Saccharomyces cerevisiae contains a homolog of human FKBP-13, a membrane-associated FK506/rapamycin binding protein.
Identifieur interne : 001B46 ( Main/Exploration ); précédent : 001B45; suivant : 001B47Saccharomyces cerevisiae contains a homolog of human FKBP-13, a membrane-associated FK506/rapamycin binding protein.
Auteurs : J A Partaledis [États-Unis] ; M A Fleming ; M W Harding ; V. BerlinSource :
- Yeast (Chichester, England) [ 0749-503X ] ; 1992.
Descripteurs français
- KwdFr :
- Cartographie chromosomique (MeSH), Clonage moléculaire (MeSH), Données de séquences moléculaires (MeSH), Famille multigénique (MeSH), Gènes fongiques (MeSH), Humains (MeSH), Protéines de liaison au tacrolimus (MeSH), Protéines de transport (génétique), Protéines de transport (isolement et purification), Saccharomyces cerevisiae (composition chimique), Saccharomyces cerevisiae (génétique), Similitude de séquences (MeSH), Séquence d'acides aminés (MeSH), Séquence nucléotidique (MeSH), Tacrolimus (métabolisme).
- MESH :
- composition chimique : Saccharomyces cerevisiae.
- génétique : Protéines de transport, Saccharomyces cerevisiae.
- isolement et purification : Protéines de transport.
- métabolisme : Tacrolimus.
- Cartographie chromosomique, Clonage moléculaire, Données de séquences moléculaires, Famille multigénique, Gènes fongiques, Humains, Protéines de liaison au tacrolimus, Similitude de séquences, Séquence d'acides aminés, Séquence nucléotidique.
English descriptors
- KwdEn :
- Amino Acid Sequence (MeSH), Base Sequence (MeSH), Carrier Proteins (genetics), Carrier Proteins (isolation & purification), Chromosome Mapping (MeSH), Cloning, Molecular (MeSH), Genes, Fungal (MeSH), Humans (MeSH), Molecular Sequence Data (MeSH), Multigene Family (MeSH), Saccharomyces cerevisiae (chemistry), Saccharomyces cerevisiae (genetics), Sequence Homology (MeSH), Tacrolimus (metabolism), Tacrolimus Binding Proteins (MeSH).
- MESH :
- chemical , genetics : Carrier Proteins.
- chemical , isolation & purification : Carrier Proteins.
- chemistry : Saccharomyces cerevisiae.
- genetics : Saccharomyces cerevisiae.
- chemical , metabolism : Tacrolimus.
- Amino Acid Sequence, Base Sequence, Chromosome Mapping, Cloning, Molecular, Genes, Fungal, Humans, Molecular Sequence Data, Multigene Family, Sequence Homology, Tacrolimus Binding Proteins.
Abstract
FKB2 encodes a homolog of human FKBP-13, a membrane-associated binding protein for the immunosuppressants FK506 and rapamycin. FKB2 is located on the right arm of chromosome IV and contains an open reading frame of 135 amino acids, of which the first 17 residues comprise a putative hydrophobic leader peptide. Yeast FKBP-13 is homologous to human FKBP-13 (52% amino acid identity) and to FKBP-12, the major cytosolic receptor for FK506. In the alignment of FKBP-13 and FKBP-12 sequences, there are 28 invariant residues. Among these conserved residues are those that comprise the drug binding and peptidyl-prolyl cis-trans isomerase active site of FKBP-12. The phylogenetic conservation of the FKBP family suggest that the proteins are involved in a basic cellular function.
