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The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume.

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The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume.

Auteurs : Michelle K. Lupton [Australie] ; Lachlan Strike [Australie] ; Narelle K. Hansell [Australie] ; Wei Wen [Australie] ; Karen A. Mather [Australie] ; Nicola J. Armstrong [Australie] ; Anbupalam Thalamuthu [Australie] ; Katie L. Mcmahon [Australie] ; Greig I. De Zubicaray [Australie] ; Amelia A. Assareh [Australie] ; Andrew Simmons [Royaume-Uni] ; Petroula Proitsi [Royaume-Uni] ; John F. Powell [Royaume-Uni] ; Grant W. Montgomery [Australie] ; Derrek P. Hibar [États-Unis] ; Eric Westman [Suède] ; Magda Tsolaki [Grèce] ; Iwona Kloszewska [Pologne] ; Hilkka Soininen [Finlande] ; Patrizia Mecocci [Italie] ; Bruno Velas [France] ; Simon Lovestone [Royaume-Uni] ; Henry Brodaty [Australie] ; David Ames [Australie] ; Julian N. Trollor [Australie] ; Nicholas G. Martin [Australie] ; Paul M. Thompson [États-Unis] ; Perminder S. Sachdev [Australie] ; Margaret J. Wright [Australie]

Source :

Neurobiology of aging [ 1558-1497 ] ; 2016.

RBID : pubmed:26973105

Descripteurs français

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Alzheimer Disease (diagnostic imaging), Alzheimer Disease (genetics), Alzheimer Disease (pathology), Amygdala (diagnostic imaging), Amygdala (pathology), Apolipoproteins E (genetics), Case-Control Studies, Cognitive Dysfunction (diagnostic imaging), Cognitive Dysfunction (genetics), Cognitive Dysfunction (pathology), Cohort Studies, Female, Genetic Association Studies, Hippocampus (diagnostic imaging), Hippocampus (pathology), Humans, Magnetic Resonance Imaging, Male, Membrane Glycoproteins (genetics), Middle Aged, Receptors, Immunologic (genetics), Risk, Young Adult.
MESH :
- chemical , genetics : Apolipoproteins E, Membrane Glycoproteins, Receptors, Immunologic.
- diagnostic imaging : Alzheimer Disease, Amygdala, Cognitive Dysfunction, Hippocampus.
- genetics : Alzheimer Disease, Cognitive Dysfunction.
- pathology : Alzheimer Disease, Amygdala, Cognitive Dysfunction, Hippocampus.
- Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Cohort Studies, Female, Genetic Association Studies, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Risk, Young Adult.

Abstract

Reduction in hippocampal and amygdala volume measured via structural magnetic resonance imaging is an early marker of Alzheimer's disease (AD). Whether genetic risk factors for AD exert an effect on these subcortical structures independent of clinical status has not been fully investigated. We examine whether increased genetic risk for AD influences hippocampal and amygdala volumes in case-control and population cohorts at different ages, in 1674 older (aged >53 years; 17% AD, 39% mild cognitive impairment [MCI]) and 467 young (16-30 years) adults. An AD polygenic risk score combining common risk variants excluding apolipoprotein E (APOE), and a single nucleotide polymorphism in TREM2, were both associated with reduced hippocampal volume in healthy older adults and those with MCI. APOE ε4 was associated with hippocampal and amygdala volume in those with AD and MCI but was not associated in healthy older adults. No associations were found in young adults. Genetic risk for AD affects the hippocampus before the clinical symptoms of AD, reflecting a neurodegenerative effect before clinical manifestations in older adults.

