A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress
Identifieur interne : 000B31 ( PascalFrancis/Checkpoint ); précédent : 000B30; suivant : 000B32A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress
Auteurs : Stuart Brody [Allemagne] ; Ragnar Preut [Allemagne] ; Kerstin Schommer [Allemagne] ; Thomas H. Schürmeyer [Allemagne]Source :
- Psychopharmacologia [ 0033-3158 ] ; 2002.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Rationale: Physiological responses to stress are considered disruptive to health. High-dose ascorbic acid has reduced indices of stress in laboratory animals, Methods: We conducted a randomized double-blind, placebo-controlled 14-day trial of sustained-release ascorbic acid (60 healthy young adults; 3x1000 mg/day Cetebe) and placebo (60 healthy young adults) for reduction of blood pressure, cortisol, and subjective response to acute psychological stress (Trier Social Stress Test, TSST, consisting of public speaking and mental arithmetic). Six subjects from each group were excluded. Results: Compared to the placebo group, the ascorbic acid group had less systolic blood pressure (an increase of 23 versus 31 mmHg), diastolic blood pressure, and subjective stress responses to the TSST; and also had faster salivary cortisol recovery (but not smaller overall cortisol response). Cortisol response to 1 pg ACTH, and reported side-effects during the trial did not differ between groups. Plasma ascorbic acid level at the end of the trial but not pre-trial was associated with reduced stress reactivity of systolic blood pressure, diastolic blood pressure, and subjective stress, and with greater salivary cortisol recovery. Conclusions: Treatment with high-dose sustained-release ascorbic acid palliates blood pressure, cortisol, and subjective response to acute psychological stress. These effects are not attributable to modification of adrenal responsiveness.
Affiliations:
- Allemagne
- Bade-Wurtemberg, District de Tübingen, Rhénanie-Palatinat
- Trèves (Allemagne), Tübingen
- Université de Trèves
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Schürmeyer</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute for Medical Psychology and Behavioral Neurobiology, University of Tübingen</s1><s2>Tübingen</s2><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">02-0150562</idno><date when="2002">2002</date><idno type="stanalyst">PASCAL 02-0150562 INIST</idno><idno type="RBID">Pascal:02-0150562</idno><idno type="wicri:Area/PascalFrancis/Corpus">000D76</idno><idno type="wicri:Area/PascalFrancis/Curation">000160</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000B31</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000B31</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress</title><author><name sortKey="Brody, Stuart" sort="Brody, Stuart" uniqKey="Brody S" first="Stuart" last="Brody">Stuart Brody</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Center for Psychosomatic and Psychobiological Research, University of Trier, Karl-Marx-Strasse 94</s1><s2>54290 Trier</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>54290 Trier</wicri:noRegion><wicri:noRegion>Karl-Marx-Strasse 94</wicri:noRegion><wicri:noRegion>54290 Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Preut, Ragnar" sort="Preut, Ragnar" uniqKey="Preut R" first="Ragnar" last="Preut">Ragnar Preut</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Center for Psychosomatic and Psychobiological Research, University of Trier, Karl-Marx-Strasse 94</s1><s2>54290 Trier</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>54290 Trier</wicri:noRegion><wicri:noRegion>Karl-Marx-Strasse 94</wicri:noRegion><wicri:noRegion>54290 Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Schommer, Kerstin" sort="Schommer, Kerstin" uniqKey="Schommer K" first="Kerstin" last="Schommer">Kerstin Schommer</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Center for Psychosomatic and Psychobiological Research, University of Trier, Karl-Marx-Strasse 94</s1><s2>54290 Trier</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>54290 Trier</wicri:noRegion><wicri:noRegion>Karl-Marx-Strasse 94</wicri:noRegion><wicri:noRegion>54290 Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Schurmeyer, Thomas H" sort="Schurmeyer, Thomas H" uniqKey="Schurmeyer T" first="Thomas H." last="Schürmeyer">Thomas H. Schürmeyer</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute for Medical Psychology and Behavioral Neurobiology, University of Tübingen</s1><s2>Tübingen</s2><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Psychopharmacologia</title><title level="j" type="abbreviated">Psychopharmacologia</title><idno type="ISSN">0033-3158</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Psychopharmacologia</title><title level="j" type="abbreviated">Psychopharmacologia</title><idno