A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress
Identifieur interne : 001D28 ( Main/Exploration ); précédent : 001D27; suivant : 001D29A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress
Auteurs : Stuart Brody [Allemagne] ; Ragnar Preut [Allemagne] ; Kerstin Schommer [Allemagne] ; Thomas H. Schürmeyer [Allemagne]Source :
- Psychopharmacologia [ 0033-3158 ] ; 2002.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Analysis of Variance, Antioxidants (administration & dosage), Ascorbic Acid (administration & dosage), Ascorbic Acid (blood), Ascorbic acid, Biological activity, Blood Pressure (drug effects), Blood Pressure (physiology), Blood pressure, Chi-Square Distribution, Controlled release form, Controlled therapeutic trial, Cortisol, Delayed-Action Preparations (administration & dosage), Double-Blind Method, Emotion emotionality, Female, Healthy subject, Human, Humans, Hydrocortisone (antagonists & inhibitors), Hydrocortisone (blood), Male, Oral administration, Stress, Stress, Psychological (blood), Stress, Psychological (drug therapy), Stress, Psychological (physiopathology), Subjective evaluation, Supplementation.
- MESH :
- chemical , administration & dosage : Antioxidants, Ascorbic Acid, Delayed-Action Preparations.
- chemical , antagonists & inhibitors : Hydrocortisone.
- chemical , blood : Ascorbic Acid, Hydrocortisone.
- blood : Stress, Psychological.
- drug effects : Blood Pressure.
- drug therapy : Stress, Psychological.
- physiology : Blood Pressure.
- physiopathology : Stress, Psychological.
- Adult, Analysis of Variance, Chi-Square Distribution, Double-Blind Method, Female, Humans, Male.
Abstract
Rationale: Physiological responses to stress are considered disruptive to health. High-dose ascorbic acid has reduced indices of stress in laboratory animals, Methods: We conducted a randomized double-blind, placebo-controlled 14-day trial of sustained-release ascorbic acid (60 healthy young adults; 3x1000 mg/day Cetebe) and placebo (60 healthy young adults) for reduction of blood pressure, cortisol, and subjective response to acute psychological stress (Trier Social Stress Test, TSST, consisting of public speaking and mental arithmetic). Six subjects from each group were excluded. Results: Compared to the placebo group, the ascorbic acid group had less systolic blood pressure (an increase of 23 versus 31 mmHg), diastolic blood pressure, and subjective stress responses to the TSST; and also had faster salivary cortisol recovery (but not smaller overall cortisol response). Cortisol response to 1 pg ACTH, and reported side-effects during the trial did not differ between groups. Plasma ascorbic acid level at the end of the trial but not pre-trial was associated with reduced stress reactivity of systolic blood pressure, diastolic blood pressure, and subjective stress, and with greater salivary cortisol recovery. Conclusions: Treatment with high-dose sustained-release ascorbic acid palliates blood pressure, cortisol, and subjective response to acute psychological stress. These effects are not attributable to modification of adrenal responsiveness.
Affiliations:
- Allemagne
- Bade-Wurtemberg, District de Tübingen, Rhénanie-Palatinat
- Trèves (Allemagne), Tübingen
- Université de Trèves
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000D76
- to stream PascalFrancis, to step Curation: 000160
- to stream PascalFrancis, to step Checkpoint: 000B31
- to stream Main, to step Merge: 001F96
- to stream PubMed, to step Corpus: 000815
- to stream PubMed, to step Curation: 000815
- to stream PubMed, to step Checkpoint: 000815
- to stream Ncbi, to step Merge: 000078
- to stream Ncbi, to step Curation: 000078
- to stream Ncbi, to step Checkpoint: 000078
- to stream Main, to step Merge: 001E66
- to stream Main, to step Curation: 001D28
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress</title>
<author><name sortKey="Brody, Stuart" sort="Brody, Stuart" uniqKey="Brody S" first="Stuart" last="Brody">Stuart Brody</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Center for Psychosomatic and Psychobiological Research, University of Trier, Karl-Marx-Strasse 94</s1>
<s2>54290 Trier</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>54290 Trier</wicri:noRegion>
<wicri:noRegion>Karl-Marx-Strasse 94</wicri:noRegion>
<wicri:noRegion>54290 Trier</wicri:noRegion>
<orgName type="university">Université de Trèves</orgName>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Preut, Ragnar" sort="Preut, Ragnar" uniqKey="Preut R" first="Ragnar" last="Preut">Ragnar Preut</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Center for Psychosomatic and Psychobiological Research, University of Trier, Karl-Marx-Strasse 94</s1>
<s2>54290 Trier</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>54290 Trier</wicri:noRegion>
<wicri:noRegion>Karl-Marx-Strasse 94</wicri:noRegion>
<wicri:noRegion>54290 Trier</wicri:noRegion>
