Evolutionary changes in CpG and methylation levels in the genome of vertebrates
Identifieur interne : 000C16 ( Istex/Curation ); précédent : 000C15; suivant : 000C17Evolutionary changes in CpG and methylation levels in the genome of vertebrates
Auteurs : Kamel Jabbari [France] ; Simone Cacci [France, Italie] ; Jean Paul Païs De Barros [France] ; Jean Desgrès [France] ; Giorgio Bernardi [France]Source :
- Gene [ 0378-1119 ] ; 1997.
Abstract
We have analysed the levels of 5-methylcytosine (5mC) in DNAs from 42 vertebrates, and compiled, including data from literature, a table of genomic 5mC and GC levels (as well as the available c-values, i.e., the haploid genome sizes) of 87 species from all vertebrate classes. An analysis of the data indicates that (i) two positive correlations hold between the 5mC and GC levels of the genomes of fishes/amphibians and mammals/birds, respectively; (ii) the genomes of fishes and amphibians are, on average, about twice as methylated as those of mammals, birds and reptiles, this difference being unrelated to the amounts of repetitive DNA sequences; (iii) the 5mC and CpG observed/expected values show no overlap between the two groups of vertebrates and suggest the existence of two equilibria. The transition separating the two equilibria appears to have taken place at the time of appearance of reptiles. Its possible cause(s) and its implications are discussed.
Url:
DOI: 10.1016/S0378-1119(97)00475-7
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000C18
Links to Exploration step
ISTEX:6C21D515B9F9DD286CA9018CD70018D6E5D6179DLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Evolutionary changes in CpG and methylation levels in the genome of vertebrates</title>
<author><name sortKey="Jabbari, Kamel" sort="Jabbari, Kamel" uniqKey="Jabbari K" first="Kamel" last="Jabbari">Kamel Jabbari</name>
<affiliation wicri:level="1"><mods:affiliation>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cacci, Simone" sort="Cacci, Simone" uniqKey="Cacci S" first="Simone" last="Cacci">Simone Cacci</name>
<affiliation wicri:level="1"><mods:affiliation>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>1 Present address: Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy</mods:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>1 Present address: Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pais De Barros, Jean Paul" sort="Pais De Barros, Jean Paul" uniqKey="Pais De Barros J" first="Jean Paul" last="Païs De Barros">Jean Paul Païs De Barros</name>
<affiliation wicri:level="1"><mods:affiliation>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Desgres, Jean" sort="Desgres, Jean" uniqKey="Desgres J" first="Jean" last="Desgrès">Jean Desgrès</name>
<affiliation wicri:level="1"><mods:affiliation>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bernardi, Giorgio" sort="Bernardi, Giorgio" uniqKey="Bernardi G" first="Giorgio" last="Bernardi">Giorgio Bernardi</name>
<affiliation><mods:affiliation>Corresponding author. Tel.: +33 1 43295824; Fax: +33 1 44277977.</mods:affiliation>
<wicri:noCountry code="no comma">Corresponding author. Tel.: +33 1 43295824; Fax: +33 1 44277977.</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:6C21D515B9F9DD286CA9018CD70018D6E5D6179D</idno>
<date when="1997" year="1997">1997</date>
<idno type="doi">10.1016/S0378-1119(97)00475-7</idno>
<idno type="url">https://api.istex.fr/document/6C21D515B9F9DD286CA9018CD70018D6E5D6179D/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000C18</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000C18</idno>
<idno type="wicri:Area/Istex/Curation">000C16</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Evolutionary changes in CpG and methylation levels in the genome of vertebrates</title>
<author><name sortKey="Jabbari, Kamel" sort="Jabbari, Kamel" uniqKey="Jabbari K" first="Kamel" last="Jabbari">Kamel Jabbari</name>
<affiliation wicri:level="1"><mods:affiliation>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cacci, Simone" sort="Cacci, Simone" uniqKey="Cacci S" first="Simone" last="Cacci">Simone Cacci</name>
<affiliation wicri:level="1"><mods:affiliation>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>1 Present address: Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy</mods:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>1 Present address: Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pais De Barros, Jean Paul" sort="Pais De Barros, Jean Paul" uniqKey="Pais De Barros J" first="Jean Paul" last="Païs De Barros">Jean Paul Païs De Barros</name>
<affiliation wicri:level="1"><mods:affiliation>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Desgres, Jean" sort="Desgres, Jean" uniqKey="Desgres J" first="Jean" last="Desgrès">Jean Desgrès</name>
<affiliation wicri:level="1"><mods:affiliation>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Biochimie Médicale, Faculté de Médecine et Centre Hospitalier Universitaire, 7 Bd Jeanne d'Arc, 21033 Dijon</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bernardi, Giorgio" sort="Bernardi, Giorgio" uniqKey="Bernardi G" first="Giorgio" last="Bernardi">Giorgio Bernardi</name>
<affiliation><mods:affiliation>Corresponding author. Tel.: +33 1 43295824; Fax: +33 1 44277977.</mods:affiliation>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 Place Jussieu, 75005 Paris</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Gene</title>
<title level="j" type="abbrev">GENE</title>
<idno type="ISSN">0378-1119</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1997">1997</date>
<biblScope unit="volume">205</biblScope>
<biblScope unit="issue">1–2</biblScope>
<biblScope unit="page" from="109">109</biblScope>
<biblScope unit="page" to="118">118</biblScope>
</imprint>
<idno type="ISSN">0378-1119</idno>
</series>
<idno type="istex">6C21D515B9F9DD286CA9018CD70018D6E5D6179D</idno>
<idno type="DOI">10.1016/S0378-1119(97)00475-7</idno>
<idno type="PII">S0378-1119(97)00475-7</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0378-1119</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We have analysed the levels of 5-methylcytosine (5mC) in DNAs from 42 vertebrates, and compiled, including data from literature, a table of genomic 5mC and GC levels (as well as the available c-values, i.e., the haploid genome sizes) of 87 species from all vertebrate classes. An analysis of the data indicates that (i) two positive correlations hold between the 5mC and GC levels of the genomes of fishes/amphibians and mammals/birds, respectively; (ii) the genomes of fishes and amphibians are, on average, about twice as methylated as those of mammals, birds and reptiles, this difference being unrelated to the amounts of repetitive DNA sequences; (iii) the 5mC and CpG observed/expected values show no overlap between the two groups of vertebrates and suggest the existence of two equilibria. The transition separating the two equilibria appears to have taken place at the time of appearance of reptiles. Its possible cause(s) and its implications are discussed.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Eau/explor/EsturgeonV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C16 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000C16 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Eau |area= EsturgeonV1 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:6C21D515B9F9DD286CA9018CD70018D6E5D6179D |texte= Evolutionary changes in CpG and methylation levels in the genome of vertebrates }}
This area was generated with Dilib version V0.6.27. |