Acute exposure of Siberian sturgeon (Acipenser baeri, Brandt) yearlings to nitrite: median-lethal concentration (LC50) determination, haematological changes and nitrite accumulation in selected tissues
Identifieur interne : 001397 ( Main/Exploration ); précédent : 001396; suivant : 001398Acute exposure of Siberian sturgeon (Acipenser baeri, Brandt) yearlings to nitrite: median-lethal concentration (LC50) determination, haematological changes and nitrite accumulation in selected tissues
Auteurs : M. Huertas [Espagne] ; E. Gisbert [Espagne] ; A. Rodriguez [Espagne] ; L. Cardona [Espagne] ; P. Williot [France] ; F. Castello-Orvay [Espagne]Source :
- Aquatic toxicology [ 0166-445X ] ; 2002.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Acipenser baeri, Acute, Animals, Biological accumulation, Exposure, Fish Diseases (chemically induced), Fishes (metabolism), Hematology, Lethal Dose 50, Lethal dose 50, Methemoglobin (analysis), Methemoglobinemia, Methemoglobinemia (chemically induced), Methemoglobinemia (veterinary), Nitrites, Nitrites (pharmacokinetics), Nitrites (toxicity), Survival Analysis, Time Factors, Tissue Distribution, Toxicity, Water Pollutants, Chemical (pharmacokinetics), Water Pollutants, Chemical (toxicity), Young animal.
- MESH :
- chemical , analysis : Methemoglobin.
- chemically induced : Fish Diseases, Methemoglobinemia.
- metabolism : Fishes.
- chemical , pharmacokinetics : Nitrites, Water Pollutants, Chemical.
- chemical , toxicity : Nitrites, Water Pollutants, Chemical.
- veterinary : Methemoglobinemia.
- Animals, Lethal Dose 50, Survival Analysis, Time Factors, Tissue Distribution.
Abstract
Exposure of Siberian sturgeon (Acipenser baeri ) yearlings (172.0 ± 18 g; mean ± S.D.) to several NO-2 -N concentrations (0, 25, 130, 180 and 275 mg/l) was studied for 72 h in static tests. At 72 h, the median-lethal concentration of NO-2-N was 130 mg/l in water with high chloride content (130.5 mg/l). Nitrite exposure produced high levels of methaemoglobin (MetHb) but did not seem to cause mortality, as surviving fish showed higher levels (82.7 ± 5.6%) than torpid specimens (60.8 ± 4.5%). Levels of MetHb were unrelated to environmental and plasmatic nitrite concentrations, as both torpid and surviving fish exposed to the highest nitrite levels (275 mg/l of NO-2-N) presented similar concentrations of MetHb to those exposed to 25 mgil of NO-2 -N, thus indicating the ability of Siberian sturgeon yearlings to regulate plasmatic nitrite levels and maintain them lower than the environmental concentration of the toxicant. Nitrite exposure caused changes in the plasmatic electrolyte balance, which is characterised by extracellular hyperkalemia, high plasmatic chloride levels and low plasmatic sodium concentration. Differences between the nitrite concentration in the liver of torpid (46.3 ± 9.0 mg/l) and surviving specimens (19.1 ± 13.1 mg/l) exposed to several concentrations of NO-2 -N suggest a significant contribution of the liver in nitrite detoxification pathways, and would thus explain a possible nitrite tolerance of Siberian sturgeon yearlings.
Affiliations:
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Huertas</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratory Acuicultura, Department of Biologia Animal, Fac. Biologia, Universitat de Barcelona, Av. Diagonal, 645</s1><s2>08028 Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Espagne</country><placeName><region nuts="2" type="communauté">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université de Barcelone</orgName></affiliation></author><author><name sortKey="Gisbert, E" sort="Gisbert, E" uniqKey="Gisbert E" first="E." last="Gisbert">E. Gisbert</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratory Acuicultura, Department of Biologia Animal, Fac. Biologia, Universitat de Barcelona, Av. Diagonal, 645</s1><s2>08028 Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Espagne</country><placeName><region nuts="2" type="communauté">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université de Barcelone</orgName></affiliation></author><author><name sortKey="Rodriguez, A" sort="Rodriguez, A" uniqKey="Rodriguez A" first="A." last="Rodriguez">A. Rodriguez</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratory Acuicultura, Department of Biologia Animal, Fac. Biologia, Universitat de Barcelona, Av. Diagonal, 645</s1><s2>08028 Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Espagne</country><placeName><region nuts="2" type="communauté">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université de Barcelone</orgName></affiliation></author><author><name sortKey="Cardona, L" sort="Cardona, L" uniqKey="Cardona L" first="L." last="Cardona">L. Cardona</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Biology, I.U.S.C., C/, Fontanella, 19</s1><s2>08010 Barcelona</s2><s3>ESP</s3><sZ>4 aut.