Functional characterization of the heterodimeric sweet taste receptor T1R2 and T1R3 from a New World monkey species (squirrel monkey) and its response to sweet-tasting proteins.
Identifieur interne : 000231 ( Main/Exploration ); précédent : 000230; suivant : 000232Functional characterization of the heterodimeric sweet taste receptor T1R2 and T1R3 from a New World monkey species (squirrel monkey) and its response to sweet-tasting proteins.
Auteurs : Bo Liu [États-Unis] ; Matthew Ha ; Xuan-Yu Meng ; Mohammed Khaleduzzaman ; Zhe Zhang ; Xia Li ; Meng CuiSource :
- Biochemical and biophysical research communications [ 1090-2104 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Aspartame (composition chimique), Aspartame (pharmacologie), Conformation des protéines (MeSH), Dérivés du benzène (pharmacologie), Goût (effets des médicaments et des substances chimiques), Goût (physiologie), Humains (MeSH), Multimérisation de protéines (MeSH), Perception du goût (effets des médicaments et des substances chimiques), Perception du goût (physiologie), Protéines végétales (composition chimique), Protéines végétales (pharmacologie), Récepteurs couplés aux protéines G (composition chimique), Récepteurs couplés aux protéines G (physiologie), Saccharine (composition chimique), Saccharine (pharmacologie), Saimiri (physiologie), Édulcorants (composition chimique), Édulcorants (pharmacologie), Électricité statique (MeSH).
- MESH :
- composition chimique : Aspartame, Protéines végétales, Récepteurs couplés aux protéines G, Saccharine, Édulcorants.
- effets des médicaments et des substances chimiques : Goût, Perception du goût.
- pharmacologie : Aspartame, Dérivés du benzène, Protéines végétales, Saccharine, Édulcorants.
- physiologie : Goût, Perception du goût, Récepteurs couplés aux protéines G, Saimiri.
- Animaux, Conformation des protéines, Humains, Multimérisation de protéines, Électricité statique.
English descriptors
- KwdEn :
- Animals (MeSH), Aspartame (chemistry), Aspartame (pharmacology), Benzene Derivatives (pharmacology), Humans (MeSH), Plant Proteins (chemistry), Plant Proteins (pharmacology), Protein Conformation (MeSH), Protein Multimerization (MeSH), Receptors, G-Protein-Coupled (chemistry), Receptors, G-Protein-Coupled (physiology), Saccharin (chemistry), Saccharin (pharmacology), Saimiri (physiology), Static Electricity (MeSH), Sweetening Agents (chemistry), Sweetening Agents (pharmacology), Taste (drug effects), Taste (physiology), Taste Perception (drug effects), Taste Perception (physiology).
- MESH :
- chemical , chemistry : Aspartame, Plant Proteins, Receptors, G-Protein-Coupled, Saccharin, Sweetening Agents.
- chemical , pharmacology : Aspartame, Benzene Derivatives, Plant Proteins, Saccharin, Sweetening Agents.
- chemical , physiology : Receptors, G-Protein-Coupled.
- drug effects : Taste, Taste Perception.
- physiology : Saimiri, Taste, Taste Perception.
- Animals, Humans, Protein Conformation, Protein Multimerization, Static Electricity.
Abstract
The family C G protein-coupled receptor (GPCR) T1R2 and T1R3 heterodimer functions as a broadly acting sweet taste receptor. Perception of sweet taste is a species-dependent physiological process. It has been widely reported that New World monkeys and rodents are not able to perceive some of the artificial sweeteners and sweet-tasting proteins that can be perceived by humans, apes, and Old World monkeys. Until now, only the sweet receptors of humans, mice and rats have been functionally characterized. Here we report characterization of the sweet taste receptor (T1R2/T1R3) from a species of New World primate, squirrel monkey. Our results show that the heterodimeric receptor of squirrel monkey does not respond to artificial sweeteners aspartame, neotame, cyclamate, saccharin and sweet-tasting protein monellin, but surprisingly, it does respond to thaumatin at high concentrations (>18 μM). This is the first report demonstrating that species of New World monkey can perceive some specific sweet-tasting proteins. Furthermore, the sweet receptor of squirrel monkey responses to the such sweeteners cannot be inhibited by the sweet inhibitor lactisole. We compared the response differences of the squirrel monkey and human receptors and found that the residues in T1R2 determine species-dependent sweet taste toward saccharin, while the residues in either T1R2 or T1R3 are responsible for the sweet taste difference between humans and squirrel monkeys toward monellin. Molecular models indicated that electrostatic properties of the receptors probably mediate the species-dependent response to sweet-tasting proteins.
