New Approach to Prepare Willow Bark Extract-Lipid Based Nanosystems with Enhanced Antioxidant Activity.
Identifieur interne : 000E70 ( Main/Exploration ); précédent : 000E69; suivant : 000E71New Approach to Prepare Willow Bark Extract-Lipid Based Nanosystems with Enhanced Antioxidant Activity.
Auteurs : Elena Mitrea ; Ioana Lacatusu ; Nicoleta Badea ; Cristina Ott ; Ovidiu Oprea ; Aurelia MegheaSource :
- Journal of nanoscience and nanotechnology [ 1533-4880 ] ; 2015.
Descripteurs français
- KwdFr :
- Antioxydants (composition chimique), Extraits de plantes (composition chimique), Huiles de poisson (composition chimique), Nanoparticules (composition chimique), Salix (composition chimique), Stabilité de médicament (MeSH), Taille de particule (MeSH), Vecteurs de médicaments (composition chimique), Écorce (composition chimique).
- MESH :
- composition chimique : Antioxydants, Extraits de plantes, Huiles de poisson, Nanoparticules, Salix, Vecteurs de médicaments, Écorce.
- Stabilité de médicament, Taille de particule.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Antioxidants, Drug Carriers, Fish Oils, Plant Extracts.
- chemistry : Nanoparticles, Plant Bark, Salix.
- Drug Stability, Particle Size.
Abstract
In this study the conventional oils used for lipid nanocarriers (NLCs) synthesis were replaced by high concentration of fish oils (e.g., fish oil concentrated in omega-3 fatty acids, fish oil enriched in omega-3 and omega-6 fatty acids and salmon oil), in order to produce appropriate lipid based nanosystems able to entrap willow bark extract (WBE). Formulation factors such as the nature of the fish oil, glycerol content and WBE loading were evaluated to produce optimum lipid based nanosystems with suitable physical stability and enhanced antioxidant activity. The synthesized WBE-NLC showed spherical and homogeneous particles and average diameters in the range of 200-250 nm, as determined by TEM measurements. The electrokinetic potentials were negative for all free- and WBE-loaded NLCs, with values between -29.1 ÷ - 35.8 mV, which reveal an excellent physical stability. By scanning calorimetry measurements it has been shown that the lipid crystallization and melting behavior of NLCs before and after loading with WBE were no significantly influenced by the type of fish oil used and only in a few NLCs formulations an obvious perturbation of lipid network have been detected. The chemiluminescence technique has been used to assess the effect of fish oil type on the in vitro antioxidant activity of WBE-NLCs. Ability of WBE entrapped within NLCs to scavange the free radicals was greater than for native WBE and fish oils. The difference between the antioxidant activity of WBE-NLC (98%) and those of pure WBE (AA% = 77.2) and fish oil (AA% = 83.7), may be explained by the occurrence of a synergistic effect between the components of lipid nanocarriers.
DOI: 10.1166/jnn.2015.9162
PubMed: 26369015
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<author><name sortKey="Lacatusu, Ioana" sort="Lacatusu, Ioana" uniqKey="Lacatusu I" first="Ioana" last="Lacatusu">Ioana Lacatusu</name>
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<author><name sortKey="Badea, Nicoleta" sort="Badea, Nicoleta" uniqKey="Badea N" first="Nicoleta" last="Badea">Nicoleta Badea</name>
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<author><name sortKey="Ott, Cristina" sort="Ott, Cristina" uniqKey="Ott C" first="Cristina" last="Ott">Cristina Ott</name>
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<author><name sortKey="Oprea, Ovidiu" sort="Oprea, Ovidiu" uniqKey="Oprea O" first="Ovidiu" last="Oprea">Ovidiu Oprea</name>
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<term>Nanoparticles (chemistry)</term>
<term>Particle Size (MeSH)</term>
<term>Plant Bark (chemistry)</term>
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<term>Salix (composition chimique)</term>
<term>Stabilité de médicament (MeSH)</term>
<term>Taille de particule (MeSH)</term>
<term>Vecteurs de médicaments (composition chimique)</term>
<term>Écorce (composition chimique)</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antioxidants</term>
<term>Drug Carriers</term>
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<term>Extraits de plantes</term>
<term>Huiles de poisson</term>
<term>Nanoparticules</term>
<term>Salix</term>
