A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy.
Identifieur interne : 000D58 ( Main/Exploration ); précédent : 000D57; suivant : 000D59A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy.
Auteurs : Guowu Hu ; Travis Mcquiston ; Amélie Bernard ; Yoon-Dong Park ; Jin Qiu ; Ali Vural ; Nannan Zhang ; Scott R. Waterman ; Nathan H. Blewett [États-Unis] ; Timothy G. Myers ; Richard J. Maraia [États-Unis] ; John H. Kehrl ; Gulbu Uzel ; Daniel J. Klionsky ; Peter R. WilliamsonSource :
- Nature cell biology [ 1476-4679 ] ; 2015.
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN messager (métabolisme), Animaux (MeSH), Auto-immunité (génétique), Autophagie (génétique), Cellules HeLa (MeSH), Cellules cultivées (MeSH), Cryptococcus neoformans (génétique), Cryptococcus neoformans (métabolisme), DEAD-box RNA helicases (génétique), DEAD-box RNA helicases (métabolisme), Endoribonucleases (génétique), Endoribonucleases (métabolisme), Femelle (MeSH), Humains (MeSH), Immunotransfert (MeSH), Inflammasomes (génétique), Inflammasomes (métabolisme), Lignée cellulaire tumorale (MeSH), Mutation (MeSH), Phosphatidylinositol 3-kinase de classe Ia (génétique), Phosphatidylinositol 3-kinase de classe Ia (métabolisme), Phosphorylation (MeSH), Protein-Serine-Threonine Kinases (métabolisme), Protéines de Saccharomyces cerevisiae (génétique), Protéines de Saccharomyces cerevisiae (métabolisme), RT-PCR (MeSH), Régulation de l'expression des gènes fongiques (MeSH), Saccharomyces cerevisiae (génétique), Saccharomyces cerevisiae (métabolisme), Souris de lignée C57BL (MeSH), Stabilité de l'ARN (génétique).
- MESH :
- génétique : ARN messager, Auto-immunité, Autophagie, Cryptococcus neoformans, DEAD-box RNA helicases, Endoribonucleases, Inflammasomes, Phosphatidylinositol 3-kinase de classe Ia, Protéines de Saccharomyces cerevisiae, Saccharomyces cerevisiae, Stabilité de l'ARN.
- métabolisme : ARN messager, Cryptococcus neoformans, DEAD-box RNA helicases, Endoribonucleases, Inflammasomes, Phosphatidylinositol 3-kinase de classe Ia, Protein-Serine-Threonine Kinases, Protéines de Saccharomyces cerevisiae, Saccharomyces cerevisiae.
- Animaux, Cellules HeLa, Cellules cultivées, Femelle, Humains, Immunotransfert, Lignée cellulaire tumorale, Mutation, Phosphorylation, RT-PCR, Régulation de l'expression des gènes fongiques, Souris de lignée C57BL.
English descriptors
- KwdEn :
- Animals (MeSH), Autoimmunity (genetics), Autophagy (genetics), Cell Line, Tumor (MeSH), Cells, Cultured (MeSH), Class Ia Phosphatidylinositol 3-Kinase (genetics), Class Ia Phosphatidylinositol 3-Kinase (metabolism), Cryptococcus neoformans (genetics), Cryptococcus neoformans (metabolism), DEAD-box RNA Helicases (genetics), DEAD-box RNA Helicases (metabolism), Endoribonucleases (genetics), Endoribonucleases (metabolism), Female (MeSH), Gene Expression Regulation, Fungal (MeSH), HeLa Cells (MeSH), Humans (MeSH), Immunoblotting (MeSH), Inflammasomes (genetics), Inflammasomes (metabolism), Mice, Inbred C57BL (MeSH), Mutation (MeSH), Phosphorylation (MeSH), Protein-Serine-Threonine Kinases (metabolism), RNA Stability (genetics), RNA, Messenger (genetics), RNA, Messenger (metabolism), Reverse Transcriptase Polymerase Chain Reaction (MeSH), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism).
