Evolutionary changes in CpG and methylation levels in the genome of vertebrates
Identifieur interne : 000C18 ( Istex/Corpus ); précédent : 000C17; suivant : 000C19Evolutionary changes in CpG and methylation levels in the genome of vertebrates
Auteurs : Kamel Jabbari ; Simone Cacci ; Jean Paul Païs De Barros ; Jean Desgrès ; Giorgio BernardiSource :
- Gene [ 0378-1119 ] ; 1997.
Abstract
We have analysed the levels of 5-methylcytosine (5mC) in DNAs from 42 vertebrates, and compiled, including data from literature, a table of genomic 5mC and GC levels (as well as the available c-values, i.e., the haploid genome sizes) of 87 species from all vertebrate classes. An analysis of the data indicates that (i) two positive correlations hold between the 5mC and GC levels of the genomes of fishes/amphibians and mammals/birds, respectively; (ii) the genomes of fishes and amphibians are, on average, about twice as methylated as those of mammals, birds and reptiles, this difference being unrelated to the amounts of repetitive DNA sequences; (iii) the 5mC and CpG observed/expected values show no overlap between the two groups of vertebrates and suggest the existence of two equilibria. The transition separating the two equilibria appears to have taken place at the time of appearance of reptiles. Its possible cause(s) and its implications are discussed.
Url:
DOI: 10.1016/S0378-1119(97)00475-7
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Evolutionary changes in CpG and methylation levels in the genome of vertebrates</title><author><name sortKey="Jabbari, Kamel" sort="Jabbari, Kamel" uniqKey="Jabbari K" first="Kamel" last="Jabbari">Kamel Jabbari</name><affiliation><mods:affiliation>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Cacci, Simone" sort="Cacci, Simone" uniqKey="Cacci S" first="Simone" last="Cacci">Simone Cacci</name><affiliation><mods:affiliation>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>1 Present address: Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pais De Barros, Jean Paul" sort="Pais De Barros, Jean Paul" uniqKey="Pais De Barros J" first="Jean Paul" last="Païs De Barros">Jean Paul Païs De Barros</name><affiliation><mods:affiliation>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon, France</mods:affiliation></affiliation></author><author><name sortKey="Desgres, Jean" sort="Desgres, Jean" uniqKey="Desgres J" first="Jean" last="Desgrès">Jean Desgrès</name><affiliation><mods:affiliation>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon, France</mods:affiliation></affiliation></author><author><name sortKey="Bernardi, Giorgio" sort="Bernardi, Giorgio" uniqKey="Bernardi G" first="Giorgio" last="Bernardi">Giorgio Bernardi</name><affiliation><mods:affiliation>Corresponding author. Tel.: +33 1 43295824; Fax: +33 1 44277977.</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6C21D515B9F9DD286CA9018CD70018D6E5D6179D</idno><date when="1997" year="1997">1997</date><idno type="doi">10.1016/S0378-1119(97)00475-7</idno><idno type="url">https://api.istex.fr/document/6C21D515B9F9DD286CA9018CD70018D6E5D6179D/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000C18</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000C18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Evolutionary changes in CpG and methylation levels in the genome of vertebrates</title><author><name sortKey="Jabbari, Kamel" sort="Jabbari, Kamel" uniqKey="Jabbari K" first="Kamel" last="Jabbari">Kamel Jabbari</name><affiliation><mods:affiliation>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Cacci, Simone" sort="Cacci, Simone" uniqKey="Cacci S" first="Simone" last="Cacci">Simone Cacci</name><affiliation><mods:affiliation>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>1 Present address: Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pais De Barros, Jean Paul" sort="Pais De Barros, Jean Paul" uniqKey="Pais De Barros J" first="Jean Paul" last="Païs De Barros">Jean Paul Païs De Barros</name><affiliation><mods:affiliation>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon, France</mods:affiliation></affiliation></author><author><name sortKey="Desgres, Jean" sort="Desgres, Jean" uniqKey="Desgres J" first="Jean" last="Desgrès">Jean Desgrès</name><affiliation><mods:affiliation>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon, France</mods:affiliation></affiliation></author><author><name sortKey="Bernardi, Giorgio" sort="Bernardi, Giorgio" uniqKey="Bernardi G" first="Giorgio" last="Bernardi">Giorgio Bernardi</name><affiliation><mods:affiliation>Corresponding author. Tel.: +33 1 43295824; Fax: +33 1 44277977.