Functional characterization of the heterodimeric sweet taste receptor T1R2 and T1R3 from a New World monkey species (squirrel monkey) and its response to sweet-tasting proteins.
Identifieur interne : 000231 ( Main/Exploration ); précédent : 000230; suivant : 000232Functional characterization of the heterodimeric sweet taste receptor T1R2 and T1R3 from a New World monkey species (squirrel monkey) and its response to sweet-tasting proteins.
Auteurs : Bo Liu [États-Unis] ; Matthew Ha ; Xuan-Yu Meng ; Mohammed Khaleduzzaman ; Zhe Zhang ; Xia Li ; Meng CuiSource :
- Biochemical and biophysical research communications [ 1090-2104 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Aspartame (composition chimique), Aspartame (pharmacologie), Conformation des protéines (MeSH), Dérivés du benzène (pharmacologie), Goût (effets des médicaments et des substances chimiques), Goût (physiologie), Humains (MeSH), Multimérisation de protéines (MeSH), Perception du goût (effets des médicaments et des substances chimiques), Perception du goût (physiologie), Protéines végétales (composition chimique), Protéines végétales (pharmacologie), Récepteurs couplés aux protéines G (composition chimique), Récepteurs couplés aux protéines G (physiologie), Saccharine (composition chimique), Saccharine (pharmacologie), Saimiri (physiologie), Édulcorants (composition chimique), Édulcorants (pharmacologie), Électricité statique (MeSH).
- MESH :
- composition chimique : Aspartame, Protéines végétales, Récepteurs couplés aux protéines G, Saccharine, Édulcorants.
- effets des médicaments et des substances chimiques : Goût, Perception du goût.
- pharmacologie : Aspartame, Dérivés du benzène, Protéines végétales, Saccharine, Édulcorants.
- physiologie : Goût, Perception du goût, Récepteurs couplés aux protéines G, Saimiri.
- Animaux, Conformation des protéines, Humains, Multimérisation de protéines, Électricité statique.
English descriptors
- KwdEn :
- Animals (MeSH), Aspartame (chemistry), Aspartame (pharmacology), Benzene Derivatives (pharmacology), Humans (MeSH), Plant Proteins (chemistry), Plant Proteins (pharmacology), Protein Conformation (MeSH), Protein Multimerization (MeSH), Receptors, G-Protein-Coupled (chemistry), Receptors, G-Protein-Coupled (physiology), Saccharin (chemistry), Saccharin (pharmacology), Saimiri (physiology), Static Electricity (MeSH), Sweetening Agents (chemistry), Sweetening Agents (pharmacology), Taste (drug effects), Taste (physiology), Taste Perception (drug effects), Taste Perception (physiology).
- MESH :
- chemical , chemistry : Aspartame, Plant Proteins, Receptors, G-Protein-Coupled, Saccharin, Sweetening Agents.
- chemical , pharmacology : Aspartame, Benzene Derivatives, Plant Proteins, Saccharin, Sweetening Agents.
- chemical , physiology : Receptors, G-Protein-Coupled.
- drug effects : Taste, Taste Perception.
- physiology : Saimiri, Taste, Taste Perception.
- Animals, Humans, Protein Conformation, Protein Multimerization, Static Electricity.
Abstract
The family C G protein-coupled receptor (GPCR) T1R2 and T1R3 heterodimer functions as a broadly acting sweet taste receptor. Perception of sweet taste is a species-dependent physiological process. It has been widely reported that New World monkeys and rodents are not able to perceive some of the artificial sweeteners and sweet-tasting proteins that can be perceived by humans, apes, and Old World monkeys. Until now, only the sweet receptors of humans, mice and rats have been functionally characterized. Here we report characterization of the sweet taste receptor (T1R2/T1R3) from a species of New World primate, squirrel monkey. Our results show that the heterodimeric receptor of squirrel monkey does not respond to artificial sweeteners aspartame, neotame, cyclamate, saccharin and sweet-tasting protein monellin, but surprisingly, it does respond to thaumatin at high concentrations (>18 μM). This is the first report demonstrating that species of New World monkey can perceive some specific sweet-tasting proteins. Furthermore, the sweet receptor of squirrel monkey responses to the such sweeteners cannot be inhibited by the sweet inhibitor lactisole. We compared the response differences of the squirrel monkey and human receptors and found that the residues in T1R2 determine species-dependent sweet taste toward saccharin, while the residues in either T1R2 or T1R3 are responsible for the sweet taste difference between humans and squirrel monkeys toward monellin. Molecular models indicated that electrostatic properties of the receptors probably mediate the species-dependent response to sweet-tasting proteins.