- MESH :
- chemical , genetics : Class Ia Phosphatidylinositol 3-Kinase, DEAD-box RNA Helicases, Endoribonucleases, Inflammasomes, RNA, Messenger, Saccharomyces cerevisiae Proteins.
- genetics : Autoimmunity, Autophagy, Cryptococcus neoformans, RNA Stability, Saccharomyces cerevisiae.
- chemical , metabolism : Class Ia Phosphatidylinositol 3-Kinase, Cryptococcus neoformans, DEAD-box RNA Helicases, Endoribonucleases, Inflammasomes, Protein-Serine-Threonine Kinases, RNA, Messenger, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins.
- Animals, Cell Line, Tumor, Cells, Cultured, Female, Gene Expression Regulation, Fungal, HeLa Cells, Humans, Immunoblotting, Mice, Inbred C57BL, Mutation, Phosphorylation, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Autophagy is an essential eukaryotic pathway requiring tight regulation to maintain homeostasis and preclude disease. Using yeast and mammalian cells, we report a conserved mechanism of autophagy regulation by RNA helicase RCK family members in association with the decapping enzyme Dcp2. Under nutrient-replete conditions, Dcp2 undergoes TOR-dependent phosphorylation and associates with RCK members to form a complex with autophagy-related (ATG) mRNA transcripts, leading to decapping, degradation and autophagy suppression. Simultaneous with the induction of ATG mRNA synthesis, starvation reverses the process, facilitating ATG mRNA accumulation and autophagy induction. This conserved post-transcriptional mechanism modulates fungal virulence and the mammalian inflammasome, the latter providing mechanistic insight into autoimmunity reported in a patient with a PIK3CD/p110δ gain-of-function mutation. We propose a dynamic model wherein RCK family members, in conjunction with Dcp2, function in controlling ATG mRNA stability to govern autophagy, which in turn modulates vital cellular processes affecting inflammation and microbial pathogenesis.
DOI: 10.1038/ncb3189
PubMed: 26098573
PubMed Central: PMC4528364
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy.</title>
<author><name sortKey="Hu, Guowu" sort="Hu, Guowu" uniqKey="Hu G" first="Guowu" last="Hu">Guowu Hu</name>
<affiliation><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mcquiston, Travis" sort="Mcquiston, Travis" uniqKey="Mcquiston T" first="Travis" last="Mcquiston">Travis Mcquiston</name>
<affiliation><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bernard, Amelie" sort="Bernard, Amelie" uniqKey="Bernard A" first="Amélie" last="Bernard">Amélie Bernard</name>
<affiliation><nlm:affiliation>Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA 48109.</nlm:affiliation>
<wicri:noCountry code="subField">USA 48109</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Park, Yoon Dong" sort="Park, Yoon Dong" uniqKey="Park Y" first="Yoon-Dong" last="Park">Yoon-Dong Park</name>
<affiliation><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Qiu, Jin" sort="Qiu, Jin" uniqKey="Qiu J" first="Jin" last="Qiu">Jin Qiu</name>
<affiliation><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Vural, Ali" sort="Vural, Ali" uniqKey="Vural A" first="Ali" last="Vural">Ali Vural</name>
<affiliation><nlm:affiliation>Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Zhang, Nannan" sort="Zhang, Nannan" uniqKey="Zhang N" first="Nannan" last="Zhang">Nannan Zhang</name>
<affiliation><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Waterman, Scott R" sort="Waterman, Scott R" uniqKey="Waterman S" first="Scott R" last="Waterman">Scott R. Waterman</name>
<affiliation><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Blewett, Nathan H" sort="Blewett, Nathan H" uniqKey="Blewett N" first="Nathan H" last="Blewett">Nathan H. Blewett</name>
<affiliation wicri:level="2"><nlm:affiliation>Intramural Research Program in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Intramural Research Program in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Myers, Timothy G" sort="Myers, Timothy G" uniqKey="Myers T" first="Timothy G" last="Myers">Timothy G. Myers</name>
<affiliation><nlm:affiliation>Genomic Technologies Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Maraia, Richard J" sort="Maraia, Richard J" uniqKey="Maraia R" first="Richard J" last="Maraia">Richard J. Maraia</name>
<affiliation wicri:level="2"><nlm:affiliation>Intramural Research Program in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Intramural Research Program in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kehrl, John H" sort="Kehrl, John H" uniqKey="Kehrl J" first="John H" last="Kehrl">John H. Kehrl</name>
<affiliation><nlm:affiliation>Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Uzel, Gulbu" sort="Uzel, Gulbu" uniqKey="Uzel G" first="Gulbu" last="Uzel">Gulbu Uzel</name>
<affiliation><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Klionsky, Daniel J" sort="Klionsky, Daniel J" uniqKey="Klionsky D" first="Daniel J" last="Klionsky">Daniel J. Klionsky</name>
<affiliation><nlm:affiliation>Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA 48109.</nlm:affiliation>
<wicri:noCountry code="subField">USA 48109</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Williamson, Peter R" sort="Williamson, Peter R" uniqKey="Williamson P" first="Peter R" last="Williamson">Peter R. Williamson</name>
