UnivTrevesV1, PascalFrancis, Corpus, bibRecord, 000D50

Effects of laser-induced thermotherapy (LITT) on proliferation and apoptosis of glioma cells in rat brain transplantation tumors

Identifieur interne : 000D50 ( PascalFrancis/Corpus ); précédent : 000D49; suivant : 000D51

Effects of laser-induced thermotherapy (LITT) on proliferation and apoptosis of glioma cells in rat brain transplantation tumors

Auteurs : Paul Christian Schulze ; Volker Adams ; Christoph Busert ; Martin Bettag ; Thomas Kahn ; Ralf Schober

Source :

Lasers in surgery and medicine [ 0196-8092 ] ; 2002.

RBID : Pascal:02-0277188

Descripteurs français

Pascal (Inist)
- Gliome, Modèle animal, Animal, Rat, Etude expérimentale, Thermothérapie, Irradiation laser, Traitement instrumental, Multiplication cellulaire, Immunohistochimie, Apoptose, Courbe survie, Efficacité traitement, Imagerie RMN.

English descriptors

KwdEn :
- Animal, Animal model, Apoptosis, Cell proliferation, Experimental study, Glioma, Immunohistochemistry, Instrumentation therapy, Laser irradiation, Nuclear magnetic resonance imaging, Rat, Survival curve, Thermotherapy, Treatment efficiency.

Abstract

Background and Objectives: Laser-induced thermotherapy (LITT) is an approach to the treatment of brain tumors especially in poorly accessible regions. Its clinical applicability with tumor cell destruction has been shown in several studies. However, no data are known about specific effects on tumors cells due to LITT in the time course of the lesion. Study Design/Materials and Methods: LITT was performed in adult Lewis rats with implanted glioma cells in the brain using a standard exposure of 3 W for 30 seconds. Before and following LITT, neoplastic lesions were monitored by MRI. Proliferation of implanted cells and gliosis were assessed by several histological techniques and immunohistochemistry. Apoptosis was detected by TUNEL staining. Results: Our experiments show a destruction of neoplastic cells by LITT but surviving tumor cells at the margin of the lesion. Apoptosis was detected following LITT restricted to residual neoplastic cells. Marginal survival of tumor cells lead to a secondary outgrowth into the necrotic lesion adjacent to sprouting capillaries. Conclusions: LITT is a suitable technique for the treatment of brain neoplasms. However, further investigations are necessary to prevent tumor recurrences after LITT.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`03`	`1`		`@1 BUSERT (Christoph)`
A11	`04`	`1`		`@1 BETTAG (Martin)`
A11	`05`	`1`		`@1 KAHN (Thomas)`
A11	`06`	`1`		`@1 SCHOBER (Ralf)`
A14	`01`			`@1 University of Leipzig, Heart Center, Department of Cardiology, Russenstrasse 19 @2 04289 Leipzig @3 DEU @Z 1 aut. @Z 2 aut.`
A14	`02`			`@1 University of Leipzig, Department of Neuropathology, Liebigstrasse 26 @2 04103 Leipzig @3 DEU @Z 1 aut. @Z 6 aut.`
A14	`03`			`@1 University of Mainz, Krankenhaus der Barmherzigen Brueder, Department of Neurosurgery, Nordallee 1 @2 54292 Trier @3 DEU @Z 3 aut. @Z 4 aut.`
A14	`04`			`@1 University of Leipzig, Department of Radiology, Liebigstrasse 20a @2 04103 Leipzig @3 DEU @Z 5 aut.`
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C01	`01`		`ENG`	@0 Background and Objectives: Laser-induced thermotherapy (LITT) is an approach to the treatment of brain tumors especially in poorly accessible regions. Its clinical applicability with tumor cell destruction has been shown in several studies. However, no data are known about specific effects on tumors cells due to LITT in the time course of the lesion. Study Design/Materials and Methods: LITT was performed in adult Lewis rats with implanted glioma cells in the brain using a standard exposure of 3 W for 30 seconds. Before and following LITT, neoplastic lesions were monitored by MRI. Proliferation of implanted cells and gliosis were assessed by several histological techniques and immunohistochemistry. Apoptosis was detected by TUNEL staining. Results: Our experiments show a destruction of neoplastic cells by LITT but surviving tumor cells at the margin of the lesion. Apoptosis was detected following LITT restricted to residual neoplastic cells. Marginal survival of tumor cells lead to a secondary outgrowth into the necrotic lesion adjacent to sprouting capillaries. Conclusions: LITT is a suitable technique for the treatment of brain neoplasms. However, further investigations are necessary to prevent tumor recurrences after LITT.
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Format Inist (serveur)

