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A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress.

Identifieur interne : 000815 ( PubMed/Curation ); précédent : 000814; suivant : 000816

A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress.

Auteurs : Stuart Brody [Allemagne] ; Ragnar Preut ; Kerstin Schommer ; Thomas H. Schürmeyer

Source :

Psychopharmacology [ 0033-3158 ] ; 2002.

RBID : pubmed:11862365

English descriptors

KwdEn :
- Adult, Analysis of Variance, Antioxidants (administration & dosage), Ascorbic Acid (administration & dosage), Ascorbic Acid (blood), Blood Pressure (drug effects), Blood Pressure (physiology), Chi-Square Distribution, Delayed-Action Preparations (administration & dosage), Double-Blind Method, Female, Humans, Hydrocortisone (antagonists & inhibitors), Hydrocortisone (blood), Male, Stress, Psychological (blood), Stress, Psychological (drug therapy), Stress, Psychological (physiopathology).
MESH :
- chemical , administration & dosage : Antioxidants, Ascorbic Acid, Delayed-Action Preparations.
- chemical , antagonists & inhibitors : Hydrocortisone.
- chemical , blood : Ascorbic Acid, Hydrocortisone.
- blood : Stress, Psychological.
- drug effects : Blood Pressure.
- drug therapy : Stress, Psychological.
- physiology : Blood Pressure.
- physiopathology : Stress, Psychological.
- Adult, Analysis of Variance, Chi-Square Distribution, Double-Blind Method, Female, Humans, Male.

Abstract

Physiological responses to stress are considered disruptive to health. High-dose ascorbic acid has reduced indices of stress in laboratory animals.