<orgName type="university">Université de Trèves</orgName>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schommer, Kerstin" sort="Schommer, Kerstin" uniqKey="Schommer K" first="Kerstin" last="Schommer">Kerstin Schommer</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Center for Psychosomatic and Psychobiological Research, University of Trier, Karl-Marx-Strasse 94</s1>
<s2>54290 Trier</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>54290 Trier</wicri:noRegion>
<wicri:noRegion>Karl-Marx-Strasse 94</wicri:noRegion>
<wicri:noRegion>54290 Trier</wicri:noRegion>
<orgName type="university">Université de Trèves</orgName>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schurmeyer, Thomas H" sort="Schurmeyer, Thomas H" uniqKey="Schurmeyer T" first="Thomas H." last="Schürmeyer">Thomas H. Schürmeyer</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute for Medical Psychology and Behavioral Neurobiology, University of Tübingen</s1>
<s2>Tübingen</s2>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">02-0150562</idno>
<date when="2002">2002</date>
<idno type="stanalyst">PASCAL 02-0150562 INIST</idno>
<idno type="RBID">Pascal:02-0150562</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000D76</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000160</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000B31</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000B31</idno>
<idno type="wicri:doubleKey">0033-3158:2002:Brody S:a:randomized:controlled</idno>
<idno type="wicri:Area/Main/Merge">001F96</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:11862365</idno>
<idno type="wicri:Area/PubMed/Corpus">000815</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000815</idno>
<idno type="wicri:Area/PubMed/Curation">000815</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000815</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000815</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000815</idno>
<idno type="wicri:Area/Ncbi/Merge">000078</idno>
<idno type="wicri:Area/Ncbi/Curation">000078</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000078</idno>
<idno type="wicri:doubleKey">0033-3158:2002:Brody S:a:randomized:controlled</idno>
<idno type="wicri:Area/Main/Merge">001E66</idno>
<idno type="wicri:Area/Main/Curation">001D28</idno>
<idno type="wicri:Area/Main/Exploration">001D28</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress</title>
<author><name sortKey="Brody, Stuart" sort="Brody, Stuart" uniqKey="Brody S" first="Stuart" last="Brody">Stuart Brody</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Center for Psychosomatic and Psychobiological Research, University of Trier, Karl-Marx-Strasse 94</s1>
<s2>54290 Trier</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>54290 Trier</wicri:noRegion>
<wicri:noRegion>Karl-Marx-Strasse 94</wicri:noRegion>
<wicri:noRegion>54290 Trier</wicri:noRegion>
<orgName type="university">Université de Trèves</orgName>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Preut, Ragnar" sort="Preut, Ragnar" uniqKey="Preut R" first="Ragnar" last="Preut">Ragnar Preut</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Center for Psychosomatic and Psychobiological Research, University of Trier, Karl-Marx-Strasse 94</s1>
<s2>54290 Trier</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>54290 Trier</wicri:noRegion>
<wicri:noRegion>Karl-Marx-Strasse 94</wicri:noRegion>
<wicri:noRegion>54290 Trier</wicri:noRegion>
<orgName type="university">Université de Trèves</orgName>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schommer, Kerstin" sort="Schommer, Kerstin" uniqKey="Schommer K" first="Kerstin" last="Schommer">Kerstin Schommer</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Center for Psychosomatic and Psychobiological Research, University of Trier, Karl-Marx-Strasse 94</s1>
<s2>54290 Trier</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>54290 Trier</wicri:noRegion>
<wicri:noRegion>Karl-Marx-Strasse 94</wicri:noRegion>
<wicri:noRegion>54290 Trier</wicri:noRegion>
<orgName type="university">Université de Trèves</orgName>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schurmeyer, Thomas H" sort="Schurmeyer, Thomas H" uniqKey="Schurmeyer T" first="Thomas H." last="Schürmeyer">Thomas H. Schürmeyer</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute for Medical Psychology and Behavioral Neurobiology, University of Tübingen</s1>
<s2>Tübingen</s2>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Psychopharmacologia</title>
<title level="j" type="abbreviated">Psychopharmacologia</title>
<idno type="ISSN">0033-3158</idno>
<imprint><date when="2002">2002</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Psychopharmacologia</title>
<title level="j" type="abbreviated">Psychopharmacologia</title>
<idno type="ISSN">0033-3158</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Analysis of Variance</term>
<term>Antioxidants (administration & dosage)</term>
<term>Ascorbic Acid (administration & dosage)</term>
