Thalamo‐telencephalic pathways in the fire‐bellied toad Bombina orientalis
Identifieur interne : 001484 ( Istex/Corpus ); précédent : 001483; suivant : 001485Thalamo‐telencephalic pathways in the fire‐bellied toad Bombina orientalis
Auteurs : Frédéric Laberge ; Sabine Mühlenbrock-Lenter ; Ursula Dicke ; Gerhard RothSource :
- Journal of Comparative Neurology [ 0021-9967 ] ; 2008-06-10.
English descriptors
- KwdEn :
Abstract
It was suggested that among extant vertebrates, anuran amphibians display a brain organization closest to the ancestral tetrapod condition, and recent research suggests that anuran brains share important similarities with the brains of amniotes. The thalamus is the major source of sensory input to the telencephalon in both amphibians and amniote vertebrates, and this sensory input is critical for higher brain functions. The present study investigated the thalamo‐telencephalic pathways in the fire‐bellied toad Bombina orientalis, a basal anuran, by using a combination of retrograde tract tracing and intracellular injections with the tracer biocytin. Intracellular labeling revealed that the majority of neurons in the anterior and central thalamic nuclei project to multiple brain targets involved in behavioral modulation either through axon collaterals or en passant varicosities. Single anterior thalamic neurons target multiple regions in the forebrain and midbrain. Of note, these neurons display abundant projections to the medial amygdala and a variety of pallial areas, predominantly the anterior medial pallium. In Bombina, telencephalic projections of central thalamic neurons are restricted to the dorsal striato‐pallidum. The bed nucleus of the pallial commissure/thalamic eminence similarly targets multiple brain regions including the ventral medial pallium, but this is accomplished through a higher variety of distinct neuron types. We propose that the amphibian diencephalon exerts widespread influence in brain regions involved in behavioral modulation and that a single dorsal thalamic neuron is in a position to integrate different sensory channels and distribute the resulting information to multiple brain regions. J. Comp. Neurol. 508:806–823, 2008. © 2008 Wiley‐Liss, Inc.
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DOI: 10.1002/cne.21720
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<fundingInfo><fundingAgency>Deutsche Forschungsgemeinschaft</fundingAgency>
<fundingNumber>SFB 517</fundingNumber>
<fundingNumber>LA 2383/1‐1</fundingNumber>
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<abstractGroup><abstract type="main" xml:lang="fr"><title type="main">Abstract</title>
<p>It was suggested that among extant vertebrates, anuran amphibians display a brain organization closest to the ancestral tetrapod condition, and recent research suggests that anuran brains share important similarities with the brains of amniotes. The thalamus is the major source of sensory input to the telencephalon in both amphibians and amniote vertebrates, and this sensory input is critical for higher brain functions. The present study investigated the thalamo‐telencephalic pathways in the fire‐bellied toad <i>Bombina orientalis</i>
, a basal anuran, by using a combination of retrograde tract tracing and intracellular injections with the tracer biocytin. Intracellular labeling revealed that the majority of neurons in the anterior and central thalamic nuclei project to multiple brain targets involved in behavioral modulation either through axon collaterals or en passant varicosities. Single anterior thalamic neurons target multiple regions in the forebrain and midbrain. Of note, these neurons display abundant projections to the medial amygdala and a variety of pallial areas, predominantly the anterior medial pallium. In <i>Bombina</i>
, telencephalic projections of central thalamic neurons are restricted to the dorsal striato‐pallidum. The bed nucleus of the pallial commissure/thalamic eminence similarly targets multiple brain regions including the ventral medial pallium, but this is accomplished through a higher variety of distinct neuron types. We propose that the amphibian diencephalon exerts widespread influence in brain regions involved in behavioral modulation and that a single dorsal thalamic neuron is in a position to integrate different sensory channels and distribute the resulting information to multiple brain regions. J. Comp. Neurol. 508:806–823, 2008. © 2008 Wiley‐Liss, Inc.</p>
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<mods version="3.6"><titleInfo lang="en"><title>Thalamo‐telencephalic pathways in the fire‐bellied toad Bombina orientalis</title>
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<titleInfo type="abbreviated" lang="en"><title>Amphibian Thalamo‐Telencephalic Pathways</title>
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<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Thalamo‐telencephalic pathways in the fire‐bellied toad Bombina orientalis</title>
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<name type="personal"><namePart type="given">Frédéric</namePart>
<namePart type="family">Laberge</namePart>
<affiliation>Brain Research Institute, University of Bremen, D‐28334 Bremen, Germany</affiliation>
<affiliation>Brain Research Institute, University of Bremen, D‐28334 Bremen, Germany</affiliation>
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<name type="personal"><namePart type="given">Sabine</namePart>
<namePart type="family">Mühlenbrock‐Lenter</namePart>
<affiliation>Brain Research Institute, University of Bremen, D‐28334 Bremen, Germany</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Ursula</namePart>
<namePart type="family">Dicke</namePart>
<affiliation>Brain Research Institute, University of Bremen, D‐28334 Bremen, Germany</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Gerhard</namePart>
<namePart type="family">Roth</namePart>
<affiliation>Brain Research Institute, University of Bremen, D‐28334 Bremen, Germany</affiliation>
<affiliation>Hanse Institute for Advanced Study, 27753 Delmenhorst, Germany</affiliation>
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<dateIssued encoding="w3cdtf">2008-06-10</dateIssued>
<dateCaptured encoding="w3cdtf">2007-09-14</dateCaptured>
<dateValid encoding="w3cdtf">2008-02-12</dateValid>
<copyrightDate encoding="w3cdtf">2008</copyrightDate>
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<abstract lang="fr">It was suggested that among extant vertebrates, anuran amphibians display a brain organization closest to the ancestral tetrapod condition, and recent research suggests that anuran brains share important similarities with the brains of amniotes. The thalamus is the major source of sensory input to the telencephalon in both amphibians and amniote vertebrates, and this sensory input is critical for higher brain functions. The present study investigated the thalamo‐telencephalic pathways in the fire‐bellied toad Bombina orientalis, a basal anuran, by using a combination of retrograde tract tracing and intracellular injections with the tracer biocytin. Intracellular labeling revealed that the majority of neurons in the anterior and central thalamic nuclei project to multiple brain targets involved in behavioral modulation either through axon collaterals or en passant varicosities. Single anterior thalamic neurons target multiple regions in the forebrain and midbrain. Of note, these neurons display abundant projections to the medial amygdala and a variety of pallial areas, predominantly the anterior medial pallium. In Bombina, telencephalic projections of central thalamic neurons are restricted to the dorsal striato‐pallidum. The bed nucleus of the pallial commissure/thalamic eminence similarly targets multiple brain regions including the ventral medial pallium, but this is accomplished through a higher variety of distinct neuron types. We propose that the amphibian diencephalon exerts widespread influence in brain regions involved in behavioral modulation and that a single dorsal thalamic neuron is in a position to integrate different sensory channels and distribute the resulting information to multiple brain regions. J. Comp. Neurol. 508:806–823, 2008. © 2008 Wiley‐Liss, Inc.</abstract>
<note type="funding">Deutsche Forschungsgemeinschaft - No. SFB 517; No. LA 2383/1‐1; </note>
<subject lang="en"><genre>keywords</genre>
<topic>amphibians</topic>
<topic>thalamus</topic>
<topic>thalamic eminence</topic>
<topic>pallium</topic>
<topic>dorsal striato‐pallidum</topic>
<topic>intracellular labeling</topic>
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<relatedItem type="host"><titleInfo><title>Journal of Comparative Neurology</title>
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<identifier type="ISSN">0021-9967</identifier>
<identifier type="eISSN">1096-9861</identifier>
<identifier type="DOI">10.1002/(ISSN)1096-9861</identifier>
<identifier type="PublisherID">CNE</identifier>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>508</number>
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<detail type="issue"><caption>no.</caption>
<number>5</number>
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<extent unit="pages"><start>806</start>
<end>823</end>
<total>18</total>
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<identifier type="DOI">10.1002/cne.21720</identifier>
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<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Wiley‐Liss, Inc.</accessCondition>
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