DOI: 10.1016/j.neurobiolaging.2015.12.023
PubMed: 26973105

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<author><name sortKey="Assareh, Amelia A" sort="Assareh, Amelia A" uniqKey="Assareh A" first="Amelia A" last="Assareh">Amelia A. Assareh</name>
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<author><name sortKey="Proitsi, Petroula" sort="Proitsi, Petroula" uniqKey="Proitsi P" first="Petroula" last="Proitsi">Petroula Proitsi</name>
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<author><name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F" last="Powell">John F. Powell</name>
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<author><name sortKey="Hibar, Derrek P" sort="Hibar, Derrek P" uniqKey="Hibar D" first="Derrek P" last="Hibar">Derrek P. Hibar</name>
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<author><name sortKey="Westman, Eric" sort="Westman, Eric" uniqKey="Westman E" first="Eric" last="Westman">Eric Westman</name>
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<author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name>
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<author><name sortKey="Kloszewska, Iwona" sort="Kloszewska, Iwona" uniqKey="Kloszewska I" first="Iwona" last="Kloszewska">Iwona Kloszewska</name>
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<wicri:regionArea>Department of Old Age Psychiatry & Psychotic Disorders, Medical University of Lodz, Lodz</wicri:regionArea>
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<author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name>
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<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio</wicri:regionArea>
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<author><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name>
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<country xml:lang="fr">Italie</country>
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<author><name sortKey="Velas, Bruno" sort="Velas, Bruno" uniqKey="Velas B" first="Bruno" last="Velas">Bruno Velas</name>
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<author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Brodaty, Henry" sort="Brodaty, Henry" uniqKey="Brodaty H" first="Henry" last="Brodaty">Henry Brodaty</name>
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<author><name sortKey="Ames, David" sort="Ames, David" uniqKey="Ames D" first="David" last="Ames">David Ames</name>
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<author><name sortKey="Trollor, Julian N" sort="Trollor, Julian N" uniqKey="Trollor J" first="Julian N" last="Trollor">Julian N. Trollor</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales</wicri:regionArea>
</affiliation>
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<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland</wicri:regionArea>
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<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M" last="Thompson">Paul M. Thompson</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Ray, CA</wicri:regionArea>
</affiliation>
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<author><name sortKey="Sachdev, Perminder S" sort="Sachdev, Perminder S" uniqKey="Sachdev P" first="Perminder S" last="Sachdev">Perminder S. Sachdev</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J" last="Wright">Margaret J. Wright</name>
<affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia; The Centre for Advanced Imaging, The University of Queensland, St Lucia, Queensland, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia; The Centre for Advanced Imaging, The University of Queensland, St Lucia, Queensland</wicri:regionArea>
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<author><name sortKey="Lupton, Michelle K" sort="Lupton, Michelle K" uniqKey="Lupton M" first="Michelle K" last="Lupton">Michelle K. Lupton</name>
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<author><name sortKey="Strike, Lachlan" sort="Strike, Lachlan" uniqKey="Strike L" first="Lachlan" last="Strike">Lachlan Strike</name>
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<country xml:lang="fr">Australie</country>
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<author><name sortKey="Hansell, Narelle K" sort="Hansell, Narelle K" uniqKey="Hansell N" first="Narelle K" last="Hansell">Narelle K. Hansell</name>
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<country xml:lang="fr">Australie</country>
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<author><name sortKey="Wen, Wei" sort="Wen, Wei" uniqKey="Wen W" first="Wei" last="Wen">Wei Wen</name>
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<author><name sortKey="Mather, Karen A" sort="Mather, Karen A" uniqKey="Mather K" first="Karen A" last="Mather">Karen A. Mather</name>
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<author><name sortKey="Armstrong, Nicola J" sort="Armstrong, Nicola J" uniqKey="Armstrong N" first="Nicola J" last="Armstrong">Nicola J. Armstrong</name>
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<country xml:lang="fr">Australie</country>
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</affiliation>
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<author><name sortKey="Thalamuthu, Anbupalam" sort="Thalamuthu, Anbupalam" uniqKey="Thalamuthu A" first="Anbupalam" last="Thalamuthu">Anbupalam Thalamuthu</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcmahon, Katie L" sort="Mcmahon, Katie L" uniqKey="Mcmahon K" first="Katie L" last="Mcmahon">Katie L. Mcmahon</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Zubicaray, Greig I" sort="De Zubicaray, Greig I" uniqKey="De Zubicaray G" first="Greig I" last="De Zubicaray">Greig I. De Zubicaray</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Queensland</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Assareh, Amelia A" sort="Assareh, Amelia A" uniqKey="Assareh A" first="Amelia A" last="Assareh">Amelia A. Assareh</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Simmons, Andrew" sort="Simmons, Andrew" uniqKey="Simmons A" first="Andrew" last="Simmons">Andrew Simmons</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychiatry, Psychology and Neuroscience, King's College London, London</wicri:regionArea>
</affiliation>
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<author><name sortKey="Proitsi, Petroula" sort="Proitsi, Petroula" uniqKey="Proitsi P" first="Petroula" last="Proitsi">Petroula Proitsi</name>
