Drug Hypersensitivity: Pharmacogenetics and Clinical Syndromes
Identifieur interne : 006533 ( Main/Merge ); précédent : 006532; suivant : 006534Drug Hypersensitivity: Pharmacogenetics and Clinical Syndromes
Auteurs : Elizabeth J. Phillips ; Wen-Hung Chung [Taïwan] ; Maja Mockenhaupt [Allemagne] ; Jean-Claude Roujeau [France] ; Simon A. MallalSource :
- The Journal of allergy and clinical immunology [ 0091-6749 ] ; 2011.
Abstract
Severe cutaneous adverse reactions (SCARs) include syndromes such as drug reaction, eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS) and Stevens-Johnson Syndrome/Toxic epidermal necrolysis (SJS/TEN). An important advance has been the discovery of associations between HLA alleles and many of these syndromes including abacavir hypersensitivity reaction, allopurinol DRESS/DIHS and SJS/TEN and SJS/TEN associated with aromatic amine anticonvulsants. These HLA associations have created the promise for prevention through screening and have additionally shed further light on the immunopathogenesis of SCARs. The roll-out of HLA-B*5701 into routine clinical practice as a genetic screening test to prevent abacavir hypersensitivity provides a translational roadmap for other drugs. Numerous hurdles exist in the widespread translation of several other drugs such as carbamazepine where the positive predictive value of HLA-B*1502 is low and the negative predictive value of HLA-B*1502 for SJS/TEN may not be 100% in all ethnic groups. International collaborative consortia have been formed with the goal of developing phenotype standardization and undertaking HLA and genome-wide analyses in diverse populations with these syndromes.
Url:
DOI: 10.1016/j.jaci.2010.11.046
PubMed: 21354501
PubMed Central: 3061439
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PMC:3061439Le document en format XML
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Phillips</name><affiliation><nlm:aff id="A1">Institute for Immunology & Infectious Diseases, Murdoch University</nlm:aff><wicri:noCountry code="subfield">Murdoch University</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Department of Clinical Immunology & Immunogenetics, Royal Perth Hospital</nlm:aff><wicri:noCountry code="subfield">Royal Perth Hospital</wicri:noCountry></affiliation><affiliation><nlm:aff id="A3">Department of Clinical Immunology, Infectious Diseases and Clinical Pharmacology/Toxicology, Sir Charles Gairdner Hospital</nlm:aff><wicri:noCountry code="subfield">Sir Charles Gairdner Hospital</wicri:noCountry></affiliation><affiliation><nlm:aff id="A4">School of Pathology & Laboratory Medicine and Biomedical, Biomolecular and Chemical Sciences, University of Western Australia</nlm:aff><wicri:noCountry code="subfield">University of Western Australia</wicri:noCountry></affiliation></author><author><name sortKey="Chung, Wen Hung" sort="Chung, Wen Hung" uniqKey="Chung W" first="Wen-Hung" last="Chung">Wen-Hung Chung</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Dermatology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, 199, Tung-Hwa North Road, Taipei 105, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Dermatology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, 199, Tung-Hwa North Road, Taipei 105</wicri:regionArea><wicri:noRegion>Taipei 105</wicri:noRegion></affiliation></author><author><name sortKey="Mockenhaupt, Maja" sort="Mockenhaupt, Maja" uniqKey="Mockenhaupt M" first="Maja" last="Mockenhaupt">Maja Mockenhaupt</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Dermatology University Medical Center, Freiburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology University Medical Center, Freiburg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Roujeau, Jean Claude" sort="Roujeau, Jean Claude" uniqKey="Roujeau J" first="Jean-Claude" last="Roujeau">Jean-Claude Roujeau</name><affiliation wicri:level="3"><nlm:aff id="A7">Department of Dermatology, Paris XII University, Créteil, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Paris XII University, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Mallal, Simon A" sort="Mallal, Simon A" uniqKey="Mallal S" first="Simon A." last="Mallal">Simon A. Mallal</name><affiliation><nlm:aff id="A1">Institute for Immunology & Infectious Diseases, Murdoch University</nlm:aff><wicri:noCountry code="subfield">Murdoch University</wicri:noCountry></affiliation><affiliation><nlm:aff id="A2">Department of Clinical Immunology & Immunogenetics, Royal Perth Hospital</nlm:aff><wicri:noCountry code="subfield">Royal Perth Hospital</wicri:noCountry></affiliation></author></analytic><series><title level="j">The Journal of allergy and clinical immunology</title><idno type="ISSN">0091-6749</idno><idno type="eISSN">1097-6825</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Severe cutaneous adverse reactions (SCARs) include syndromes such as drug reaction, eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS) and Stevens-Johnson Syndrome/Toxic epidermal necrolysis (SJS/TEN). An important advance has been the discovery of associations between HLA alleles and many of these syndromes including abacavir hypersensitivity reaction, allopurinol DRESS/DIHS and SJS/TEN and SJS/TEN associated with aromatic amine anticonvulsants. These HLA associations have created the promise for prevention through screening and have additionally shed further light on the immunopathogenesis of SCARs. The roll-out of HLA-B*5701 into routine clinical practice as a genetic screening test to prevent abacavir hypersensitivity provides a translational roadmap for other drugs. Numerous hurdles exist in the widespread translation of several other drugs such as carbamazepine where the positive predictive value of HLA-B*1502 is low and the negative predictive value of HLA-B*1502 for SJS/TEN may not be 100% in all ethnic groups. International collaborative consortia have been formed with the goal of developing phenotype standardization and undertaking HLA and genome-wide analyses in diverse populations with these syndromes.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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