type="ISSN">0033-3158</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Ascorbic acid</term><term>Biological activity</term><term>Blood pressure</term><term>Controlled release form</term><term>Controlled therapeutic trial</term><term>Cortisol</term><term>Emotion emotionality</term><term>Healthy subject</term><term>Human</term><term>Oral administration</term><term>Stress</term><term>Subjective evaluation</term><term>Supplementation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Acide ascorbique</term><term>Stress</term><term>Emotion émotivité</term><term>Supplémentation</term><term>Pression sanguine</term><term>Cortisol</term><term>Evaluation subjective</term><term>Forme libération contrôlée</term><term>Essai thérapeutique contrôlé</term><term>Activité biologique</term><term>Homme</term><term>Individu sain</term><term>Voie orale</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rationale: Physiological responses to stress are considered disruptive to health. High-dose ascorbic acid has reduced indices of stress in laboratory animals, Methods: We conducted a randomized double-blind, placebo-controlled 14-day trial of sustained-release ascorbic acid (60 healthy young adults; 3x1000 mg/day Cetebe) and placebo (60 healthy young adults) for reduction of blood pressure, cortisol, and subjective response to acute psychological stress (Trier Social Stress Test, TSST, consisting of public speaking and mental arithmetic). Six subjects from each group were excluded. Results: Compared to the placebo group, the ascorbic acid group had less systolic blood pressure (an increase of 23 versus 31 mmHg), diastolic blood pressure, and subjective stress responses to the TSST; and also had faster salivary cortisol recovery (but not smaller overall cortisol response). Cortisol response to 1 pg ACTH, and reported side-effects during the trial did not differ between groups. Plasma ascorbic acid level at the end of the trial but not pre-trial was associated with reduced stress reactivity of systolic blood pressure, diastolic blood pressure, and subjective stress, and with greater salivary cortisol recovery. Conclusions: Treatment with high-dose sustained-release ascorbic acid palliates blood pressure, cortisol, and subjective response to acute psychological stress. These effects are not attributable to modification of adrenal responsiveness.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0033-3158</s0></fA01><fA03 i2="1"><s0>Psychopharmacologia</s0></fA03><fA05><s2>159</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress</s1></fA08><fA11 i1="01" i2="1"><s1>BRODY (Stuart)</s1></fA11><fA11 i1="02" i2="1"><s1>PREUT (Ragnar)</s1></fA11><fA11 i1="03" i2="1"><s1>SCHOMMER (Kerstin)</s1></fA11><fA11 i1="04" i2="1"><s1>SCHÜRMEYER (Thomas H.)</s1></fA11><fA14 i1="01"><s1>Center for Psychosomatic and Psychobiological Research, University of Trier, Karl-Marx-Strasse 94</s1><s2>54290 Trier</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="02"><s1>Institute for Medical Psychology and Behavioral Neurobiology, University of Tübingen</s1><s2>Tübingen</s2><s3>DEU</s3><sZ>4 aut.</sZ></fA14><fA20><s1>319-324</s1></fA20><fA21><s1>2002</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>1761</s2><s5>354000103567650110</s5></fA43><fA44><s0>0000</s0><s1>© 2002 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>1 p.1/4</s0></fA45><fA47 i1="01" i2="1"><s0>02-0150562</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Psychopharmacologia</s0></fA64><fA66 i1="01"><s0>DEU</s0></fA66><fC01 i1="01" l="ENG"><s0>Rationale: Physiological responses to stress are considered disruptive to health. High-dose ascorbic acid has reduced indices of stress in laboratory animals, Methods: We conducted a randomized double-blind, placebo-controlled 14-day trial of sustained-release ascorbic acid (60 healthy young adults; 3x1000 mg/day Cetebe) and placebo (60 healthy young adults) for reduction of blood pressure, cortisol, and subjective response to acute psychological stress (Trier Social Stress Test, TSST, consisting of public speaking and mental arithmetic). Six subjects from each group were excluded. Results: Compared to the placebo group, the ascorbic acid group had less systolic blood pressure (an increase of 23 versus 31 mmHg), diastolic blood pressure, and subjective stress responses to the TSST; and also had faster salivary cortisol recovery (but not smaller overall cortisol response). Cortisol response to 1 pg ACTH, and reported side-effects during the trial did not differ between groups. Plasma ascorbic acid level at the end of the trial but not pre-trial was associated with reduced stress reactivity of systolic blood pressure, diastolic blood pressure, and subjective stress, and with greater salivary cortisol recovery. Conclusions: Treatment with high-dose sustained-release ascorbic acid palliates blood pressure, cortisol, and subjective response to acute psychological stress. These effects are not attributable to modification of adrenal responsiveness.