<affiliation><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:26098573</idno>
<idno type="pmid">26098573</idno>
<idno type="doi">10.1038/ncb3189</idno>
<idno type="pmc">PMC4528364</idno>
<idno type="wicri:Area/Main/Corpus">000C34</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000C34</idno>
<idno type="wicri:Area/Main/Curation">000C34</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000C34</idno>
<idno type="wicri:Area/Main/Exploration">000C34</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy.</title>
<author><name sortKey="Hu, Guowu" sort="Hu, Guowu" uniqKey="Hu G" first="Guowu" last="Hu">Guowu Hu</name>
<affiliation><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mcquiston, Travis" sort="Mcquiston, Travis" uniqKey="Mcquiston T" first="Travis" last="Mcquiston">Travis Mcquiston</name>
<affiliation><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bernard, Amelie" sort="Bernard, Amelie" uniqKey="Bernard A" first="Amélie" last="Bernard">Amélie Bernard</name>
<affiliation><nlm:affiliation>Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA 48109.</nlm:affiliation>
<wicri:noCountry code="subField">USA 48109</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Park, Yoon Dong" sort="Park, Yoon Dong" uniqKey="Park Y" first="Yoon-Dong" last="Park">Yoon-Dong Park</name>
<affiliation><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Qiu, Jin" sort="Qiu, Jin" uniqKey="Qiu J" first="Jin" last="Qiu">Jin Qiu</name>
<affiliation><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Vural, Ali" sort="Vural, Ali" uniqKey="Vural A" first="Ali" last="Vural">Ali Vural</name>
<affiliation><nlm:affiliation>Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Zhang, Nannan" sort="Zhang, Nannan" uniqKey="Zhang N" first="Nannan" last="Zhang">Nannan Zhang</name>
<affiliation><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Waterman, Scott R" sort="Waterman, Scott R" uniqKey="Waterman S" first="Scott R" last="Waterman">Scott R. Waterman</name>
<affiliation><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Blewett, Nathan H" sort="Blewett, Nathan H" uniqKey="Blewett N" first="Nathan H" last="Blewett">Nathan H. Blewett</name>
<affiliation wicri:level="2"><nlm:affiliation>Intramural Research Program in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Intramural Research Program in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Myers, Timothy G" sort="Myers, Timothy G" uniqKey="Myers T" first="Timothy G" last="Myers">Timothy G. Myers</name>
<affiliation><nlm:affiliation>Genomic Technologies Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Maraia, Richard J" sort="Maraia, Richard J" uniqKey="Maraia R" first="Richard J" last="Maraia">Richard J. Maraia</name>
<affiliation wicri:level="2"><nlm:affiliation>Intramural Research Program in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Intramural Research Program in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kehrl, John H" sort="Kehrl, John H" uniqKey="Kehrl J" first="John H" last="Kehrl">John H. Kehrl</name>
<affiliation><nlm:affiliation>Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Uzel, Gulbu" sort="Uzel, Gulbu" uniqKey="Uzel G" first="Gulbu" last="Uzel">Gulbu Uzel</name>
<affiliation><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Klionsky, Daniel J" sort="Klionsky, Daniel J" uniqKey="Klionsky D" first="Daniel J" last="Klionsky">Daniel J. Klionsky</name>
<affiliation><nlm:affiliation>Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA 48109.</nlm:affiliation>
<wicri:noCountry code="subField">USA 48109</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Williamson, Peter R" sort="Williamson, Peter R" uniqKey="Williamson P" first="Peter R" last="Williamson">Peter R. Williamson</name>
<affiliation><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</nlm:affiliation>
<wicri:noCountry code="subField">20892</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature cell biology</title>
<idno type="eISSN">1476-4679</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Autoimmunity (genetics)</term>
<term>Autophagy (genetics)</term>
<term>Cell Line, Tumor (MeSH)</term>
<term>Cells, Cultured (MeSH)</term>
<term>Class Ia Phosphatidylinositol 3-Kinase (genetics)</term>
<term>Class Ia Phosphatidylinositol 3-Kinase (metabolism)</term>
<term>Cryptococcus neoformans (genetics)</term>
<term>Cryptococcus neoformans (metabolism)</term>
<term>DEAD-box RNA Helicases (genetics)</term>
<term>DEAD-box RNA Helicases (metabolism)</term>
<term>Endoribonucleases (genetics)</term>
<term>Endoribonucleases (metabolism)</term>
<term>Female (MeSH)</term>
<term>Gene Expression Regulation, Fungal (MeSH)</term>
<term>HeLa Cells (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunoblotting (MeSH)</term>
<term>Inflammasomes (genetics)</term>
<term>Inflammasomes (metabolism)</term>
<term>Mice, Inbred C57BL (MeSH)</term>
<term>Mutation (MeSH)</term>
<term>Phosphorylation (MeSH)</term>
<term>Protein-Serine-Threonine Kinases (metabolism)</term>
<term>RNA Stability (genetics)</term>