DOI: 10.1016/j.bbrc.2012.09.083
PubMed: 23000410
PubMed Central: PMC3479362
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Functional characterization of the heterodimeric sweet taste receptor T1R2 and T1R3 from a New World monkey species (squirrel monkey) and its response to sweet-tasting proteins.</title><author><name sortKey="Liu, Bo" sort="Liu, Bo" uniqKey="Liu B" first="Bo" last="Liu">Bo Liu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Physiology and Biophysics, Virginia Commonwealth University, 1220 East Broad Street, P.O. Box 980551, Richmond, VA 23298, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physiology and Biophysics, Virginia Commonwealth University, 1220 East Broad Street, P.O. Box 980551, Richmond, VA 23298</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Ha, Matthew" sort="Ha, Matthew" uniqKey="Ha M" first="Matthew" last="Ha">Matthew Ha</name></author><author><name sortKey="Meng, Xuan Yu" sort="Meng, Xuan Yu" uniqKey="Meng X" first="Xuan-Yu" last="Meng">Xuan-Yu Meng</name></author><author><name sortKey="Khaleduzzaman, Mohammed" sort="Khaleduzzaman, Mohammed" uniqKey="Khaleduzzaman M" first="Mohammed" last="Khaleduzzaman">Mohammed Khaleduzzaman</name></author><author><name sortKey="Zhang, Zhe" sort="Zhang, Zhe" uniqKey="Zhang Z" first="Zhe" last="Zhang">Zhe Zhang</name></author><author><name sortKey="Li, Xia" sort="Li, Xia" uniqKey="Li X" first="Xia" last="Li">Xia Li</name></author><author><name sortKey="Cui, Meng" sort="Cui, Meng" uniqKey="Cui M" first="Meng" last="Cui">Meng Cui</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:23000410</idno><idno type="pmid">23000410</idno><idno type="doi">10.1016/j.bbrc.2012.09.083</idno><idno type="pmc">PMC3479362</idno><idno type="wicri:Area/Main/Corpus">000213</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000213</idno><idno type="wicri:Area/Main/Curation">000213</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000213</idno><idno type="wicri:Area/Main/Exploration">000213</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Functional characterization of the heterodimeric sweet taste receptor T1R2 and T1R3 from a New World monkey species (squirrel monkey) and its response to sweet-tasting proteins.</title><author><name sortKey="Liu, Bo" sort="Liu, Bo" uniqKey="Liu B" first="Bo" last="Liu">Bo Liu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Physiology and Biophysics, Virginia Commonwealth University, 1220 East Broad Street, P.O. Box 980551, Richmond, VA 23298, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physiology and Biophysics, Virginia Commonwealth University, 1220 East Broad Street, P.O. Box 980551, Richmond, VA 23298</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Ha, Matthew" sort="Ha, Matthew" uniqKey="Ha M" first="Matthew" last="Ha">Matthew Ha</name></author><author><name sortKey="Meng, Xuan Yu" sort="Meng, Xuan Yu" uniqKey="Meng X" first="Xuan-Yu" last="Meng">Xuan-Yu Meng</name></author><author><name sortKey="Khaleduzzaman, Mohammed" sort="Khaleduzzaman, Mohammed" uniqKey="Khaleduzzaman M" first="Mohammed" last="Khaleduzzaman">Mohammed Khaleduzzaman</name></author><author><name sortKey="Zhang, Zhe" sort="Zhang, Zhe" uniqKey="Zhang Z" first="Zhe" last="Zhang">Zhe Zhang</name></author><author><name sortKey="Li, Xia" sort="Li, Xia" uniqKey="Li X" first="Xia" last="Li">Xia Li</name></author><author><name sortKey="Cui, Meng" sort="Cui, Meng" uniqKey="Cui M" first="Meng" last="Cui">Meng Cui</name></author></analytic><series><title level="j">Biochemical and biophysical research communications</title><idno type="eISSN">1090-2104</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Aspartame (chemistry)</term><term>Aspartame (pharmacology)</term><term>Benzene Derivatives (pharmacology)</term><term>Humans (MeSH)</term><term>Plant Proteins (chemistry)</term><term>Plant Proteins (pharmacology)</term><term>Protein Conformation (MeSH)</term><term>Protein Multimerization (MeSH)</term><term>Receptors, G-Protein-Coupled (chemistry)</term><term>Receptors, G-Protein-Coupled (physiology)</term><term>Saccharin (chemistry)</term><term>Saccharin (pharmacology)</term><term>Saimiri (physiology)</term><term>Static Electricity (MeSH)</term><term>Sweetening Agents (chemistry)</term><term>Sweetening Agents (pharmacology)</term><term>Taste (drug effects)</term><term>Taste (physiology)</term><term>Taste Perception (drug