Evolutionary changes in CpG and methylation levels in the genome of vertebrates
Identifieur interne : 001921 ( Main/Merge ); précédent : 001920; suivant : 001922Evolutionary changes in CpG and methylation levels in the genome of vertebrates
Auteurs : Kamel Jabbari [France] ; Simone Cacci [France, Italie] ; Jean Paul Païs De Barros [France] ; Jean Desgrès [France] ; Giorgio Bernardi [France]Source :
- Gene [ 0378-1119 ] ; 1997.
Abstract
We have analysed the levels of 5-methylcytosine (5mC) in DNAs from 42 vertebrates, and compiled, including data from literature, a table of genomic 5mC and GC levels (as well as the available c-values, i.e., the haploid genome sizes) of 87 species from all vertebrate classes. An analysis of the data indicates that (i) two positive correlations hold between the 5mC and GC levels of the genomes of fishes/amphibians and mammals/birds, respectively; (ii) the genomes of fishes and amphibians are, on average, about twice as methylated as those of mammals, birds and reptiles, this difference being unrelated to the amounts of repetitive DNA sequences; (iii) the 5mC and CpG observed/expected values show no overlap between the two groups of vertebrates and suggest the existence of two equilibria. The transition separating the two equilibria appears to have taken place at the time of appearance of reptiles. Its possible cause(s) and its implications are discussed.
Url:
DOI: 10.1016/S0378-1119(97)00475-7
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000C18
- to stream Istex, to step Curation: 000C16
- to stream Istex, to step Checkpoint: 000E73
Links to Exploration step
ISTEX:6C21D515B9F9DD286CA9018CD70018D6E5D6179DLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Evolutionary changes in CpG and methylation levels in the genome of vertebrates</title><author><name sortKey="Jabbari, Kamel" sort="Jabbari, Kamel" uniqKey="Jabbari K" first="Kamel" last="Jabbari">Kamel Jabbari</name></author><author><name sortKey="Cacci, Simone" sort="Cacci, Simone" uniqKey="Cacci S" first="Simone" last="Cacci">Simone Cacci</name></author><author><name sortKey="Pais De Barros, Jean Paul" sort="Pais De Barros, Jean Paul" uniqKey="Pais De Barros J" first="Jean Paul" last="Païs De Barros">Jean Paul Païs De Barros</name></author><author><name sortKey="Desgres, Jean" sort="Desgres, Jean" uniqKey="Desgres J" first="Jean" last="Desgrès">Jean Desgrès</name></author><author><name sortKey="Bernardi, Giorgio" sort="Bernardi, Giorgio" uniqKey="Bernardi G" first="Giorgio" last="Bernardi">Giorgio Bernardi</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6C21D515B9F9DD286CA9018CD70018D6E5D6179D</idno><date when="1997" year="1997">1997</date><idno type="doi">10.1016/S0378-1119(97)00475-7</idno><idno type="url">https://api.istex.fr/document/6C21D515B9F9DD286CA9018CD70018D6E5D6179D/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000C18</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000C18</idno><idno type="wicri:Area/Istex/Curation">000C16</idno><idno type="wicri:Area/Istex/Checkpoint">000E73</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000E73</idno><idno type="wicri:doubleKey">0378-1119:1997:Jabbari K:evolutionary:changes:in</idno><idno type="wicri:Area/Main/Merge">001921</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Evolutionary changes in CpG and methylation levels in the genome of vertebrates</title><author><name sortKey="Jabbari, Kamel" sort="Jabbari, Kamel" uniqKey="Jabbari K" first="Kamel" last="Jabbari">Kamel Jabbari</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cacci, Simone" sort="Cacci, Simone" uniqKey="Cacci S" first="Simone" last="Cacci">Simone Cacci</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>1 Present address: Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Pais De Barros, Jean Paul" sort="Pais De Barros, Jean Paul" uniqKey="Pais De Barros J" first="Jean Paul" last="Païs De Barros">Jean Paul Païs De Barros</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon</wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Desgres, Jean" sort="Desgres, Jean" uniqKey="Desgres J" first="Jean" last="Desgrès">Jean Desgrès</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon</wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Bernardi, Giorgio" sort="Bernardi, Giorgio" uniqKey="Bernardi G" first="Giorgio" last="Bernardi">Giorgio Bernardi</name><affiliation></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Gene</title><title level="j" type="abbrev">GENE</title><idno type="ISSN">0378-1119</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">205</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="109">109</biblScope><biblScope unit="page" to="118">118</biblScope></imprint><idno type="ISSN">0378-1119</idno></series><idno type="istex">6C21D515B9F9DD286CA9018CD70018D6E5D6179D</idno><idno type="DOI">10.1016/S0378-1119(97)00475-7</idno><idno type="PII">S0378-1119(97)00475-7</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0378-1119</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have analysed the levels of 5-methylcytosine (5mC) in DNAs from 42 vertebrates, and compiled, including data from literature, a table of genomic 5mC and GC levels (as well as the available c-values, i.e., the haploid genome sizes) of 87 species from all vertebrate classes. An analysis of the data indicates that (i) two positive correlations hold between the 5mC and GC levels of the genomes of fishes/amphibians and mammals/birds, respectively; (ii) the genomes of fishes and amphibians are, on average, about twice as methylated as those of mammals, birds and reptiles, this difference being unrelated to the amounts of repetitive DNA sequences; (iii) the 5mC and CpG observed/expected values show no overlap between the two groups of vertebrates and suggest the existence of two equilibria. The transition separating the two equilibria appears to have taken place at the time of appearance of reptiles. Its possible cause(s) and its implications are discussed.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Eau/explor/EsturgeonV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001921 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001921 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Eau
|area= EsturgeonV1
|flux= Main
|étape= Merge
|type= RBID
|clé= ISTEX:6C21D515B9F9DD286CA9018CD70018D6E5D6179D
|texte= Evolutionary changes in CpG and methylation levels in the genome of vertebrates
}}
| This area was generated with Dilib version V0.6.27. |  |