DOI: 10.1002/yea.320080812
PubMed: 1279908
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
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<author><name sortKey="Fleming, M A" sort="Fleming, M A" uniqKey="Fleming M" first="M A" last="Fleming">M A Fleming</name>
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<author><name sortKey="Harding, M W" sort="Harding, M W" uniqKey="Harding M" first="M W" last="Harding">M W Harding</name>
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<author><name sortKey="Berlin, V" sort="Berlin, V" uniqKey="Berlin V" first="V" last="Berlin">V. Berlin</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (MeSH)</term>
<term>Base Sequence (MeSH)</term>
<term>Carrier Proteins (genetics)</term>
<term>Carrier Proteins (isolation & purification)</term>
<term>Chromosome Mapping (MeSH)</term>
<term>Cloning, Molecular (MeSH)</term>
<term>Genes, Fungal (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Molecular Sequence Data (MeSH)</term>
<term>Multigene Family (MeSH)</term>
<term>Saccharomyces cerevisiae (chemistry)</term>
<term>Saccharomyces cerevisiae (genetics)</term>
<term>Sequence Homology (MeSH)</term>
<term>Tacrolimus (metabolism)</term>
<term>Tacrolimus Binding Proteins (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Cartographie chromosomique (MeSH)</term>
<term>Clonage moléculaire (MeSH)</term>
<term>Données de séquences moléculaires (MeSH)</term>
<term>Famille multigénique (MeSH)</term>
<term>Gènes fongiques (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Protéines de liaison au tacrolimus (MeSH)</term>
<term>Protéines de transport (génétique)</term>
<term>Protéines de transport (isolement et purification)</term>
<term>Saccharomyces cerevisiae (composition chimique)</term>
<term>Saccharomyces cerevisiae (génétique)</term>
<term>Similitude de séquences (MeSH)</term>
<term>Séquence d'acides aminés (MeSH)</term>
<term>Séquence nucléotidique (MeSH)</term>
<term>Tacrolimus (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Carrier Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Carrier Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Saccharomyces cerevisiae</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines de transport</term>
<term>Saccharomyces cerevisiae</term>
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<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Protéines de transport</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Tacrolimus</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Tacrolimus</term>
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<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Base Sequence</term>
<term>Chromosome Mapping</term>
<term>Cloning, Molecular</term>
<term>Genes, Fungal</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Multigene Family</term>
<term>Sequence Homology</term>
<term>Tacrolimus Binding Proteins</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Cartographie chromosomique</term>
<term>Clonage moléculaire</term>
<term>Données de séquences moléculaires</term>
<term>Famille multigénique</term>
<term>Gènes fongiques</term>
<term>Humains</term>
<term>Protéines de liaison au tacrolimus</term>
<term>Similitude de séquences</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
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<front><div type="abstract" xml:lang="en">FKB2 encodes a homolog of human FKBP-13, a membrane-associated binding protein for the immunosuppressants FK506 and rapamycin. FKB2 is located on the right arm of chromosome IV and contains an open reading frame of 135 amino acids, of which the first 17 residues comprise a putative hydrophobic leader peptide. Yeast FKBP-13 is homologous to human FKBP-13 (52% amino acid identity) and to FKBP-12, the major cytosolic receptor for FK506. In the alignment of FKBP-13 and FKBP-12 sequences, there are 28 invariant residues. Among these conserved residues are those that comprise the drug binding and peptidyl-prolyl cis-trans isomerase active site of FKBP-12. The phylogenetic conservation of the FKBP family suggest that the proteins are involved in a basic cellular function.</div>
</front>
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<DateCompleted><Year>1992</Year>
<Month>12</Month>
<Day>07</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
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<JournalIssue CitedMedium="Print"><Volume>8</Volume>
<Issue>8</Issue>
<PubDate><Year>1992</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>Yeast (Chichester, England)</Title>
<ISOAbbreviation>Yeast</ISOAbbreviation>
</Journal>
<ArticleTitle>Saccharomyces cerevisiae contains a homolog of human FKBP-13, a membrane-associated FK506/rapamycin binding protein.</ArticleTitle>
<Pagination><MedlinePgn>673-80</MedlinePgn>
</Pagination>
<Abstract><AbstractText>FKB2 encodes a homolog of human FKBP-13, a membrane-associated binding protein for the immunosuppressants FK506 and rapamycin. FKB2 is located on the right arm of chromosome IV and contains an open reading frame of 135 amino acids, of which the first 17 residues comprise a putative hydrophobic leader peptide. Yeast FKBP-13 is homologous to human FKBP-13 (52% amino acid identity) and to FKBP-12, the major cytosolic receptor for FK506. In the alignment of FKBP-13 and FKBP-12 sequences, there are 28 invariant residues. Among these conserved residues are those that comprise the drug binding and peptidyl-prolyl cis-trans isomerase active site of FKBP-12. The phylogenetic conservation of the FKBP family suggest that the proteins are involved in a basic cellular function.</AbstractText>
</Abstract>
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<Language>eng</Language>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
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<Chemical><RegistryNumber>EC 5.2.1.-</RegistryNumber>
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<MeshHeading><DescriptorName UI="D002352" MajorTopicYN="N">Carrier Proteins</DescriptorName>
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<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
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