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<country xml:lang="fr">États-Unis</country>
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<country xml:lang="fr">Suède</country>
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<country xml:lang="fr">Grèce</country>
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</affiliation>
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<country xml:lang="fr">Pologne</country>
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<country xml:lang="fr">Finlande</country>
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<author><name sortKey="Velas, Bruno" sort="Velas, Bruno" uniqKey="Velas B" first="Bruno" last="Velas">Bruno Velas</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Brodaty, Henry" sort="Brodaty, Henry" uniqKey="Brodaty H" first="Henry" last="Brodaty">Henry Brodaty</name>
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<country xml:lang="fr">Australie</country>
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<author><name sortKey="Ames, David" sort="Ames, David" uniqKey="Ames D" first="David" last="Ames">David Ames</name>
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<author><name sortKey="Trollor, Julian N" sort="Trollor, Julian N" uniqKey="Trollor J" first="Julian N" last="Trollor">Julian N. Trollor</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales</wicri:regionArea>
</affiliation>
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<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name>
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<country xml:lang="fr">Australie</country>
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</affiliation>
</author>
<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M" last="Thompson">Paul M. Thompson</name>
<affiliation wicri:level="1"><nlm:affiliation>Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Ray, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Ray, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sachdev, Perminder S" sort="Sachdev, Perminder S" uniqKey="Sachdev P" first="Perminder S" last="Sachdev">Perminder S. Sachdev</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J" last="Wright">Margaret J. Wright</name>
<affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia; The Centre for Advanced Imaging, The University of Queensland, St Lucia, Queensland, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia; The Centre for Advanced Imaging, The University of Queensland, St Lucia, Queensland</wicri:regionArea>
</affiliation>
</author>
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<series><title level="j">Neurobiology of aging</title>
<idno type="eISSN">1558-1497</idno>
<imprint><date when="2016" type="published">2016</date>
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<term>Alzheimer Disease (genetics)</term>
<term>Alzheimer Disease (pathology)</term>
<term>Amygdala (diagnostic imaging)</term>
<term>Amygdala (pathology)</term>
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<term>Genetic Association Studies</term>
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<term>Hippocampus (pathology)</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
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<term>Membrane Glycoproteins (genetics)</term>
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<term>Receptors, Immunologic (genetics)</term>
<term>Risk</term>
<term>Young Adult</term>
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<front><div type="abstract" xml:lang="en">Reduction in hippocampal and amygdala volume measured via structural magnetic resonance imaging is an early marker of Alzheimer's disease (AD). Whether genetic risk factors for AD exert an effect on these subcortical structures independent of clinical status has not been fully investigated. We examine whether increased genetic risk for AD influences hippocampal and amygdala volumes in case-control and population cohorts at different ages, in 1674 older (aged >53 years; 17% AD, 39% mild cognitive impairment [MCI]) and 467 young (16-30 years) adults. An AD polygenic risk score combining common risk variants excluding apolipoprotein E (APOE), and a single nucleotide polymorphism in TREM2, were both associated with reduced hippocampal volume in healthy older adults and those with MCI. APOE ε4 was associated with hippocampal and amygdala volume in those with AD and MCI but was not associated in healthy older adults. No associations were found in young adults. Genetic risk for AD affects the hippocampus before the clinical symptoms of AD, reflecting a neurodegenerative effect before clinical manifestations in older adults.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26973105</PMID>
<DateCreated><Year>2016</Year>
<Month>03</Month>
<Day>14</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>12</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1558-1497</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>40</Volume>
<PubDate><Year>2016</Year>
<Month>Apr</Month>
</PubDate>
</JournalIssue>
<Title>Neurobiology of aging</Title>
<ISOAbbreviation>Neurobiol. Aging</ISOAbbreviation>
</Journal>
<ArticleTitle>The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume.</ArticleTitle>
<Pagination><MedlinePgn>68-77</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neurobiolaging.2015.12.023</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0197-4580(15)00639-9</ELocationID>
<Abstract><AbstractText>Reduction in hippocampal and amygdala volume measured via structural magnetic resonance imaging is an early marker of Alzheimer's disease (AD). Whether genetic risk factors for AD exert an effect on these subcortical structures independent of clinical status has not been fully investigated. We examine whether increased genetic risk for AD influences hippocampal and amygdala volumes in case-control and population cohorts at different ages, in 1674 older (aged >53 years; 17% AD, 39% mild cognitive impairment [MCI]) and 467 young (16-30 years) adults. An AD polygenic risk score combining common risk variants excluding apolipoprotein E (APOE), and a single nucleotide polymorphism in TREM2, were both associated with reduced hippocampal volume in healthy older adults and those with MCI. APOE ε4 was associated with hippocampal and amygdala volume in those with AD and MCI but was not associated in healthy older adults. No associations were found in young adults. Genetic risk for AD affects the hippocampus before the clinical symptoms of AD, reflecting a neurodegenerative effect before clinical manifestations in older adults.</AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lupton</LastName>
