New Approach to Prepare Willow Bark Extract-Lipid Based Nanosystems with Enhanced Antioxidant Activity.
Identifieur interne : 000E19 ( Main/Corpus ); précédent : 000E18; suivant : 000E20New Approach to Prepare Willow Bark Extract-Lipid Based Nanosystems with Enhanced Antioxidant Activity.
Auteurs : Elena Mitrea ; Ioana Lacatusu ; Nicoleta Badea ; Cristina Ott ; Ovidiu Oprea ; Aurelia MegheaSource :
- Journal of nanoscience and nanotechnology [ 1533-4880 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Antioxidants, Drug Carriers, Fish Oils, Plant Extracts.
- chemistry : Nanoparticles, Plant Bark, Salix.
- Drug Stability, Particle Size.
Abstract
In this study the conventional oils used for lipid nanocarriers (NLCs) synthesis were replaced by high concentration of fish oils (e.g., fish oil concentrated in omega-3 fatty acids, fish oil enriched in omega-3 and omega-6 fatty acids and salmon oil), in order to produce appropriate lipid based nanosystems able to entrap willow bark extract (WBE). Formulation factors such as the nature of the fish oil, glycerol content and WBE loading were evaluated to produce optimum lipid based nanosystems with suitable physical stability and enhanced antioxidant activity. The synthesized WBE-NLC showed spherical and homogeneous particles and average diameters in the range of 200-250 nm, as determined by TEM measurements. The electrokinetic potentials were negative for all free- and WBE-loaded NLCs, with values between -29.1 ÷ - 35.8 mV, which reveal an excellent physical stability. By scanning calorimetry measurements it has been shown that the lipid crystallization and melting behavior of NLCs before and after loading with WBE were no significantly influenced by the type of fish oil used and only in a few NLCs formulations an obvious perturbation of lipid network have been detected. The chemiluminescence technique has been used to assess the effect of fish oil type on the in vitro antioxidant activity of WBE-NLCs. Ability of WBE entrapped within NLCs to scavange the free radicals was greater than for native WBE and fish oils. The difference between the antioxidant activity of WBE-NLC (98%) and those of pure WBE (AA% = 77.2) and fish oil (AA% = 83.7), may be explained by the occurrence of a synergistic effect between the components of lipid nanocarriers.
DOI: 10.1166/jnn.2015.9162
PubMed: 26369015
Links to Exploration step
pubmed:26369015Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">New Approach to Prepare Willow Bark Extract-Lipid Based Nanosystems with Enhanced Antioxidant Activity.</title><author><name sortKey="Mitrea, Elena" sort="Mitrea, Elena" uniqKey="Mitrea E" first="Elena" last="Mitrea">Elena Mitrea</name></author><author><name sortKey="Lacatusu, Ioana" sort="Lacatusu, Ioana" uniqKey="Lacatusu I" first="Ioana" last="Lacatusu">Ioana Lacatusu</name></author><author><name sortKey="Badea, Nicoleta" sort="Badea, Nicoleta" uniqKey="Badea N" first="Nicoleta" last="Badea">Nicoleta Badea</name></author><author><name sortKey="Ott, Cristina" sort="Ott, Cristina" uniqKey="Ott C" first="Cristina" last="Ott">Cristina Ott</name></author><author><name sortKey="Oprea, Ovidiu" sort="Oprea, Ovidiu" uniqKey="Oprea O" first="Ovidiu" last="Oprea">Ovidiu Oprea</name></author><author><name sortKey="Meghea, Aurelia" sort="Meghea, Aurelia" uniqKey="Meghea A" first="Aurelia" last="Meghea">Aurelia Meghea</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26369015</idno><idno type="pmid">26369015</idno><idno type="doi">10.1166/jnn.2015.9162</idno><idno type="wicri:Area/Main/Corpus">000E19</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000E19</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">New Approach to Prepare Willow Bark Extract-Lipid Based Nanosystems with Enhanced Antioxidant Activity.</title><author><name sortKey="Mitrea, Elena" sort="Mitrea, Elena" uniqKey="Mitrea E" first="Elena" last="Mitrea">Elena Mitrea</name></author><author><name sortKey="Lacatusu, Ioana" sort="Lacatusu, Ioana" uniqKey="Lacatusu I" first="Ioana" last="Lacatusu">Ioana Lacatusu</name></author><author><name sortKey="Badea, Nicoleta" sort="Badea, Nicoleta" uniqKey="Badea N" first="Nicoleta" last="Badea">Nicoleta Badea</name></author><author><name sortKey="Ott, Cristina" sort="Ott, Cristina" uniqKey="Ott C" first="Cristina" last="Ott">Cristina Ott</name></author><author><name sortKey="Oprea, Ovidiu" sort="Oprea, Ovidiu" uniqKey="Oprea O" first="Ovidiu" last="Oprea">Ovidiu Oprea</name></author><author><name sortKey="Meghea, Aurelia" sort="Meghea, Aurelia" uniqKey="Meghea A" first="Aurelia" last="Meghea">Aurelia Meghea</name></author></analytic><series><title level="j">Journal of nanoscience and nanotechnology</title><idno type="ISSN">1533-4880</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antioxidants (chemistry)</term><term>Drug Carriers (chemistry)</term><term>Drug Stability (MeSH)</term><term>Fish Oils (chemistry)</term><term>Nanoparticles (chemistry)</term><term>Particle Size (MeSH)</term><term>Plant Bark (chemistry)</term><term>Plant Extracts (chemistry)</term><term>Salix (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antioxidants</term><term>Drug Carriers</term><term>Fish Oils</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanoparticles</term><term>Plant Bark</term><term>Salix</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Stability</term><term>Particle Size</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study the conventional oils used for lipid nanocarriers (NLCs) synthesis were replaced by high concentration of fish oils (e.g., fish oil concentrated in omega-3 fatty acids, fish oil enriched in omega-3 and omega-6 fatty acids