<term>Vecteurs de médicaments</term>
<term>Écorce</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Drug Stability</term>
<term>Particle Size</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Stabilité de médicament</term>
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<front><div type="abstract" xml:lang="en">In this study the conventional oils used for lipid nanocarriers (NLCs) synthesis were replaced by high concentration of fish oils (e.g., fish oil concentrated in omega-3 fatty acids, fish oil enriched in omega-3 and omega-6 fatty acids and salmon oil), in order to produce appropriate lipid based nanosystems able to entrap willow bark extract (WBE). Formulation factors such as the nature of the fish oil, glycerol content and WBE loading were evaluated to produce optimum lipid based nanosystems with suitable physical stability and enhanced antioxidant activity. The synthesized WBE-NLC showed spherical and homogeneous particles and average diameters in the range of 200-250 nm, as determined by TEM measurements. The electrokinetic potentials were negative for all free- and WBE-loaded NLCs, with values between -29.1 ÷ - 35.8 mV, which reveal an excellent physical stability. By scanning calorimetry measurements it has been shown that the lipid crystallization and melting behavior of NLCs before and after loading with WBE were no significantly influenced by the type of fish oil used and only in a few NLCs formulations an obvious perturbation of lipid network have been detected. The chemiluminescence technique has been used to assess the effect of fish oil type on the in vitro antioxidant activity of WBE-NLCs. Ability of WBE entrapped within NLCs to scavange the free radicals was greater than for native WBE and fish oils. The difference between the antioxidant activity of WBE-NLC (98%) and those of pure WBE (AA% = 77.2) and fish oil (AA% = 83.7), may be explained by the occurrence of a synergistic effect between the components of lipid nanocarriers.</div>
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<Abstract><AbstractText>In this study the conventional oils used for lipid nanocarriers (NLCs) synthesis were replaced by high concentration of fish oils (e.g., fish oil concentrated in omega-3 fatty acids, fish oil enriched in omega-3 and omega-6 fatty acids and salmon oil), in order to produce appropriate lipid based nanosystems able to entrap willow bark extract (WBE). Formulation factors such as the nature of the fish oil, glycerol content and WBE loading were evaluated to produce optimum lipid based nanosystems with suitable physical stability and enhanced antioxidant activity. The synthesized WBE-NLC showed spherical and homogeneous particles and average diameters in the range of 200-250 nm, as determined by TEM measurements. The electrokinetic potentials were negative for all free- and WBE-loaded NLCs, with values between -29.1 ÷ - 35.8 mV, which reveal an excellent physical stability. By scanning calorimetry measurements it has been shown that the lipid crystallization and melting behavior of NLCs before and after loading with WBE were no significantly influenced by the type of fish oil used and only in a few NLCs formulations an obvious perturbation of lipid network have been detected. The chemiluminescence technique has been used to assess the effect of fish oil type on the in vitro antioxidant activity of WBE-NLCs. Ability of WBE entrapped within NLCs to scavange the free radicals was greater than for native WBE and fish oils. The difference between the antioxidant activity of WBE-NLC (98%) and those of pure WBE (AA% = 77.2) and fish oil (AA% = 83.7), may be explained by the occurrence of a synergistic effect between the components of lipid nanocarriers.</AbstractText>
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<name sortKey="Lacatusu, Ioana" sort="Lacatusu, Ioana" uniqKey="Lacatusu I" first="Ioana" last="Lacatusu">Ioana Lacatusu</name>
<name sortKey="Meghea, Aurelia" sort="Meghea, Aurelia" uniqKey="Meghea A" first="Aurelia" last="Meghea">Aurelia Meghea</name>
<name sortKey="Mitrea, Elena" sort="Mitrea, Elena" uniqKey="Mitrea E" first="Elena" last="Mitrea">Elena Mitrea</name>
<name sortKey="Oprea, Ovidiu" sort="Oprea, Ovidiu" uniqKey="Oprea O" first="Ovidiu" last="Oprea">Ovidiu Oprea</name>
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