</s0></fC01><fC02 i1="01" i2="X"><s0>002B02A04</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Acide ascorbique</s0><s2>NK</s2><s2>FR</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Ascorbic acid</s0><s2>NK</s2><s2>FR</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Acido ascórbico</s0><s2>NK</s2><s2>FR</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Stress</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Stress</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Estrés</s0><s5>04</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Emotion émotivité</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Emotion emotionality</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Emoción emotividad</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Supplémentation</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Supplementation</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Suplementación</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Pression sanguine</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Blood pressure</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Presión sanguínea</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Cortisol</s0><s2>NK</s2><s5>12</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Cortisol</s0><s2>NK</s2><s5>12</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Cortisol</s0><s2>NK</s2><s5>12</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Evaluation subjective</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Subjective evaluation</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Evaluación subjetiva</s0><s5>13</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Forme libération contrôlée</s0><s5>14</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Controlled release form</s0><s5>14</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Forma liberación controlada</s0><s5>14</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Essai thérapeutique contrôlé</s0><s5>15</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Controlled therapeutic trial</s0><s5>15</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Ensayo terapéutico controlado</s0><s5>15</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Activité biologique</s0><s5>16</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Biological activity</s0><s5>16</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Actividad biológica</s0><s5>16</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Homme</s0><s5>17</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Human</s0><s5>17</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Hombre</s0><s5>17</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Individu sain</s0><s5>18</s5></fC03><fC03 i1="12" i2="X" l="ENG"><s0>Healthy subject</s0><s5>18</s5></fC03><fC03 i1="12" i2="X" l="SPA"><s0>Individuo sano</s0><s5>18</s5></fC03><fC03 i1="13" i2="X" l="FRE"><s0>Voie orale</s0><s5>19</s5></fC03><fC03 i1="13" i2="X" l="ENG"><s0>Oral administration</s0><s5>19</s5></fC03><fC03 i1="13" i2="X" l="SPA"><s0>Vía oral</s0><s5>19</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Glucocorticoïde</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Glucocorticoid</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Glucocorticoide</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Hormone stéroïde</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Steroid hormone</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Hormona esteroide</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Hormone surrénalienne</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Adrenal hormone</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Hormona suprarrenal</s0><s5>39</s5></fC07><fN21><s1>084</s1></fN21><fN82><s1>PSI</s1></fN82></pA></standard></inist><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li><li>Rhénanie-Palatinat</li></region><settlement><li>Trèves (Allemagne)</li><li>Tübingen</li></settlement><orgName><li>Université de Trèves</li></orgName></list><tree><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Brody, Stuart" sort="Brody, Stuart" uniqKey="Brody S" first="Stuart" last="Brody">Stuart Brody</name></region><name sortKey="Preut, Ragnar" sort="Preut, Ragnar" uniqKey="Preut R" first="Ragnar" last="Preut">Ragnar Preut</name><name sortKey="Schommer, Kerstin" sort="Schommer, Kerstin" uniqKey="Schommer K" first="Kerstin" last="Schommer">Kerstin Schommer</name><name sortKey="Schurmeyer, Thomas H" sort="Schurmeyer, Thomas H" uniqKey="Schurmeyer T" first="Thomas H." last="Schürmeyer">Thomas H. 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