<ForeName>Michelle K</ForeName>
<Initials>MK</Initials>
<AffiliationInfo><Affiliation>Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Electronic address: Michelle.Lupton@qimrberghofer.edu.au.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Strike</LastName>
<ForeName>Lachlan</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hansell</LastName>
<ForeName>Narelle K</ForeName>
<Initials>NK</Initials>
<AffiliationInfo><Affiliation>Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wen</LastName>
<ForeName>Wei</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mather</LastName>
<ForeName>Karen A</ForeName>
<Initials>KA</Initials>
<AffiliationInfo><Affiliation>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Armstrong</LastName>
<ForeName>Nicola J</ForeName>
<Initials>NJ</Initials>
<AffiliationInfo><Affiliation>Mathematics and Statistics, Murdoch University, Perth, Western Australia, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thalamuthu</LastName>
<ForeName>Anbupalam</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McMahon</LastName>
<ForeName>Katie L</ForeName>
<Initials>KL</Initials>
<AffiliationInfo><Affiliation>Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Zubicaray</LastName>
<ForeName>Greig I</ForeName>
<Initials>GI</Initials>
<AffiliationInfo><Affiliation>Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Assareh</LastName>
<ForeName>Amelia A</ForeName>
<Initials>AA</Initials>
<AffiliationInfo><Affiliation>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Simmons</LastName>
<ForeName>Andrew</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Proitsi</LastName>
<ForeName>Petroula</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Powell</LastName>
<ForeName>John F</ForeName>
<Initials>JF</Initials>
<AffiliationInfo><Affiliation>Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Montgomery</LastName>
<ForeName>Grant W</ForeName>
<Initials>GW</Initials>
<AffiliationInfo><Affiliation>Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hibar</LastName>
<ForeName>Derrek P</ForeName>
<Initials>DP</Initials>
<AffiliationInfo><Affiliation>Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Ray, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Westman</LastName>
<ForeName>Eric</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Alzheimer's Disease Research Centre, Karolinska Institute, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tsolaki</LastName>
<ForeName>Magda</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Memory and Dementia Centre, Aristotle University of Thessaloniki, Thessaloniki, Greece.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kloszewska</LastName>
<ForeName>Iwona</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Department of Old Age Psychiatry & Psychotic Disorders, Medical University of Lodz, Lodz, Poland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Soininen</LastName>
<ForeName>Hilkka</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mecocci</LastName>
<ForeName>Patrizia</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Velas</LastName>
<ForeName>Bruno</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Gerontopole, CHU, UMR INSERM 1027, University of Toulouse, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lovestone</LastName>
<ForeName>Simon</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>Alzheimer's Disease Neuroimaging Initiative</CollectiveName>
</Author>
<Author ValidYN="Y"><LastName>Brodaty</LastName>
<ForeName>Henry</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ames</LastName>
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<Initials>D</Initials>
<AffiliationInfo><Affiliation>National Ageing Research Institute, Parkville, Victoria, Australia; Academic Unit for Psychiatry of Old Age, University of Melbourne, Kew, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Trollor</LastName>
<ForeName>Julian N</ForeName>
<Initials>JN</Initials>
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<ForeName>Nicholas G</ForeName>
<Initials>NG</Initials>
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<ForeName>Paul M</ForeName>
<Initials>PM</Initials>
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<ForeName>Perminder S</ForeName>
<Initials>PS</Initials>
<AffiliationInfo><Affiliation>Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
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<Initials>MJ</Initials>
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<Country>United Kingdom</Country>
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<Month>01</Month>
<Day>11</Day>
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<Initials>JQ</Initials>
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<Investigator ValidYN="Y"><LastName>Green</LastName>
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<Initials>J</Initials>
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<Investigator ValidYN="Y"><LastName>Shaw</LastName>
<ForeName>Leslie M</ForeName>
<Initials>LM</Initials>
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<Initials>Z</Initials>
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<Initials>G</Initials>
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<Initials>D</Initials>
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<Initials>MM</Initials>
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<Initials>P</Initials>
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<ForeName>Adam</ForeName>
<Initials>A</Initials>
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<Investigator ValidYN="Y"><LastName>Green</LastName>
<ForeName>Robert C</ForeName>
<Initials>RC</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Montine</LastName>
<ForeName>Tom</ForeName>
<Initials>T</Initials>
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<Investigator ValidYN="Y"><LastName>Petersen</LastName>
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<Initials>R</Initials>
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<Investigator ValidYN="Y"><LastName>Thomas</LastName>
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<Initials>T</Initials>
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<Investigator ValidYN="Y"><LastName>Jiminez</LastName>
<ForeName>Gus</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Balasubramanian</LastName>
