" uniqKey="El Massri N" first="Nabil" last="El Massri">Nabil El Massri</name><affiliation wicri:level="4"><nlm:affiliation>a Department of Anatomy F13, University of Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>a Department of Anatomy F13, University of Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Johnstone, Daniel M" sort="Johnstone, Daniel M" uniqKey="Johnstone D" first="Daniel M" last="Johnstone">Daniel M. Johnstone</name><affiliation wicri:level="4"><nlm:affiliation>b Department of Physiology F13, University of Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>b Department of Physiology F13, University of Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Peoples, Cassandra L" sort="Peoples, Cassandra L" uniqKey="Peoples C" first="Cassandra L" last="Peoples">Cassandra L. Peoples</name><affiliation wicri:level="4"><nlm:affiliation>a Department of Anatomy F13, University of Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>a Department of Anatomy F13, University of Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Moro, Cecile" sort="Moro, Cecile" uniqKey="Moro C" first="Cécile" last="Moro">Cécile Moro</name><affiliation wicri:level="3"><nlm:affiliation>c University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>c University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Reinhart, Florian" sort="Reinhart, Florian" uniqKey="Reinhart F" first="Florian" last="Reinhart">Florian Reinhart</name><affiliation wicri:level="3"><nlm:affiliation>c University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>c University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Torres, Napoleon" sort="Torres, Napoleon" uniqKey="Torres N" first="Napoleon" last="Torres">Napoleon Torres</name><affiliation wicri:level="3"><nlm:affiliation>c University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>c University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Stone, Jonathan" sort="Stone, Jonathan" uniqKey="Stone J" first="Jonathan" last="Stone">Jonathan Stone</name><affiliation wicri:level="4"><nlm:affiliation>b Department of Physiology F13, University of Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>b Department of Physiology F13, University of Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation wicri:level="3"><nlm:affiliation>c University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>c University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Mitrofanis, John" sort="Mitrofanis, John" uniqKey="Mitrofanis J" first="John" last="Mitrofanis">John Mitrofanis</name><affiliation wicri:level="4"><nlm:affiliation>a Department of Anatomy F13, University of Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>a Department of Anatomy F13, University of Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author></analytic><series><title level="j">The International journal of neuroscience</title><idno type="eISSN">1563-5279</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (administration & dosage)</term><term>Animals</term><term>Astrocytes (pathology)</term><term>Astrocytes (radiation effects)</term><term>Caudate Nucleus (pathology)</term><term>Caudate Nucleus (radiation effects)</term><term>Cell Count</term><term>Cell Survival (radiation effects)</term><term>Dopaminergic Neurons (drug effects)</term><term>Dopaminergic Neurons (radiation effects)</term><term>Dose-Response Relationship, Drug</term><term>Dose-Response Relationship, Radiation</term><term>Gliosis (pathology)</term><term>Gliosis (radiotherapy)</term><term>Infrared Rays (therapeutic use)</term><term>MPTP Poisoning (pathology)</term><term>MPTP Poisoning (radiotherapy)</term><term>Male</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Nerve Tissue Proteins (analysis)</term><term>Parkinsonian Disorders (pathology)</term><term>Parkinsonian Disorders (radiotherapy)</term><term>Pars Compacta (pathology)</term><term>Pars Compacta (radiation effects)</term><term>Putamen (pathology)</term><term>Putamen (radiation effects)</term><term>Tyrosine 3-Monooxygenase (analysis)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>1-Méthyl-4-phényl-1,2,3,6-tétrahydropyridine (administration et posologie)</term><term>Animaux</term><term>Astrocytes (anatomopathologie)</term><term>Astrocytes (effets des radiations)</term><term>Gliose (anatomopathologie)</term><term>Gliose (radiothérapie)</term><term>Intoxication au MPTP (anatomopathologie)</term><term>Intoxication au MPTP (radiothérapie)</term><term>Mâle</term><term>Neurones dopaminergiques ()</term><term>Neurones dopaminergiques (effets