UnivTrevesV1, Main, Exploration, bibRecord, 001D28

A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress

Identifieur interne : 001D28 ( Main/Exploration ); précédent : 001D27; suivant : 001D29

A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress

Auteurs : Stuart Brody [Allemagne] ; Ragnar Preut [Allemagne] ; Kerstin Schommer [Allemagne] ; Thomas H. Schürmeyer [Allemagne]

Source :

Psychopharmacologia [ 0033-3158 ] ; 2002.

RBID : Pascal:02-0150562

Descripteurs français

Pascal (Inist)
- Acide ascorbique, Stress, Emotion émotivité, Supplémentation, Pression sanguine, Cortisol, Evaluation subjective, Forme libération contrôlée, Essai thérapeutique contrôlé, Activité biologique, Homme, Individu sain, Voie orale.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Analysis of Variance, Antioxidants (administration & dosage), Ascorbic Acid (administration & dosage), Ascorbic Acid (blood), Ascorbic acid, Biological activity, Blood Pressure (drug effects), Blood Pressure (physiology), Blood pressure, Chi-Square Distribution, Controlled release form, Controlled therapeutic trial, Cortisol, Delayed-Action Preparations (administration & dosage), Double-Blind Method, Emotion emotionality, Female, Healthy subject, Human, Humans, Hydrocortisone (antagonists & inhibitors), Hydrocortisone (blood), Male, Oral administration, Stress, Stress, Psychological (blood), Stress, Psychological (drug therapy), Stress, Psychological (physiopathology), Subjective evaluation, Supplementation.
MESH :
- chemical , administration & dosage : Antioxidants, Ascorbic Acid, Delayed-Action Preparations.
- chemical , antagonists & inhibitors : Hydrocortisone.
- chemical , blood : Ascorbic Acid, Hydrocortisone.
- blood : Stress, Psychological.
- drug effects : Blood Pressure.
- drug therapy : Stress, Psychological.
- physiology : Blood Pressure.
- physiopathology : Stress, Psychological.
- Adult, Analysis of Variance, Chi-Square Distribution, Double-Blind Method, Female, Humans, Male.

Abstract

Rationale: Physiological responses to stress are considered disruptive to health. High-dose ascorbic acid has reduced indices of stress in laboratory animals, Methods: We conducted a randomized double-blind, placebo-controlled 14-day trial of sustained-release ascorbic acid (60 healthy young adults; 3x1000 mg/day Cetebe) and placebo (60 healthy young adults) for reduction of blood pressure, cortisol, and subjective response to acute psychological stress (Trier Social Stress Test, TSST, consisting of public speaking and mental arithmetic). Six subjects from each group were excluded. Results: Compared to the placebo group, the ascorbic acid group had less systolic blood pressure (an increase of 23 versus 31 mmHg), diastolic blood pressure, and subjective stress responses to the TSST; and also had faster salivary cortisol recovery (but not smaller overall cortisol response). Cortisol response to 1 pg ACTH, and reported side-effects during the trial did not differ between groups. Plasma ascorbic acid level at the end of the trial but not pre-trial was associated with reduced stress reactivity of systolic blood pressure, diastolic blood pressure, and subjective stress, and with greater salivary cortisol recovery. Conclusions: Treatment with high-dose sustained-release ascorbic acid palliates blood pressure, cortisol, and subjective response to acute psychological stress. These effects are not attributable to modification of adrenal responsiveness.

Affiliations:

Le document en format XML

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<term>Healthy subject</term>
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<term>Emotion émotivité</term>
<term>Supplémentation</term>
<term>Pression sanguine</term>
<term>Cortisol</term>
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<term>Essai thérapeutique contrôlé</term>
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<front><div type="abstract" xml:lang="en">Rationale: Physiological responses to stress are considered disruptive to health. High-dose ascorbic acid has reduced indices of stress in laboratory animals, Methods: We conducted a randomized double-blind, placebo-controlled 14-day trial of sustained-release ascorbic acid (60 healthy young adults; 3x1000 mg/day Cetebe) and placebo (60 healthy young adults) for reduction of blood pressure, cortisol, and subjective response to acute psychological stress (Trier Social Stress Test, TSST, consisting of public speaking and mental arithmetic). Six subjects from each group were excluded. Results: Compared to the placebo group, the ascorbic acid group had less systolic blood pressure (an increase of 23 versus 31 mmHg), diastolic blood pressure, and subjective stress responses to the TSST; and also had faster salivary cortisol recovery (but not smaller overall cortisol response). Cortisol response to 1 pg ACTH, and reported side-effects during the trial did not differ between groups. Plasma ascorbic acid level at the end of the trial but not pre-trial was associated with reduced stress reactivity of systolic blood pressure, diastolic blood pressure, and subjective stress, and with greater salivary cortisol recovery. Conclusions: Treatment with high-dose sustained-release ascorbic acid palliates blood pressure, cortisol, and subjective response to acute psychological stress. These effects are not attributable to modification of adrenal responsiveness.</div>
</front>
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<name sortKey="Schurmeyer, Thomas H" sort="Schurmeyer, Thomas H" uniqKey="Schurmeyer T" first="Thomas H." last="Schürmeyer">Thomas H. Schürmeyer</name>
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A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress

A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress

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Descripteurs français

English descriptors

Abstract

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