NO :	PASCAL 02-0277188 INIST
ET :	Effects of laser-induced thermotherapy (LITT) on proliferation and apoptosis of glioma cells in rat brain transplantation tumors
AU :	SCHULZE (Paul Christian); ADAMS (Volker); BUSERT (Christoph); BETTAG (Martin); KAHN (Thomas); SCHOBER (Ralf)
AF :	University of Leipzig, Heart Center, Department of Cardiology, Russenstrasse 19/04289 Leipzig/Allemagne (1 aut., 2 aut.); University of Leipzig, Department of Neuropathology, Liebigstrasse 26/04103 Leipzig/Allemagne (1 aut., 6 aut.); University of Mainz, Krankenhaus der Barmherzigen Brueder, Department of Neurosurgery, Nordallee 1/54292 Trier/Allemagne (3 aut., 4 aut.); University of Leipzig, Department of Radiology, Liebigstrasse 20a/04103 Leipzig/Allemagne (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Lasers in surgery and medicine; ISSN 0196-8092; Coden LSMEDI; Etats-Unis; Da. 2002; Vol. 30; No. 3; Pp. 227-232; Bibl. 16 ref.
LA :	Anglais
EA :	Background and Objectives: Laser-induced thermotherapy (LITT) is an approach to the treatment of brain tumors especially in poorly accessible regions. Its clinical applicability with tumor cell destruction has been shown in several studies. However, no data are known about specific effects on tumors cells due to LITT in the time course of the lesion. Study Design/Materials and Methods: LITT was performed in adult Lewis rats with implanted glioma cells in the brain using a standard exposure of 3 W for 30 seconds. Before and following LITT, neoplastic lesions were monitored by MRI. Proliferation of implanted cells and gliosis were assessed by several histological techniques and immunohistochemistry. Apoptosis was detected by TUNEL staining. Results: Our experiments show a destruction of neoplastic cells by LITT but surviving tumor cells at the margin of the lesion. Apoptosis was detected following LITT restricted to residual neoplastic cells. Marginal survival of tumor cells lead to a secondary outgrowth into the necrotic lesion adjacent to sprouting capillaries. Conclusions: LITT is a suitable technique for the treatment of brain neoplasms. However, further investigations are necessary to prevent tumor recurrences after LITT.
CC :	002B04H04; 002B17E
FD :	Gliome; Modèle animal; Animal; Rat; Etude expérimentale; Thermothérapie; Irradiation laser; Traitement instrumental; Multiplication cellulaire; Immunohistochimie; Apoptose; Courbe survie; Efficacité traitement; Imagerie RMN
FG :	Rodentia; Mammalia; Vertebrata; Système nerveux pathologie; Système nerveux central pathologie; Tumeur; Anatomopathologie
ED :	Glioma; Animal model; Animal; Rat; Experimental study; Thermotherapy; Laser irradiation; Instrumentation therapy; Cell proliferation; Immunohistochemistry; Apoptosis; Survival curve; Treatment efficiency; Nuclear magnetic resonance imaging
EG :	Rodentia; Mammalia; Vertebrata; Nervous system diseases; Central nervous system disease; Tumor; Pathology
SD :	Glioma; Modelo animal; Animal; Rata; Estudio experimental; Termoterapia; Irradiación láser; Tratamiento instrumental; Multiplicación celular; Inmunohistoquímica; Apoptosis; Curva sobrevivencia; Eficacia tratamiento; Imaginería RMN
LO :	INIST-18391.354000107921590080
ID :	02-0277188