<term>RNA, Messenger (genetics)</term>
<term>RNA, Messenger (metabolism)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction (MeSH)</term>
<term>Saccharomyces cerevisiae (genetics)</term>
<term>Saccharomyces cerevisiae (metabolism)</term>
<term>Saccharomyces cerevisiae Proteins (genetics)</term>
<term>Saccharomyces cerevisiae Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term>
<term>ARN messager (métabolisme)</term>
<term>Animaux (MeSH)</term>
<term>Auto-immunité (génétique)</term>
<term>Autophagie (génétique)</term>
<term>Cellules HeLa (MeSH)</term>
<term>Cellules cultivées (MeSH)</term>
<term>Cryptococcus neoformans (génétique)</term>
<term>Cryptococcus neoformans (métabolisme)</term>
<term>DEAD-box RNA helicases (génétique)</term>
<term>DEAD-box RNA helicases (métabolisme)</term>
<term>Endoribonucleases (génétique)</term>
<term>Endoribonucleases (métabolisme)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Immunotransfert (MeSH)</term>
<term>Inflammasomes (génétique)</term>
<term>Inflammasomes (métabolisme)</term>
<term>Lignée cellulaire tumorale (MeSH)</term>
<term>Mutation (MeSH)</term>
<term>Phosphatidylinositol 3-kinase de classe Ia (génétique)</term>
<term>Phosphatidylinositol 3-kinase de classe Ia (métabolisme)</term>
<term>Phosphorylation (MeSH)</term>
<term>Protein-Serine-Threonine Kinases (métabolisme)</term>
<term>Protéines de Saccharomyces cerevisiae (génétique)</term>
<term>Protéines de Saccharomyces cerevisiae (métabolisme)</term>
<term>RT-PCR (MeSH)</term>
<term>Régulation de l'expression des gènes fongiques (MeSH)</term>
<term>Saccharomyces cerevisiae (génétique)</term>
<term>Saccharomyces cerevisiae (métabolisme)</term>
<term>Souris de lignée C57BL (MeSH)</term>
<term>Stabilité de l'ARN (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Class Ia Phosphatidylinositol 3-Kinase</term>
<term>DEAD-box RNA Helicases</term>
<term>Endoribonucleases</term>
<term>Inflammasomes</term>
<term>RNA, Messenger</term>
<term>Saccharomyces cerevisiae Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Autoimmunity</term>
<term>Autophagy</term>
<term>Cryptococcus neoformans</term>
<term>RNA Stability</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term>
<term>Auto-immunité</term>
<term>Autophagie</term>
<term>Cryptococcus neoformans</term>
<term>DEAD-box RNA helicases</term>
<term>Endoribonucleases</term>
<term>Inflammasomes</term>
<term>Phosphatidylinositol 3-kinase de classe Ia</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Saccharomyces cerevisiae</term>
<term>Stabilité de l'ARN</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Class Ia Phosphatidylinositol 3-Kinase</term>
<term>Cryptococcus neoformans</term>
<term>DEAD-box RNA Helicases</term>
<term>Endoribonucleases</term>
<term>Inflammasomes</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>RNA, Messenger</term>
<term>Saccharomyces cerevisiae</term>
<term>Saccharomyces cerevisiae Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term>
<term>Cryptococcus neoformans</term>
<term>DEAD-box RNA helicases</term>
<term>Endoribonucleases</term>
<term>Inflammasomes</term>
<term>Phosphatidylinositol 3-kinase de classe Ia</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line, Tumor</term>
<term>Cells, Cultured</term>
<term>Female</term>
<term>Gene Expression Regulation, Fungal</term>
<term>HeLa Cells</term>
<term>Humans</term>
<term>Immunoblotting</term>
<term>Mice, Inbred C57BL</term>
<term>Mutation</term>
<term>Phosphorylation</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules HeLa</term>
<term>Cellules cultivées</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunotransfert</term>
<term>Lignée cellulaire tumorale</term>
<term>Mutation</term>
<term>Phosphorylation</term>
<term>RT-PCR</term>
<term>Régulation de l'expression des gènes fongiques</term>
<term>Souris de lignée C57BL</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Autophagy is an essential eukaryotic pathway requiring tight regulation to maintain homeostasis and preclude disease. Using yeast and mammalian cells, we report a conserved mechanism of autophagy regulation by RNA helicase RCK family members in association with the decapping enzyme Dcp2. Under nutrient-replete conditions, Dcp2 undergoes TOR-dependent phosphorylation and associates with RCK members to form a complex with autophagy-related (ATG) mRNA transcripts, leading to decapping, degradation and autophagy suppression. Simultaneous with the induction of ATG mRNA synthesis, starvation reverses the process, facilitating ATG mRNA accumulation and autophagy induction. This conserved post-transcriptional mechanism modulates fungal virulence and the mammalian inflammasome, the latter providing mechanistic insight into autoimmunity reported in a patient with a PIK3CD/p110δ gain-of-function mutation. We propose a dynamic model wherein RCK family members, in conjunction with Dcp2, function in controlling ATG mRNA stability to govern autophagy, which in turn modulates vital cellular processes affecting inflammation and microbial pathogenesis. </div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26098573</PMID>
<DateCompleted><Year>2015</Year>
