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Orm proteins integrate multiple signals to maintain sphingolipid homeostasis.

Identifieur interne : 001008 ( Main/Exploration ); précédent : 001007; suivant : 001009

Orm proteins integrate multiple signals to maintain sphingolipid homeostasis.

Auteurs : Charulatha Gururaj [États-Unis] ; Ross S. Federman ; Ross Federman ; Amy Chang

Source :

RBID : pubmed:23737533

Descripteurs français

English descriptors

Abstract

Sphingolipids are structural components of membranes, and sphingolipid metabolites serve as signaling molecules. The first and rate-limiting step in sphingolipid synthesis is catalyzed by serine palmitoyltransferase (SPT). The recently discovered SPT-associated proteins, Orm1 and Orm2, are critical regulators of sphingolipids. Orm protein phosphorylation mediating feedback regulation of SPT activity occurs in response to multiple sphingolipid intermediates, including long chain base and complex sphingolipids. Both branches of the TOR signaling network, TORC1 and TORC2, participate in regulating sphingolipid synthesis via Orm phosphorylation in response to sphingolipid intermediates as well as nutritional conditions. Moreover, sphingolipid synthesis is regulated in response to endoplasmic reticulum (ER) stress by activation of a calcium- and calcineurin-dependent pathway via transcriptional induction of ORM2. Conversely, the calcium- and calcineurin-dependent pathway signals ER stress response upon lipid dysregulation in the absence of the Orm proteins to restore ER homeostasis.

DOI: 10.1074/jbc.M113.472860
PubMed: 23737533
PubMed Central: PMC3711311


Affiliations:

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Le document en format XML

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<term>Calcium (metabolism)</term>
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<term>Calcium (métabolisme)</term>
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<term>Phosphorylation (MeSH)</term>
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<term>Protéines adaptatrices de la transduction du signal (métabolisme)</term>
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<div type="abstract" xml:lang="en">Sphingolipids are structural components of membranes, and sphingolipid metabolites serve as signaling molecules. The first and rate-limiting step in sphingolipid synthesis is catalyzed by serine palmitoyltransferase (SPT). The recently discovered SPT-associated proteins, Orm1 and Orm2, are critical regulators of sphingolipids. Orm protein phosphorylation mediating feedback regulation of SPT activity occurs in response to multiple sphingolipid intermediates, including long chain base and complex sphingolipids. Both branches of the TOR signaling network, TORC1 and TORC2, participate in regulating sphingolipid synthesis via Orm phosphorylation in response to sphingolipid intermediates as well as nutritional conditions. Moreover, sphingolipid synthesis is regulated in response to endoplasmic reticulum (ER) stress by activation of a calcium- and calcineurin-dependent pathway via transcriptional induction of ORM2. Conversely, the calcium- and calcineurin-dependent pathway signals ER stress response upon lipid dysregulation in the absence of the Orm proteins to restore ER homeostasis. </div>
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