Free Cortisol Levels after Awakening: A Reliable Biological Marker for the Assessment of Adrenocortical Activity
Identifieur interne : 002445 ( Main/Exploration ); précédent : 002444; suivant : 002446Free Cortisol Levels after Awakening: A Reliable Biological Marker for the Assessment of Adrenocortical Activity
Auteurs : J. C. Pruessner [Allemagne] ; O. T. Wolf [Allemagne] ; D. H. Hellhammer [Allemagne] ; A. Buske-Kirschbaum [Allemagne] ; K. Von Auer [Allemagne] ; S. Jobst [Allemagne] ; F. Kaspers [Allemagne] ; C. Kirschbaum [Allemagne]Source :
- Life Sciences [ 0024-3205 ] ; 1997.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Hydrocortisone.
- chemical , metabolism : Hydrocortisone.
- chemical : Biomarkers, Contraceptives, Oral.
- chemistry : Saliva.
- physiology : Adrenal Cortex, Premenopause, Sleep, Wakefulness.
- Adult, Aged, Aging, Child, Circadian Rhythm, Female, Humans, Kinetics, Male, Smoking.
Abstract
In three independent studies, free cortisol levels after morning awakening were repeatedly measured in children, adults and elderly subjects (total n= 152). Cortisol was assessed by sampling saliva at 10 or 15 minute intervals for 30–60 minutes, beginning at the time of awakening for two days (Study 1 and 2) or one (Study 3) day, respectively. In all three studies, free cortisol levels increased by 50–75% within the first 30 minutes after awakening in both sexes on all days. Premenopausal women consistently showed a stronger increase with a delayed peak after awakening compared to men on all days. In Study 2, there was a tendency for lower early morning free cortisol levels for women taking oral contraceptives (p=.10). Stability of the area under the curve (AUC) of the early morning free cortisol levels over the three (Study 1 and 2) or two (Study 3) days ranged between r=.39 and r=.67 (p<.001). Neither age, weight, nor smoking showed an effect on baseline or peak cortisol levels. Sleep duration, time of awakening and alcohol consumption also appeared to be unrelated to early morning free cortisol levels. From these data we conclude that in contrast to single assessments at fixed times, early morning cortisol levels can be a reliable biological marker for the individual's adrenocortical activity when measured repeatedly with strict reference to the time of awakening.
Url:
DOI: 10.1016/S0024-3205(97)01008-4
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001256
- to stream Istex, to step Curation: 001144
- to stream Istex, to step Checkpoint: 000F17
- to stream Main, to step Merge: 002880
- to stream PubMed, to step Corpus: 000945
- to stream PubMed, to step Curation: 000945
- to stream PubMed, to step Checkpoint: 000945
- to stream Ncbi, to step Merge: 000B54
- to stream Ncbi, to step Curation: 000B54
- to stream Ncbi, to step Checkpoint: 000B54
- to stream Main, to step Merge: 002848
- to stream Main, to step Curation: 002445
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Free Cortisol Levels after Awakening: A Reliable Biological Marker for the Assessment of Adrenocortical Activity</title>
<author><name sortKey="Pruessner, J C" sort="Pruessner, J C" uniqKey="Pruessner J" first="J. C." last="Pruessner">J. C. Pruessner</name>
</author>
<author><name sortKey="Wolf, O T" sort="Wolf, O T" uniqKey="Wolf O" first="O. T." last="Wolf">O. T. Wolf</name>
</author>
<author><name sortKey="Hellhammer, D H" sort="Hellhammer, D H" uniqKey="Hellhammer D" first="D. H." last="Hellhammer">D. H. Hellhammer</name>
</author>
<author><name sortKey="Buske Kirschbaum, A" sort="Buske Kirschbaum, A" uniqKey="Buske Kirschbaum A" first="A." last="Buske-Kirschbaum">A. Buske-Kirschbaum</name>
</author>
<author><name sortKey="Von Auer, K" sort="Von Auer, K" uniqKey="Von Auer K" first="K." last="Von Auer">K. Von Auer</name>
</author>
<author><name sortKey="Jobst, S" sort="Jobst, S" uniqKey="Jobst S" first="S." last="Jobst">S. Jobst</name>
</author>
<author><name sortKey="Kaspers, F" sort="Kaspers, F" uniqKey="Kaspers F" first="F." last="Kaspers">F. Kaspers</name>
</author>
<author><name sortKey="Kirschbaum, C" sort="Kirschbaum, C" uniqKey="Kirschbaum C" first="C." last="Kirschbaum">C. Kirschbaum</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:68B092720E725044039C647075760BFEB4A72717</idno>
<date when="1997" year="1997">1997</date>
<idno type="doi">10.1016/S0024-3205(97)01008-4</idno>
<idno type="url">https://api.istex.fr/document/68B092720E725044039C647075760BFEB4A72717/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001256</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001256</idno>
<idno type="wicri:Area/Istex/Curation">001144</idno>
<idno type="wicri:Area/Istex/Checkpoint">000F17</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000F17</idno>
<idno type="wicri:doubleKey">0024-3205:1997:Pruessner J:free:cortisol:levels</idno>
<idno type="wicri:Area/Main/Merge">002880</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:9416776</idno>
<idno type="wicri:Area/PubMed/Corpus">000945</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000945</idno>
<idno type="wicri:Area/PubMed/Curation">000945</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000945</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000945</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000945</idno>
<idno type="wicri:Area/Ncbi/Merge">000B54</idno>
<idno type="wicri:Area/Ncbi/Curation">000B54</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000B54</idno>
<idno type="wicri:doubleKey">0024-3205:1997:Pruessner J:free:cortisol:levels</idno>
<idno type="wicri:Area/Main/Merge">002848</idno>
<idno type="wicri:Area/Main/Curation">002445</idno>
<idno type="wicri:Area/Main/Exploration">002445</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Free Cortisol Levels after Awakening: A Reliable Biological Marker for the Assessment of Adrenocortical Activity</title>
<author><name sortKey="Pruessner, J C" sort="Pruessner, J C" uniqKey="Pruessner J" first="J. C." last="Pruessner">J. C. Pruessner</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Psychobiological and Psychosomatic Research, University of Trier</wicri:regionArea>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
</affiliation>
</author>
<author><name sortKey="Wolf, O T" sort="Wolf, O T" uniqKey="Wolf O" first="O. T." last="Wolf">O. T. Wolf</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Psychobiological and Psychosomatic Research, University of Trier</wicri:regionArea>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
</affiliation>
</author>
<author><name sortKey="Hellhammer, D H" sort="Hellhammer, D H" uniqKey="Hellhammer D" first="D. H." last="Hellhammer">D. H. Hellhammer</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Psychobiological and Psychosomatic Research, University of Trier</wicri:regionArea>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
</affiliation>
</author>
<author><name sortKey="Buske Kirschbaum, A" sort="Buske Kirschbaum, A" uniqKey="Buske Kirschbaum A" first="A." last="Buske-Kirschbaum">A. Buske-Kirschbaum</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Psychobiological and Psychosomatic Research, University of Trier</wicri:regionArea>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
</affiliation>
</author>
<author><name sortKey="Von Auer, K" sort="Von Auer, K" uniqKey="Von Auer K" first="K." last="Von Auer">K. Von Auer</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Psychobiological and Psychosomatic Research, University of Trier</wicri:regionArea>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
</affiliation>
</author>
<author><name sortKey="Jobst, S" sort="Jobst, S" uniqKey="Jobst S" first="S." last="Jobst">S. Jobst</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Psychobiological and Psychosomatic Research, University of Trier</wicri:regionArea>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
</affiliation>
</author>
<author><name sortKey="Kaspers, F" sort="Kaspers, F" uniqKey="Kaspers F" first="F." last="Kaspers">F. Kaspers</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Psychobiological and Psychosomatic Research, University of Trier</wicri:regionArea>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
</affiliation>
</author>
<author><name sortKey="Kirschbaum, C" sort="Kirschbaum, C" uniqKey="Kirschbaum C" first="C." last="Kirschbaum">C. Kirschbaum</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Psychobiological and Psychosomatic Research, University of Trier</wicri:regionArea>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Life Sciences</title>
<title level="j" type="abbrev">LFS</title>
<idno type="ISSN">0024-3205</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1997">1997</date>
<biblScope unit="volume">61</biblScope>
<biblScope unit="issue">26</biblScope>
<biblScope unit="page" from="2539">2539</biblScope>
<biblScope unit="page" to="2549">2549</biblScope>
</imprint>
<idno type="ISSN">0024-3205</idno>
</series>
<idno type="istex">68B092720E725044039C647075760BFEB4A72717</idno>
<idno type="DOI">10.1016/S0024-3205(97)01008-4</idno>
<idno type="PII">S0024-3205(97)01008-4</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0024-3205</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Cortex (physiology)</term>
<term>Adult</term>
<term>Aged</term>
<term>Aging</term>
<term>Biomarkers</term>
<term>Child</term>
<term>Circadian Rhythm</term>
<term>Contraceptives, Oral</term>
<term>Female</term>
<term>Humans</term>
<term>Hydrocortisone (analysis)</term>
<term>Hydrocortisone (metabolism)</term>
<term>Kinetics</term>
<term>Male</term>
<term>Premenopause (physiology)</term>
<term>Saliva (chemistry)</term>
<term>Sleep (physiology)</term>
<term>Smoking</term>
<term>Wakefulness (physiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Hydrocortisone</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hydrocortisone</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biomarkers</term>
<term>Contraceptives, Oral</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Saliva</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Adrenal Cortex</term>
<term>Premenopause</term>
<term>Sleep</term>
<term>Wakefulness</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aging</term>
<term>Child</term>
<term>Circadian Rhythm</term>
<term>Female</term>
<term>Humans</term>
<term>Kinetics</term>
<term>Male</term>
<term>Smoking</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In three independent studies, free cortisol levels after morning awakening were repeatedly measured in children, adults and elderly subjects (total n= 152). Cortisol was assessed by sampling saliva at 10 or 15 minute intervals for 30–60 minutes, beginning at the time of awakening for two days (Study 1 and 2) or one (Study 3) day, respectively. In all three studies, free cortisol levels increased by 50–75% within the first 30 minutes after awakening in both sexes on all days. Premenopausal women consistently showed a stronger increase with a delayed peak after awakening compared to men on all days. In Study 2, there was a tendency for lower early morning free cortisol levels for women taking oral contraceptives (p=.10). Stability of the area under the curve (AUC) of the early morning free cortisol levels over the three (Study 1 and 2) or two (Study 3) days ranged between r=.39 and r=.67 (p<.001). Neither age, weight, nor smoking showed an effect on baseline or peak cortisol levels. Sleep duration, time of awakening and alcohol consumption also appeared to be unrelated to early morning free cortisol levels. From these data we conclude that in contrast to single assessments at fixed times, early morning cortisol levels can be a reliable biological marker for the individual's adrenocortical activity when measured repeatedly with strict reference to the time of awakening.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Rhénanie-Palatinat</li>
</region>
<settlement><li>Trèves (Allemagne)</li>
</settlement>
<orgName><li>Université de Trèves</li>
</orgName>
</list>
<tree><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Pruessner, J C" sort="Pruessner, J C" uniqKey="Pruessner J" first="J. C." last="Pruessner">J. C. Pruessner</name>
</region>
<name sortKey="Buske Kirschbaum, A" sort="Buske Kirschbaum, A" uniqKey="Buske Kirschbaum A" first="A." last="Buske-Kirschbaum">A. Buske-Kirschbaum</name>
<name sortKey="Hellhammer, D H" sort="Hellhammer, D H" uniqKey="Hellhammer D" first="D. H." last="Hellhammer">D. H. Hellhammer</name>
<name sortKey="Jobst, S" sort="Jobst, S" uniqKey="Jobst S" first="S." last="Jobst">S. Jobst</name>
<name sortKey="Kaspers, F" sort="Kaspers, F" uniqKey="Kaspers F" first="F." last="Kaspers">F. Kaspers</name>
<name sortKey="Kirschbaum, C" sort="Kirschbaum, C" uniqKey="Kirschbaum C" first="C." last="Kirschbaum">C. Kirschbaum</name>
<name sortKey="Von Auer, K" sort="Von Auer, K" uniqKey="Von Auer K" first="K." last="Von Auer">K. Von Auer</name>
<name sortKey="Wolf, O T" sort="Wolf, O T" uniqKey="Wolf O" first="O. T." last="Wolf">O. T. Wolf</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Rhénanie/explor/UnivTrevesV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002445 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002445 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Rhénanie |area= UnivTrevesV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:68B092720E725044039C647075760BFEB4A72717 |texte= Free Cortisol Levels after Awakening: A Reliable Biological Marker for the Assessment of Adrenocortical Activity }}
This area was generated with Dilib version V0.6.31. |