</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Gene</title><title level="j" type="abbrev">GENE</title><idno type="ISSN">0378-1119</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">205</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="109">109</biblScope><biblScope unit="page" to="118">118</biblScope></imprint><idno type="ISSN">0378-1119</idno></series><idno type="istex">6C21D515B9F9DD286CA9018CD70018D6E5D6179D</idno><idno type="DOI">10.1016/S0378-1119(97)00475-7</idno><idno type="PII">S0378-1119(97)00475-7</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0378-1119</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have analysed the levels of 5-methylcytosine (5mC) in DNAs from 42 vertebrates, and compiled, including data from literature, a table of genomic 5mC and GC levels (as well as the available c-values, i.e., the haploid genome sizes) of 87 species from all vertebrate classes. An analysis of the data indicates that (i) two positive correlations hold between the 5mC and GC levels of the genomes of fishes/amphibians and mammals/birds, respectively; (ii) the genomes of fishes and amphibians are, on average, about twice as methylated as those of mammals, birds and reptiles, this difference being unrelated to the amounts of repetitive DNA sequences; (iii) the 5mC and CpG observed/expected values show no overlap between the two groups of vertebrates and suggest the existence of two equilibria. The transition separating the two equilibria appears to have taken place at the time of appearance of reptiles. Its possible cause(s) and its implications are discussed.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Kamel Jabbari</name><affiliations><json:string>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</json:string></affiliations></json:item><json:item><name>Simone Cacciò</name><affiliations><json:string>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</json:string><json:string>1 Present address: Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy</json:string></affiliations></json:item><json:item><name>Jean Paul Païs de Barros</name><affiliations><json:string>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon, France</json:string></affiliations></json:item><json:item><name>Jean Desgrès</name><affiliations><json:string>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon, France</json:string></affiliations></json:item><json:item><name>Giorgio Bernardi</name><affiliations><json:string>Corresponding author. Tel.: +33 1 43295824; Fax: +33 1 44277977.</json:string><json:string>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>CpG dinucleotide</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Isochore</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Vertebrate evolution</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Br84 : 8-bromoguanosine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>5mC : 5-methylcytosine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>GC : molar fraction of guanine+cytosine in DNA</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>HPLC : high-performance liquid chromatography</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>We have analysed the levels of 5-methylcytosine (5mC) in DNAs from 42 vertebrates, and compiled, including data from literature, a table of genomic 5mC and GC levels (as well as the available c-values, i.e., the haploid genome sizes) of 87 species from all vertebrate classes. An analysis of the data indicates that (i) two positive correlations hold between the 5mC and GC levels of the genomes of fishes/amphibians and mammals/birds, respectively; (ii) the genomes of fishes and amphibians are, on average, about twice as methylated as those of mammals, birds and reptiles, this difference being unrelated to the amounts of repetitive DNA sequences; (iii) the 5mC and CpG observed/expected values show no overlap between the two groups of vertebrates and suggest the existence of two equilibria. The transition separating the two equilibria appears to have taken place at the time of appearance of reptiles. Its possible cause(s) and its implications are discussed.</abstract><qualityIndicators><score>6.824</score><pdfVersion>1.2</pdfVersion><pdfPageSize>584 x 807 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>7</keywordCount><abstractCharCount>967</abstractCharCount><pdfWordCount>7066</pdfWordCount><pdfCharCount>39636</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>152</abstractWordCount></qualityIndicators><title>Evolutionary changes in CpG and methylation levels in the genome of vertebrates</title><pii><json:string>S0378-1119(97)00475-7</json:string></pii><genre><json:string>research-article</json:string></genre><serie><volume>74</volume><pages><last>3946</last><first>3942</first></pages><language><json:string>unknown</json:string></language><title>Proc. Natl. Acad. Sci. 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Tel.: +33 1 43295824; Fax: +33 1 44277977.