Links to Exploration step

Pascal:02-0277188

Le document en format XML

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<term>Immunohistochemistry</term>
<term>Instrumentation therapy</term>
<term>Laser irradiation</term>
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<front><div type="abstract" xml:lang="en">Background and Objectives: Laser-induced thermotherapy (LITT) is an approach to the treatment of brain tumors especially in poorly accessible regions. Its clinical applicability with tumor cell destruction has been shown in several studies. However, no data are known about specific effects on tumors cells due to LITT in the time course of the lesion. Study Design/Materials and Methods: LITT was performed in adult Lewis rats with implanted glioma cells in the brain using a standard exposure of 3 W for 30 seconds. Before and following LITT, neoplastic lesions were monitored by MRI. Proliferation of implanted cells and gliosis were assessed by several histological techniques and immunohistochemistry. Apoptosis was detected by TUNEL staining. Results: Our experiments show a destruction of neoplastic cells by LITT but surviving tumor cells at the margin of the lesion. Apoptosis was detected following LITT restricted to residual neoplastic cells. Marginal survival of tumor cells lead to a secondary outgrowth into the necrotic lesion adjacent to sprouting capillaries. Conclusions: LITT is a suitable technique for the treatment of brain neoplasms. However, further investigations are necessary to prevent tumor recurrences after LITT.</div>
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<fA14 i1="03"><s1>University of Mainz, Krankenhaus der Barmherzigen Brueder, Department of Neurosurgery, Nordallee 1</s1>
<s2>54292 Trier</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>University of Leipzig, Department of Radiology, Liebigstrasse 20a</s1>
<s2>04103 Leipzig</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA20><s1>227-232</s1>
</fA20>
<fA21><s1>2002</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
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<fA43 i1="01"><s1>INIST</s1>
<s2>18391</s2>
<s5>354000107921590080</s5>
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<s1>© 2002 INIST-CNRS. All rights reserved.</s1>
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</fA45>
<fA47 i1="01" i2="1"><s0>02-0277188</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Lasers in surgery and medicine</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background and Objectives: Laser-induced thermotherapy (LITT) is an approach to the treatment of brain tumors especially in poorly accessible regions. Its clinical applicability with tumor cell destruction has been shown in several studies. However, no data are known about specific effects on tumors cells due to LITT in the time course of the lesion. Study Design/Materials and Methods: LITT was performed in adult Lewis rats with implanted glioma cells in the brain using a standard exposure of 3 W for 30 seconds. Before and following LITT, neoplastic lesions were monitored by MRI. Proliferation of implanted cells and gliosis were assessed by several histological techniques and immunohistochemistry. Apoptosis was detected by TUNEL staining. Results: Our experiments show a destruction of neoplastic cells by LITT but surviving tumor cells at the margin of the lesion. Apoptosis was detected following LITT restricted to residual neoplastic cells. Marginal survival of tumor cells lead to a secondary outgrowth into the necrotic lesion adjacent to sprouting capillaries. Conclusions: LITT is a suitable technique for the treatment of brain neoplasms. However, further investigations are necessary to prevent tumor recurrences after LITT.</s0>
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<s5>01</s5>
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<fC03 i1="02" i2="X" l="FRE"><s0>Modèle animal</s0>
<s5>02</s5>
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<s5>02</s5>
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<s5>03</s5>
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<s5>03</s5>
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<s5>03</s5>
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<s5>04</s5>
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<s5>04</s5>
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<fC03 i1="05" i2="X" l="FRE"><s0>Etude expérimentale</s0>
<s5>05</s5>
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<s5>05</s5>
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<s5>05</s5>
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<s5>06</s5>
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<fC03 i1="06" i2="X" l="ENG"><s0>Thermotherapy</s0>
<s5>06</s5>
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<fC03 i1="06" i2="X" l="SPA"><s0>Termoterapia</s0>
<s5>06</s5>
</fC03>
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<s5>07</s5>
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<s5>07</s5>
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<s5>09</s5>
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<s5>10</s5>
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<s5>10</s5>
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<fC03 i1="10" i2="X" l="SPA"><s0>Inmunohistoquímica</s0>
<s5>10</s5>
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<fC03 i1="11" i2="X" l="FRE"><s0>Apoptose</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Apoptosis</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Apoptosis</s0>