DOI: 10.1007/s00213-001-0929-6
PubMed: 11862365

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Le document en format XML

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<author><name sortKey="Brody, Stuart" sort="Brody, Stuart" uniqKey="Brody S" first="Stuart" last="Brody">Stuart Brody</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for psychomatic and Psychobiological Research, University of Trier, Trier, Germany. stuartbrody@hotmail.com</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for psychomatic and Psychobiological Research, University of Trier, Trier</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Preut, Ragnar" sort="Preut, Ragnar" uniqKey="Preut R" first="Ragnar" last="Preut">Ragnar Preut</name>
</author>
<author><name sortKey="Schommer, Kerstin" sort="Schommer, Kerstin" uniqKey="Schommer K" first="Kerstin" last="Schommer">Kerstin Schommer</name>
</author>
<author><name sortKey="Schurmeyer, Thomas H" sort="Schurmeyer, Thomas H" uniqKey="Schurmeyer T" first="Thomas H" last="Schürmeyer">Thomas H. Schürmeyer</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress.</title>
<author><name sortKey="Brody, Stuart" sort="Brody, Stuart" uniqKey="Brody S" first="Stuart" last="Brody">Stuart Brody</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for psychomatic and Psychobiological Research, University of Trier, Trier, Germany. stuartbrody@hotmail.com</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for psychomatic and Psychobiological Research, University of Trier, Trier</wicri:regionArea>
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<author><name sortKey="Preut, Ragnar" sort="Preut, Ragnar" uniqKey="Preut R" first="Ragnar" last="Preut">Ragnar Preut</name>
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<author><name sortKey="Schommer, Kerstin" sort="Schommer, Kerstin" uniqKey="Schommer K" first="Kerstin" last="Schommer">Kerstin Schommer</name>
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<author><name sortKey="Schurmeyer, Thomas H" sort="Schurmeyer, Thomas H" uniqKey="Schurmeyer T" first="Thomas H" last="Schürmeyer">Thomas H. Schürmeyer</name>
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<series><title level="j">Psychopharmacology</title>
<idno type="ISSN">0033-3158</idno>
<imprint><date when="2002" type="published">2002</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Analysis of Variance</term>
<term>Antioxidants (administration & dosage)</term>
<term>Ascorbic Acid (administration & dosage)</term>
<term>Ascorbic Acid (blood)</term>
<term>Blood Pressure (drug effects)</term>
<term>Blood Pressure (physiology)</term>
<term>Chi-Square Distribution</term>
<term>Delayed-Action Preparations (administration & dosage)</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Hydrocortisone (antagonists & inhibitors)</term>
<term>Hydrocortisone (blood)</term>
<term>Male</term>
<term>Stress, Psychological (blood)</term>
<term>Stress, Psychological (drug therapy)</term>
<term>Stress, Psychological (physiopathology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antioxidants</term>
<term>Ascorbic Acid</term>
<term>Delayed-Action Preparations</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Hydrocortisone</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Ascorbic Acid</term>
<term>Hydrocortisone</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Stress, Psychological</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blood Pressure</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Stress, Psychological</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Pressure</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Stress, Psychological</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Analysis of Variance</term>
<term>Chi-Square Distribution</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
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<front><div type="abstract" xml:lang="en">Physiological responses to stress are considered disruptive to health. High-dose ascorbic acid has reduced indices of stress in laboratory animals.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11862365</PMID>
<DateCreated><Year>2002</Year>
<Month>02</Month>
<Day>25</Day>
</DateCreated>
<DateCompleted><Year>2002</Year>
<Month>05</Month>
<Day>07</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0033-3158</ISSN>
<JournalIssue CitedMedium="Print"><Volume>159</Volume>
<Issue>3</Issue>
<PubDate><Year>2002</Year>
<Month>Jan</Month>
</PubDate>
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<Title>Psychopharmacology</Title>
<ISOAbbreviation>Psychopharmacology (Berl.)</ISOAbbreviation>
</Journal>
<ArticleTitle>A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress.</ArticleTitle>
<Pagination><MedlinePgn>319-24</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="RATIONALE" NlmCategory="BACKGROUND">Physiological responses to stress are considered disruptive to health. High-dose ascorbic acid has reduced indices of stress in laboratory animals.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a randomized double-blind, placebo-controlled 14-day trial of sustained-release ascorbic acid (60 healthy young adults; 3 x1000 mg/day Cetebe) and placebo (60 healthy young adults) for reduction of blood pressure, cortisol, and subjective response to acute psychological stress (Trier Social Stress Test, TSST, consisting of public speaking and mental arithmetic). Six subjects from each group were excluded.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Compared to the placebo group, the ascorbic acid group had less systolic blood pressure (an increase of 23 versus 31 mmHg), diastolic blood pressure, and subjective stress responses to the TSST; and also had faster salivary cortisol recovery (but not smaller overall cortisol response). Cortisol response to 1 microg ACTH, and reported side-effects during the trial did not differ between groups. Plasma ascorbic acid level at the end of the trial but not pre-trial was associated with reduced stress reactivity of systolic blood pressure, diastolic blood pressure, and subjective stress, and with greater salivary cortisol recovery.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Treatment with high-dose sustained-release ascorbic acid palliates blood pressure, cortisol, and subjective response to acute psychological stress. These effects are not attributable to modification of adrenal responsiveness.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Brody</LastName>
<ForeName>Stuart</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Center for psychomatic and Psychobiological Research, University of Trier, Trier, Germany. stuartbrody@hotmail.com</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Preut</LastName>
<ForeName>Ragnar</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schommer</LastName>
<ForeName>Kerstin</ForeName>
<Initials>K</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schürmeyer</LastName>
<ForeName>Thomas H</ForeName>
<Initials>TH</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType>
<PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2001</Year>
<Month>11</Month>
<Day>20</Day>
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<MedlineJournalInfo><Country>Germany</Country>
<MedlineTA>Psychopharmacology (Berl)</MedlineTA>
<NlmUniqueID>7608025</NlmUniqueID>
<ISSNLinking>0033-3158</ISSNLinking>
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<NameOfSubstance UI="D006854">Hydrocortisone</NameOfSubstance>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName>
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<MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
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<MeshHeading><DescriptorName UI="D001205" MajorTopicYN="N">Ascorbic Acid</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
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<MeshHeading><DescriptorName UI="D001794" MajorTopicYN="N">Blood Pressure</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016009" MajorTopicYN="N">Chi-Square Distribution</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003692" MajorTopicYN="N">Delayed-Action Preparations</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
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<MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName>
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<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006854" MajorTopicYN="N">Hydrocortisone</DescriptorName>
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<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013315" MajorTopicYN="N">Stress, Psychological</DescriptorName>
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<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2001</Year>
<Month>06</Month>
<Day>12</Day>
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<PubMedPubDate PubStatus="accepted"><Year>2001</Year>
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A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress.

A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress.

Source :

English descriptors

Abstract

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