RapamycinFungusV1, Main, Exploration, bibRecord, 000F77

Species-specific impact of the autophagy machinery on Chikungunya virus infection.

Identifieur interne : 000F77 ( Main/Exploration ); précédent : 000F76; suivant : 000F78

Species-specific impact of the autophagy machinery on Chikungunya virus infection.

Auteurs : Delphine Judith [France] ; Serge Mostowy ; Mehdi Bourai ; Nicolas Gangneux ; Mickaël Lelek ; Marianne Lucas-Hourani ; Nadège Cayet ; Yves Jacob ; Marie-Christine Prévost ; Philippe Pierre ; Frédéric Tangy ; Christophe Zimmer ; Pierre-Olivier Vidalain ; Thérèse Couderc ; Marc Lecuit

Source :

EMBO reports [ 1469-3178 ] ; 2013.

RBID : pubmed:23619093

Descripteurs français

English descriptors

KwdEn :
- Adaptor Proteins, Signal Transducing (metabolism), Alphavirus Infections (virology), Animals (MeSH), Autophagy (MeSH), Capsid (metabolism), Chikungunya Fever (MeSH), Chikungunya virus (physiology), HeLa Cells (MeSH), Host-Pathogen Interactions (MeSH), Humans (MeSH), Immunity, Innate (MeSH), Mice (MeSH), Microtubule-Associated Proteins (metabolism), Nuclear Proteins (metabolism), Phagosomes (metabolism), Phagosomes (virology), Protein Binding (MeSH), Protein Transport (MeSH), Sequestosome-1 Protein (MeSH), Sirolimus (pharmacology), Species Specificity (MeSH), Viral Nonstructural Proteins (metabolism), Virus Replication (MeSH).
MESH :
- chemical , metabolism : Adaptor Proteins, Signal Transducing, Microtubule-Associated Proteins, Nuclear Proteins, Viral Nonstructural Proteins.
- metabolism : Capsid, Phagosomes.
- chemical , pharmacology : Sirolimus.
- physiology : Chikungunya virus.
- virology : Alphavirus Infections, Phagosomes.
- Animals, Autophagy, Chikungunya Fever, HeLa Cells, Host-Pathogen Interactions, Humans, Immunity, Innate, Mice, Protein Binding, Protein Transport, Sequestosome-1 Protein, Species Specificity, Virus Replication.

Abstract

Chikungunya virus (CHIKV) is a recently re-emerged arbovirus that triggers autophagy. Here, we show that CHIKV interacts with components of the autophagy machinery during its replication cycle, inducing a cytoprotective effect. The autophagy receptor p62 protects cells from death by binding ubiquitinated capsid and targeting it to autophagolysosomes. By contrast, the human autophagy receptor NDP52--but not its mouse orthologue--interacts with the non-structural protein nsP2, thereby promoting viral replication. These results highlight the distinct roles of p62 and NDP52 in viral infection, and identify NDP52 as a cellular factor that accounts for CHIKV species specificity.

DOI: 10.1038/embor.2013.51
PubMed: 23619093
PubMed Central: PMC3674439

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 001038
to stream Main, to step Curation: 001038

Le document en format XML

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<term>Autophagy (MeSH)</term>
<term>Capsid (metabolism)</term>
<term>Chikungunya Fever (MeSH)</term>
<term>Chikungunya virus (physiology)</term>
<term>HeLa Cells (MeSH)</term>
<term>Host-Pathogen Interactions (MeSH)</term>
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<term>Phagosomes (metabolism)</term>
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<term>Sequestosome-1 Protein (MeSH)</term>
<term>Sirolimus (pharmacology)</term>
<term>Species Specificity (MeSH)</term>
<term>Viral Nonstructural Proteins (metabolism)</term>
<term>Virus Replication (MeSH)</term>
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<term>Autophagie (MeSH)</term>
<term>Capside (métabolisme)</term>
<term>Cellules HeLa (MeSH)</term>
<term>Fièvre chikungunya (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Immunité innée (MeSH)</term>
<term>Infections à alphavirus (virologie)</term>
<term>Interactions hôte-pathogène (MeSH)</term>
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<term>Protéines virales non structurales (métabolisme)</term>
<term>Réplication virale (MeSH)</term>
<term>Sirolimus (pharmacologie)</term>
<term>Souris (MeSH)</term>
<term>Spécificité d'espèce (MeSH)</term>
<term>Séquestosome-1 (MeSH)</term>
<term>Transport des protéines (MeSH)</term>
<term>Virus du chikungunya (physiologie)</term>
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<term>Protéines adaptatrices de la transduction du signal</term>
<term>Protéines associées aux microtubules</term>
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<term>Protéines virales non structurales</term>
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<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Sirolimus</term>
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<term>Protein Transport</term>
<term>Sequestosome-1 Protein</term>
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<term>Virus Replication</term>
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<term>Autophagie</term>
<term>Cellules HeLa</term>
<term>Fièvre chikungunya</term>
<term>Humains</term>
<term>Immunité innée</term>
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<term>Liaison aux protéines</term>
<term>Réplication virale</term>
<term>Souris</term>
<term>Spécificité d'espèce</term>
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<front><div type="abstract" xml:lang="en">Chikungunya virus (CHIKV) is a recently re-emerged arbovirus that triggers autophagy. Here, we show that CHIKV interacts with components of the autophagy machinery during its replication cycle, inducing a cytoprotective effect. The autophagy receptor p62 protects cells from death by binding ubiquitinated capsid and targeting it to autophagolysosomes. By contrast, the human autophagy receptor NDP52--but not its mouse orthologue--interacts with the non-structural protein nsP2, thereby promoting viral replication. These results highlight the distinct roles of p62 and NDP52 in viral infection, and identify NDP52 as a cellular factor that accounts for CHIKV species specificity.</div>
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<Abstract><AbstractText>Chikungunya virus (CHIKV) is a recently re-emerged arbovirus that triggers autophagy. Here, we show that CHIKV interacts with components of the autophagy machinery during its replication cycle, inducing a cytoprotective effect. The autophagy receptor p62 protects cells from death by binding ubiquitinated capsid and targeting it to autophagolysosomes. By contrast, the human autophagy receptor NDP52--but not its mouse orthologue--interacts with the non-structural protein nsP2, thereby promoting viral replication. These results highlight the distinct roles of p62 and NDP52 in viral infection, and identify NDP52 as a cellular factor that accounts for CHIKV species specificity.</AbstractText>
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Species-specific impact of the autophagy machinery on Chikungunya virus infection.

Species-specific impact of the autophagy machinery on Chikungunya virus infection.

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