DOI: 10.1016/j.bbrc.2012.09.083
PubMed: 23000410
PubMed Central: PMC3479362
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<term>Aspartame (chemistry)</term>
<term>Aspartame (pharmacology)</term>
<term>Benzene Derivatives (pharmacology)</term>
<term>Humans (MeSH)</term>
<term>Plant Proteins (chemistry)</term>
<term>Plant Proteins (pharmacology)</term>
<term>Protein Conformation (MeSH)</term>
<term>Protein Multimerization (MeSH)</term>
<term>Receptors, G-Protein-Coupled (chemistry)</term>
<term>Receptors, G-Protein-Coupled (physiology)</term>
<term>Saccharin (chemistry)</term>
<term>Saccharin (pharmacology)</term>
<term>Saimiri (physiology)</term>
<term>Static Electricity (MeSH)</term>
<term>Sweetening Agents (chemistry)</term>
<term>Sweetening Agents (pharmacology)</term>
<term>Taste (drug effects)</term>
<term>Taste (physiology)</term>
<term>Taste Perception (drug effects)</term>
<term>Taste Perception (physiology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Aspartame (composition chimique)</term>
<term>Aspartame (pharmacologie)</term>
<term>Conformation des protéines (MeSH)</term>
<term>Dérivés du benzène (pharmacologie)</term>
<term>Goût (effets des médicaments et des substances chimiques)</term>
<term>Goût (physiologie)</term>
<term>Humains (MeSH)</term>
<term>Multimérisation de protéines (MeSH)</term>
<term>Perception du goût (effets des médicaments et des substances chimiques)</term>
<term>Perception du goût (physiologie)</term>
<term>Protéines végétales (composition chimique)</term>
<term>Protéines végétales (pharmacologie)</term>
<term>Récepteurs couplés aux protéines G (composition chimique)</term>
<term>Récepteurs couplés aux protéines G (physiologie)</term>
<term>Saccharine (composition chimique)</term>
<term>Saccharine (pharmacologie)</term>
<term>Saimiri (physiologie)</term>
<term>Édulcorants (composition chimique)</term>
<term>Édulcorants (pharmacologie)</term>
<term>Électricité statique (MeSH)</term>
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<term>Receptors, G-Protein-Coupled</term>
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<term>Sweetening Agents</term>
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<term>Benzene Derivatives</term>
<term>Plant Proteins</term>
<term>Saccharin</term>
<term>Sweetening Agents</term>
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<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Receptors, G-Protein-Coupled</term>
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<term>Protéines végétales</term>
<term>Récepteurs couplés aux protéines G</term>
<term>Saccharine</term>
<term>Édulcorants</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Taste</term>
<term>Taste Perception</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Goût</term>
<term>Perception du goût</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Aspartame</term>
<term>Dérivés du benzène</term>
<term>Protéines végétales</term>
<term>Saccharine</term>
<term>Édulcorants</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Goût</term>
<term>Perception du goût</term>
<term>Récepteurs couplés aux protéines G</term>
<term>Saimiri</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Saimiri</term>
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<term>Taste Perception</term>
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<term>Humans</term>
<term>Protein Conformation</term>
<term>Protein Multimerization</term>
<term>Static Electricity</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Conformation des protéines</term>
<term>Humains</term>
<term>Multimérisation de protéines</term>
<term>Électricité statique</term>
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<front><div type="abstract" xml:lang="en">The family C G protein-coupled receptor (GPCR) T1R2 and T1R3 heterodimer functions as a broadly acting sweet taste receptor. Perception of sweet taste is a species-dependent physiological process. It has been widely reported that New World monkeys and rodents are not able to perceive some of the artificial sweeteners and sweet-tasting proteins that can be perceived by humans, apes, and Old World monkeys. Until now, only the sweet receptors of humans, mice and rats have been functionally characterized. Here we report characterization of the sweet taste receptor (T1R2/T1R3) from a species of New World primate, squirrel monkey. Our results show that the heterodimeric receptor of squirrel monkey does not respond to artificial sweeteners aspartame, neotame, cyclamate, saccharin and sweet-tasting protein monellin, but surprisingly, it does respond to thaumatin at high concentrations (>18 μM). This is the first report demonstrating that species of New World monkey can perceive some specific sweet-tasting proteins. Furthermore, the sweet receptor of squirrel monkey responses to the such sweeteners cannot be inhibited by the sweet inhibitor lactisole. We compared the response differences of the squirrel monkey and human receptors and found that the residues in T1R2 determine species-dependent sweet taste toward saccharin, while the residues in either T1R2 or T1R3 are responsible for the sweet taste difference between humans and squirrel monkeys toward monellin. Molecular models indicated that electrostatic properties of the receptors probably mediate the species-dependent response to sweet-tasting proteins.</div>
</front>
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<Abstract><AbstractText>The family C G protein-coupled receptor (GPCR) T1R2 and T1R3 heterodimer functions as a broadly acting sweet taste receptor. Perception of sweet taste is a species-dependent physiological process. It has been widely reported that New World monkeys and rodents are not able to perceive some of the artificial sweeteners and sweet-tasting proteins that can be perceived by humans, apes, and Old World monkeys. Until now, only the sweet receptors of humans, mice and rats have been functionally characterized. Here we report characterization of the sweet taste receptor (T1R2/T1R3) from a species of New World primate, squirrel monkey. Our results show that the heterodimeric receptor of squirrel monkey does not respond to artificial sweeteners aspartame, neotame, cyclamate, saccharin and sweet-tasting protein monellin, but surprisingly, it does respond to thaumatin at high concentrations (>18 μM). This is the first report demonstrating that species of New World monkey can perceive some specific sweet-tasting proteins. Furthermore, the sweet receptor of squirrel monkey responses to the such sweeteners cannot be inhibited by the sweet inhibitor lactisole. We compared the response differences of the squirrel monkey and human receptors and found that the residues in T1R2 determine species-dependent sweet taste toward saccharin, while the residues in either T1R2 or T1R3 are responsible for the sweet taste difference between humans and squirrel monkeys toward monellin. Molecular models indicated that electrostatic properties of the receptors probably mediate the species-dependent response to sweet-tasting proteins.</AbstractText>
<CopyrightInformation>Copyright © 2012 Elsevier Inc. All rights reserved.</CopyrightInformation>
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<ForeName>Bo</ForeName>
<Initials>B</Initials>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
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<MeshHeading><DescriptorName UI="D001218" MajorTopicYN="N">Aspartame</DescriptorName>
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<MeshHeading><DescriptorName UI="D055503" MajorTopicYN="N">Protein Multimerization</DescriptorName>
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<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
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<MeshHeading><DescriptorName UI="D055672" MajorTopicYN="N">Static Electricity</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D013649" MajorTopicYN="N">Taste</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055697" MajorTopicYN="N">Taste Perception</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
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