<Month>09</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>10</Month>
<Day>08</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-4679</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>17</Volume>
<Issue>7</Issue>
<PubDate><Year>2015</Year>
<Month>Jul</Month>
</PubDate>
</JournalIssue>
<Title>Nature cell biology</Title>
<ISOAbbreviation>Nat Cell Biol</ISOAbbreviation>
</Journal>
<ArticleTitle>A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy.</ArticleTitle>
<Pagination><MedlinePgn>930-942</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/ncb3189</ELocationID>
<Abstract><AbstractText>Autophagy is an essential eukaryotic pathway requiring tight regulation to maintain homeostasis and preclude disease. Using yeast and mammalian cells, we report a conserved mechanism of autophagy regulation by RNA helicase RCK family members in association with the decapping enzyme Dcp2. Under nutrient-replete conditions, Dcp2 undergoes TOR-dependent phosphorylation and associates with RCK members to form a complex with autophagy-related (ATG) mRNA transcripts, leading to decapping, degradation and autophagy suppression. Simultaneous with the induction of ATG mRNA synthesis, starvation reverses the process, facilitating ATG mRNA accumulation and autophagy induction. This conserved post-transcriptional mechanism modulates fungal virulence and the mammalian inflammasome, the latter providing mechanistic insight into autoimmunity reported in a patient with a PIK3CD/p110δ gain-of-function mutation. We propose a dynamic model wherein RCK family members, in conjunction with Dcp2, function in controlling ATG mRNA stability to govern autophagy, which in turn modulates vital cellular processes affecting inflammation and microbial pathogenesis. </AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Hu</LastName>
<ForeName>Guowu</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y" EqualContrib="Y"><LastName>McQuiston</LastName>
<ForeName>Travis</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y" EqualContrib="Y"><LastName>Bernard</LastName>
<ForeName>Amélie</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA 48109.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Yoon-Dong</ForeName>
<Initials>YD</Initials>
<AffiliationInfo><Affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Qiu</LastName>
<ForeName>Jin</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vural</LastName>
<ForeName>Ali</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Nannan</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Waterman</LastName>
<ForeName>Scott R</ForeName>
<Initials>SR</Initials>
<AffiliationInfo><Affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blewett</LastName>
<ForeName>Nathan H</ForeName>
<Initials>NH</Initials>
<AffiliationInfo><Affiliation>Intramural Research Program in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Myers</LastName>
<ForeName>Timothy G</ForeName>
<Initials>TG</Initials>
<AffiliationInfo><Affiliation>Genomic Technologies Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, MD, USA, 20892.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Maraia</LastName>
<ForeName>Richard J</ForeName>
<Initials>RJ</Initials>
<AffiliationInfo><Affiliation>Intramural Research Program in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kehrl</LastName>
<ForeName>John H</ForeName>
<Initials>JH</Initials>
<AffiliationInfo><Affiliation>Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Uzel</LastName>
<ForeName>Gulbu</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Klionsky</LastName>
<ForeName>Daniel J</ForeName>
<Initials>DJ</Initials>
<AffiliationInfo><Affiliation>Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA 48109.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Williamson</LastName>
<ForeName>Peter R</ForeName>
<Initials>PR</Initials>
<AffiliationInfo><Affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, 20892.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>ZIA AI001123-02</GrantID>
<Agency>Intramural NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>ZIA AI001124-03</GrantID>
<Agency>Intramural NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>GM088565</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>GM053396</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>Z99 AI999999</GrantID>
<Agency>Intramural NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>ZIA AI001123-01</GrantID>
<Agency>Intramural NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>ZIA AI001124-02</GrantID>
<Agency>Intramural NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 GM053396</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>ZIA AI001124-04</GrantID>
<Agency>Intramural NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>ZIA AI001123-03</GrantID>
<Agency>Intramural NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>ZIA AI001123-04</GrantID>
<Agency>Intramural NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>ZIA AI001124-05</GrantID>
<Agency>Intramural NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>ZIA AI001124-01</GrantID>
<Agency>Intramural NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>ZIA AI001123-05</GrantID>