<ForeName>Archana B</ForeName>
<Initials>AB</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mason</LastName>
<ForeName>Jennifer</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sim</LastName>
<ForeName>Iris</ForeName>
<Initials>I</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Beckett</LastName>
<ForeName>Laurel</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Harvey</LastName>
<ForeName>Danielle</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Donohue</LastName>
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<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jack</LastName>
<ForeName>Clifford R</ForeName>
<Initials>CR</Initials>
<Suffix>Jr</Suffix>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bernstein</LastName>
<ForeName>Matthew</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Fox</LastName>
<ForeName>Nick</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Thompson</LastName>
<ForeName>Paul</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Schuff</LastName>
<ForeName>Norbert</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>DeCarli</LastName>
<ForeName>Charles</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Borowski</LastName>
<ForeName>Bret</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Gunter</LastName>
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<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Senjem</LastName>
<ForeName>Matt</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Vemuri</LastName>
<ForeName>Prashanthi</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jones</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Kantarci</LastName>
<ForeName>Kejal</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ward</LastName>
<ForeName>Chad</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jagust</LastName>
<ForeName>William</ForeName>
<Initials>W</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Koeppe</LastName>
<ForeName>Robert A</ForeName>
<Initials>RA</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Foster</LastName>
<ForeName>Norm</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Reiman</LastName>
<ForeName>Eric M</ForeName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Kewei</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mathis</LastName>
<ForeName>Chet</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Landau</LastName>
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<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Morris</LastName>
<ForeName>John C</ForeName>
<Initials>JC</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cairns</LastName>
<ForeName>Nigel J</ForeName>
<Initials>NJ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Franklin</LastName>
<ForeName>Erin</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Taylor-Reinwald</LastName>
<ForeName>Lisa</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Shaw</LastName>
<ForeName>Leslie M</ForeName>
<Initials>LM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Trojanowki</LastName>
<ForeName>John Q</ForeName>
<Initials>JQ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Virginia</ForeName>
<Initials>V</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Korecka</LastName>
<ForeName>Magdalena</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Figurski</LastName>
<ForeName>Michal</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Toga</LastName>
<ForeName>Arthur W</ForeName>
<Initials>AW</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Crawford</LastName>
<ForeName>Karen</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Neu</LastName>
<ForeName>Scott</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Saykin</LastName>
<ForeName>Andrew J</ForeName>
<Initials>AJ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Foroud</LastName>
<ForeName>Tatiana M</ForeName>
<Initials>TM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Potkin</LastName>
<ForeName>Steven</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Shen</LastName>
<ForeName>Li</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Faber</LastName>
<ForeName>Kelley</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Sungeun</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Nho</LastName>
<ForeName>Kwangsik</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Weiner</LastName>
<ForeName>Michael W</ForeName>
<Initials>MW</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Thal</LastName>
<ForeName>Lean</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Khachaturian</LastName>
<ForeName>Zaven</ForeName>
<Initials>Z</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Thal</LastName>
<ForeName>Leon</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Buckholtz</LastName>
<ForeName>Neil</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Weiner</LastName>
<ForeName>Michael W</ForeName>
<Initials>MW</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Snyder</LastName>
<ForeName>Peter J</ForeName>
<Initials>PJ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Potter</LastName>
<ForeName>William</ForeName>
<Initials>W</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Paul</LastName>
<ForeName>Steven</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Albert</LastName>
<ForeName>Marilyn</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Frank</LastName>
<ForeName>Richard</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Khachaturian</LastName>
<ForeName>Zaven</ForeName>
<Initials>Z</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hsiao</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Kaye</LastName>
<ForeName>Jeffrey</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Quinn</LastName>
<ForeName>Joseph</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Silbert</LastName>
<ForeName>Lisa</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lind</LastName>
<ForeName>Betty</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Carter</LastName>
<ForeName>Raina</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Dolen</LastName>
<ForeName>Sara</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Schneider</LastName>
<ForeName>Lon S</ForeName>
<Initials>LS</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pawluczyk</LastName>
<ForeName>Sonia</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Becerra</LastName>
<ForeName>Mauricio</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Teodoro</LastName>
