Drug Hypersensitivity: Pharmacogenetics and Clinical Syndromes
Identifieur interne : 000A06 ( Ncbi/Merge ); précédent : 000A05; suivant : 000A07Drug Hypersensitivity: Pharmacogenetics and Clinical Syndromes
Auteurs : Elizabeth J. Phillips ; Wen-Hung Chung [Taïwan] ; Maja Mockenhaupt [Allemagne] ; Jean-Claude Roujeau [France] ; Simon A. MallalSource :
- The Journal of allergy and clinical immunology [ 0091-6749 ] ; 2011.
Abstract
Severe cutaneous adverse reactions (SCARs) include syndromes such as drug reaction, eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS) and Stevens-Johnson Syndrome/Toxic epidermal necrolysis (SJS/TEN). An important advance has been the discovery of associations between HLA alleles and many of these syndromes including abacavir hypersensitivity reaction, allopurinol DRESS/DIHS and SJS/TEN and SJS/TEN associated with aromatic amine anticonvulsants. These HLA associations have created the promise for prevention through screening and have additionally shed further light on the immunopathogenesis of SCARs. The roll-out of HLA-B*5701 into routine clinical practice as a genetic screening test to prevent abacavir hypersensitivity provides a translational roadmap for other drugs. Numerous hurdles exist in the widespread translation of several other drugs such as carbamazepine where the positive predictive value of HLA-B*1502 is low and the negative predictive value of HLA-B*1502 for SJS/TEN may not be 100% in all ethnic groups. International collaborative consortia have been formed with the goal of developing phenotype standardization and undertaking HLA and genome-wide analyses in diverse populations with these syndromes.
Url:
DOI: 10.1016/j.jaci.2010.11.046
PubMed: 21354501
PubMed Central: 3061439
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<front><div type="abstract" xml:lang="en"><p id="P1">Severe cutaneous adverse reactions (SCARs) include syndromes such as drug reaction, eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS) and Stevens-Johnson Syndrome/Toxic epidermal necrolysis (SJS/TEN). An important advance has been the discovery of associations between HLA alleles and many of these syndromes including abacavir hypersensitivity reaction, allopurinol DRESS/DIHS and SJS/TEN and SJS/TEN associated with aromatic amine anticonvulsants. These HLA associations have created the promise for prevention through screening and have additionally shed further light on the immunopathogenesis of SCARs. The roll-out of HLA-B*5701 into routine clinical practice as a genetic screening test to prevent abacavir hypersensitivity provides a translational roadmap for other drugs. Numerous hurdles exist in the widespread translation of several other drugs such as carbamazepine where the positive predictive value of HLA-B*1502 is low and the negative predictive value of HLA-B*1502 for SJS/TEN may not be 100% in all ethnic groups. International collaborative consortia have been formed with the goal of developing phenotype standardization and undertaking HLA and genome-wide analyses in diverse populations with these syndromes.</p>
</div>
</front>
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<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">1275002</journal-id>
<journal-id journal-id-type="pubmed-jr-id">4431</journal-id>
<journal-id journal-id-type="nlm-ta">J Allergy Clin Immunol</journal-id>
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<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Drug Hypersensitivity: Pharmacogenetics and Clinical Syndromes</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Phillips</surname>
<given-names>Elizabeth J.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A4">4</xref>
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<contrib contrib-type="author"><name><surname>Chung</surname>
<given-names>Wen-Hung</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A5">5</xref>
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<contrib contrib-type="author"><name><surname>Mockenhaupt</surname>
<given-names>Maja</given-names>
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<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A6">6</xref>
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<contrib contrib-type="author"><name><surname>Roujeau</surname>
<given-names>Jean-Claude</given-names>
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<degrees>MD</degrees>
<xref ref-type="aff" rid="A7">7</xref>
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<contrib contrib-type="author"><name><surname>Mallal</surname>
<given-names>Simon A.</given-names>
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<aff id="A1"><label>1</label>
Institute for Immunology & Infectious Diseases, Murdoch University</aff>
<aff id="A2"><label>2</label>
Department of Clinical Immunology & Immunogenetics, Royal Perth Hospital</aff>
<aff id="A3"><label>3</label>
Department of Clinical Immunology, Infectious Diseases and Clinical Pharmacology/Toxicology, Sir Charles Gairdner Hospital</aff>
<aff id="A4"><label>4</label>
School of Pathology & Laboratory Medicine and Biomedical, Biomolecular and Chemical Sciences, University of Western Australia</aff>
<aff id="A5"><label>5</label>
Department of Dermatology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, 199, Tung-Hwa North Road, Taipei 105, Taiwan</aff>
<aff id="A6"><label>6</label>
Department of Dermatology University Medical Center, Freiburg, Germany</aff>
<aff id="A7"><label>7</label>
Department of Dermatology, Paris XII University, Créteil, France</aff>
<author-notes><corresp id="CR1"><underline>Corresponding Author:</underline>
Professor Elizabeth J. Phillips Institute for Immunology & Infectious Diseases Discovery Way Murdoch, Western Australia 6150 Australia Tel: +61893601385; Fax: +61893601352 <email>e.phillips@iiid.com.au</email>
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<volume>127</volume>
<issue>3 Suppl</issue>
<fpage>S60</fpage>
<lpage>S66</lpage>
<permissions><copyright-statement>© 2010 American Academy of Allergy, Asthma and Immunology. Published by Mosby, Inc. All rights reserved</copyright-statement>
<copyright-year>2010</copyright-year>
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<abstract><p id="P1">Severe cutaneous adverse reactions (SCARs) include syndromes such as drug reaction, eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS) and Stevens-Johnson Syndrome/Toxic epidermal necrolysis (SJS/TEN). An important advance has been the discovery of associations between HLA alleles and many of these syndromes including abacavir hypersensitivity reaction, allopurinol DRESS/DIHS and SJS/TEN and SJS/TEN associated with aromatic amine anticonvulsants. These HLA associations have created the promise for prevention through screening and have additionally shed further light on the immunopathogenesis of SCARs. The roll-out of HLA-B*5701 into routine clinical practice as a genetic screening test to prevent abacavir hypersensitivity provides a translational roadmap for other drugs. Numerous hurdles exist in the widespread translation of several other drugs such as carbamazepine where the positive predictive value of HLA-B*1502 is low and the negative predictive value of HLA-B*1502 for SJS/TEN may not be 100% in all ethnic groups. International collaborative consortia have been formed with the goal of developing phenotype standardization and undertaking HLA and genome-wide analyses in diverse populations with these syndromes.</p>
</abstract>
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<kwd>TEN/SJS</kwd>
<kwd>pharmacogenetics</kwd>
<kwd>SCAR</kwd>
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<affiliations><list><country><li>Allemagne</li>
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