<Agency>Intramural NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 GM088565</GrantID>
<Acronym>GM</Acronym>
<Agency>NIGMS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>06</Month>
<Day>22</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Nat Cell Biol</MedlineTA>
<NlmUniqueID>100890575</NlmUniqueID>
<ISSNLinking>1465-7392</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D058847">Inflammasomes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C030052">mRNA decapping enzymes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.137</RegistryNumber>
<NameOfSubstance UI="D058543">Class Ia Phosphatidylinositol 3-Kinase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D017346">Protein-Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="C500749">target of rapamycin protein, S cerevisiae</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.1.-</RegistryNumber>
<NameOfSubstance UI="C400572">DCP2 protein, S cerevisiae</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.1.-</RegistryNumber>
<NameOfSubstance UI="D004722">Endoribonucleases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.6.1.-</RegistryNumber>
<NameOfSubstance UI="C445083">DHH1 protein, S cerevisiae</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.6.4.13</RegistryNumber>
<NameOfSubstance UI="D053487">DEAD-box RNA Helicases</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Dev Cell. 2015 Jul 27;34(2):132-4</RefSource>
<PMID Version="1">26218319</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="CommentIn"><RefSource>Autophagy. 2015;11(12):2390-2</RefSource>
<PMID Version="1">26569496</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="CommentIn"><RefSource>Microb Cell. 2015 Jul 30;2(8):302-304</RefSource>
<PMID Version="1">28357306</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015551" MajorTopicYN="N">Autoimmunity</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058543" MajorTopicYN="N">Class Ia Phosphatidylinositol 3-Kinase</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003455" MajorTopicYN="N">Cryptococcus neoformans</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053487" MajorTopicYN="N">DEAD-box RNA Helicases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004722" MajorTopicYN="N">Endoribonucleases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015966" MajorTopicYN="N">Gene Expression Regulation, Fungal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006367" MajorTopicYN="N">HeLa Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015151" MajorTopicYN="N">Immunoblotting</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058847" MajorTopicYN="N">Inflammasomes</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017346" MajorTopicYN="N">Protein-Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020871" MajorTopicYN="N">RNA Stability</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year>
<Month>06</Month>
<Day>28</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2015</Year>
<Month>05</Month>
<Day>14</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2015</Year>
<Month>6</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2015</Year>
<Month>6</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2015</Year>
<Month>9</Month>
<Day>30</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">26098573</ArticleId>
<ArticleId IdType="doi">10.1038/ncb3189</ArticleId>
<ArticleId IdType="pmc">PMC4528364</ArticleId>
<ArticleId IdType="mid">NIHMS692013</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2896-901</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10077608</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 1999 Oct 1;18(19):5411-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10508173</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2004 Nov 5;306(5698):990-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15528435</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2005 Mar;115(3):632-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15765146</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>RNA. 2005 Apr;11(4):371-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15703442</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2010 Sep 10;39(5):773-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20832728</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2011 Jan 20;469(7330):323-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21248839</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>RNA. 2011 Mar;17(3):419-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21224379</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2011 Mar;39(4):1501-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20959291</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2011 Jun 10;332(6035):1317-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21659604</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2011 Jun 17;332(6036):1429-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21617040</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2012 Mar;13(3):255-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22286270</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2012 