</sZ></inist:fA14><country>Espagne</country><placeName><region nuts="2" type="communauté">Catalogne</region></placeName></affiliation></author><author><name sortKey="Williot, P" sort="Williot, P" uniqKey="Williot P" first="P." last="Williot">P. Williot</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Cemagref, Group. Bordeaux, Unité de Ressources Aquatiques Continentales, 50 av. de Verdum</s1><s2>33611 Gazinet</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Gazinet</settlement></placeName></affiliation></author><author><name sortKey="Castello Orvay, F" sort="Castello Orvay, F" uniqKey="Castello Orvay F" first="F." last="Castello-Orvay">F. Castello-Orvay</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratory Acuicultura, Department of Biologia Animal, Fac. Biologia, Universitat de Barcelona, Av. Diagonal, 645</s1><s2>08028 Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Espagne</country><placeName><region nuts="2" type="communauté">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université de Barcelone</orgName></affiliation></author></analytic><series><title level="j" type="main">Aquatic toxicology</title><title level="j" type="abbreviated">Aquat. toxicol.</title><idno type="ISSN">0166-445X</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Aquatic toxicology</title><title level="j" type="abbreviated">Aquat. toxicol.</title><idno type="ISSN">0166-445X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acipenser baeri</term><term>Acute</term><term>Animals</term><term>Biological accumulation</term><term>Exposure</term><term>Fish Diseases (chemically induced)</term><term>Fishes (metabolism)</term><term>Hematology</term><term>Lethal Dose 50</term><term>Lethal dose 50</term><term>Methemoglobin (analysis)</term><term>Methemoglobinemia</term><term>Methemoglobinemia (chemically induced)</term><term>Methemoglobinemia (veterinary)</term><term>Nitrites</term><term>Nitrites (pharmacokinetics)</term><term>Nitrites (toxicity)</term><term>Survival Analysis</term><term>Time Factors</term><term>Tissue Distribution</term><term>Toxicity</term><term>Water Pollutants, Chemical (pharmacokinetics)</term><term>Water Pollutants, Chemical (toxicity)</term><term>Young animal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Methemoglobin</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Fish Diseases</term><term>Methemoglobinemia</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Fishes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Nitrites</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Nitrites</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Methemoglobinemia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Lethal Dose 50</term><term>Survival Analysis</term><term>Time Factors</term><term>Tissue Distribution</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Aigu</term><term>Exposition</term><term>Animal jeune</term><term>Nitrite</term><term>Accumulation biologique</term><term>Toxicité</term><term>Dose létale 50</term><term>Hématologie</term><term>Méthémoglobinémie</term><term>Acipenser baeri</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Exposure of Siberian sturgeon (Acipenser baeri ) yearlings (172.0 ± 18 g; mean ± S.D.) to several NO<sup>-</sup><sub>2</sub> -N concentrations (0, 25, 130, 180 and 275 mg/l) was studied for 72 h in static tests. At 72 h, the median-lethal concentration of NO<sup>-</sup><sub>2</sub>-N was 130 mg/l in water with high chloride content (130.5 mg/l). Nitrite exposure produced high levels of methaemoglobin (MetHb) but did not seem to cause mortality, as surviving fish showed higher levels (82.7 ± 5.6%) than torpid specimens (60.8 ± 4.5%). Levels of MetHb were unrelated to environmental and plasmatic nitrite concentrations, as both torpid and surviving fish exposed to the highest nitrite levels (275 mg/l of NO<sup>-</sup><sub>2</sub>-N) presented similar concentrations of MetHb to those exposed to 25 mgil of NO<sup>-</sup><sub>2</sub> -N, thus indicating the ability of Siberian sturgeon yearlings to regulate plasmatic nitrite levels and maintain them lower than the environmental concentration of the toxicant. Nitrite exposure caused changes in the plasmatic electrolyte balance, which is characterised by extracellular hyperkalemia, high plasmatic chloride levels and low plasmatic sodium concentration. Differences between the nitrite concentration in the liver of torpid (46.3 ± 9.0 mg/l) and surviving specimens (19.1 ± 13.1 mg/l) exposed to several concentrations of NO<sup>-</sup><sub>2</sub> -N suggest a significant contribution of the liver in nitrite detoxification pathways, and would thus explain a possible nitrite tolerance of Siberian sturgeon yearlings.</div></front></TEI><affiliations><list><country><li>Espagne</li><li>France</li></country><region><li>Aquitaine</li><li>Catalogne</li><li>Nouvelle-Aquitaine</li></region><settlement><li>Barcelone</li><li>Gazinet</li></settlement><orgName><li>Université de Barcelone</li></orgName></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Huertas, M" sort="Huertas, M" uniqKey="Huertas M" first="M." last="Huertas">M. Huertas</name></region><name sortKey="Cardona, L" sort="Cardona, L" uniqKey="Cardona L" first="L." last="Cardona">L. Cardona</name><name sortKey="Castello Orvay, F" sort="Castello Orvay, F" uniqKey="Castello Orvay F" first="F." last="Castello-Orvay">F. Castello-Orvay</name><name sortKey="Gisbert, E" sort="Gisbert, E" uniqKey="Gisbert E" first="E." last="Gisbert">E. Gisbert</name><name sortKey="Rodriguez, A" sort="Rodriguez, A" uniqKey="Rodriguez A" first="A." last="Rodriguez">A. Rodriguez</name></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Williot, P" sort="Williot, P" uniqKey="Williot P" first="P." last="Williot">P. Williot</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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