and salmon oil), in order to produce appropriate lipid based nanosystems able to entrap willow bark extract (WBE). Formulation factors such as the nature of the fish oil, glycerol content and WBE loading were evaluated to produce optimum lipid based nanosystems with suitable physical stability and enhanced antioxidant activity. The synthesized WBE-NLC showed spherical and homogeneous particles and average diameters in the range of 200-250 nm, as determined by TEM measurements. The electrokinetic potentials were negative for all free- and WBE-loaded NLCs, with values between -29.1 ÷ - 35.8 mV, which reveal an excellent physical stability. By scanning calorimetry measurements it has been shown that the lipid crystallization and melting behavior of NLCs before and after loading with WBE were no significantly influenced by the type of fish oil used and only in a few NLCs formulations an obvious perturbation of lipid network have been detected. The chemiluminescence technique has been used to assess the effect of fish oil type on the in vitro antioxidant activity of WBE-NLCs. Ability of WBE entrapped within NLCs to scavange the free radicals was greater than for native WBE and fish oils. The difference between the antioxidant activity of WBE-NLC (98%) and those of pure WBE (AA% = 77.2) and fish oil (AA% = 83.7), may be explained by the occurrence of a synergistic effect between the components of lipid nanocarriers.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26369015</PMID><DateCompleted><Year>2015</Year><Month>11</Month><Day>06</Day></DateCompleted><DateRevised><Year>2019</Year><Month>07</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1533-4880</ISSN><JournalIssue CitedMedium="Print"><Volume>15</Volume><Issue>6</Issue><PubDate><Year>2015</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Journal of nanoscience and nanotechnology</Title><ISOAbbreviation>J Nanosci Nanotechnol</ISOAbbreviation></Journal><ArticleTitle>New Approach to Prepare Willow Bark Extract-Lipid Based Nanosystems with Enhanced Antioxidant Activity.</ArticleTitle><Pagination><MedlinePgn>4080-9</MedlinePgn></Pagination><Abstract><AbstractText>In this study the conventional oils used for lipid nanocarriers (NLCs) synthesis were replaced by high concentration of fish oils (e.g., fish oil concentrated in omega-3 fatty acids, fish oil enriched in omega-3 and omega-6 fatty acids and salmon oil), in order to produce appropriate lipid based nanosystems able to entrap willow bark extract (WBE). Formulation factors such as the nature of the fish oil, glycerol content and WBE loading were evaluated to produce optimum lipid based nanosystems with suitable physical stability and enhanced antioxidant activity. The synthesized WBE-NLC showed spherical and homogeneous particles and average diameters in the range of 200-250 nm, as determined by TEM measurements. The electrokinetic potentials were negative for all free- and WBE-loaded NLCs, with values between -29.1 ÷ - 35.8 mV, which reveal an excellent physical stability. By scanning calorimetry measurements it has been shown that the lipid crystallization and melting behavior of NLCs before and after loading with WBE were no significantly influenced by the type of fish oil used and only in a few NLCs formulations an obvious perturbation of lipid network have been detected. The chemiluminescence technique has been used to assess the effect of fish oil type on the in vitro antioxidant activity of WBE-NLCs. Ability of WBE entrapped within NLCs to scavange the free radicals was greater than for native WBE and fish oils. The difference between the antioxidant activity of WBE-NLC (98%) and those of pure WBE (AA% = 77.2) and fish oil (AA% = 83.7), may be explained by the occurrence of a synergistic effect between the components of lipid nanocarriers.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mitrea</LastName><ForeName>Elena</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Lacatusu</LastName><ForeName>Ioana</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Badea</LastName><ForeName>Nicoleta</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Ott</LastName><ForeName>Cristina</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Oprea</LastName><ForeName>Ovidiu</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Meghea</LastName><ForeName>Aurelia</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Nanosci Nanotechnol</MedlineTA><NlmUniqueID>101088195</NlmUniqueID><ISSNLinking>1533-4880</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004337">Drug Carriers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005395">Fish Oils</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004337" MajorTopicYN="N">Drug Carriers</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004355" MajorTopicYN="N">Drug Stability</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005395" MajorTopicYN="N">Fish Oils</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053758" MajorTopicYN="N">Nanoparticles</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010316" MajorTopicYN="N">Particle Size</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D024301" MajorTopicYN="N">Plant Bark</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032108" MajorTopicYN="N">Salix</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>9</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>9</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>11</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26369015</ArticleId><ArticleId IdType="doi">10.1166/jnn.2015.9162</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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