des radiations)</term><term>Noyau caudé (anatomopathologie)</term><term>Noyau caudé (effets des radiations)</term><term>Numération cellulaire</term><term>Pars compacta (anatomopathologie)</term><term>Pars compacta (effets des radiations)</term><term>Protéines de tissu nerveux (analyse)</term><term>Putamen (anatomopathologie)</term><term>Putamen (effets des radiations)</term><term>Rayons infrarouges (usage thérapeutique)</term><term>Relation dose-effet des médicaments</term><term>Relation dose-effet des radiations</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Survie cellulaire (effets des radiations)</term><term>Syndromes parkinsoniens (anatomopathologie)</term><term>Syndromes parkinsoniens (radiothérapie)</term><term>Tyrosine 3-monooxygenase (analyse)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Nerve Tissue Proteins</term><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>1-Méthyl-4-phényl-1,2,3,6-tétrahydropyridine</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Protéines de tissu nerveux</term><term>Tyrosine 3-monooxygenase</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Astrocytes</term><term>Gliose</term><term>Intoxication au MPTP</term><term>Noyau caudé</term><term>Pars compacta</term><term>Putamen</term><term>Syndromes parkinsoniens</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Dopaminergic Neurons</term></keywords><keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Astrocytes</term><term>Neurones dopaminergiques</term><term>Noyau caudé</term><term>Pars compacta</term><term>Putamen</term><term>Survie cellulaire</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Astrocytes</term><term>Caudate Nucleus</term><term>Gliosis</term><term>MPTP Poisoning</term><term>Parkinsonian Disorders</term><term>Pars Compacta</term><term>Putamen</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Astrocytes</term><term>Caudate Nucleus</term><term>Cell Survival</term><term>Dopaminergic Neurons</term><term>Pars Compacta</term><term>Putamen</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Gliosis</term><term>MPTP Poisoning</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Gliose</term><term>Intoxication au MPTP</term><term>Syndromes parkinsoniens</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Infrared Rays</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Rayons infrarouges</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Count</term><term>Dose-Response Relationship, Drug</term><term>Dose-Response Relationship, Radiation</term><term>Male</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Mâle</term><term>Neurones dopaminergiques</term><term>Numération cellulaire</term><term>Relation dose-effet des médicaments</term><term>Relation dose-effet des radiations</term><term>Souris</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have used the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model to explore whether (i) the neuroprotective effect of near infrared light (NIr) treatment in the SNc is dose-dependent and (ii) the relationship between tyrosine hydroxylase (TH)+ terminal density and glial cells in the caudate-putamen complex (CPu). Mice received MPTP injections (50 mg/kg) and 2 J/cm2 NIr dose with either 2 d or 7 d survival period. In another series, with a longer 14 d survival period, mice had a stronger MPTP regime (100 mg/kg) and either 2 J/cm2 or 4 J/cm2 NIr dose. Brains were processed for routine immunohistochemistry and cell counts were made using stereology. Our findings were that in the 2 d series, no change in SNc TH+ cell number was evident after any treatment. In the 7 d series however, MPTP insult resulted in ∼45% reduction in TH+ cell number; after NIr (2 J/cm2) treatment, many cells were protected from the toxic insult. In the 14 d series, MPTP induced a similar reduction in TH+ cell number. NIr mitigated the loss of TH+ cells, but only at the higher dose of 4 J/cm2; the lower dose of 2 J/cm2 had no neuroprotective effect in this series. The higher dose of NIr, unlike the lower dose, also mitigated the MPTP- induced increase in CPu astrocytes after 14 d; these changes were independent of TH+ terminal density, of which, did not vary across the different experimental groups. In summary, we showed that neuroprotection by NIr irradiation in MPTP-treated mice was dose-dependent; with increasing MPTP toxicity, higher doses of NIr were required to protect cells and reduce astrogliosis.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:25469453" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |