Pituitary and adrenal hormone responses to pharmacological, physical, and psychological stimulation in habitual smokers and nonsmokers
Identifieur interne : 002A91 ( Main/Exploration ); précédent : 002A90; suivant : 002A92Pituitary and adrenal hormone responses to pharmacological, physical, and psychological stimulation in habitual smokers and nonsmokers
Auteurs : C. Kirschbaum [Allemagne] ; G. Scherer [Allemagne] ; C. J. Strasburger [Allemagne]Source :
- The clinical investigator [ 0941-0198 ] ; 1994-10-01.
English descriptors
- KwdEn :
- Adrenocorticotropic Hormone (secretion), Adult, Circadian Rhythm, Corticotropin-Releasing Hormone, Cotinine (blood), Exercise Test, Growth Hormone (secretion), Humans, Hydrocortisone (analysis), Hydrocortisone (secretion), Male, Nicotine (blood), Pituitary-Adrenal System (drug effects), Pituitary-Adrenal System (secretion), Prolactin (secretion), Saliva (chemistry), Smoking (physiopathology), Stress, Psychological (physiopathology).
- MESH :
- chemical , analysis : Hydrocortisone.
- chemical , blood : Cotinine, Nicotine.
- chemical , secretion : Adrenocorticotropic Hormone, Growth Hormone, Hydrocortisone, Prolactin.
- chemistry : Saliva.
- drug effects : Pituitary-Adrenal System.
- physiopathology : Smoking, Stress, Psychological.
- secretion : Pituitary-Adrenal System.
- Adult, Circadian Rhythm, Corticotropin-Releasing Hormone, Exercise Test, Humans, Male.
Abstract
Abstract: Hormone responses to injection of corticotropin-releasing hormone following bicycle ergometry and psychological stress were studied in ten habitual smokers and ten nonsmokers. Compared to injection of saline, significant increases were found in adrenocorticotropin, prolactin, growth hormone, total serum cortisol, and salivary cortisol under all three stimulations except for salivary cortisol under ergometry. Furthermore, the smokers showed significant elevations of all five hormones investigated following the smoking of two cigarettes of the subject's preferred brand. Comparisons of hormone responses between smokers and nonsmokers revealed a general trend towards stronger responses in nonsmokers. However, due to the small number of subjects investigated and considerable variation in the individual hormone responses these differences reached statistical significance only for growth hormone responses following ergometry and salivary cortisol responses after psychological stress. In addition, the circadian rhythm of salivary cortisol was measured on two occasions between 9 a.m. and 9 p.m. in the subject's natural environment. The typical circadian pattern of decreasing cortisol levels was observed, with no significant differences between smokers and nonsmokers. We conclude that chronic nicotine consumption may lead to lower responses of multiple hormones not only to nicotine but to a variety of stimuli, and that these alterations do not necessarily affect unstimulated circadian profiles of free cortisol.
Url:
DOI: 10.1007/BF00180552
Affiliations:
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Le document en format XML
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Kirschbaum</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Forschungszentrum für Psychobiologie und Psychosomatik, Universität Trier, Universitätsring 15, D-54286, Trier</wicri:regionArea><wicri:noRegion>54286, Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Scherer, G" sort="Scherer, G" uniqKey="Scherer G" first="G." last="Scherer">G. Scherer</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Analytisch-biologisches Forschungslabor, Prof. Dr. F. Adlkofer, Munchen</wicri:regionArea><wicri:noRegion>Munchen</wicri:noRegion><wicri:noRegion>Munchen</wicri:noRegion></affiliation></author><author><name sortKey="Strasburger, C J" sort="Strasburger, C J" uniqKey="Strasburger C" first="C. J." last="Strasburger">C. J. Strasburger</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universität München, Klinikum Innenstadt, Klinik für Innere Medizin, München</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">The clinical investigator</title><title level="j" type="abbrev">Clin Investig</title><idno type="ISSN">0941-0198</idno><idno type="eISSN">1432-1440</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1994-10-01">1994-10-01</date><biblScope unit="volume">72</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="804">804</biblScope><biblScope unit="page" to="810">810</biblScope></imprint><idno type="ISSN">0941-0198</idno></series><idno type="istex">284710DE860987A53652400E229CAD6ADFC3A320</idno><idno type="DOI">10.1007/BF00180552</idno><idno type="ArticleID">BF00180552</idno><idno type="ArticleID">Art15</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0941-0198</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenocorticotropic Hormone (secretion)</term><term>Adult</term><term>Circadian Rhythm</term><term>Corticotropin-Releasing Hormone</term><term>Cotinine (blood)</term><term>Exercise Test</term><term>Growth Hormone (secretion)</term><term>Humans</term><term>Hydrocortisone (analysis)</term><term>Hydrocortisone (secretion)</term><term>Male</term><term>Nicotine (blood)</term><term>Pituitary-Adrenal System (drug effects)</term><term>Pituitary-Adrenal System (secretion)</term><term>Prolactin (secretion)</term><term>Saliva (chemistry)</term><term>Smoking (physiopathology)</term><term>Stress, Psychological (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Hydrocortisone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cotinine</term><term>Nicotine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Adrenocorticotropic Hormone</term><term>Growth Hormone</term><term>Hydrocortisone</term><term>Prolactin</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Saliva</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Pituitary-Adrenal System</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Smoking</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="secretion" xml:lang="en"><term>Pituitary-Adrenal System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Circadian Rhythm</term><term>Corticotropin-Releasing Hormone</term><term>Exercise Test</term><term>Humans</term><term>Male</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Hormone responses to injection of corticotropin-releasing hormone following bicycle ergometry and psychological stress were studied in ten habitual smokers and ten nonsmokers. Compared to injection of saline, significant increases were found in adrenocorticotropin, prolactin, growth hormone, total serum cortisol, and salivary cortisol under all three stimulations except for salivary cortisol under ergometry. Furthermore, the smokers showed significant elevations of all five hormones investigated following the smoking of two cigarettes of the subject's preferred brand. Comparisons of hormone responses between smokers and nonsmokers revealed a general trend towards stronger responses in nonsmokers. However, due to the small number of subjects investigated and considerable variation in the individual hormone responses these differences reached statistical significance only for growth hormone responses following ergometry and salivary cortisol responses after psychological stress. In addition, the circadian rhythm of salivary cortisol was measured on two occasions between 9 a.m. and 9 p.m. in the subject's natural environment. The typical circadian pattern of decreasing cortisol levels was observed, with no significant differences between smokers and nonsmokers. We conclude that chronic nicotine consumption may lead to lower responses of multiple hormones not only to nicotine but to a variety of stimuli, and that these alterations do not necessarily affect unstimulated circadian profiles of free cortisol.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Kirschbaum, C" sort="Kirschbaum, C" uniqKey="Kirschbaum C" first="C." last="Kirschbaum">C. Kirschbaum</name></noRegion><name sortKey="Scherer, G" sort="Scherer, G" uniqKey="Scherer G" first="G." last="Scherer">G. Scherer</name><name sortKey="Strasburger, C J" sort="Strasburger, C J" uniqKey="Strasburger C" first="C. J." last="Strasburger">C. J. Strasburger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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