The Development of the Metanephric Kidney in the Pig
Identifieur interne : 000991 ( Istex/Corpus ); précédent : 000990; suivant : 000992The Development of the Metanephric Kidney in the Pig
Auteurs : H. BragullaSource :
- Anatomia, Histologia, Embryologia [ 0340-2096 ] ; 2005-12.
Abstract
Aims: The metanephric kidneys of the pig are used as xenotransplants in human medicine. In order for transplants to fit within the host organisms, the subcapsular blastema and blood vessels are crucial for the development of new nephrons to sustain the organ functions. The aim of this study is to obtain data concerning the post‐natal development of metanephric nephrons in the porcine kidney.
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DOI: 10.1111/j.1439-0264.2005.00669_15.x
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Bragulla</name><affiliation><mods:affiliation>Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Freie Universität Berlin, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:583EE27BABF90E74E27530DD559D1CA1748E75C1</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1111/j.1439-0264.2005.00669_15.x</idno><idno type="url">https://api.istex.fr/document/583EE27BABF90E74E27530DD559D1CA1748E75C1/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000991</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000991</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The Development of the Metanephric Kidney in the Pig</title><author><name sortKey="Bragulla, H" sort="Bragulla, H" uniqKey="Bragulla H" first="H." last="Bragulla">H. Bragulla</name><affiliation><mods:affiliation>Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Freie Universität Berlin, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Anatomia, Histologia, Embryologia</title><idno type="ISSN">0340-2096</idno><idno type="eISSN">1439-0264</idno><imprint><publisher>Blackwell Verlag GmbH</publisher><pubPlace>Berlin, Germany</pubPlace><date type="published" when="2005-12">2005-12</date><biblScope unit="volume">34</biblScope><biblScope unit="supplement">s1</biblScope><biblScope unit="page" from="7">7</biblScope><biblScope unit="page" to="7">7</biblScope></imprint><idno type="ISSN">0340-2096</idno></series><idno type="istex">583EE27BABF90E74E27530DD559D1CA1748E75C1</idno><idno type="DOI">10.1111/j.1439-0264.2005.00669_15.x</idno><idno type="ArticleID">AHE669_15_15</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0340-2096</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Aims: The metanephric kidneys of the pig are used as xenotransplants in human medicine. 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In order for transplants to fit within the host organisms, the subcapsular blastema and blood vessels are crucial for the development of new nephrons to sustain the organ functions. The aim of this study is to obtain data concerning the post‐natal development of metanephric nephrons in the porcine kidney.</p></abstract><abstract><p>Materials and Methods: The metanephric kidneys of six porcine fetuses with a crown‐rump length ranging from 40 mm to 220 mm of eight piglets aged between 6 to 10 weeks and of three adult pigs were studied. Eight lectins as well as anti‐actin and anti‐myosin antibodies were used for lectin‐ and immunohistochemistry to study the subcapsular metanephric blastema, to visualize the blood‐urine barrier in the nephrons and collecting tubules, and to study the blood vessels in both the renal cortex and marrow.</p></abstract><abstract><p>Results and Conclusions: A subcapsular metanephric blastema was still present in the kidney of 10‐week‐old piglets. Dense condensation of mesenchymal cells surrounded the terminal branches of the collecting ducts and showed first signs of mesenchymal‐epithelial transformation. Characteristic comma‐shaped and s‐shaped bodies were found in and underneath the subcapsular blastema. In the fibrous renal capsule of six‐week‐old piglets, a first faint binding reaction of anti‐actin was visible and intensified in the fibrous renal capsule in ten‐week‐old piglets and in adult pigs. In addition, the smooth‐muscle layers of the blood vessels were stained by the anti‐actin and anti‐myosin antibodies. The lectins showed various affinities to the endothelium of blood vessels and to the epithelial cells lining of the capsules of the metanephric renal corpuscles, the various parts of the renal tubules, as well as the collecting tubules and the renal pelvis. The affinity of the epithelial cells to a specific lectin varies in neighbouring cells, indicating different cell activities or cell cycles.</p></abstract></profileDesc><revisionDesc><change when="2005-12">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-12-13">References added</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-02-9">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/583EE27BABF90E74E27530DD559D1CA1748E75C1/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley component found"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Verlag GmbH</publisherName><publisherLoc>Berlin, Germany</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1439-0264</doi><issn type="print">0340-2096</issn><issn type="electronic">1439-0264</issn><idGroup><id type="product" value="AHE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ANATOMIA HISTOLOGIA EMBRYOLOGIA">Anatomia, Histologia, Embryologia</title></titleGroup></publicationMeta><publicationMeta level="part" position="12000"><doi origin="wiley">10.1111/ahe.2005.34.issue-s1</doi><numberingGroup><numbering type="journalVolume" number="34">34</numbering><numbering type="supplement">s1</numbering></numberingGroup><coverDate startDate="2005-12">December 2005</coverDate></publicationMeta><publicationMeta level="unit" type="abstract" position="1" status="forIssue"><doi origin="wiley">10.1111/j.1439-0264.2005.00669_15.x</doi><idGroup><id type="unit" value="AHE669_15_15"></id></idGroup><titleGroup><title type="tocHeading1">Abstracts of the XXVth Congress of the European Association of Veterinary Anatomists (EAVA), Oslo, 28–31 July 2004</title></titleGroup><eventGroup><event type="firstOnline" date="2005-11-22"></event><event type="publishedOnlineFinalForm" date="2005-11-22"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.6 mode:FullText source:Header result:Header" date="2010-04-14"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="7">7</numbering><numbering type="pageLast" number="7">7</numbering></numberingGroup><linkGroup><link type="toTypesetVersion" href="file:AHE.AHE669_15_15.