<ForeName>Liberty</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Spann</LastName>
<ForeName>Bryan M</ForeName>
<Initials>BM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Brewer</LastName>
<ForeName>James</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Vanderswag</LastName>
<ForeName>Helen</ForeName>
<Initials>H</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Fleisher</LastName>
<ForeName>Adam</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Heidebrink</LastName>
<ForeName>Judith L</ForeName>
<Initials>JL</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lord</LastName>
<ForeName>Joanne L</ForeName>
<Initials>JL</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Petersen</LastName>
<ForeName>Ronald</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mason</LastName>
<ForeName>Sara S</ForeName>
<Initials>SS</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Albers</LastName>
<ForeName>Colleen S</ForeName>
<Initials>CS</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Knopman</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Johnson</LastName>
<ForeName>Kris</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Doody</LastName>
<ForeName>Rachelle S</ForeName>
<Initials>RS</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Villanueva-Meyer</LastName>
<ForeName>Javier</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pavlik</LastName>
<ForeName>Valory</ForeName>
<Initials>V</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Shibley</LastName>
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<Initials>V</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Chowdhury</LastName>
<ForeName>Munir</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rountree</LastName>
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<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Dang</LastName>
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<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Stern</LastName>
<ForeName>Yaakov</ForeName>
<Initials>Y</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Honig</LastName>
<ForeName>Lawrence S</ForeName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Bell</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Ances</LastName>
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<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Morris</LastName>
<ForeName>John C</ForeName>
<Initials>JC</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Carroll</LastName>
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<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Creech</LastName>
<ForeName>Mary L</ForeName>
<Initials>ML</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Franklin</LastName>
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<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mintun</LastName>
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<Initials>MA</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Schneider</LastName>
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<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Oliver</LastName>
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<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Marson</LastName>
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<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Geldmacher</LastName>
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<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Love</LastName>
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</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Clark</LastName>
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<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Brockington</LastName>
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<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Roberson</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Grossman</LastName>
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<Initials>H</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mitsis</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Shah</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>deToledo-Morrell</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Duara</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Greig-Custo</LastName>
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<Initials>MT</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Barker</LastName>
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<Initials>W</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Albert</LastName>
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<Investigator ValidYN="Y"><LastName>Onyike</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>D'Agostino</LastName>
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<Initials>D</Initials>
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<Investigator ValidYN="Y"><LastName>Kielb</LastName>
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<Investigator ValidYN="Y"><LastName>Sadowski</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Sheikh</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Ulysse</LastName>
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<Investigator ValidYN="Y"><LastName>Gaikwad</LastName>
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<Investigator ValidYN="Y"><LastName>Doraiswamy</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Petrella</LastName>
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<Investigator ValidYN="Y"><LastName>Borges-Neto</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Wong</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Coleman</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Arnold</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Karlawish</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Wolk</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Clark</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Smith</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Jicha</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Sinha</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Oates</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Conrad</LastName>
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<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lopez</LastName>
<ForeName>Oscar L</ForeName>
<Initials>OL</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Oakley</LastName>
