Acute exposure of Siberian sturgeon (Acipenser baeri, Brandt) yearlings to nitrite: median-lethal concentration (LC(50)) determination, haematological changes and nitrite accumulation in selected tissues.
Identifieur interne : 000050 ( Ncbi/Merge ); précédent : 000049; suivant : 000051Acute exposure of Siberian sturgeon (Acipenser baeri, Brandt) yearlings to nitrite: median-lethal concentration (LC(50)) determination, haematological changes and nitrite accumulation in selected tissues.
Auteurs : M. Huertas [Espagne] ; Enric Gisbert [Espagne] ; A. Rodríguez ; L. Cardona ; Patrick Williot [France] ; F. Castell OrvaySource :
- Aquatic toxicology (Amsterdam, Netherlands) [ 0166-445X ] ; 2002.
English descriptors
- KwdEn :
- Animals, Fish Diseases (chemically induced), Fishes (metabolism), Lethal Dose 50, Methemoglobin (analysis), Methemoglobinemia (chemically induced), Methemoglobinemia (veterinary), Nitrites (pharmacokinetics), Nitrites (toxicity), Survival Analysis, Time Factors, Tissue Distribution, Water Pollutants, Chemical (pharmacokinetics), Water Pollutants, Chemical (toxicity).
- MESH :
- chemical , analysis : Methemoglobin.
- chemically induced : Fish Diseases, Methemoglobinemia.
- metabolism : Fishes.
- chemical , pharmacokinetics : Nitrites, Water Pollutants, Chemical.
- chemical , toxicity : Nitrites, Water Pollutants, Chemical.
- veterinary : Methemoglobinemia.
- Animals, Lethal Dose 50, Survival Analysis, Time Factors, Tissue Distribution.
Abstract
Exposure of Siberian sturgeon (Acipenser baeri) yearlings (172.0+/-18 g; mean+/-S.D.) to several NO(2)(-)-N concentrations (0, 25, 130, 180 and 275 mg/l) was studied for 72 h in static tests. At 72 h, the median-lethal concentration of NO(2)(-)-N was 130 mg/l in water with high chloride content (130.5 mg/l). Nitrite exposure produced high levels of methaemoglobin (MetHb) but did not seem to cause mortality, as surviving fish showed higher levels (82.7+/-5.6%) than torpid specimens (60.8+/-4.5%). Levels of MetHb were unrelated to environmental and plasmatic nitrite concentrations, as both torpid and surviving fish exposed to the highest nitrite levels (275 mg/l of NO(2)(-)-N) presented similar concentrations of MetHb to those exposed to 25 mg/l of NO(2)(-)-N, thus indicating the ability of Siberian sturgeon yearlings to regulate plasmatic nitrite levels and maintain them lower than the environmental concentration of the toxicant. Nitrite exposure caused changes in the plasmatic electrolyte balance, which is characterised by extracellular hyperkalemia, high plasmatic chloride levels and low plasmatic sodium concentration. Differences between the nitrite concentration in the liver of torpid (46.3+/-9.0 mg/l) and surviving specimens (19.1+/-13.1 mg/l) exposed to several concentrations of NO(2)(-)-N suggest a significant contribution of the liver in nitrite detoxification pathways, and would thus explain a possible nitrite tolerance of Siberian sturgeon yearlings.
