Drug Hypersensitivity: Pharmacogenetics and Clinical Syndromes
Identifieur interne : 006171 ( Main/Exploration ); précédent : 006170; suivant : 006172Drug Hypersensitivity: Pharmacogenetics and Clinical Syndromes
Auteurs : Elizabeth J. Phillips ; Wen-Hung Chung [Taïwan] ; Maja Mockenhaupt [Allemagne] ; Jean-Claude Roujeau [France] ; Simon A. MallalSource :
- The Journal of allergy and clinical immunology [ 0091-6749 ] ; 2011.
Abstract
Severe cutaneous adverse reactions (SCARs) include syndromes such as drug reaction, eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS) and Stevens-Johnson Syndrome/Toxic epidermal necrolysis (SJS/TEN). An important advance has been the discovery of associations between HLA alleles and many of these syndromes including abacavir hypersensitivity reaction, allopurinol DRESS/DIHS and SJS/TEN and SJS/TEN associated with aromatic amine anticonvulsants. These HLA associations have created the promise for prevention through screening and have additionally shed further light on the immunopathogenesis of SCARs. The roll-out of HLA-B*5701 into routine clinical practice as a genetic screening test to prevent abacavir hypersensitivity provides a translational roadmap for other drugs. Numerous hurdles exist in the widespread translation of several other drugs such as carbamazepine where the positive predictive value of HLA-B*1502 is low and the negative predictive value of HLA-B*1502 for SJS/TEN may not be 100% in all ethnic groups. International collaborative consortia have been formed with the goal of developing phenotype standardization and undertaking HLA and genome-wide analyses in diverse populations with these syndromes.
Url:
DOI: 10.1016/j.jaci.2010.11.046
PubMed: 21354501
PubMed Central: 3061439
Affiliations:
- Allemagne, France, Taïwan
- Bade-Wurtemberg, District de Fribourg-en-Brisgau, Île-de-France
- Créteil, Fribourg-en-Brisgau
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001445
- to stream Pmc, to step Curation: 001305
- to stream Pmc, to step Checkpoint: 002338
- to stream Ncbi, to step Merge: 000A06
- to stream Ncbi, to step Curation: 000A06
- to stream Ncbi, to step Checkpoint: 000A06
- to stream Main, to step Merge: 006533
- to stream Main, to step Curation: 006171
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Drug Hypersensitivity: Pharmacogenetics and Clinical Syndromes</title>
<author><name sortKey="Phillips, Elizabeth J" sort="Phillips, Elizabeth J" uniqKey="Phillips E" first="Elizabeth J." last="Phillips">Elizabeth J. Phillips</name>
<affiliation><nlm:aff id="A1">Institute for Immunology & Infectious Diseases, Murdoch University</nlm:aff>
<wicri:noCountry code="subfield">Murdoch University</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Clinical Immunology & Immunogenetics, Royal Perth Hospital</nlm:aff>
<wicri:noCountry code="subfield">Royal Perth Hospital</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A3">Department of Clinical Immunology, Infectious Diseases and Clinical Pharmacology/Toxicology, Sir Charles Gairdner Hospital</nlm:aff>
<wicri:noCountry code="subfield">Sir Charles Gairdner Hospital</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A4">School of Pathology & Laboratory Medicine and Biomedical, Biomolecular and Chemical Sciences, University of Western Australia</nlm:aff>
<wicri:noCountry code="subfield">University of Western Australia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Chung, Wen Hung" sort="Chung, Wen Hung" uniqKey="Chung W" first="Wen-Hung" last="Chung">Wen-Hung Chung</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Department of Dermatology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, 199, Tung-Hwa North Road, Taipei 105, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Dermatology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, 199, Tung-Hwa North Road, Taipei 105</wicri:regionArea>
<wicri:noRegion>Taipei 105</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mockenhaupt, Maja" sort="Mockenhaupt, Maja" uniqKey="Mockenhaupt M" first="Maja" last="Mockenhaupt">Maja Mockenhaupt</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Dermatology University Medical Center, Freiburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Dermatology University Medical Center, Freiburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roujeau, Jean Claude" sort="Roujeau, Jean Claude" uniqKey="Roujeau J" first="Jean-Claude" last="Roujeau">Jean-Claude Roujeau</name>
<affiliation wicri:level="3"><nlm:aff id="A7">Department of Dermatology, Paris XII University, Créteil, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Dermatology, Paris XII University, Créteil</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mallal, Simon A" sort="Mallal, Simon A" uniqKey="Mallal S" first="Simon A." last="Mallal">Simon A. Mallal</name>
<affiliation><nlm:aff id="A1">Institute for Immunology & Infectious Diseases, Murdoch University</nlm:aff>
<wicri:noCountry code="subfield">Murdoch University</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Clinical Immunology & Immunogenetics, Royal Perth Hospital</nlm:aff>
<wicri:noCountry code="subfield">Royal Perth Hospital</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21354501</idno>
<idno type="pmc">3061439</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061439</idno>
<idno type="RBID">PMC:3061439</idno>
<idno type="doi">10.1016/j.jaci.2010.11.046</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">001445</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001445</idno>
<idno type="wicri:Area/Pmc/Curation">001305</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001305</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002338</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002338</idno>
<idno type="wicri:Area/Ncbi/Merge">000A06</idno>
<idno type="wicri:Area/Ncbi/Curation">000A06</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000A06</idno>
<idno type="wicri:doubleKey">0091-6749:2011:Phillips E:drug:hypersensitivity:pharmacogenetics</idno>