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">The Development of the Metanephric Kidney in the Pig</title><title type="short">Abstracts</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#aff-1-1"><personName><givenNames>H.</givenNames><familyName>Bragulla</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="aff-1-1" countryCode="DE"><unparsedAffiliation>Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Freie Universität Berlin, Germany</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Aims: </b> The metanephric kidneys of the pig are used as xenotransplants in human medicine. In order for transplants to fit within the host organisms, the subcapsular blastema and blood vessels are crucial for the development of new nephrons to sustain the organ functions. The aim of this study is to obtain data concerning the post‐natal development of metanephric nephrons in the porcine kidney.</p><p><b>Materials and Methods: </b> The metanephric kidneys of six porcine fetuses with a crown‐rump length ranging from 40 mm to 220 mm of eight piglets aged between 6 to 10 weeks and of three adult pigs were studied. Eight lectins as well as anti‐actin and anti‐myosin antibodies were used for lectin‐ and immunohistochemistry to study the subcapsular metanephric blastema, to visualize the blood‐urine barrier in the nephrons and collecting tubules, and to study the blood vessels in both the renal cortex and marrow.</p><p><b>Results and Conclusions: </b> A subcapsular metanephric blastema was still present in the kidney of 10‐week‐old piglets. Dense condensation of mesenchymal cells surrounded the terminal branches of the collecting ducts and showed first signs of mesenchymal‐epithelial transformation. Characteristic comma‐shaped and s‐shaped bodies were found in and underneath the subcapsular blastema. In the fibrous renal capsule of six‐week‐old piglets, a first faint binding reaction of anti‐actin was visible and intensified in the fibrous renal capsule in ten‐week‐old piglets and in adult pigs. In addition, the smooth‐muscle layers of the blood vessels were stained by the anti‐actin and anti‐myosin antibodies. The lectins showed various affinities to the endothelium of blood vessels and to the epithelial cells lining of the capsules of the metanephric renal corpuscles, the various parts of the renal tubules, as well as the collecting tubules and the renal pelvis. The affinity of the epithelial cells to a specific lectin varies in neighbouring cells, indicating different cell activities or cell cycles.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The Development of the Metanephric Kidney in the Pig</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Abstracts</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The Development of the Metanephric Kidney in the Pig</title></titleInfo><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Bragulla</namePart><affiliation>Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Freie Universität Berlin, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="abstract" displayLabel="abstract"></genre><originInfo><publisher>Blackwell Verlag GmbH</publisher><place><placeTerm type="text">Berlin, Germany</placeTerm></place><dateIssued encoding="w3cdtf">2005-12</dateIssued><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Aims: The metanephric kidneys of the pig are used as xenotransplants in human medicine. In order for transplants to fit within the host organisms, the subcapsular blastema and blood vessels are crucial for the development of new nephrons to sustain the organ functions. The aim of this study is to obtain data concerning the post‐natal development of metanephric nephrons in the porcine kidney.</abstract><abstract>Materials and Methods: The metanephric kidneys of six porcine fetuses with a crown‐rump length ranging from 40 mm to 220 mm of eight piglets aged between 6 to 10 weeks and of three adult pigs were studied. Eight lectins as well as anti‐actin and anti‐myosin antibodies were used for lectin‐ and immunohistochemistry to study the subcapsular metanephric blastema, to visualize the blood‐urine barrier in the nephrons and collecting tubules, and to study the blood vessels in both the renal cortex and marrow.</abstract><abstract>Results and Conclusions: A subcapsular metanephric blastema was still present in the kidney of 10‐week‐old piglets. Dense condensation of mesenchymal cells surrounded the terminal branches of the collecting ducts and showed first signs of mesenchymal‐epithelial transformation. Characteristic comma‐shaped and s‐shaped bodies were found in and underneath the subcapsular blastema. In the fibrous renal capsule of six‐week‐old piglets, a first faint binding reaction of anti‐actin was visible and intensified in the fibrous renal capsule in ten‐week‐old piglets and in adult pigs. In addition, the smooth‐muscle layers of the blood vessels were stained by the anti‐actin and anti‐myosin antibodies. The lectins showed various affinities to the endothelium of blood vessels and to the epithelial cells lining of the capsules of the metanephric renal corpuscles, the various parts of the renal tubules, as well as the collecting tubules and the renal pelvis. 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