<ForeName>MaryAnn</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Simpson</LastName>
<ForeName>Donna M</ForeName>
<Initials>DM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Porsteinsson</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Goldstein</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Martin</LastName>
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<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Makino</LastName>
<ForeName>Kelly M</ForeName>
<Initials>KM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ismail</LastName>
<ForeName>M Saleem</ForeName>
<Initials>MS</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Brand</LastName>
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<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Potkin</LastName>
<ForeName>Steven G</ForeName>
<Initials>SG</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Preda</LastName>
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<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Nguyen</LastName>
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<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Womack</LastName>
<ForeName>Kyle</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mathews</LastName>
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<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Quiceno</LastName>
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<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Levey</LastName>
<ForeName>Allan I</ForeName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Lah</LastName>
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<Initials>JJ</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cellar</LastName>
<ForeName>Janet S</ForeName>
<Initials>JS</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Burns</LastName>
<ForeName>Jeffrey M</ForeName>
<Initials>JM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Swerdlow</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Apostolova</LastName>
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<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Tingus</LastName>
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<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Woo</LastName>
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<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Silverman</LastName>
<ForeName>Daniel H S</ForeName>
<Initials>DH</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lu</LastName>
<ForeName>Po H</ForeName>
<Initials>PH</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bartzokis</LastName>
<ForeName>George</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Graff-Radford</LastName>
<ForeName>Neill R</ForeName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Parfitt</LastName>
<ForeName>Francine</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Poki-Walker</LastName>
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<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Farlow</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Hake</LastName>
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<Initials>AM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Matthews</LastName>
<ForeName>Brandy R</ForeName>
<Initials>BR</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Brosch</LastName>
<ForeName>Jared R</ForeName>
<Initials>JR</Initials>
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<Investigator ValidYN="Y"><LastName>Herring</LastName>
<ForeName>Scott</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>van Dyck</LastName>
<ForeName>Christopher H</ForeName>
<Initials>CH</Initials>
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<Investigator ValidYN="Y"><LastName>Carson</LastName>
<ForeName>Richard E</ForeName>
<Initials>RE</Initials>
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<Investigator ValidYN="Y"><LastName>MacAvoy</LastName>
<ForeName>Martha G</ForeName>
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<Investigator ValidYN="Y"><LastName>Chertkow</LastName>
<ForeName>Howard</ForeName>
<Initials>H</Initials>
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<Investigator ValidYN="Y"><LastName>Bergman</LastName>
<ForeName>Howard</ForeName>
<Initials>H</Initials>
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<Investigator ValidYN="Y"><LastName>Hosein</LastName>
<ForeName>Chris</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Black</LastName>
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<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Stefanovic</LastName>
<ForeName>Bojana</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Caldwell</LastName>
<ForeName>Curtis</ForeName>
<Initials>C</Initials>
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<Investigator ValidYN="Y"><LastName>Hsiung</LastName>
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<Investigator ValidYN="Y"><LastName>Mudge</LastName>
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<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sossi</LastName>
<ForeName>Vesna</ForeName>
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<Investigator ValidYN="Y"><LastName>Feldman</LastName>
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<Investigator ValidYN="Y"><LastName>Assaly</LastName>
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<Investigator ValidYN="Y"><LastName>Finger</LastName>
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<Investigator ValidYN="Y"><LastName>Pasternack</LastName>
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<Investigator ValidYN="Y"><LastName>Rachisky</LastName>
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<Investigator ValidYN="Y"><LastName>Trost</LastName>
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<Investigator ValidYN="Y"><LastName>Bernick</LastName>
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<Investigator ValidYN="Y"><LastName>Munic</LastName>
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<Investigator ValidYN="Y"><LastName>Mesulam</LastName>
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<Investigator ValidYN="Y"><LastName>Rogalski</LastName>
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<Investigator ValidYN="Y"><LastName>Lipowski</LastName>
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<Investigator ValidYN="Y"><LastName>Weintraub</LastName>
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<Investigator ValidYN="Y"><LastName>Bonakdarpour</LastName>