<term>Ascorbic Acid (blood)</term>
<term>Ascorbic acid</term>
<term>Biological activity</term>
<term>Blood Pressure (drug effects)</term>
<term>Blood Pressure (physiology)</term>
<term>Blood pressure</term>
<term>Chi-Square Distribution</term>
<term>Controlled release form</term>
<term>Controlled therapeutic trial</term>
<term>Cortisol</term>
<term>Delayed-Action Preparations (administration & dosage)</term>
<term>Double-Blind Method</term>
<term>Emotion emotionality</term>
<term>Female</term>
<term>Healthy subject</term>
<term>Human</term>
<term>Humans</term>
<term>Hydrocortisone (antagonists & inhibitors)</term>
<term>Hydrocortisone (blood)</term>
<term>Male</term>
<term>Oral administration</term>
<term>Stress</term>
<term>Stress, Psychological (blood)</term>
<term>Stress, Psychological (drug therapy)</term>
<term>Stress, Psychological (physiopathology)</term>
<term>Subjective evaluation</term>
<term>Supplementation</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antioxidants</term>
<term>Ascorbic Acid</term>
<term>Delayed-Action Preparations</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Hydrocortisone</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Ascorbic Acid</term>
<term>Hydrocortisone</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Stress, Psychological</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blood Pressure</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Stress, Psychological</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Pressure</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Stress, Psychological</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Analysis of Variance</term>
<term>Chi-Square Distribution</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Acide ascorbique</term>
<term>Stress</term>
<term>Emotion émotivité</term>
<term>Supplémentation</term>
<term>Pression sanguine</term>
<term>Cortisol</term>
<term>Evaluation subjective</term>
<term>Forme libération contrôlée</term>
<term>Essai thérapeutique contrôlé</term>
<term>Activité biologique</term>
<term>Homme</term>
<term>Individu sain</term>
<term>Voie orale</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Rationale: Physiological responses to stress are considered disruptive to health. High-dose ascorbic acid has reduced indices of stress in laboratory animals, Methods: We conducted a randomized double-blind, placebo-controlled 14-day trial of sustained-release ascorbic acid (60 healthy young adults; 3x1000 mg/day Cetebe) and placebo (60 healthy young adults) for reduction of blood pressure, cortisol, and subjective response to acute psychological stress (Trier Social Stress Test, TSST, consisting of public speaking and mental arithmetic). Six subjects from each group were excluded. Results: Compared to the placebo group, the ascorbic acid group had less systolic blood pressure (an increase of 23 versus 31 mmHg), diastolic blood pressure, and subjective stress responses to the TSST; and also had faster salivary cortisol recovery (but not smaller overall cortisol response). Cortisol response to 1 pg ACTH, and reported side-effects during the trial did not differ between groups. Plasma ascorbic acid level at the end of the trial but not pre-trial was associated with reduced stress reactivity of systolic blood pressure, diastolic blood pressure, and subjective stress, and with greater salivary cortisol recovery. Conclusions: Treatment with high-dose sustained-release ascorbic acid palliates blood pressure, cortisol, and subjective response to acute psychological stress. These effects are not attributable to modification of adrenal responsiveness.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>District de Tübingen</li>
<li>Rhénanie-Palatinat</li>
</region>
<settlement><li>Trèves (Allemagne)</li>
<li>Tübingen</li>
</settlement>
<orgName><li>Université de Trèves</li>
</orgName>
</list>
<tree><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Brody, Stuart" sort="Brody, Stuart" uniqKey="Brody S" first="Stuart" last="Brody">Stuart Brody</name>
</region>
<name sortKey="Preut, Ragnar" sort="Preut, Ragnar" uniqKey="Preut R" first="Ragnar" last="Preut">Ragnar Preut</name>
<name sortKey="Schommer, Kerstin" sort="Schommer, Kerstin" uniqKey="Schommer K" first="Kerstin" last="Schommer">Kerstin Schommer</name>
<name sortKey="Schurmeyer, Thomas H" sort="Schurmeyer, Thomas H" uniqKey="Schurmeyer T" first="Thomas H." last="Schürmeyer">Thomas H. Schürmeyer</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Rhénanie/explor/UnivTrevesV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D28 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001D28 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Rhénanie |area= UnivTrevesV1 |flux= Main |étape= Exploration |type= RBID |clé= Pascal:02-0150562 |texte= A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress }}
This area was generated with Dilib version V0.6.31. |