May 3;485(7396):109-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22552098</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2012 Jul 1;189(1):15-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22723639</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11206-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22733735</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12710-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22802624</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2012 Apr;8(4):445-544</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22966490</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2012 Oct;32(20):4181-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22890846</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Methods Mol Biol. 2013;968:71-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23296886</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):590-603</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23517755</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2013 Aug;1829(8):817-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23528737</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2013 Sep;41(17):8377-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23851565</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2014 Jan;15(1):88-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24165795</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Mol Cell Biol. 2014 Jan;15(1):65-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24326622</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Res. 2014 Jan;24(1):24-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24366339</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Biol. 2013;14(2):R13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23409723</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Immun. 2009 Sep;77(9):3749-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19564388</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Cell. 2000 Mar;11(3):833-48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10712503</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2000 May 9;97(10):5273-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10792032</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Genet. 2000 Jun;16(6):276-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10827456</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Immun. 2000 Jul;68(7):4225-37</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10858240</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Biol. 2000 Sep 18;150(6):1507-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10995454</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 2000 Nov 1;19(21):5720-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11060023</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2001 Mar 2;276(9):6463-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11096087</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Biol. 2002 Jun 18;3(7):RESEARCH0034</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12184808</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Microbiol. 2003 Feb;47(4):1007-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12581355</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2004;32(3):1037-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14960716</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proteomics. 2004 Jun;4(6):1633-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15174133</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2004 Aug 15;18(16):1926-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15314020</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 1985 Aug;76(2):757-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4031071</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 1993 Oct 25;333(1-2):169-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8224160</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 1996 Aug 1;184(2):377-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8760791</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14866-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10611304</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Bacteriol. 1997 Feb;179(4):1068-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9023185</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 1997 Sep 1;25(17):3389-402</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9254694</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eukaryot Cell. 2005 Aug;4(8):1420-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16087747</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2005 Sep 23;122(6):875-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16179257</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2006;34(10):3082-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16769775</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W362-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16845026</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Microbiol. 2006 Sep;61(5):1132-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16879414</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Mol Cell Biol. 2007 Feb;8(2):113-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17245413</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Protoc. 2007;2(2):383-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17406599</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Cell. 2007 May;19(5):1549-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17513503</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2007 Jul;35(Web Server issue):W588-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17517770</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Cell. 2007 Oct;18(10):4180-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17699586</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2008 Mar;118(3):1186-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18259613</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Biol. 2008 Oct 28;6(10):e255</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18959479</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Struct Mol Biol. 2008 Dec;15(12):1263-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19011635</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Methods Enzymol. 2009;452:165-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19200882</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>AIDS. 2009 Feb 20;23(4):525-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19182676</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>RNA. 2009 Jun;15(6):1110-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19369426</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2009 Aug 15;23(16):1929-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19684113</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Cell Biol. 2009 Oct;11(10):1225-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19767740</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Mol Biol. 2009;10:99</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19874630</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2010 Mar 19;140(6):821-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20303873</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2010 Apr 23;38(2):250-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20417603</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Biol. 2010 May 31;189(5):813-27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20513766</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Microbiology. 2010 Aug;156(Pt 8):2558-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20430817</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Maryland</li>
</region>
</list>
<tree><noCountry><name sortKey="Bernard, Amelie" sort="Bernard, Amelie" uniqKey="Bernard A" first="Amélie" last="Bernard">Amélie Bernard</name>
<name sortKey="Hu, Guowu" sort="Hu, Guowu" uniqKey="Hu G" first="Guowu" last="Hu">Guowu Hu</name>
<name sortKey="Kehrl, John H" sort="Kehrl, John H" uniqKey="Kehrl J" first="John H" last="Kehrl">John H. Kehrl</name>
<name sortKey="Klionsky, Daniel J" sort="Klionsky, Daniel J" uniqKey="Klionsky D" first="Daniel J" last="Klionsky">Daniel J. Klionsky</name>
<name sortKey="Mcquiston, Travis" sort="Mcquiston, Travis" uniqKey="Mcquiston T" first="Travis" last="Mcquiston">Travis Mcquiston</name>
<name sortKey="Myers, Timothy G" sort="Myers, Timothy G" uniqKey="Myers T" first="Timothy G" last="Myers">Timothy G. Myers</name>
<name sortKey="Park, Yoon Dong" sort="Park, Yoon Dong" uniqKey="Park Y" first="Yoon-Dong" last="Park">Yoon-Dong Park</name>
<name sortKey="Qiu, Jin" sort="Qiu, Jin" uniqKey="Qiu J" first="Jin" last="Qiu">Jin Qiu</name>
<name sortKey="Uzel, Gulbu" sort="Uzel, Gulbu" uniqKey="Uzel G" first="Gulbu" last="Uzel">Gulbu Uzel</name>
<name sortKey="Vural, Ali" sort="Vural, Ali" uniqKey="Vural A" first="Ali" last="Vural">Ali Vural</name>
<name sortKey="Waterman, Scott R" sort="Waterman, Scott R" uniqKey="Waterman S" first="Scott R" last="Waterman">Scott R. Waterman</name>
<name sortKey="Williamson, Peter R" sort="Williamson, Peter R" uniqKey="Williamson P" first="Peter R" last="Williamson">Peter R. Williamson</name>
<name sortKey="Zhang, Nannan" sort="Zhang, Nannan" uniqKey="Zhang N" first="Nannan" last="Zhang">Nannan Zhang</name>
</noCountry>
<country name="États-Unis"><region name="Maryland"><name sortKey="Blewett, Nathan H" sort="Blewett, Nathan H" uniqKey="Blewett N" first="Nathan H" last="Blewett">Nathan H. Blewett</name>
</region>
<name sortKey="Maraia, Richard J" sort="Maraia, Richard J" uniqKey="Maraia R" first="Richard J" last="Maraia">Richard J. Maraia</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D58 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000D58 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Bois |area= RapamycinFungusV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:26098573 |texte= A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26098573" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a RapamycinFungusV1
![]() | This area was generated with Dilib version V0.6.38. | ![]() |