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<Initials>B</Initials>
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<Investigator ValidYN="Y"><LastName>Kerwin</LastName>
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<Investigator ValidYN="Y"><LastName>Wu</LastName>
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<Investigator ValidYN="Y"><LastName>Johnson</LastName>
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<Investigator ValidYN="Y"><LastName>Sadowsky</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Villena</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Turner</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Johnson</LastName>
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<Investigator ValidYN="Y"><LastName>Reynolds</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Sperling</LastName>
<ForeName>Reisa A</ForeName>
<Initials>RA</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Johnson</LastName>
<ForeName>Keith A</ForeName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Marshall</LastName>
<ForeName>Gad</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Yesavage</LastName>
<ForeName>Jerome</ForeName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Taylor</LastName>
<ForeName>Joy L</ForeName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Lane</LastName>
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<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rosen</LastName>
<ForeName>Allyson</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Tinklenberg</LastName>
<ForeName>Jared</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sabbagh</LastName>
<ForeName>Marwan N</ForeName>
<Initials>MN</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Belden</LastName>
<ForeName>Christine M</ForeName>
<Initials>CM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jacobson</LastName>
<ForeName>Sandra A</ForeName>
<Initials>SA</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sirrel</LastName>
<ForeName>Sherye A</ForeName>
<Initials>SA</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Kowall</LastName>
<ForeName>Neil</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Killiany</LastName>
<ForeName>Ronald</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Budson</LastName>
<ForeName>Andrew E</ForeName>
<Initials>AE</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Norbash</LastName>
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<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Johnson</LastName>
<ForeName>Patricia Lynn</ForeName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Obisesan</LastName>
<ForeName>Thomas O</ForeName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Wolday</LastName>
<ForeName>Saba</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Allard</LastName>
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<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lerner</LastName>
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<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ogrocki</LastName>
<ForeName>Paula</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Tatsuoka</LastName>
<ForeName>Curtis</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Fatica</LastName>
<ForeName>Parianne</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Fletcher</LastName>
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<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Maillard</LastName>
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<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Olichney</LastName>
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<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>DeCarli</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Carmichael</LastName>
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<Initials>O</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Kittur</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Borrie</LastName>
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<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lee</LastName>
<ForeName>T-Y</ForeName>
<Initials>TY</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bartha</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Johnson</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Asthana</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Carlsson</LastName>
<ForeName>Cynthia M</ForeName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Potkin</LastName>
<ForeName>Steven G</ForeName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Preda</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Nguyen</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Tariot</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Burke</LastName>
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<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Milliken</LastName>
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<Initials>AM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Trncic</LastName>
<ForeName>Nadira</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Fleisher</LastName>
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</Investigator>
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</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Capote</LastName>
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</Investigator>
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<Investigator ValidYN="Y"><LastName>Scharre</LastName>
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<Investigator ValidYN="Y"><LastName>Celmins</LastName>
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<Investigator ValidYN="Y"><LastName>Pearlson</LastName>
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<Investigator ValidYN="Y"><LastName>Sink</LastName>
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<Investigator ValidYN="Y"><LastName>Rosen</LastName>
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<Investigator ValidYN="Y"><LastName>Shaw</LastName>
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<Investigator ValidYN="Y"><LastName>Morrison</LastName>
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	Serveur d'exploration sur les relations entre la France et l'Australie
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The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume.

The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume.

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