effects)</term><term>Taste Perception (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Aspartame (composition chimique)</term><term>Aspartame (pharmacologie)</term><term>Conformation des protéines (MeSH)</term><term>Dérivés du benzène (pharmacologie)</term><term>Goût (effets des médicaments et des substances chimiques)</term><term>Goût (physiologie)</term><term>Humains (MeSH)</term><term>Multimérisation de protéines (MeSH)</term><term>Perception du goût (effets des médicaments et des substances chimiques)</term><term>Perception du goût (physiologie)</term><term>Protéines végétales (composition chimique)</term><term>Protéines végétales (pharmacologie)</term><term>Récepteurs couplés aux protéines G (composition chimique)</term><term>Récepteurs couplés aux protéines G (physiologie)</term><term>Saccharine (composition chimique)</term><term>Saccharine (pharmacologie)</term><term>Saimiri (physiologie)</term><term>Édulcorants (composition chimique)</term><term>Édulcorants (pharmacologie)</term><term>Électricité statique (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Aspartame</term><term>Plant Proteins</term><term>Receptors, G-Protein-Coupled</term><term>Saccharin</term><term>Sweetening Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Aspartame</term><term>Benzene Derivatives</term><term>Plant Proteins</term><term>Saccharin</term><term>Sweetening Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Receptors, G-Protein-Coupled</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Aspartame</term><term>Protéines végétales</term><term>Récepteurs couplés aux protéines G</term><term>Saccharine</term><term>Édulcorants</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Taste</term><term>Taste Perception</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Goût</term><term>Perception du goût</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Aspartame</term><term>Dérivés du benzène</term><term>Protéines végétales</term><term>Saccharine</term><term>Édulcorants</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Goût</term><term>Perception du goût</term><term>Récepteurs couplés aux protéines G</term><term>Saimiri</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Saimiri</term><term>Taste</term><term>Taste Perception</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Protein Conformation</term><term>Protein Multimerization</term><term>Static Electricity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Conformation des protéines</term><term>Humains</term><term>Multimérisation de protéines</term><term>Électricité statique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The family C G protein-coupled receptor (GPCR) T1R2 and T1R3 heterodimer functions as a broadly acting sweet taste receptor. Perception of sweet taste is a species-dependent physiological process. It has been widely reported that New World monkeys and rodents are not able to perceive some of the artificial sweeteners and sweet-tasting proteins that can be perceived by humans, apes, and Old World monkeys. Until now, only the sweet receptors of humans, mice and rats have been functionally characterized. Here we report characterization of the sweet taste receptor (T1R2/T1R3) from a species of New World primate, squirrel monkey. Our results show that the heterodimeric receptor of squirrel monkey does not respond to artificial sweeteners aspartame, neotame, cyclamate, saccharin and sweet-tasting protein monellin, but surprisingly, it does respond to thaumatin at high concentrations (>18 μM). This is the first report demonstrating that species of New World monkey can perceive some specific sweet-tasting proteins. Furthermore, the sweet receptor of squirrel monkey responses to the such sweeteners cannot be inhibited by the sweet inhibitor lactisole. We compared the response differences of the squirrel monkey and human receptors and found that the residues in T1R2 determine species-dependent sweet taste toward saccharin, while the residues in either T1R2 or T1R3 are responsible for the sweet taste difference between humans and squirrel monkeys toward monellin. Molecular models indicated that electrostatic properties of the receptors probably mediate the species-dependent response to sweet-tasting proteins.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23000410</PMID><DateCompleted><Year>2013</Year><Month>03</Month><Day>05</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1090-2104</ISSN><JournalIssue CitedMedium="Internet"><Volume>427</Volume><Issue>2</Issue><PubDate><Year>2012</Year><Month>Oct</Month><Day>19</Day></PubDate></JournalIssue><Title>Biochemical and biophysical research communications</Title><ISOAbbreviation>Biochem Biophys Res Commun</ISOAbbreviation></Journal><ArticleTitle>Functional characterization of the heterodimeric sweet taste receptor T1R2 and T1R3 from a New World monkey species (squirrel monkey) and its response to sweet-tasting proteins.</ArticleTitle><Pagination><MedlinePgn>431-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbrc.2012.09.083</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0006-291X(12)01830-X</ELocationID><Abstract><AbstractText>The family C G protein-coupled receptor (GPCR) T1R2 and T1R3 heterodimer functions as a broadly acting sweet taste receptor. Perception of sweet taste is a species-dependent physiological process. It has been widely reported that New World monkeys and rodents are not able to perceive some of the artificial sweeteners and sweet-tasting proteins that can be perceived by humans, apes, and Old World monkeys. Until now, only the sweet receptors of humans, mice and rats have been functionally characterized. Here we report characterization of the sweet taste receptor (T1R2/T1R3) from a species of New World primate, squirrel monkey. Our results show that the heterodimeric receptor of squirrel monkey does not respond to artificial sweeteners aspartame, neotame, cyclamate, saccharin and sweet-tasting protein monellin, but surprisingly, it does respond to thaumatin at high concentrations (>18 μM). This is the first report demonstrating that species of New World monkey can perceive some specific sweet-tasting proteins. Furthermore, the sweet receptor of squirrel monkey responses to the such sweeteners cannot be inhibited by the sweet inhibitor lactisole. We compared the response differences of the squirrel monkey and human receptors and found that the residues in T1R2 determine species-dependent sweet taste toward saccharin, while the residues in either T1R2 or T1R3 are responsible for the sweet taste difference between humans and squirrel monkeys toward monellin. Molecular models indicated that electrostatic properties of the receptors probably mediate the species-dependent response to sweet-tasting proteins.</AbstractText><CopyrightInformation>Copyright © 2012 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Bo</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Physiology and Biophysics, Virginia Commonwealth University, 1220 East Broad Street, P.O. Box 980551, Richmond, VA 23298, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ha</LastName><ForeName>Matthew</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Meng</LastName><ForeName>Xuan-Yu</ForeName><Initials>XY</Initials></Author><Author ValidYN="Y"><LastName>Khaleduzzaman</LastName><ForeName>Mohammed</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Zhe</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Xia</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Cui</LastName><ForeName>Meng</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R21 DC008996</GrantID><Acronym>DC</Acronym><Agency>NIDCD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>S10 RR027411</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>DC008996</GrantID><Acronym>DC</Acronym><Agency>NIDCD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>S10RR027411</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>09</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Biochem Biophys Res Commun</MedlineTA><NlmUniqueID>0372516</NlmUniqueID><ISSNLinking>0006-291X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001555">Benzene Derivatives</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010940">Plant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D043562">Receptors, G-Protein-Coupled</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013549">Sweetening Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C002541">monellin protein, Dioscoreophyllum cumminsii</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C431926">taste receptors, type 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>53850-34-3</RegistryNumber><NameOfSubstance UI="C003427">thaumatin protein, plant</NameOfSubstance></Chemical><Chemical><RegistryNumber>FST467XS7D</RegistryNumber><NameOfSubstance UI="D012439">Saccharin</NameOfSubstance></Chemical><Chemical><RegistryNumber>Z0H242BBR1</RegistryNumber><NameOfSubstance UI="D001218">Aspartame</NameOfSubstance></Chemical><Chemical><RegistryNumber>ZU3D90W5GZ</RegistryNumber><NameOfSubstance UI="C495512">lactisole</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001218" MajorTopicYN="N">Aspartame</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001555" MajorTopicYN="N">Benzene Derivatives</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010940" MajorTopicYN="N">Plant Proteins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011487" MajorTopicYN="N">Protein Conformation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055503" MajorTopicYN="N">Protein Multimerization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D043562" MajorTopicYN="N">Receptors, G-Protein-Coupled</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012439" MajorTopicYN="N">Saccharin</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012453" MajorTopicYN="N">Saimiri</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055672" MajorTopicYN="N">Static Electricity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013549" MajorTopicYN="N">Sweetening Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013649" MajorTopicYN="N">Taste</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055697" MajorTopicYN="N">Taste Perception</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>09</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>09</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>9</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>9</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>3</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23000410</ArticleId><ArticleId IdType="pii">S0006-291X(12)01830-X</ArticleId><ArticleId IdType="doi">10.1016/j.bbrc.2012.09.083</ArticleId><ArticleId IdType="pmc">PMC3479362</ArticleId><ArticleId IdType="mid">NIHMS408488</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>PLoS One. 2012;7(4):e35380</Citation><ArticleIdList><ArticleId IdType="pubmed">22536376</ArticleId></ArticleIdList></Reference><Reference><Citation>FEBS J. 2008 Jul;275(14):3644-52</Citation><ArticleIdList><ArticleId IdType="pubmed">18544096</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2000 Oct 26;407(6807):971-7</Citation><ArticleIdList><ArticleId IdType="pubmed">11069170</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Neurosci. 2001 May;4(5):492-8</Citation><ArticleIdList><ArticleId IdType="pubmed">11319557</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2001 Aug 10;106(3):381-90</Citation><ArticleIdList><ArticleId IdType="pubmed">11509186</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2660-5</Citation><ArticleIdList><ArticleId IdType="pubmed">11867751</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4692-6</Citation><ArticleIdList><ArticleId IdType="pubmed">11917125</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochim Biophys Acta. 2009 Mar;1794(3):410-20</Citation><ArticleIdList><ArticleId IdType="pubmed">19100868</ArticleId></ArticleIdList></Reference><Reference><Citation>J Hered. 2009 Jul-Aug;100 Suppl 1:S90-100</Citation><ArticleIdList><ArticleId IdType="pubmed">19366814</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4752-7</Citation><ArticleIdList><ArticleId IdType="pubmed">20173095</ArticleId></ArticleIdList></Reference><Reference><Citation>Chem Senses. 2011 Jun;36(5):453-75</Citation><ArticleIdList><ArticleId IdType="pubmed">21414996</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Neurosci. 2003 Mar 4;4:5</Citation><ArticleIdList><ArticleId IdType="pubmed">12617752</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurosci. 2003 Aug 13;23(19):7376-80</Citation><ArticleIdList><ArticleId IdType="pubmed">12917372</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2003 Oct 31;115(3):255-66</Citation><ArticleIdList><ArticleId IdType="pubmed">14636554</ArticleId></ArticleIdList></Reference><Reference><Citation>J Dent Res. 2004 Jun;83(6):448-53</Citation><ArticleIdList><ArticleId IdType="pubmed">15153450</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurophysiol. 2004 Aug;92(2):1067-76</Citation><ArticleIdList><ArticleId IdType="pubmed">15071088</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14258-63</Citation><ArticleIdList><ArticleId IdType="pubmed">15353592</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2004 Oct 22;279(43):45068-75</Citation><ArticleIdList><ArticleId IdType="pubmed">15299024</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1965 Oct 22;150(3695):506-7</Citation><ArticleIdList><ArticleId IdType="pubmed">4953700</ArticleId></ArticleIdList></Reference><Reference><Citation>Acta Physiol Scand. 1973 Dec;89(4):550-7</Citation><ArticleIdList><ArticleId IdType="pubmed">4204310</ArticleId></ArticleIdList></Reference><Reference><Citation>Ukr Biokhim Zh. 1975 May-Jun;47(3):352-7</Citation><ArticleIdList><ArticleId IdType="pubmed">1216351</ArticleId></ArticleIdList></Reference><Reference><Citation>Proteins. 1991;11(4):281-96</Citation><ArticleIdList><ArticleId IdType="pubmed">1758883</ArticleId></ArticleIdList></Reference><Reference><Citation>Proteins. 1992 Apr;12(4):345-64</Citation><ArticleIdList><ArticleId IdType="pubmed">1579569</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Biol. 1993 Dec 5;234(3):779-815</Citation><ArticleIdList><ArticleId IdType="pubmed">8254673</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 1994 Nov 11;22(22):4673-80</Citation><ArticleIdList><ArticleId IdType="pubmed">7984417</ArticleId></ArticleIdList></Reference><Reference><Citation>Physiol Rev. 1996 Jul;76(3):718-66</Citation><ArticleIdList><ArticleId IdType="pubmed">8757787</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurophysiol. 1998 Oct;80(4):2102-12</Citation><ArticleIdList><ArticleId IdType="pubmed">9772264</ArticleId></ArticleIdList></Reference><Reference><Citation>Chem Senses. 2005 Jan;30 Suppl 1:i17-8</Citation><ArticleIdList><ArticleId IdType="pubmed">15738096</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2005 Apr 15;280(15):15238-46</Citation><ArticleIdList><ArticleId IdType="pubmed">15668251</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Neurosci. 2005;6:22</Citation><ArticleIdList><ArticleId IdType="pubmed">15817126</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2005 Oct 7;280(40):34296-305</Citation><ArticleIdList><ArticleId IdType="pubmed">16076846</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Biol. 2005 Nov 8;15(21):1948-52</Citation><ArticleIdList><ArticleId IdType="pubmed">16271873</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Pharm Des. 2006;12(35):4591-600</Citation><ArticleIdList><ArticleId IdType="pubmed">17168764</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3759-64</Citation><ArticleIdList><ArticleId IdType="pubmed">17360426</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Struct Biol. 2007;7:66</Citation><ArticleIdList><ArticleId IdType="pubmed">17935609</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurosci. 2011 Jul 27;31(30):11070-6</Citation><ArticleIdList><ArticleId IdType="pubmed">21795555</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Virginie</li></region></list><tree><noCountry><name sortKey="Cui, Meng" sort="Cui, Meng" uniqKey="Cui M" first="Meng" last="Cui">Meng Cui</name><name sortKey="Ha, Matthew" sort="Ha, Matthew" uniqKey="Ha M" first="Matthew" last="Ha">Matthew Ha</name><name sortKey="Khaleduzzaman, Mohammed" sort="Khaleduzzaman, Mohammed" uniqKey="Khaleduzzaman M" first="Mohammed" last="Khaleduzzaman">Mohammed Khaleduzzaman</name><name sortKey="Li, Xia" sort="Li, Xia" uniqKey="Li X" first="Xia" last="Li">Xia Li</name><name sortKey="Meng, Xuan Yu" sort="Meng, Xuan Yu" uniqKey="Meng X" first="Xuan-Yu" last="Meng">Xuan-Yu Meng</name><name sortKey="Zhang, Zhe" sort="Zhang, Zhe" uniqKey="Zhang Z" first="Zhe" last="Zhang">Zhe Zhang</name></noCountry><country name="États-Unis"><region name="Virginie"><name sortKey="Liu, Bo" sort="Liu, Bo" uniqKey="Liu B" first="Bo" last="Liu">Bo Liu</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/ThaumatinV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000231 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000231 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= ThaumatinV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:23000410
|texte= Functional characterization of the heterodimeric sweet taste receptor T1R2 and T1R3 from a New World monkey species (squirrel monkey) and its response to sweet-tasting proteins.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23000410" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ThaumatinV1
| This area was generated with Dilib version V0.6.37. |  |