<s5>11</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Courbe survie</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Survival curve</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Curva sobrevivencia</s0>
<s5>12</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Efficacité traitement</s0>
<s5>13</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Treatment efficiency</s0>
<s5>13</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Eficacia tratamiento</s0>
<s5>13</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Imagerie RMN</s0>
<s5>14</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Nuclear magnetic resonance imaging</s0>
<s5>14</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Imaginería RMN</s0>
<s5>14</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
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<fC07 i1="02" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
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<fC07 i1="02" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
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<s2>NS</s2>
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<fC07 i1="03" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
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<fC07 i1="03" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>37</s5>
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<fC07 i1="04" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>37</s5>
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<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Tumeur</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Tumor</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Tumor</s0>
<s5>39</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Anatomopathologie</s0>
<s5>61</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Pathology</s0>
<s5>61</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Anatomía patológica</s0>
<s5>61</s5>
</fC07>
<fN21><s1>161</s1>
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<fN82><s1>PSI</s1>
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<server><NO>PASCAL 02-0277188 INIST</NO>
<ET>Effects of laser-induced thermotherapy (LITT) on proliferation and apoptosis of glioma cells in rat brain transplantation tumors</ET>
<AU>SCHULZE (Paul Christian); ADAMS (Volker); BUSERT (Christoph); BETTAG (Martin); KAHN (Thomas); SCHOBER (Ralf)</AU>
<AF>University of Leipzig, Heart Center, Department of Cardiology, Russenstrasse 19/04289 Leipzig/Allemagne (1 aut., 2 aut.); University of Leipzig, Department of Neuropathology, Liebigstrasse 26/04103 Leipzig/Allemagne (1 aut., 6 aut.); University of Mainz, Krankenhaus der Barmherzigen Brueder, Department of Neurosurgery, Nordallee 1/54292 Trier/Allemagne (3 aut., 4 aut.); University of Leipzig, Department of Radiology, Liebigstrasse 20a/04103 Leipzig/Allemagne (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Lasers in surgery and medicine; ISSN 0196-8092; Coden LSMEDI; Etats-Unis; Da. 2002; Vol. 30; No. 3; Pp. 227-232; Bibl. 16 ref.</SO>
<LA>Anglais</LA>
<EA>Background and Objectives: Laser-induced thermotherapy (LITT) is an approach to the treatment of brain tumors especially in poorly accessible regions. Its clinical applicability with tumor cell destruction has been shown in several studies. However, no data are known about specific effects on tumors cells due to LITT in the time course of the lesion. Study Design/Materials and Methods: LITT was performed in adult Lewis rats with implanted glioma cells in the brain using a standard exposure of 3 W for 30 seconds. Before and following LITT, neoplastic lesions were monitored by MRI. Proliferation of implanted cells and gliosis were assessed by several histological techniques and immunohistochemistry. Apoptosis was detected by TUNEL staining. Results: Our experiments show a destruction of neoplastic cells by LITT but surviving tumor cells at the margin of the lesion. Apoptosis was detected following LITT restricted to residual neoplastic cells. Marginal survival of tumor cells lead to a secondary outgrowth into the necrotic lesion adjacent to sprouting capillaries. Conclusions: LITT is a suitable technique for the treatment of brain neoplasms. However, further investigations are necessary to prevent tumor recurrences after LITT.</EA>
<CC>002B04H04; 002B17E</CC>
<FD>Gliome; Modèle animal; Animal; Rat; Etude expérimentale; Thermothérapie; Irradiation laser; Traitement instrumental; Multiplication cellulaire; Immunohistochimie; Apoptose; Courbe survie; Efficacité traitement; Imagerie RMN</FD>
<FG>Rodentia; Mammalia; Vertebrata; Système nerveux pathologie; Système nerveux central pathologie; Tumeur; Anatomopathologie</FG>
<ED>Glioma; Animal model; Animal; Rat; Experimental study; Thermotherapy; Laser irradiation; Instrumentation therapy; Cell proliferation; Immunohistochemistry; Apoptosis; Survival curve; Treatment efficiency; Nuclear magnetic resonance imaging</ED>
<EG>Rodentia; Mammalia; Vertebrata; Nervous system diseases; Central nervous system disease; Tumor; Pathology</EG>
<SD>Glioma; Modelo animal; Animal; Rata; Estudio experimental; Termoterapia; Irradiación láser; Tratamiento instrumental; Multiplicación celular; Inmunohistoquímica; Apoptosis; Curva sobrevivencia; Eficacia tratamiento; Imaginería RMN</SD>
<LO>INIST-18391.354000107921590080</LO>
<ID>02-0277188</ID>
</server>
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Effects of laser-induced thermotherapy (LITT) on proliferation and apoptosis of glioma cells in rat brain transplantation tumors

Effects of laser-induced thermotherapy (LITT) on proliferation and apoptosis of glioma cells in rat brain transplantation tumors

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