</affiliation><affiliation>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</affiliation></author></analytic><monogr><title level="j">Gene</title><title level="j" type="abbrev">GENE</title><idno type="pISSN">0378-1119</idno><idno type="PII">S0378-1119(00)X0089-3</idno><meeting><addName>Junk DNA: The Role and the Evolution of Non-Coding Sequences, Guanacaste, Costa Rica</addName><date>19970106</date><date>19970110</date></meeting><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997"></date><biblScope unit="volume">205</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="109">109</biblScope><biblScope unit="page" to="118">118</biblScope></imprint></monogr><idno type="istex">6C21D515B9F9DD286CA9018CD70018D6E5D6179D</idno><idno type="DOI">10.1016/S0378-1119(97)00475-7</idno><idno type="PII">S0378-1119(97)00475-7</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1997</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We have analysed the levels of 5-methylcytosine (5mC) in DNAs from 42 vertebrates, and compiled, including data from literature, a table of genomic 5mC and GC levels (as well as the available c-values, i.e., the haploid genome sizes) of 87 species from all vertebrate classes. An analysis of the data indicates that (i) two positive correlations hold between the 5mC and GC levels of the genomes of fishes/amphibians and mammals/birds, respectively; (ii) the genomes of fishes and amphibians are, on average, about twice as methylated as those of mammals, birds and reptiles, this difference being unrelated to the amounts of repetitive DNA sequences; (iii) the 5mC and CpG observed/expected values show no overlap between the two groups of vertebrates and suggest the existence of two equilibria. The transition separating the two equilibria appears to have taken place at the time of appearance of reptiles. Its possible cause(s) and its implications are discussed.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>CpG dinucleotide</term></item><item><term>Isochore</term></item><item><term>Vertebrate evolution</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>Abbreviations</head><item><term>Br84</term><term>8-bromoguanosine</term></item><item><term>5mC</term><term>5-methylcytosine</term></item><item><term>GC</term><term>molar fraction of guanine+cytosine in DNA</term></item><item><term>HPLC</term><term>high-performance liquid chromatography</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1997">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/6C21D515B9F9DD286CA9018CD70018D6E5D6179D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>GENE</jid><aid>97004757</aid><ce:pii>S0378-1119(97)00475-7</ce:pii><ce:doi>10.1016/S0378-1119(97)00475-7</ce:doi><ce:copyright type="unknown" year="1997"></ce:copyright></item-info><head><ce:title>Evolutionary changes in CpG and methylation levels in the genome of vertebrates</ce:title><ce:author-group><ce:author><ce:given-name>Kamel</ce:given-name><ce:surname>Jabbari</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Simone</ce:given-name><ce:surname>Cacciò</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="FN1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Jean Paul</ce:given-name><ce:surname>Païs de Barros</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Jean</ce:given-name><ce:surname>Desgrès</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Giorgio</ce:given-name><ce:surname>Bernardi</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon, France</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Corresponding author. Tel.: +33 1 43295824; Fax: +33 1 44277977.</ce:text></ce:correspondence><ce:footnote id="FN1"><ce:label>1</ce:label><ce:note-para>Present address: Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy</ce:note-para></ce:footnote></ce:author-group><ce:date-accepted day="31" month="7" year="1997"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>We have analysed the levels of 5-methylcytosine (5mC) in DNAs from 42 vertebrates, and compiled, including data from literature, a table of genomic 5mC and GC levels (as well as the available c-values, i.e., the haploid genome sizes) of 87 species from all vertebrate classes. An analysis of the data indicates that (i) two positive correlations hold between the 5mC and GC levels of the genomes of fishes/amphibians and mammals/birds, respectively; (ii) the genomes of fishes and amphibians are, on average, about twice as methylated as those of mammals, birds and reptiles, this difference being unrelated to the amounts of repetitive DNA sequences; (iii) the 5mC and CpG observed/expected values show no overlap between the two groups of vertebrates and suggest the existence of two equilibria. The transition separating the two equilibria appears to have taken place at the time of appearance of reptiles. Its possible cause(s) and its implications are discussed.