<idno type="wicri:Area/Main/Merge">006533</idno>
<idno type="wicri:Area/Main/Curation">006171</idno>
<idno type="wicri:Area/Main/Exploration">006171</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Drug Hypersensitivity: Pharmacogenetics and Clinical Syndromes</title>
<author><name sortKey="Phillips, Elizabeth J" sort="Phillips, Elizabeth J" uniqKey="Phillips E" first="Elizabeth J." last="Phillips">Elizabeth J. Phillips</name>
<affiliation><nlm:aff id="A1">Institute for Immunology & Infectious Diseases, Murdoch University</nlm:aff>
<wicri:noCountry code="subfield">Murdoch University</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Clinical Immunology & Immunogenetics, Royal Perth Hospital</nlm:aff>
<wicri:noCountry code="subfield">Royal Perth Hospital</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A3">Department of Clinical Immunology, Infectious Diseases and Clinical Pharmacology/Toxicology, Sir Charles Gairdner Hospital</nlm:aff>
<wicri:noCountry code="subfield">Sir Charles Gairdner Hospital</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A4">School of Pathology & Laboratory Medicine and Biomedical, Biomolecular and Chemical Sciences, University of Western Australia</nlm:aff>
<wicri:noCountry code="subfield">University of Western Australia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Chung, Wen Hung" sort="Chung, Wen Hung" uniqKey="Chung W" first="Wen-Hung" last="Chung">Wen-Hung Chung</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Department of Dermatology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, 199, Tung-Hwa North Road, Taipei 105, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Dermatology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, 199, Tung-Hwa North Road, Taipei 105</wicri:regionArea>
<wicri:noRegion>Taipei 105</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mockenhaupt, Maja" sort="Mockenhaupt, Maja" uniqKey="Mockenhaupt M" first="Maja" last="Mockenhaupt">Maja Mockenhaupt</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Dermatology University Medical Center, Freiburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Dermatology University Medical Center, Freiburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roujeau, Jean Claude" sort="Roujeau, Jean Claude" uniqKey="Roujeau J" first="Jean-Claude" last="Roujeau">Jean-Claude Roujeau</name>
<affiliation wicri:level="3"><nlm:aff id="A7">Department of Dermatology, Paris XII University, Créteil, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Dermatology, Paris XII University, Créteil</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mallal, Simon A" sort="Mallal, Simon A" uniqKey="Mallal S" first="Simon A." last="Mallal">Simon A. Mallal</name>
<affiliation><nlm:aff id="A1">Institute for Immunology & Infectious Diseases, Murdoch University</nlm:aff>
<wicri:noCountry code="subfield">Murdoch University</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Clinical Immunology & Immunogenetics, Royal Perth Hospital</nlm:aff>
<wicri:noCountry code="subfield">Royal Perth Hospital</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of allergy and clinical immunology</title>
<idno type="ISSN">0091-6749</idno>
<idno type="eISSN">1097-6825</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Severe cutaneous adverse reactions (SCARs) include syndromes such as drug reaction, eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS) and Stevens-Johnson Syndrome/Toxic epidermal necrolysis (SJS/TEN). An important advance has been the discovery of associations between HLA alleles and many of these syndromes including abacavir hypersensitivity reaction, allopurinol DRESS/DIHS and SJS/TEN and SJS/TEN associated with aromatic amine anticonvulsants. These HLA associations have created the promise for prevention through screening and have additionally shed further light on the immunopathogenesis of SCARs. The roll-out of HLA-B*5701 into routine clinical practice as a genetic screening test to prevent abacavir hypersensitivity provides a translational roadmap for other drugs. Numerous hurdles exist in the widespread translation of several other drugs such as carbamazepine where the positive predictive value of HLA-B*1502 is low and the negative predictive value of HLA-B*1502 for SJS/TEN may not be 100% in all ethnic groups. International collaborative consortia have been formed with the goal of developing phenotype standardization and undertaking HLA and genome-wide analyses in diverse populations with these syndromes.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>France</li>
<li>Taïwan</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>District de Fribourg-en-Brisgau</li>
<li>Île-de-France</li>
</region>
<settlement><li>Créteil</li>
<li>Fribourg-en-Brisgau</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Mallal, Simon A" sort="Mallal, Simon A" uniqKey="Mallal S" first="Simon A." last="Mallal">Simon A. Mallal</name>
<name sortKey="Phillips, Elizabeth J" sort="Phillips, Elizabeth J" uniqKey="Phillips E" first="Elizabeth J." last="Phillips">Elizabeth J. Phillips</name>
</noCountry>
<country name="Taïwan"><noRegion><name sortKey="Chung, Wen Hung" sort="Chung, Wen Hung" uniqKey="Chung W" first="Wen-Hung" last="Chung">Wen-Hung Chung</name>
</noRegion>
</country>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Mockenhaupt, Maja" sort="Mockenhaupt, Maja" uniqKey="Mockenhaupt M" first="Maja" last="Mockenhaupt">Maja Mockenhaupt</name>
</region>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Roujeau, Jean Claude" sort="Roujeau, Jean Claude" uniqKey="Roujeau J" first="Jean-Claude" last="Roujeau">Jean-Claude Roujeau</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006171 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 006171 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:3061439 |texte= Drug Hypersensitivity: Pharmacogenetics and Clinical Syndromes }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:21354501" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |