Inositol-6 phosphate inhibits the mTOR pathway and induces autophagy-mediated death in HT-29 colon cancer cells.
Identifieur interne : 000571 ( Main/Exploration ); précédent : 000570; suivant : 000572Inositol-6 phosphate inhibits the mTOR pathway and induces autophagy-mediated death in HT-29 colon cancer cells.
Auteurs : Ashok Kumar Pandurangan [Malaisie] ; Salmiah Ismail [Malaisie] ; Norhaizan Mohd Esa [Malaisie] ; Murugan A. Munusamy [Arabie saoudite]Source :
- Archives of medical science : AMS [ 1734-1922 ] ; 2018.
Abstract
Introduction
Colorectal cancer (CRC) is common, with a worldwide incidence estimated at more than 1 million cases annually. Therefore, the search for agents for CRC treatment is highly warranted. Inositol-6 phosphate (IP
Material and methods
Autophagy was assessed by acridine orange (AO) staining, transmission electron microscopy, and western blotting to detect LC3-II and Beclin 1. Akt/mTOR signaling protein expression was also analyzed by western blotting. Apoptosis was analyzed by annexin V staining.
Results
Incubation of cells with IP
Conclusions
Our results clearly indicate that IP6 induces autophagy by inhibiting the Akt/mTOR pathway.
DOI: 10.5114/aoms.2018.76935
PubMed: 30393482
PubMed Central: PMC6209706
Affiliations:
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Munusamy</name><affiliation wicri:level="1"><nlm:affiliation>Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Botany and Microbiology, College of Science, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author></analytic><series><title level="j">Archives of medical science : AMS</title><idno type="ISSN">1734-1922</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Introduction</b></p><p>Colorectal cancer (CRC) is common, with a worldwide incidence estimated at more than 1 million cases annually. Therefore, the search for agents for CRC treatment is highly warranted. Inositol-6 phosphate (IP</p></div><div type="abstract" xml:lang="en"><p><b>Material and methods</b></p><p>Autophagy was assessed by acridine orange (AO) staining, transmission electron microscopy, and western blotting to detect LC3-II and Beclin 1. Akt/mTOR signaling protein expression was also analyzed by western blotting. Apoptosis was analyzed by annexin V staining.</p></div><div type="abstract" xml:lang="en"><p><b>Results</b></p><p>Incubation of cells with IP</p></div><div type="abstract" xml:lang="en"><p><b>Conclusions</b></p><p>Our results clearly indicate that IP6 induces autophagy by inhibiting the Akt/mTOR pathway.</p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">30393482</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1734-1922</ISSN><JournalIssue CitedMedium="Print"><Volume>14</Volume><Issue>6</Issue><PubDate><Year>2018</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Archives of medical science : AMS</Title><ISOAbbreviation>Arch Med Sci</ISOAbbreviation></Journal><ArticleTitle>Inositol-6 phosphate inhibits the mTOR pathway and induces autophagy-mediated death in HT-29 colon cancer cells.</ArticleTitle><Pagination><MedlinePgn>1281-1288</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.5114/aoms.2018.76935</ELocationID><Abstract><AbstractText Label="Introduction" NlmCategory="UNASSIGNED">Colorectal cancer (CRC) is common, with a worldwide incidence estimated at more than 1 million cases annually. Therefore, the search for agents for CRC treatment is highly warranted. Inositol-6 phosphate (IP<sub>6</sub>) is enriched in rice bran and possesses many beneficial effects. In the present study the effect of IP6 on autophagy-mediated death by modulating the mTOR pathway in HT-29 colon cancer cells was studied.</AbstractText><AbstractText Label="Material and methods" NlmCategory="UNASSIGNED">Autophagy was assessed by acridine orange (AO) staining, transmission electron microscopy, and western blotting to detect LC3-II and Beclin 1. Akt/mTOR signaling protein expression was also analyzed by western blotting. Apoptosis was analyzed by annexin V staining.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">Incubation of cells with IP<sub>6</sub> resulted in downregulation of the p-Akt at 3h. Along with that confocal microscopic analysis of p-AKT, IP<sub>6</sub> administration resulted that a diminished expression of p-Akt. mTOR pathway regulates autophagy and incubation with IP6 to HT-29 cells showed decreased expression of p-70S6Kinase, 4-EBP-1 in a time-dependent manner. Inositol-6 phosphate (10 μg/ml, 24 and 48 h) induced autophagic vesicles, as confirmed by AO staining and transmission electron microscopy. We also found increased expression of LC3-II and Beclin 1 in a time-dependent manner after incubation with IP<sub>6</sub>. Furthermore, IP<sub>6</sub> induced apoptosis, as revealed by annexin V staining.</AbstractText><AbstractText Label="Conclusions" NlmCategory="UNASSIGNED">Our results clearly indicate that IP6 induces autophagy by inhibiting the Akt/mTOR pathway.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pandurangan</LastName><ForeName>Ashok Kumar</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ismail</LastName><ForeName>Salmiah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Esa</LastName><ForeName>Norhaizan Mohd</ForeName><Initials>NM</Initials><AffiliationInfo><Affiliation>Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Munusamy</LastName><ForeName>Murugan A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>07</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>Poland</Country><MedlineTA>Arch Med Sci</MedlineTA><NlmUniqueID>101258257</NlmUniqueID><ISSNLinking>1734-1922</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">apoptosis</Keyword><Keyword MajorTopicYN="N">autophagy</Keyword><Keyword MajorTopicYN="N">colorectal cancer</Keyword><Keyword MajorTopicYN="N">inositol-6-phosphate</Keyword><Keyword MajorTopicYN="N">mammalian target of rapamycin</Keyword></KeywordList><CoiStatement>The authors declare no conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>01</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>01</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>11</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>11</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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last="Pandurangan">Ashok Kumar Pandurangan</name></noRegion><name sortKey="Esa, Norhaizan Mohd" sort="Esa, Norhaizan Mohd" uniqKey="Esa N" first="Norhaizan Mohd" last="Esa">Norhaizan Mohd Esa</name><name sortKey="Ismail, Salmiah" sort="Ismail, Salmiah" uniqKey="Ismail S" first="Salmiah" last="Ismail">Salmiah Ismail</name><name sortKey="Pandurangan, Ashok Kumar" sort="Pandurangan, Ashok Kumar" uniqKey="Pandurangan A" first="Ashok Kumar" last="Pandurangan">Ashok Kumar Pandurangan</name></country><country name="Arabie saoudite"><noRegion><name sortKey="Munusamy, Murugan A" sort="Munusamy, Murugan A" uniqKey="Munusamy M" first="Murugan A" last="Munusamy">Murugan A. 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