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>CpG dinucleotide</ce:text></ce:keyword><ce:keyword><ce:text>Isochore</ce:text></ce:keyword><ce:keyword><ce:text>Vertebrate evolution</ce:text></ce:keyword></ce:keywords><ce:keywords class="abr"><ce:section-title>Abbreviations</ce:section-title><ce:keyword><ce:text>Br84</ce:text><ce:keyword><ce:text>8-bromoguanosine</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>5mC</ce:text><ce:keyword><ce:text>5-methylcytosine</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>GC</ce:text><ce:keyword><ce:text>molar fraction of guanine+cytosine in DNA</ce:text></ce:keyword></ce:keyword><ce:keyword><ce:text>HPLC</ce:text><ce:keyword><ce:text>high-performance liquid chromatography</ce:text></ce:keyword></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Evolutionary changes in CpG and methylation levels in the genome of vertebrates</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Evolutionary changes in CpG and methylation levels in the genome of vertebrates</title></titleInfo><name type="personal"><namePart type="given">Kamel</namePart><namePart type="family">Jabbari</namePart><affiliation>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Simone</namePart><namePart type="family">Cacciò</namePart><affiliation>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</affiliation><affiliation>1 Present address: Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean Paul</namePart><namePart type="family">Païs de Barros</namePart><affiliation>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean</namePart><namePart type="family">Desgrès</namePart><affiliation>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giorgio</namePart><namePart type="family">Bernardi</namePart><affiliation>Corresponding author. Tel.: +33 1 43295824; Fax: +33 1 44277977.</affiliation><affiliation>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1997</dateIssued><copyrightDate encoding="w3cdtf">1997</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">We have analysed the levels of 5-methylcytosine (5mC) in DNAs from 42 vertebrates, and compiled, including data from literature, a table of genomic 5mC and GC levels (as well as the available c-values, i.e., the haploid genome sizes) of 87 species from all vertebrate classes. An analysis of the data indicates that (i) two positive correlations hold between the 5mC and GC levels of the genomes of fishes/amphibians and mammals/birds, respectively; (ii) the genomes of fishes and amphibians are, on average, about twice as methylated as those of mammals, birds and reptiles, this difference being unrelated to the amounts of repetitive DNA sequences; (iii) the 5mC and CpG observed/expected values show no overlap between the two groups of vertebrates and suggest the existence of two equilibria. The transition separating the two equilibria appears to have taken place at the time of appearance of reptiles. Its possible cause(s) and its implications are discussed.</abstract><subject><genre>Keywords</genre><topic>CpG dinucleotide</topic><topic>Isochore</topic><topic>Vertebrate evolution</topic></subject><subject><genre>Abbreviations</genre><topic>Br84 : 8-bromoguanosine</topic><topic>5mC : 5-methylcytosine</topic><topic>GC : molar fraction of guanine+cytosine in DNA</topic><topic>HPLC : high-performance liquid chromatography</topic></subject><relatedItem type="host"><titleInfo><title>Gene</title></titleInfo><titleInfo type="abbreviated"><title>GENE</title></titleInfo><name type="conference"><namePart>Junk DNA: The Role and the Evolution of Non-Coding Sequences, Guanacaste, Costa Rica</namePart><namePart type="date">19970106</namePart><namePart type="date">19970110</namePart></name><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19971231</dateIssued></originInfo><identifier type="ISSN">0378-1119</identifier><identifier type="PII">S0378-1119(00)X0089-3</identifier><part><date>19971231</date><detail type="issue"><title>Junk DNA: The Role and the Evolution of Non-Coding Sequences, Guanacaste, Costa Rica</title></detail><detail type="volume"><number>205</number><caption>vol.</caption></detail><detail type="issue"><number>1–2</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>346</end></extent><extent unit="pages"><start>109</start><end>118</end></extent></part></relatedItem><identifier type="istex">6C21D515B9F9DD286CA9018CD70018D6E5D6179D</identifier><identifier type="DOI">10.1016/S0378-1119(97)00475-7</identifier><identifier type="PII">S0378-1119(97)00475-7</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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