PubMed: 11932005
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pubmed:11932005Le document en format XML
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Cardona</name></author><author><name sortKey="Williot, P" sort="Williot, P" uniqKey="Williot P" first="P" last="Williot">Patrick Williot</name><affiliation><country>France</country><placeName><settlement type="city">Bordeaux</settlement><settlement type="town">Cestas</settlement><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName><orgName type="laboratoire" n="5">Cemagref - centre de Bordeaux</orgName><orgName type="institution">Centre national du machinisme agricole, du génie rural, des eaux et des forêts</orgName><orgName type="institution">Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture</orgName></affiliation></author><author><name sortKey="Castell Orvay, F" sort="Castell Orvay, F" uniqKey="Castell Orvay F" first="F" last="Castell Orvay">F. 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Huertas</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory Acuicultura, Department of Biologia Animal, Fac. Biologia, Universitat de Barcelona, Av. Diagonal, 645, E-08028 Barcelona, Spain. huertas@porthos.bio.ub.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Laboratory Acuicultura, Department of Biologia Animal, Fac. Biologia, Universitat de Barcelona, Av. Diagonal, 645, E-08028 Barcelona</wicri:regionArea><placeName><region nuts="2" type="communauté">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université de Barcelone</orgName></affiliation></author><author><name sortKey="Gisbert, E" sort="Gisbert, E" uniqKey="Gisbert E" first="E" last="Gisbert">Enric Gisbert</name><affiliation><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université de Barcelone</orgName></affiliation></author><author><name sortKey="Rodriguez, A" sort="Rodriguez, A" uniqKey="Rodriguez A" first="A" last="Rodríguez">A. Rodríguez</name></author><author><name sortKey="Cardona, L" sort="Cardona, L" uniqKey="Cardona L" first="L" last="Cardona">L. Cardona</name></author><author><name sortKey="Williot, P" sort="Williot, P" uniqKey="Williot P" first="P" last="Williot">Patrick Williot</name><affiliation><country>France</country><placeName><settlement type="city">Bordeaux</settlement><settlement type="town">Cestas</settlement><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName><orgName type="laboratoire" n="5">Cemagref - centre de Bordeaux</orgName><orgName type="institution">Centre national du machinisme agricole, du génie rural, des eaux et des forêts</orgName><orgName type="institution">Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture</orgName></affiliation></author><author><name sortKey="Castell Orvay, F" sort="Castell Orvay, F" uniqKey="Castell Orvay F" first="F" last="Castell Orvay">F. Castell Orvay</name></author></analytic><series><title level="j">Aquatic toxicology (Amsterdam, Netherlands)</title><idno type="ISSN">0166-445X</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Fish Diseases (chemically induced)</term><term>Fishes (metabolism)</term><term>Lethal Dose 50</term><term>Methemoglobin (analysis)</term><term>Methemoglobinemia (chemically induced)</term><term>Methemoglobinemia (veterinary)</term><term>Nitrites (pharmacokinetics)</term><term>Nitrites (toxicity)</term><term>Survival Analysis</term><term>Time Factors</term><term>Tissue Distribution</term><term>Water Pollutants, Chemical (pharmacokinetics)</term><term>Water Pollutants, Chemical (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Methemoglobin</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Fish Diseases</term><term>Methemoglobinemia</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Fishes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Nitrites</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Nitrites</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Methemoglobinemia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Lethal Dose 50</term><term>Survival Analysis</term><term>Time Factors</term><term>Tissue Distribution</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Exposure of Siberian sturgeon (Acipenser baeri) yearlings (172.0+/-18 g; mean+/-S.D.) to several NO(2)(-)-N concentrations (0, 25, 130, 180 and 275 mg/l) was studied for 72 h in static tests. At 72 h, the median-lethal concentration of NO(2)(-)-N was 130 mg/l in water with high chloride content (130.5 mg/l). Nitrite exposure produced high levels of methaemoglobin (MetHb) but did not seem to cause mortality, as surviving fish showed higher levels (82.7+/-5.6%) than torpid specimens (60.8+/-4.5%). Levels of MetHb were unrelated to environmental and plasmatic nitrite concentrations, as both torpid and surviving fish exposed to the highest nitrite levels (275 mg/l of NO(2)(-)-N) presented similar concentrations of MetHb to those exposed to 25 mg/l of NO(2)(-)-N, thus indicating the ability of Siberian sturgeon yearlings to regulate plasmatic nitrite levels and maintain them lower than the environmental concentration of the toxicant. Nitrite exposure caused changes in the plasmatic electrolyte balance, which is characterised by extracellular hyperkalemia, high plasmatic chloride levels and low plasmatic sodium concentration. Differences between the nitrite concentration in the liver of torpid (46.3+/-9.0 mg/l) and surviving specimens (19.1+/-13.1 mg/l) exposed to several concentrations of NO(2)(-)-N suggest a significant contribution of the liver in nitrite detoxification pathways, and would thus explain a possible nitrite tolerance of Siberian sturgeon yearlings.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11932005</PMID><DateCreated><Year>2002</Year><Month>04</Month><Day>04</Day></DateCreated><DateCompleted><Year>2002</Year><Month>08</Month><Day>06</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0166-445X</ISSN><JournalIssue CitedMedium="Print"><Volume>57</Volume><Issue>4</Issue><PubDate><Year>2002</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Aquatic toxicology (Amsterdam, Netherlands)</Title><ISOAbbreviation>Aquat. Toxicol.</ISOAbbreviation></Journal><ArticleTitle>Acute exposure of Siberian sturgeon (Acipenser baeri, Brandt) yearlings to nitrite: median-lethal concentration (LC(50)) determination, haematological changes and nitrite accumulation in selected tissues.</ArticleTitle><Pagination><MedlinePgn>257-66</MedlinePgn></Pagination><Abstract><AbstractText>Exposure of Siberian sturgeon (Acipenser baeri) yearlings (172.0+/-18 g; mean+/-S.D.) to several NO(2)(-)-N concentrations (0, 25, 130, 180 and 275 mg/l) was studied for 72 h in static tests. At 72 h, the median-lethal concentration of NO(2)(-)-N was 130 mg/l in water with high chloride content (130.5 mg/l). Nitrite exposure produced high levels of methaemoglobin (MetHb) but did not seem to cause mortality, as surviving fish showed higher levels (82.7+/-5.6%) than torpid specimens (60.8+/-4.5%). Levels of MetHb were unrelated to environmental and plasmatic nitrite concentrations, as both torpid and surviving fish exposed to the highest nitrite levels (275 mg/l of NO(2)(-)-N) presented similar concentrations of MetHb to those exposed to 25 mg/l of NO(2)(-)-N, thus indicating the ability of Siberian sturgeon yearlings to regulate plasmatic nitrite levels and maintain them lower than the environmental concentration of the toxicant. Nitrite exposure caused changes in the plasmatic electrolyte balance, which is characterised by extracellular hyperkalemia, high plasmatic chloride levels and low plasmatic sodium concentration. Differences between the nitrite concentration in the liver of torpid (46.3+/-9.0 mg/l) and surviving specimens (19.1+/-13.1 mg/l) exposed to several concentrations of NO(2)(-)-N suggest a significant contribution of the liver in nitrite detoxification pathways, and would thus explain a possible nitrite tolerance of Siberian sturgeon yearlings.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Huertas</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory Acuicultura, Department of Biologia Animal, Fac. Biologia, Universitat de Barcelona, Av. Diagonal, 645, E-08028 Barcelona, Spain. huertas@porthos.bio.ub.es</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gisbert</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Rodríguez</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Cardona</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Williot</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Castelló-Orvay</LastName><ForeName>F</ForeName><Initials>F</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Aquat Toxicol</MedlineTA><NlmUniqueID>8500246</NlmUniqueID><ISSNLinking>0166-445X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009573">Nitrites</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014874">Water Pollutants, Chemical</NameOfSubstance></Chemical><Chemical><RegistryNumber>9008-37-1</RegistryNumber><NameOfSubstance UI="D008706">Methemoglobin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005393" MajorTopicYN="N">Fish Diseases</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005399" MajorTopicYN="N">Fishes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007928" MajorTopicYN="N">Lethal Dose 50</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008706" MajorTopicYN="N">Methemoglobin</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008708" MajorTopicYN="N">Methemoglobinemia</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009573" MajorTopicYN="N">Nitrites</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014018" MajorTopicYN="N">Tissue Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014874" MajorTopicYN="N">Water Pollutants, Chemical</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>4</Month><Day>5</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>8</Month><Day>7</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2002</Year><Month>4</Month><Day>5</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11932005</ArticleId><ArticleId IdType="pii">S0166445X01002077</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li><li>France</li></country><region><li>Aquitaine</li><li>Catalogne</li><li>Nouvelle-Aquitaine</li></region><settlement><li>Barcelone</li><li>Bordeaux</li><li>Cestas</li></settlement><orgName><li>Cemagref - centre de Bordeaux</li><li>Centre national du machinisme agricole, du génie rural, des eaux et des forêts</li><li>Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture</li><li>Université de Barcelone</li></orgName></list><tree><noCountry><name sortKey="Cardona, L" sort="Cardona, L" uniqKey="Cardona L" first="L" last="Cardona">L. Cardona</name><name sortKey="Castell Orvay, F" sort="Castell Orvay, F" uniqKey="Castell Orvay F" first="F" last="Castell Orvay">F. Castell Orvay</name><name sortKey="Rodriguez, A" sort="Rodriguez, A" uniqKey="Rodriguez A" first="A" last="Rodríguez">A. Rodríguez</name></noCountry><country name="Espagne"><region name="Catalogne"><name sortKey="Huertas, M" sort="Huertas, M" uniqKey="Huertas M" first="M" last="Huertas">M. Huertas</name></region><name sortKey="Gisbert, E" sort="Gisbert, E" uniqKey="Gisbert E" first="E" last="Gisbert">Enric Gisbert</name></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Williot, P" sort="Williot, P" uniqKey="Williot P" first="P" last="Williot">Patrick Williot</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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